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1

A Novel Approach to Determine the Mixing Time in a Water Model of an AOD Converter

Wuppermann, Christian, Giesselmann, Nils, R^|^uuml, ckert, Antje, Pfeifer, Herbert, Odenthal, Hans-J^|^uuml, rgen, Hovest^|^auml, dt, Erich

Journal:

ISIJ International

Year:

2012

File:

PDF, 1.20 MB

2012

2

Genetically engineered CAR NK cells display selective cytotoxicity against FLT3-positive B-ALL and inhibit in vivo leukemia growth

Oelsner, Sarah, Waldmann, Anja, Billmeier, Arne, Röder, Jasmin, Lindner, Aline, Ullrich, Evelyn, Marschalek, Rolf, Dotti, Gianpietro, Jung, Gundram, Große-Hovest, Ludger, Oberoi, Pranav, Bader, Peter,

Journal:

International Journal of Cancer

Year:

2019

Language:

english

File:

PDF, 3.67 MB

english, 2019

3

Reduction of minimal residual disease in pediatric B-lineage acute lymphoblastic leukemia by an Fc-optimized CD19 antibody

Seidel, Ursula Jördis Eva, Schlegel, Patrick, Grosse-Hovest, Ludger, Hofmann, Martin, Aulwurm, Steffen, Pyz, Elwira, Schuster, Friedhelm R., Meisel, Roland, Ebinger, Martin, Feuchtinger, Tobias, Telts

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 2.53 MB

english, 2016

4

Fc-Optimized NKG2D-Fc Constructs Induce NK Cell Antibody-Dependent Cellular Cytotoxicity against Breast Cancer Cells Independently of HER2/neu Expression Status

Raab, S., Steinbacher, J., Schmiedel, B. J., Kousis, P. C., Steinle, A., Jung, G., Grosse-Hovest, L., Salih, H. R.

Journal:

The Journal of Immunology

Year:

2014

Language:

english

File:

PDF, 2.00 MB

english, 2014

5

Hydrophobic Interaction Chromatography for Bottom-Up Proteomics Analysis of Single Proteins and Protein Complexes

Rackiewicz, Michal, Große-Hovest, Ludger, Alpert, Andrew J., Zarei, Mostafa, Dengjel, Jörn

Journal:

Journal of Proteome Research

Year:

2017

Language:

english

File:

PDF, 1.26 MB

english, 2017

6

Receptor Activator for NF- B Ligand in Acute Myeloid Leukemia: Expression, Function, and Modulation of NK Cell Immunosurveillance

Schmiedel, B. J., Nuebling, T., Steinbacher, J., Malinovska, A., Wende, C. M., Azuma, M., Schneider, P., Grosse-Hovest, L., Salih, H. R.

Journal:

The Journal of Immunology

Year:

2013

Language:

english

File:

PDF, 1.96 MB

english, 2013

7

DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control

Kretzmer, Helene, Bernhart, Stephan H, Wang, Wei, Haake, Andrea, Weniger, Marc A, Bergmann, Anke K, Betts, Matthew J, Carrillo-de-Santa-Pau, Enrique, Doose, Gero, Gutwein, Jana, Richter, Julia, Hovest

Journal:

Nature Genetics

Year:

2015

Language:

english

File:

PDF, 8.53 MB

english, 2015

8

Bispecific NKG2D-CD3 and NKG2D-CD16 fusion proteins for induction of NK and T cell reactivity against acute myeloid leukemia

Märklin, Melanie, Hagelstein, Ilona, Koerner, Samuel P., Rothfelder, Kathrin, Pfluegler, Martin S., Schumacher, Andreas, Grosse-Hovest, Ludger, Jung, Gundram, Salih, Helmut R.

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2019

Language:

english

File:

PDF, 2.14 MB

english, 2019

9

Generation, selection and preclinical characterization of an Fc-optimized FLT3 antibody for the treatment of myeloid leukemia

Hofmann, M, Große-Hovest, L, Nübling, T, Pyż, E, Bamberg, M L, Aulwurm, S, Bühring, H-J, Schwartz, K, Haen, S P, Schilbach, K, Rammensee, H-G, Salih, H R, Jung, G

Journal:

Year:

2012

Language:

english

File:

PDF, 583 KB

english, 2012

10

Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody

Krawczyk, A., Arndt, M. A. E., Grosse-Hovest, L., Weichert, W., Giebel, B., Dittmer, U., Hengel, H., Jager, D., Schneweis, K. E., Eis-Hubinger, A. M., Roggendorf, M., Krauss, J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 106 KB

english, 2013

11

Cloned transgenic farm animals produce a bispecific antibody for T cell-mediated tumor cell killing

Grosse-Hovest, L., Muller, S., Minoia, R., Wolf, E., Zakhartchenko, V., Wenigerkind, H., Lassnig, C., Besenfelder, U., Muller, M., Lytton, S. D., Jung, G., Brem, G.

