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1

Cell Lines as In Vitro Models for Drug Screening and Toxicity Studies

Allen, David D., Caviedes, Raúl, Cárdenas, Ana María, Shimahara, Takeshi, Segura-Aguilar, Juan, Caviedes, Pablo A.

Journal:

Drug Development and Industrial Pharmacy

Year:

2005

Language:

english

File:

PDF, 288 KB

english, 2005

2

Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases

Costa, Silvia Lima, Silva, Victor Diogenes Amaral, dos Santos Souza, Cleide, Santos, Cleonice Creusa, Paris, Irmgard, Muñoz, Patricia, Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Year:

2016

Language:

english

File:

PDF, 620 KB

english, 2016

3

Reduction of Brain Antioxidant Defense Upon Treatment with Butylated Hydroxyanisole (BHA) and Sudan III in Syrian Golden Hamster

Francisco J. Romero, Joaquín Romá, Francisco Bosch-Morell, Belén Romero, Juan Segura-Aguilar, Antonio Llombart-Bosch, Lars Ernster

Journal:

Neurochemical Research

Year:

2000

Language:

english

File:

PDF, 21 KB

english, 2000

4

Nitrobenzimidazoles as Substrates for DT-Diaphorase and Redox Cycling Compounds: Their Enzymatic Reactions and Cytotoxicity

Jonas šarlauskas, Egl≐ Dičkancait≐, Aušra Nemeikait≐, Žilvinas Anusevičius, Henrikas Nivinskas, Juan Segura-Aguilar, Narimantas č≐nas

Journal:

Archives of Biochemistry and Biophysics

Year:

1997

Language:

english

File:

PDF, 206 KB

english, 1997

5

Dopamine Oxidation and Autophagy

Muñoz, Patricia, Huenchuguala, Sandro, Paris, Irmgard, Segura-Aguilar, Juan

Journal:

Parkinson's Disease

Year:

2012

Language:

english

File:

PDF, 3.15 MB

english, 2012

6

ChemInform Abstract: The Role of Metal Ions in Dopaminergic Neuron Degeneration in Parkinsonism and Parkinson′s Disease

Irmgard Paris, Juan Segura-Aguilar

Journal:

Year:

2011

File:

PDF, 18 KB

2011

7

Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome

Ana María Cárdenas, David D. Allen, Christian Arriagada, Alexis Olivares, Lori B. Bennett, Raúl Caviedes, Alexies Dagnino-Subiabre, Isabel E. Mendoza, Juan Segura-Aguilar, Stanley I. Rapoport, Pablo C

Journal:

Journal of Neuroscience Research

Year:

2002

Language:

english

File:

PDF, 486 KB

english, 2002

8

Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome

Patricia Opazo, Katherine Saud, Michelle de Saint Pierre, Ana María Cárdenas, David D. Allen, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviedes

Journal:

Journal of Neuroscience Research

Year:

2006

Language:

english

File:

PDF, 307 KB

english, 2006

9

Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line

Irmgard Paris, Alexies Dagnino-Subiabre, Katherine Marcelain, Lori B. Bennett, Pablo Caviedes, Raúl Caviedes, Claudio Olea Azar, Juan Segura-Aguilar

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 694 KB

english, 2001

10

Oxygen toxicity in the nervous tissue: Comparison of the antioxidant defense of rat brain and sciatic nerve

Francisco J. Romero, Elena Monsalve, Carlos Hermenegildo, Francisco J. Puertas, Victoria Higueras, Eberhard Nies, Juan Segura-Aguilar, Joaquín Romá

Journal:

Neurochemical Research

Year:

1991

Language:

english

File:

PDF, 494 KB

english, 1991

11

MPP+-induced degeneration is potentiated by dicoumarol in cultures of the RCSN-3 dopaminergic cell line. Implications of neuromelanin in oxidative metabolism of dopamine neurotoxicity

R. Aguilar Hernández, M. J. Sánchez De Las Matas, C. Arriagada, C. Barcia, P. Caviedes, M. T. Herrero, J. Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2003

Language:

english

File:

PDF, 263 KB

english, 2003

12

Inhibition of DT-Diaphorase potentiates thein vivoneurotoxic effect of intranigral injection of salsolinol in rats

G. Díaz-Véliz, S. Mora, H. Lungenstrass, J. Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2003

Language:

english

File:

PDF, 898 KB

english, 2003

13

The possible role of one-electron reduction of aminochrome in the neurodegenerative process of the dopaminergic system

Juan Segura-Aguilar, Diana Metodiewa, Sofia Baez

Journal:

Neurotoxicity Research

Year:

2001

Language:

english

File:

PDF, 1.91 MB

english, 2001

14

Effects of the DT-diaphorase inhibitor dicumarol on striatal monoamine levels in L-DOPA and L-deprenyl pre-treated rats

Diego Bustamante, L. Bustamante, Juan Segura-Aguilar, Michel Goiny, Mario Herrera-Marschitz

Journal:

Neurotoxicity Research

Year:

