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1

Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay

Yan Li, David H. Chen, Jian Yan, Ying Chen, Roberta A. Mittelstaedt, Yongbin Zhang, Alexandru S. Biris, Robert H. Heflich, Tao Chen

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2012

Language:

english

File:

PDF, 461 KB

english, 2012

2

Molecular analysis of in vivo mutations induced by N-ethyl-N-nitrosourea in the autosomal Tk and the X-linked Hprt genes of mouse lymphocytes

Vasily N. Dobrovolsky, Tao Chen, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1999

Language:

english

File:

PDF, 146 KB

english, 1999

3

Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea – comparison with other in vivo genotoxicity endpoints

Zoryana Cammerer, Javed A. Bhalli, Xuefei Cao, Stephanie L. Coffing, Donna Dickinson, Krista L. Dobo, Vasily N. Dobrovolsky, Maria Engel, Ronald D. Fiedler, William C. Gunther, Robert H. Heflich, Maso

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 1.01 MB

english, 2011

4

In vivo assessment of Pig-a gene mutation—recent developments and assay validation

Stephen D. Dertinger, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 58 KB

english, 2011

5

A comparison of the toxic and SCE-inducing effects of inhibitors of ADP-ribosyl transferase in Chinese hamster ovary cells

S.M. Morris, R.H. Heflich

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1984

Language:

english

File:

PDF, 668 KB

english, 1984

6

Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests: II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test

D.J. Tweats, D. Blakey, R.H. Heflich, A. Jacobs, S.D. Jacobsen, T. Morita, T. Nohmi, M.R. O’Donovan, Y.F. Sasaki, T. Sofuni, R. Tice

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 321 KB

english, 2007

7

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup

Gollapudi, B. Bhaskar, Lynch, Anthony M., Heflich, Robert H., Dertinger, Stephen D., Dobrovolsky, Vasily N., Froetschl, Roland, Horibata, Katsuyoshi, Kenyon, Michelle O., Kimoto, Takafumi, Lovell, Dav

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2015

Language:

english

File:

PDF, 846 KB

english, 2015

8

Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide

De-Jin Zhan, Robert H. Heflich, Peter P. Fu

Journal:

Environmental and Molecular Mutagenesis

Year:

1996

Language:

english

File:

PDF, 1.00 MB

english, 1996

9

DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene

Robert H. Heflich, Roberta A. Mittelstaedt, Mugimane G. Manjanatha, Lascelles E. Lyn-Cook, Anane Aidoo

Journal:

Environmental and Molecular Mutagenesis

Year:

1996

Language:

english

File:

PDF, 799 KB

english, 1996

10

Other transgenic mutation assays: Development of a novel mouse tk+/− embryonic stem cell line for use in mutagenicity studies

Vasily N. Dobrovolsky, Daniel A. Casciano, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1996

Language:

english

File:

PDF, 663 KB

english, 1996

11

Molecular characterization of hprt mutations from chinese hamster ovary cells treated with 1-, 3-, and 6-Nitrosobenz[a]pyrene

De-Jin Zhan, Li-Hsueh Chiu, Robert H. Heflich, Peter P. Fu

Journal:

Environmental and Molecular Mutagenesis

Year:

1998

Language:

english

File:

PDF, 93 KB

english, 1998

12

Expansion of rat 6-thioguanine-resistant T-lymphocyte clones by stimulation with ionomycin and a phorbol ester

Tao Chen, Anane Aidoo, Daniel A. Casciano, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1998

Language:

english

File:

PDF, 137 KB

english, 1998

13

Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue® rats

Roberta A. Mittelstaedt, Mugimane G. Manjanatha, Sharon D. Shelton, Lascelles E. Lyn-Cook, James B. Chen, Anane Aidoo, Daniel A. Casciano, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1998

Language:

english

File:

PDF, 141 KB

english, 1998

14

Mutational response at the splenic T-Lymphocyte hprt locus in mice treated as neonates: Contrasting effects of the carcinogens N-ethyl-N-nitrosourea, dimethylnitrosamine, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

S. Balachandra Dass, Robert H. Heflich, Daniel A. Casciano

Journal:

Environmental and Molecular Mutagenesis

Year:

1998

Language:

english

File:

PDF, 138 KB

english, 1998

15

Sensitivity of the ΦX174 am3 allele in relation to the endogenous Hprt gene for detecting mutation in transgenic mice

James B. Chen, S. Balachandra Dass, James G. Burkhart, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1998

Language:

english

File:

PDF, 159 KB

english, 1998

16

Detection of basepair substitution mutation at a frequency of 1 × 10−7 by combining two genotypic selection methods, MutEx enrichment and allele-specific competitive blocker PCR

Barbara L. Parsons, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1998

Language:

english

File:

PDF, 361 KB

english, 1998

17

7,12-dimethylbenz[a]anthracene-induced mutation in the Tk gene of Tk+/− mice: Automated scoring of lymphocyte clones using a fluorescent viability indicator