Journal:

Proceedings of the National Academy of Sciences

Year:

2004

Language:

english

File:

PDF, 547 KB

english, 2004

12

A “vicious cycle” of NK-cell immune evasion in acute myeloid leukemia mediated by RANKL?

Schmiedel, Benjamin Joachim, Grosse-Hovest, Ludger, Salih, Helmut Rainer

Journal:

Year:

2013

Language:

english

File:

PDF, 333 KB

english, 2013

13

Senescence of Human Fibroblasts after Psoralen Photoactivation Is Mediated by ATR Kinase and Persistent DNA Damage Foci at Telomeres

Journal:

Molecular Biology of the Cell

Year:

2006

Language:

english

File:

PDF, 527 KB

english, 2006

14

A recombinant bispecific single-chain antibody induces targeted, supra-agonistic CD28-stimulation and tumor cell killing

Ludger Grosse-Hovest, Ingo Hartlapp, Wolfgang Marwan, Gottfried Brem, Hans-Georg Rammensee, Gundram Jung

Journal:

European Journal of Immunology

Year:

2003

Language:

english

File:

PDF, 154 KB

english, 2003

15

Characterization of a Bispecific FLT3 X CD3 Antibody in an Improved, Recombinant Format for the Treatment of Leukemia

Durben, Michael, Schmiedel, Dominik, Hofmann, Martin, Vogt, Fabian, Nübling, Tina, Pyz, Elwira, Bühring, Hans-Jörg, Rammensee, Hans-Georg, Salih, Helmut R, Große-Hovest, Ludger, Jung, Gundram

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 1.29 MB

english, 2015

16

4-1BB ligand modulates direct and Rituximab-induced NK-cell reactivity in chronic lymphocytic leukemia

Corina Buechele, Tina Baessler, Benjamin J. Schmiedel, Carla E. Schumacher, Ludger Grosse-Hovest, Kilian Rittig, Helmut R. Salih

Journal:

European Journal of Immunology

Year:

2012

Language:

english

File:

PDF, 919 KB

english, 2012

17

An Fc-optimized CD133 antibody for induction of NK cell reactivity against myeloid leukemia

Koerner, S P, André, M C, Leibold, J S, Kousis, P C, Kübler, A, Pal, M, Haen, S P, Bühring, H-J, Grosse-Hovest, L, Jung, G, Salih, H R

Journal:

Year:

2016

Language:

english

File:

PDF, 1.81 MB

english, 2016

18

Stimulus Dependence of the Action of Small-Molecule Inhibitors in the CD3/CD28 Signalling Network

Karsten Köhler, Alexander Ganser, Thomas André, Günter Roth, Ludger Grosse-Hovest, Gundram Jung, Roland Brock

Journal:

Year:

2008

Language:

english

File:

PDF, 558 KB

english, 2008

19

Generation and Preclinical Characterization of a Fc-optimized GITR-Ig Fusion Protein for Induction of NK Cell Reactivity Against Leukemia

Schmiedel, Benjamin Joachim, Werner, Antje, Steinbacher, Julia, Nuebling, Tina, Buechele, Corina, Grosse-Hovest, Ludger, Salih, Helmut Rainer

Journal:

Molecular Therapy

Year:

2013

Language:

english

File:

PDF, 727 KB

english, 2013

20

Î³Î´ T Cell-Mediated Antibody-Dependent Cellular Cytotoxicity with CD19 Antibodies Assessed by an Impedance-Based Label-Free Real-Time Cytotoxicity Assay

Seidel, Ursula JÃ¶rdis Eva, Vogt, Fabian, Grosse-Hovest, Ludger, Jung, Gundram, Handgretinger, Rupert, Lang, Peter

Journal:

Frontiers in Immunology

Year:

2014

Language:

english

File:

PDF, 2.25 MB

english, 2014

21

Role of target antigen in bispecific-antibody-mediated killing of human glioblastoma cells: A pre-clinical study

