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1

The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression

Ji Hoon Yu, Bing-Mei Zhu, Mark Wickre, Gregory Riedlinger, Weiping Chen, Atsushi Hosui, Gertraud W. Robinson, Lothar Hennighausen

Journal:

Year:

2010

Language:

english

File:

PDF, 841 KB

english, 2010

2

Bak deficiency inhibits liver carcinogenesis: A causal link between apoptosis and carcinogenesis

Hayato Hikita, Takahiro Kodama, Satoshi Shimizu, Wei Li, Minoru Shigekawa, Satoshi Tanaka, Atsushi Hosui, Takuya Miyagi, Tomohide Tatsumi, Tatsuya Kanto, Naoki Hiramatsu, Eiichi Morii, Norio Hayashi,

Journal:

Journal of Hepatology

Year:

2012

Language:

english

File:

PDF, 1.91 MB

english, 2012

3

Sorafenib inhibits the shedding of major histocompatibility complex class I–related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9

Keisuke Kohga, Tetsuo Takehara, Tomohide Tatsumi, Hisashi Ishida, Takuya Miyagi, Atsushi Hosui, Norio Hayashi

Journal:

Year:

2010

Language:

english

File:

PDF, 815 KB

english, 2010

4

The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice

Aketa, Hiroshi, Tatsumi, Tomohide, Kohga, Keisuke, Tsunematsu, Hinako, Aono, Satoshi, Shimizu, Satoshi, Kodama, Takahiro, Nawa, Takatoshi, Shigekawa, Minoru, Hikita, Hayato, Sakamori, Ryotaro, Hosui,

Journal:

International Journal of Cancer

Year:

2013

Language:

english

File:

PDF, 541 KB

english, 2013

5

STAT5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression

Hosui, Atsushi, Tatsumi, Tomohide, Hikita, Hayato, Saito, Yoshinobu, Hiramatsu, Naoki, Tsujii, Masahiko, Hennighausen, Lothar, Takehara, Tetsuo

Journal:

Hepatology Research

Year:

2016

Language:

english

File:

PDF, 650 KB

english, 2016

6

Effects of Zinc Acetate on Serum Zinc Concentrations in Chronic Liver Diseases: a Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial and a Dose Adjustment Trial

Katayama, Kazuhiro, Hosui, Atsushi, Sakai, Yoshiyuki, Itou, Minoru, Matsuzaki, Yasushi, Takamori, Yoriyuki, Hosho, Keiko, Tsuru, Tomomi, Takikawa, Yasuhiro, Michitaka, Kojiro, Ogawa, Eishin, Miyoshi,

Journal:

Biological Trace Element Research

Year:

2019

Language:

english

File:

PDF, 598 KB

english, 2019

7

Delayed-onset caspase-dependent massive hepatocyte apoptosis upon fas activation in bak/bax-deficient mice

Hayato Hikita, Tetsuo Takehara, Takahiro Kodama, Satoshi Shimizu, Minoru Shigekawa, Atsushi Hosui, Takuya Miyagi, Tomohide Tatsumi, Hisashi Ishida, Wei Li, Tatsuya Kanto, Naoki Hiramatsu, Shigeomi Shi

Journal:

Year:

2011

Language:

english

File:

PDF, 1.09 MB

english, 2011

8

Amino acid substitution in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated with peginterferon and ribavirin

Yuko Inoue, Naoki Hiramatsu, Tsugiko Oze, Takayuki Yakushijin, Kiyoshi Mochizuki, Kazuto Fukuda, Eiji Mita, Yoshimichi Haruna, Atsuo Inoue, Yasuharu Imai, Atsushi Hosui, Takuya Miyagi, Yuichi Yoshida,

Journal:

Journal of Medical Virology

Year:

2011

Language:

english

File:

PDF, 347 KB

english, 2011

9

A NEW STROBOSCOPE

Hosui, M., Kirikae, I., Watanabe, S.

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1950

File:

PDF, 38 KB

1950

10

Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma

Keisuke Kohga, Tomohide Tatsumi, Hinako Tsunematsu, Satoshi Aono, Satoshi Shimizu, Takahiro Kodama, Hayato Hikita, Masashi Yamamoto, Tsugiko Oze, Hiroshi Aketa, Atsushi Hosui, Takuya Miyagi, Hisashi I

Journal:

Cancer Immunology, Immunotherapy

Year:

2012

Language:

english

File:

PDF, 425 KB

english, 2012

11

Changes in gene expression profile by HCV core protein in cultured liver cells: analysis by DNA array assay

Kazuyoshi Ohkawa, Hisashi Ishida, Fumihiko Nakanishi, Atsushi Hosui, Aki Sato, Keiji Ueda, Tetsuo Takehara, Akinori Kasahara, Yutaka Sasaki, Masatsugu Hori, Norio Hayashi

Journal:

Hepatology Research

Year:

2003

Language:

english

File:

PDF, 370 KB

english, 2003

12

CHEMOTHERAPY IN CHRONIC SINUSITI

OSAWA, R., HOSUI, M., HIGUTI, T., AKAIKE, K., OTSUKA, R., SAKAI, Y., NAKAMURA, Y.