Vasily N. Dobrovolsky, Joseph G. Shaddock, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2000

Language:

english

File:

PDF, 194 KB

english, 2000

18

A Response-Additive Model for Analyzing Mixtures of Two Chemicals in the Salmonella Reversion Assay

Dr. James J. Chen, Robert H. Heflich, Bruce S. Hass

Journal:

Biometrical Journal

Year:

1989

Language:

english

File:

PDF, 524 KB

english, 1989

19

On the use of the T-REx™ tetracycline-inducible gene expression system in vivo

Vasily N. Dobrovolsky, Robert H. Heflich

Journal:

Biotechnology and Bioengineering

Year:

2007

Language:

english

File:

PDF, 223 KB

english, 2007

20

Editorial

Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2002

Language:

english

File:

PDF, 37 KB

english, 2002

21

Mutagenicity of γ-radiation, mitomycin C, and etoposide in the Hprt and Tk genes of Tk+/− mice

Vasily N. Dobrovolsky, Joseph G. Shaddock, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2002

Language:

english

File:

PDF, 117 KB

english, 2002

22

Editorial

Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2002

Language:

english

File:

PDF, 34 KB

english, 2002

23

The Journal celebrates an anniversary

Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2004

Language:

english

File:

PDF, 31 KB

english, 2004

24

Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene–treated Big Blue® rats

Tao Chen, Roberta A. Mittelstaedt, Anane Aidoo, L. Patrice Hamilton, Frederick A. Beland, Daniel A. Casciano, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2001

Language:

english

File:

PDF, 115 KB

english, 2001

25

Gene- and tissue-specificity of mutation in Big Blue® rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene

Tao Chen, Roberta A. Mittelstaedt, Sharon D. Shelton, S. Balachandra Dass, Mugimane G. Manjanatha, Daniel A. Casciano, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2001

Language:

english

File:

PDF, 102 KB

english, 2001

26

Special section: The 25th anniversary of Environmental and Molecular Mutagenesis

Suzanne M. Morris, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2004

Language:

english

File:

PDF, 33 KB

english, 2004

27

Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine

Linda S. Von Tungeln, Lee D. Williams, Daniel R. Doerge, Joseph G. Shaddock, Lynda J. McGarrity, Suzanne M. Morris, Roberta A. Mittelstaedt, Robert H. Heflich, Frederick A. Beland

Journal:

Environmental and Molecular Mutagenesis

Year:

2007

Language:

english

File:

PDF, 194 KB

english, 2007

28

Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC

Vasily N. Dobrovolsky, Joseph G. Shaddock, Roberta A. Mittelstaedt, Michelle E. Bishop, Sherry M. Lewis, Fei W. Lee, Anane Aidoo, Julian E.A. Leakey, June K. Dunnick, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2007

Language:

english

File:

PDF, 281 KB

english, 2007

29

Effect of chronic azathioprine treatment on germ-line transmission of Hprt mutation in mice

Sachin V. Bendre, Joseph G. Shaddock, Vasily N. Dobrovolsky, Richard J. Albertini, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2007

Language:

english

File:

PDF, 294 KB

english, 2007

30

Development of an in vivo gene mutation assay using the endogenous Pig-A gene: II. Selection of Pig-A mutant rat spleen T-cells with proaerolysin and sequencing Pig-A cDNA from the mutants

Daishiro Miura, Vasily N. Dobrovolsky, Roberta A. Mittelstaedt, Yoshinori Kasahara, Yasuhiro Katsuura, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2008

Language:

english

File:

PDF, 365 KB

english, 2008

31

Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat

Daishiro Miura, Vasily N. Dobrovolsky, Yoshinori Kasahara, Yasuhiro Katsuura, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2008

Language:

english

File:

PDF, 351 KB

english, 2008

32

Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice

Tao Chen, Robert H. Heflich, Martha M. Moore, Nan Mei

Journal:

Environmental and Molecular Mutagenesis

Year:

2010

Language:

english

File:

PDF, 121 KB

english, 2010

33

Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats

Vasily N. Dobrovolsky, Sherin Y. Boctor, Nathan C. Twaddle, Daniel R. Doerge, Michelle E. Bishop, Mugimane G. Manjanatha, Takafumi Kimoto, Daishiro Miura, Robert H. Heflich, Sherry A. Ferguson

Journal:

Environmental and Molecular Mutagenesis

Year:

2010

Language:

english

File:

PDF, 443 KB

english, 2010

34

The in vivo pig-a gene mutation assay, a potential tool for regulatory safety assessment

Vasily N. Dobrovolsky, Daishiro Miura, Robert H. Heflich, Stephen D. Dertinger

Journal:

Environmental and Molecular Mutagenesis

Year:

2010

Language:

english

File:

PDF, 608 KB

english, 2010

35

The 40th anniversary of the Environmental Mutagen Society

Suzanne M. Morris, Anane Aidoo, Vasily Dobrovolsky, Robert Heflich, Mugimane Manjanatha, Page McKinzie, Barbara Parsons

Journal:

Environmental and Molecular Mutagenesis

Year:

2010

Language:

english

File:

PDF, 29 KB

english, 2010

36

Analysis of mutations in the Pig-a gene of spleen T-cells from N-ethyl-N-nitrosourea-treated fisher 344 rats

Daishiro Miura, Joseph G. Shaddock, Roberta A. Mittelstaedt, Vasily N. Dobrovolsky, Takafumi Kimoto, Yoshinori Kasahara, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 92 KB

english, 2011

37

Report on stage III Pig-a mutation assays using benzo[a]pyrene

Javed A. Bhalli, Joseph G. Shaddock, Mason G. Pearce, Vasily N. Dobrovolsky, Xuefei Cao, Robert H. Heflich, Hans-Werner Vohr

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 434 KB

english, 2011

38

Monitoring humans for somatic mutation in the endogenous pig-a gene using red blood cells

Vasily N. Dobrovolsky, Rosalie K. Elespuru, C. Anita H. Bigger, Timothy W. Robison, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 1.07 MB

english, 2011

39

Further development of the rat Pig-a mutation assay: Measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes

Takafumi Kimoto, Satsuki Chikura, Kumiko Suzuki, Xiao mei Kobayashi, Yasuhiro Itano, Katsuyoshi Horibata, Masamitsu Honma, Vasily N. Dobrovolsky, Robert H. Heflich, Daishiro Miura, Yoshinori Kasahara

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 834 KB

english, 2011

40

Manifestation and persistence of Pig-a mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea

Javed A. Bhalli, Mason G. Pearce, Vasily N. Dobrovolsky, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 696 KB

english, 2011

41

Metabolism of 2-acetylaminofluorene in the chinese hamster ovary cell mutation assay

Dr. Robert H. Heflich, Daniel A. Casciano, Dr. Zhou Zhuo, Dr. Zora Djurić, Nancy F. Fullerton, Frederick A. Beland

Journal:

Environmental and Molecular Mutagenesis

Year:

1988

Language:

english

File:

PDF, 948 KB

english, 1988

42

Role of nitroreduction in the synergistic mutational response induced by mixtures of 1- and 3- nitrobenzo[a]pyrene in Salmonella typhimurium

Janice R. Thornton-Manning, Warren L. Campbell, Bruce S. Hass, James J. Chen, Peter P. Fu, Carl E. Cerniglia, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1989

Language:

english

File:

PDF, 686 KB

english, 1989

43

Pretreatment with mixed-function oxidase inducers increases the sensitivity of the hepatocyte/DNA repair assay

J. G. Shaddock, R. H. Heflich, D. C. McMillan, J. A. Hinson, D. A. Casciano

Journal:

Environmental and Molecular Mutagenesis

Year:

1989

Language:

english

File:

PDF, 752 KB

english, 1989

44

Induction of 6-thioguanine-resistant lymphocytes in fischer 344 rats following in vivo exposure to n-ethyl-n-nitrosourea and cyclophosphamide

Anane Aidoo, Lascelles E. Lyn-Cook, Roberta A. Mittelstaedt, Robert H. Heflich, Daniel A. Casciano, J. Cole

Journal:

Environmental and Molecular Mutagenesis

Year:

1991

Language:

english

File:

PDF, 1.76 MB

english, 1991

45

Nitro group orientation, reduction potential, and direct-acting mutagenicity of nitro-polycyclic aromatic hydrocarbons

Hyewook Jung, Robert H. Heflich, Peter P. Fu, Ali U. Shaikh, P. E. Hartman

Journal:

Environmental and Molecular Mutagenesis

Year:

1991

Language:

english

File:

PDF, 1013 KB

english, 1991

46

Analysis of solvent control and 1-Nitrosopyrene-induced chinese hamster ovary cell mutants by southern and northern blots and the polymerase chain reaction

Ronald K. Newton, Roberta A. Mittelstaedt, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1992

Language:

english

File:

PDF, 1.26 MB

english, 1992

47

Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of chinese hamster ovary cells

Carrie R. Valentine, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1995

Language:

english

File:

PDF, 1023 KB

english, 1995

48

Analysis of in vivo mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes

Roberta A. Mittelstaedt, Beverly A. Smith, Robert H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1995

Language:

english

File:

PDF, 819 KB

english, 1995

49

Effect of bacterial concentration on reversions induced in salmonella typhimurium TA1538 by N-hydroxy-2-acetylaminofluorene

G. L. White, D. T. Beranek, R. H. Heflich

Journal:

Environmental and Molecular Mutagenesis

Year:

1983

Language:

english

File:

PDF, 618 KB

english, 1983

50

Comparison of mutagenicities in a salmonella reversion assay mediated by uninduced hepatocytes and hepatocytes from rats pretreated for 1 or 5 days with aroclor 1254

B. S. Hass, R. H. Heflich, J. G. Shaddock, D. A. Casciano

Journal:

Environmental and Molecular Mutagenesis

Year:

1985

Language:

english

File:

PDF, 814 KB

english, 1985