Achim Pfosser, Martina Brandl, Helmut Salih, Ludger Grosse-Hovest, Gundram Jung

Journal:

International Journal of Cancer

Year:

1999

Language:

english

File:

PDF, 85 KB

english, 1999

22

Workflows für das frühe Universum – Die ProC-Workflowengine

Wolfgang Hovest, Jörg Knoche, Torsten Enßlin

Journal:

Informatik-Spektrum

Year:

2009

Language:

german

File:

PDF, 635 KB

german, 2009

23

An Fc-Optimized CD133 Antibody for Induction of Natural Killer Cell Reactivity against Colorectal Cancer

Schmied,, Riegg,, Zekri,, Grosse-Hovest,, Bühring,, Jung,, Salih,

Journal:

Year:

2019

Language:

english

File:

PDF, 931 KB

english, 2019

24

Supraagonistic, bispecific single-chain antibody purified from the serum of cloned, transgenic cows induces T-cell-mediated killing of glioblastoma cells in vitro and in vivo

Ludger Grosse-Hovest, Wolfgang Wick, Rosa Minoia, Michael Weller, Hans-Georg Rammensee, Gottfried Brem, Gundram Jung

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 202 KB

english, 2005

25

Vache transgénique pour production d'anti-cancéreux

L. Grosse-Hovest

Journal:

Revue Française des Laboratoires

Year:

2004

File:

PDF, 532 KB

2004

26

Tumor growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: The role of targeted T-cell costimulation via CD28

L. Große Hovest, W. Marwan, K. Bauer, R. Mocikat, M. Dohlsten, W. Wilmanns, G. Jung

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 186 KB

english, 1997

27

Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence

Miriam G. Hovest, Thomas Krieg, Gernot Herrmann

Journal:

Experimental Dermatology

Year:

2011

Language:

english

File:

PDF, 704 KB

english, 2011

28

Bispecific antibody fragments with CD20 × CD28 specificity allow effective autologous and allogeneic T-cell activation against malignant cells in peripheral blood and bone marrow cultures from patients with B-cell lineage leukemia and lymphoma

Martina Brandl, Ludger Große-Hovest, Ernst Holler, Hans-Jochem Kolb, Gundram Jung

Journal:

Experimental Hematology

Year:

1999

Language:

english

File:

PDF, 137 KB

english, 1999

29

An Fc-optimized NKG2D-immunoglobulin G fusion protein for induction of natural killer cell reactivity against leukemia

Steinbacher, Julia, Baltz-Ghahremanpour, Katrin, Schmiedel, Benjamin Joachim, Steinle, Alexander, Jung, Gundram, Kübler, Ayline, André, Maya Caroline, Grosse-Hovest, Ludger, Salih, Helmut Rainer

Journal:

International Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 847 KB

english, 2015

30

A Recombinant Bispecific CD20×CD95 Antibody With Superior Activity Against Normal and Malignant B-cells

Nalivaiko, Kristina, Hofmann, Martin, Kober, Karina, Teichweyde, Nadine, Krammer, Peter H, Rammensee, Hans-Georg, Grosse-Hovest, Ludger, Jung, Gundram

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 2.75 MB

english, 2015

31

High treatment efficacy by dual targeting of Burkitt’s lymphoma xenografted mice with a177Lu-based CD22-specific radioimmunoconjugate and rituximab

T. Weber, B. Bötticher, W. Mier, M. Sauter, S. Krämer, K. Leotta, A. Keller, A. Schlegelmilch, L. Grosse-hovest, D. Jäger, U. Haberkorn, M. A. E. Arndt, J. Krauss

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2016

Language:

english

File:

PDF, 1.03 MB

english, 2016

32

The effect of arginine on coagulation and fibrinolysis in vitro

A.S. Hovest, M.K. Horne III

Journal:

Fibrinolysis and Proteolysis

Year:

1999

Language:

english

File:

PDF, 390 KB

english, 1999

33

RANKL Expression, Function, and Therapeutic Targeting in Multiple Myeloma and Chronic Lymphocytic Leukemia

Schmiedel, B. J., Scheible, C. A., Nuebling, T., Kopp, H.-G., Wirths, S., Azuma, M., Schneider, P., Jung, G., Grosse-Hovest, L., Salih, H. R.