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1951

File:

PDF, 656 KB

1951

13

Influence of increased physical activity without body weight loss on hepatic inflammation in patients with nonalcoholic fatty liver disease

Asada, Fuminari, Nomura, Takuo, Hosui, Atsushi, Kubota, Masashi

Journal:

Environmental Health and Preventive Medicine

Year:

2020

File:

PDF, 636 KB

2020

14

Interferon-α suppresses hepatitis B virus enhancer II activity via the protein kinase C pathway

Takatoshi Nawa, Hisashi Ishida, Tomohide Tatsumi, Wei Li, Satoshi Shimizu, Takahiro Kodama, Hayato Hikita, Atsushi Hosui, Takuya Miyagi, Tatsuya Kanto, Naoki Hiramatsu, Norio Hayashi, Tetsuo Takehara

Journal:

Year:

2012

Language:

english

File:

PDF, 844 KB

english, 2012

15

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages

Kodama, T, Hikita, H, Kawaguchi, T, Shigekawa, M, Shimizu, S, Hayashi, Y, Li, W, Miyagi, T, Hosui, A, Tatsumi, T, Kanto, T, Hiramatsu, N, Kiyomizu, K, Tadokoro, S, Tomiyama, Y, Hayashi, N, Takehara, T

Journal:

Cell Death & Differentiation

Year:

2012

Language:

english

File:

PDF, 1.14 MB

english, 2012

16

Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection

Mika Kurokawa, Naoki Hiramatsu, Tsugiko Oze, Takayuki Yakushijin, Masanori Miyazaki, Atsushi Hosui, Takuya Miyagi, Yuichi Yoshida, Hisashi Ishida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akino

Journal:

Journal of Gastroenterology

Year:

2012

Language:

english

File:

PDF, 225 KB

english, 2012

17

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF- and STAT3 activation

Hosui, A., Kimura, A., Yamaji, D., Zhu, B.-m., Na, R., Hennighausen, L.

Journal:

Journal of Experimental Medicine

Year:

2009

Language:

english

File:

PDF, 8.02 MB

english, 2009

18

REPORT ON A CASE OF ZENKER'S HYPOPHARYNX DIVERTICLE AND ITS TREATMENT

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1962

File:

PDF, 2.63 MB

1962

19

CHEMOTHERAPY IN CHRONIC SINUSITI

OSAWA, R., HOSUI, M., HIGUTI, T., AKAIKE, K., OTSUKA, R., SAKAI, Y., NAKAMURA, Y.

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1950

File:

PDF, 607 KB

1950

20

Thrombocytopenia Exacerbates Cholestasis-Induced Liver Fibrosis in Mice

Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, Satoshi Shimizu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Seiji Tadokoro, Akio Ido, Hirohito Tsubouchi, Norio Hayashi

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 3.93 MB

english, 2010

21

A NEW STROBOSCOP

HOSUI, M., KIRIKAE, I., WATANABE, S.

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1950

File:

PDF, 709 KB

1950

22

Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

Hayato Hikita, Tetsuo Takehara, Satoshi Shimizu, Takahiro Kodama, Wei Li, Takuya Miyagi, Atsushi Hosui, Hisashi Ishida, Kazuyoshi Ohkawa, Tatsuya Kanto, Naoki Hiramatsu, Xiao-Ming Yin, Lothar Hennigha

Journal:

Year:

2009

Language:

english

File:

PDF, 1.78 MB

english, 2009

23

The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

Satoshi Shimizu, Tetsuo Takehara, Hayato Hikita, Takahiro Kodama, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Takehiro Noda, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Norio Hayas

Journal:

Journal of Hepatology

Year:

2010

Language:

english

File:

PDF, 935 KB

english, 2010

24

Su1586 The Impact of Interferon Therapy for Chronic Hepatitis C on Methylation Status in the Liver

Shimizu, Satoshi, Oze, Tsugiko, Shigekawa, Minoru, Kodama, Takahiro, Hikita, Hayato, Miyagi, Takuya, Hosui, Atsushi, Yoshihara, Harumasa, Tatsumi, Tomohide, Takehara, Tetsuo

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 72 KB

english, 2012

25

Hepatitis C Virus Core Protein Differently Regulates the JAK-STAT Signaling Pathway under Interleukin-6 and Interferon- Stimuli

Hosui, A., Ohkawa, K., Ishida, H., Sato, A., Nakanishi, F., Ueda, K., Takehara, T., Kasahara, A., Sasaki, Y., Hori, M., Hayashi, N.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 875 KB

english, 2003

26

CHEMOTHERAPY IN CHRONIC SINUSITIS

OSAWA, R., HOSUI, M., HIGUTI, T., AKAIKE, K., OTSUKA, R., SAKAI, Y., NAKAMURA, Y.

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1951

File:

PDF, 386 KB

1951

27

VOCAL CORD ADHESION AFTER INTUBATION

NISHIYAMA, AKIO, BONO, KEIJI, HOSUI, MASAFUMI, ISHIHARA, YU, WATANABE, TEIKICHI

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1976

Language:

english

File:

PDF, 1.80 MB

english, 1976

28

α-Fetoprotein impairs activation of natural killer cells by inhibiting the function of dendritic cells

M. Yamamoto, T. Tatsumi, T. Miyagi, H. Tsunematsu, H. Aketa, A. Hosui, T. Kanto, N. Hiramatsu, N. Hayashi, T. Takehara

Journal:

Clinical & Experimental Immunology

Year:

2011

Language:

english

File:

PDF, 753 KB

english, 2011

29

80 Pancreatic STAT3 Protects Caerulein-Induced Acute Pancreatitis in Mice via the PAP1 Induction

Minoru Shigekawa, Hayato Hikita, Tomohide Tatsumi, Takahiro Kodama, Satoshi Shimizu, Takuya Miyagi, Atsushi Hosui, Tatsuya Kanto, Naoki Hiramatsu, Tetsuo Takehara

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 66 KB

english, 2012

30

Loss of Sexually Dimorphic Liver Gene Expression upon Hepatocyte-Specific Deletion of Stat5a-Stat5b Locus

Holloway, Minita G., Cui, Yongzhi, Laz, Ekaterina V., Hosui, Atsushi, Hennighausen, Lothar, Waxman, David J.

Journal:

Year:

2007

Language:

english

File:

PDF, 481 KB

english, 2007

31

STROBOSCOPIC AND STROBOCINEMATOGRAPHIC STUDY OF LARYNGEAL DISORDER

KIRIKAE, I., HOSUI, M.

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1951

Language:

english

File:

PDF, 68 KB

english, 1951

32

Fibroblast growth factor-2 enhances NK sensitivity of hepatocellular carcinoma cells

Hinako Tsunematsu, Tomohide Tatsumi, Keisuke Kohga, Masashi Yamamoto, Hiroshi Aketa, Takuya Miyagi, Atsushi Hosui, Naoki Hiramatsu, Tatsuya Kanto, Norio Hayashi, Tetsuo Takehara

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 948 KB

english, 2012

33

Pancreatic STAT3 Protects Mice against Caerulein-Induced Pancreatitis via PAP1 Induction

Shigekawa, Minoru, Hikita, Hayato, Kodama, Takahiro, Shimizu, Satoshi, Li, Wei, Uemura, Akio, Miyagi, Takuya, Hosui, Atsushi, Kanto, Tatsuya, Hiramatsu, Naoki, Tatsumi, Tomohide, Takeda, Kiyoshi, Akir

Journal:

The American Journal of Pathology

Year:

2012

Language:

english

File:

PDF, 2.89 MB

english, 2012

34

Identification of Multiple Transcription Factors, HLF, FTF, and E4BP4, Controlling Hepatitis B Virus Enhancer II

Ishida, H., Ueda, K., Ohkawa, K., Kanazawa, Y., Hosui, A., Nakanishi, F., Mita, E., Kasahara, A., Sasaki, Y., Hori, M., Hayashi, N.

Journal:

Journal of Virology

Year:

2000

Language:

english

File:

PDF, 548 KB

english, 2000

35

Suppression of signal transducers and activators of transcription 1 in hepatocellular carcinoma is associated with tumor progression

Atsushi Hosui, Peter Klover, Tomohide Tatsumi, Akio Uemura, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, Naoki Hiramatsu, Tatsuya Kanto, Lothar Hennighausen, Norio Hayashi, Tetsuo Takehara

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

36

Su1070 Features of Upper Gastrointestinal Abnormalities in Non-Alcoholic Steatohepatitis (NASH) Patients

Yamamoto, Shunsuke, Komori, Masato, Sato, Masako, Okahara, Toru, Suzuki, Mana, Nakamura, Masashi, Sueyoshi, Hironari, Yoshii, Shunsuke, Arimoto, Yuki, Hirao, Motohiro, Hosui, Atsushi, Yoshihara, Harum

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 48 KB

english, 2013

37

Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma

Hosui, Atsushi, Kimura, Eiji, Abe, Sumiko, Tanimoto, Takashi, Onishi, Kousaku, Kusumoto, Yukihiro, Sueyoshi, Yuka, Matsumoto, Kengo, Hirao, Motohiro, Yamada, Takuya, Hiramatsu, Naoki