Journal:

Cancer Research

Year:

2013

Language:

english

File:

PDF, 954 KB

english, 2013

34

Alternative Variants of Human HYDIN Are Novel Cancer-Associated Antigens Recognized by Adaptive Immunity

Laske, K., Shebzukhov, Y. V., Grosse-Hovest, L., Kuprash, D. V., Khlgatian, S. V., Koroleva, E. P., Sazykin, A. Y., Penkov, D. N., Belousov, P. V., Stevanovic, S., Vass, V., Walter, S., Eisel, D., Sch

Journal:

Cancer Immunology Research

Year:

2013

Language:

english

File:

PDF, 1.23 MB

english, 2013

35

Large-Scale Purification of r28M: A Bispecific scFv Antibody Targeting Human Melanoma Produced in Transgenic Cattle

Spiesberger, Katrin, Paulfranz, Florian, Egger, Anton, Reiser, Judith, Vogl, Claus, Rudolf-Scholik, Judith, Mayrhofer, Corina, Grosse-Hovest, Ludger, Brem, Gottfried, Ansari, Aftab A.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.54 MB

english, 2015

36

Construction of Optimized Bispecific Antibodies for Selective Activation of the Death Receptor CD95

Herrmann, T., Grosse-Hovest, L., Otz, T., Krammer, P. H., Rammensee, H.-G., Jung, G.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 528 KB

english, 2008

37

Tumor-growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: The role of targeted T-cell co-stimulation via CD28

Ludger Grosse-Hovest, Martina Brandl, Mikael Dohlsten, Terje Kalland, Wolfgang Wilmanns, Gundram Jung

Journal:

International Journal of Cancer

Year:

1999

Language:

english

File:

PDF, 144 KB

english, 1999

38

A bispecific single-chain antibody that mediates target cell-restricted, supra-agonistic CD28 stimulation and killing of lymphoma cells

Rammensee, H-G, Jung, G, Otz, T, Große-Hovest, L, Hofmann, M

Journal:

Year:

2008

Language:

english

File:

PDF, 284 KB

english, 2008

39

Comprehensive Analysis of NKG2D Ligand Expression and Release in Leukemia: Implications for NKG2D-Mediated NK Cell Responses

Hilpert, J., Grosse-Hovest, L., Grunebach, F., Buechele, C., Nuebling, T., Raum, T., Steinle, A., Salih, H. R.

Journal:

The Journal of Immunology

Year:

2012

Language:

english

File:

PDF, 1.33 MB

english, 2012

40

Molecular cloning and characterization of a novel anti-TLR9 intrabody

Reimer, Elisa, Somplatzki, Stefan, Zegenhagen, Diana, HÃ¤nel, Svenja, Fels, Alina, Bollhorst, Thorsten, Hovest, Ludger Grosse, Bauer, Stefan, Kirschning, Carsten J., BÃ¶ldicke, Thomas

Journal:

Cellular & Molecular Biology Letters

Year:

2013

Language:

english

File:

PDF, 725 KB

english, 2013

41

A Humanized Anti-CD22-Onconase Antibody-Drug Conjugate Mediates Highly Potent Destruction of Targeted Tumor Cells

Weber, Tobias, Mavratzas, Athanasios, Kiesgen, Stefan, Haase, Stephanie, Bötticher, Benedikt, Exner, Evelyn, Mier, Walter, Grosse-Hovest, Ludger, Jäger, Dirk, Arndt, Michaela A. E., Krauss, Jürgen

Journal:

Journal of Immunology Research

Year:

2015

Language:

english

File:

PDF, 1.98 MB

english, 2015

42

Tumor immunotherapy with bispecific antibodies: from bench- to bedside

Gundram Jung, Ludger Große-Hovest, Martina Brandl, Achim Pfosser, Wofgang Wilmanns

Journal:

European Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 123 KB

english, 1997

43

Preclinical evaluation of a diabody-based 177Lu-radioimmunoconjugate for CD22-directed radioimmunotherapy in a non-Hodgkin lymphoma mouse model

Weber, Tobias, Bötticher, Benedikt, Arndt, Michaela A.E., Mier, Walter, Sauter, Max, Exner, Evelyn, Keller, Armin, Krämer, Susanne, Leotta, Karin, Wischnjow, Artjom, Grosse-Hovest, Ludger, Strumberg,

Journal:

Year:

2016

Language:

english

File:

PDF, 2.17 MB

english, 2016

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