Journal:

Year:

2018

Language:

english

File:

PDF, 3.02 MB

english, 2018

38

The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib

Hayato Hikita, Tetsuo Takehara, Satoshi Shimizu, Takahiro Kodama, Minoru Shigekawa, Kyoko Iwase, Atsushi Hosui, Takuya Miyagi, Tomohide Tatsumi, Hisashi Ishida, Wei Li, Tatsuya Kanto, Naoki Hiramatsu,

Journal:

Year:

2010

Language:

english

File:

PDF, 703 KB

english, 2010

39

Treatment of Aphthous Stomatitis

Osawa, Rinnosuke, Hosui, Masafumi

Journal:

Practica Oto-Rhino-Laryngologica

Year:

1973

File:

PDF, 263 KB

1973

40

BH3-only protein bid participates in the Bcl-2 network in healthy liver cells

Hayato Hikita, Tetsuo Takehara, Takahiro Kodama, Satoshi Shimizu, Atsushi Hosui, Takuya Miyagi, Tomohide Tatsumi, Hisashi Ishida, Kazuyoshi Ohkawa, Wei Li, Tatsuya Kanto, Naoki Hiramatsu, Lothar Henni

Journal:

Year:

2009

Language:

english

File:

PDF, 2.02 MB

english, 2009

41

Involvement of p38 signaling pathway in interferon-α-mediated antiviral activity toward hepatitis C virus

Hisashi Ishida, Kazuyoshi Ohkawa, Atsushi Hosui, Naoki Hiramatsu, Tatsuya Kanto, Keiji Ueda, Tetsuo Takehara, Norio Hayashi

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 423 KB

english, 2004

42

A CASE OF NEURILEMMOMA ARISING PRIMARY IN THE LARYNX

HOSUI, MASAFUMI, SAKABE, NAGAMASA, KUDO, YOSHITADA

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1964

File:

PDF, 1.58 MB

1964

43

CHEMOTHERAPY IN CHRONIC SINUSITIS

OSAWA, R., HOSUI, M., HIGUTI, T., AKAIKE, K., OTSUKA, R., SAKAI, Y., NAKAMURA, Y.

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1951

File:

PDF, 360 KB

1951

44

Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir

Kurashige, Nao, Ohkawa, Kazuyoshi, Hiramatsu, Naoki, Oze, Tsugiko, Yakushijin, Takayuki, Mochizuki, Kiyoshi, Hosui, Atsushi, Miyagi, Takuya, Ishida, Hisashi, Tatsumi, Tomohide, Kanto, Tatsuya, Takehar

Journal:

Antiviral Therapy

Year:

2009

Language:

english

File:

PDF, 291 KB

english, 2009

45

Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration

Yongzhi Cui, Atsushi Hosui, Rui Sun, Kezhen Shen, Oksana Gavrilova, Weiping Chen, Margaret C. Cam, Bin Gao, Gertraud W. Robinson, Lothar Hennighausen

Journal:

Year:

2007

Language:

english

File:

PDF, 3.77 MB

english, 2007

46

Alteration in Gene Expression Profile by Full-Length Hepatitis B Virus Genome

Nakanishi, Fumihiko, Ohkawa, Kazuyoshi, Ishida, Hisashi, Hosui, Atsushi, Sato, Aki, Hiramatsu, Naoki, Ueda, Keiji, Takehara, Tetsuo, Kasahara, Akinori, Sasaki, Yutaka, Hori, Masatsugu, Hayashi, Norio

Journal:

Year:

2005

Language:

english

File:

PDF, 150 KB

english, 2005

47

10.3950/jibiinkoka.86.295

HOSUI, MASAFUMI, MUTO, JIRO, BOHNO, KEIJI, NISHIYAMA, AKEO

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1983

Language:

english

File:

PDF, 2.60 MB

english, 1983

48

STROBOSCOPIC AND STROBO-CINEMATOGRAPHIC STUDY OF LARYNGEAL DISORDER

KIRIKAE, I., HOSUI, M.

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1951

File:

PDF, 1.67 MB

1951

49

CHEMOTHERAPY IN CHRONIC SINUSITIS

OSAWA, R., HOSUI, M., HIGUTI, T., AKAIKE, K., OTSUKA, R., SAKAI, Y., NAKAMURA, Y.

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

1951

File:

PDF, 650 KB

1951

50

BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency: MOLECULAR REQUISITES FOR THE MITOCHONDRIAL PATHWAY TO APOPTOSIS IN PLATELETS

Kodama, T., Takehara, T., Hikita, H., Shimizu, S., Shigekawa, M., Li, W., Miyagi, T., Hosui, A., Tatsumi, T., Ishida, H., Kanto, T., Hiramatsu, N., Yin, X.-M., Hayashi, N.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

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