2003

Language:

english

File:

PDF, 689 KB

english, 2003

15

Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. A review

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2003

Language:

english

File:

PDF, 281 KB

english, 2003

16

Neurotoxins and neurotoxicity mechanisms. an overview

Juan Segura-Aguilar, Richard M. Kostrzewa

Journal:

Neurotoxicity Research

Year:

2006

Language:

english

File:

PDF, 1.17 MB

english, 2006

17

Neurotoxins and neurotoxic species implicated in neurodegeneration

Juan Segura-Aguilar, Richard M. Kostrzewa

Journal:

Neurotoxicity Research

Year:

2004

Language:

english

File:

PDF, 179 KB

english, 2004

18

Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson’s disease

Irmgard Paris, Sergio Cardenas, Jorge Lozano, Carolina Perez-Pastene, Rebecca Graumann, Alejandra Riveros, Pablo Caviedes, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2007

Language:

english

File:

PDF, 825 KB

english, 2007

19

Botulinum neurotoxin: Evolution from poison, to research tool - onto medicinal therapeutic and future pharmaceutical panacea

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2007

Language:

english

File:

PDF, 1.50 MB

english, 2007

20

The role of metal ions in dopaminergic neuron degeneration in Parkinsonism and Parkinson’s disease

Irmgard Paris, Juan Segura-Aguilar

Journal:

Monatshefte für Chemie - Chemical Monthly

Year:

2011

Language:

english

File:

PDF, 1013 KB

english, 2011

21

Studies of aminochrome toxicity in a mouse derived neuronal cell line: is this toxicity mediated via glutamate transmission?

C. Arriagada, A. Dagnino-Subiabre, P. Caviedes, J. Martin Armero, R. Caviedes, J. Segura-Aguilar

Journal:

Year:

2000

Language:

english

File:

PDF, 319 KB

english, 2000

22

Molecular and Neurochemical Mechanisms in PD Pathogenesis

Irmgard Paris, Jorge Lozano, Carolina Perez-Pastene, Patricia Muñoz, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2009

Language:

english

File:

PDF, 269 KB

english, 2009

23

Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line

Irmgard Paris, Carolina Perez-Pastene, Sergio Cardenas, Patricio Iturra, Patricia Muñoz, Eduardo Couve, Pablo Caviedes, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2010

Language:

english

File:

PDF, 631 KB

english, 2010

24

Erratum to: Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line

Irmgard Paris, Carolina Perez-Pastene, Sergio Cardenas, Patricio Iturriaga-Vasquez, Patricia Muñoz, Eduardo Couve, Pablo Caviedes, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2010

File:

PDF, 86 KB

2010

25

Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra

Irmgard Paris, Pedro Martinez-Alvarado, Carolina Perez-Pastene, Marcelo N. N. Vieira, Claudio Olea-Azar, Rita Raisman-Vozari, Sergio Cardenas, Rebeca Graumann, Pablo Caviedes, Juan Segura-Aguilar

Journal:

Journal of Neurochemistry

Year:

2005

Language:

english

File:

PDF, 430 KB

english, 2005

26

Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome

Alexies Dagnino-Subiabre, Katerine Marcelain, Christian Arriagada, Irmgard Paris, Pablo Caviedes, Raul Caviedes, Juan Segura-Aguilar

Journal:

Molecular and Cellular Biochemistry

Year:

2000

Language:

english

File:

PDF, 205 KB

english, 2000

27

Interplay Between CYP3A-Mediated Metabolism and Polarized Efflux of Terfenadine and Its Metabolites in Intestinal Epithelial Caco-2 (TC7) Cell Monolayers

Shamsi D. Raeissi, Ismael J. Hidalgo, Juan Segura-Aguilar, Per Artursson

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1.32 MB

1999

28

Inhibition of DT-diaphorase is a requirement for Mn3+to produce a 6-OH-dopamine like rotational behaviour

J. Segura-aguilar, G. Diaz-Veliz, S. Mora, M. Herrera-Marschitz

Journal:

Neurotoxicity Research

Year:

2002

Language:

english

File:

PDF, 459 KB

english, 2002

29

Neurotoxicity of some MAO inhibitors in adult rat hypothalamic cell culture

C. Hurtado-Guzmán, P. Martínez-Alvarado, A. Dagnino-Subiabre, I. Paris, P. Caviedes, R. Caviedes, B. K. Cassets, J. Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2002

Language:

english

File:

PDF, 298 KB

english, 2002

30

Program and abstracts of the First Int’l Meeting: Mechanisms for Neurodegenerative Disorders—Alzheimer, Amyotropic Lateral Sclerosis (ALS) and Parkinson’s Disease

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2002

Language:

english

File:

PDF, 1.90 MB

english, 2002

31

Neurotoxicological and neuroprotective elements in Parkinson’s disease

Richard M. Kostrzewa, Juan Segura-Aguilar

Journal:

Neurotoxicity Research

Year:

2002

Language:

english

File:

PDF, 411 KB

english, 2002

32

Peroxidase Activity of Liver Microsomal Vitamin D 25-Hydroxylase and Cytochrome P450 1A2 Catalyzes 25-Hydroxylation of Vitamin D3and Oxidation of Dopamine to Aminochrome

Juan Segura-Aguilar

Journal:

Biochemical and Molecular Medicine

Year:

1996

Language:

english

File:

PDF, 139 KB

english, 1996

33

Effects of Four Organohalogen Environmental Contaminants on Cytochrome P450 Forms That Catalyze 4- and 2-Hydroxylation of Estradiol in the Rat Liver

Juan Segura-Aguilar, Victor Castro, Åke Bergman

Journal:

Biochemical and Molecular Medicine

Year:

1997

Language:

english

File:

PDF, 94 KB

english, 1997

34

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1

Pabla Aguirre, Pamela Urrutia, Victoria Tapia, Monica Villa, Irmgad Paris, Juan Segura-Aguilar, Marco T. Núñez

Journal:

Year:

2012

Language:

english

File:

PDF, 421 KB

english, 2012

35

Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson’s Disease

Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Carlos Cuevas, Monica Villa, Pablo Caviedes, Juan Segura-Aguilar, Yousef Tizabi

Journal:

Neurotoxicity Research

Year:

2012

Language:

english

File:

PDF, 259 KB

english, 2012

36

Altered Voltage Dependent Calcium Currents in a Neuronal Cell Line Derived From the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Down Syndrome

Mario A. Acuña, Ramón Pérez-Nuñez, Jorge Noriega, Ana María Cárdenas, Juan Bacigalupo, Ricardo Delgado, Christian Arriagada, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviedes

Journal:

Neurotoxicity Research

Year:

2012

Language:

english

File:

PDF, 551 KB

english, 2012

37

On the mechanism of the Mn3+-induced neurotoxicity of dopamine: Prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase

Juan Segura-Aguilar, Christina Lind

Journal:

Chemico-Biological Interactions

Year:

1989

Language:

english

File:

PDF, 778 KB

english, 1989

38

A new direct method for determining superoxide dismutase activity by measuring hydrogen peroxide formation

Juan Segura-Aguilar

Journal:

Chemico-Biological Interactions

Year:

1993

Language:

english

File:

PDF, 488 KB

english, 1993

39

Superoxide dismutase and catalase prevent the formation of reactive oxygen species during reduction of cyclized dopa ortho-quinone by DT-diaphorase

Sofia Baez, Ylva Linderson, Juan Segura-Aguilar

Journal:

Chemico-Biological Interactions

Year:

1994

Language:

english

File:

PDF, 641 KB

english, 1994

40

The cytotoxic effects of 5-OH-1,4-naphthoquinone and 5,8-diOH-1,4-naphthoquinone on doxorubicin-resistant human leukemia cells (HL-60)

Juan Segura-Aguilar, Kerstin Jönsson, Ulf Tidefelt, Christer Paul

Journal:

Leukemia Research

Year:

1992

Language:

english

File:

PDF, 586 KB

english, 1992

41

Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol

Juan Segura-Aguilar, Rudolf Kaiser, Christina Lind

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1992

Language:

english

File:

PDF, 863 KB

english, 1992

42

DT-diaphorase-catalyzed two-electron reduction of various p-benzoquinone- and 1,4-naphthoquinone epoxides

Anders Brunmark, Enrique Cadenas, Juan Segura-Aguilar, Christina Lind, Lars Ernster

Journal:

Free Radical Biology and Medicine

Year:

1988

Language:

english

File:

PDF, 866 KB

english, 1988

43

Antioxidant and glutathione-related enzymatic activities in rat sciatic nerve

Francisco J. Romero, Juan Segura-Aguilar, Elena Monsalve, Carlos Hermenegildo, Eberhard Nies, Francisco J. Puertas, Joaquín Romá

Journal:

Neurotoxicology and Teratology

Year:

1990

Language:

english

File:

PDF, 298 KB

english, 1990

44

Knockdown of amyloid precursor protein gene corrects altered intracellular Ca2+ signals in a cell line derived from the cerebral cortex of trisomy 16 mouse: An animal model of Down syndrome

Gonzalo Encina, Christian Arriagada, Patricia Opazo, Guillermo Rojas, Michelle de Saint Pierre, Ana María Cárdenas, Takeshi Shimahara, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviedes

Journal:

Journal of Physiology-Paris

Year:

2006

Language:

english

File:

PDF, 79 KB

english, 2006

45

Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor

Gabriela Dı&amp, #x0301, az-Véliz, Sergio Mora, Patricia Gómez, Ma Teresa Dossi, Juan Montiel, Christian Arriagada, Francisco Aboitiz, Juan Segura-Aguilar

Journal:

Pharmacology Biochemistry and Behavior

Year:

2004

Language:

english

File:

PDF, 368 KB

english, 2004

46

Behavioral effects of aminochrome and dopachrome injected in the rat substantia nigra

G. Dı́az-Véliz, S. Mora, M.T. Dossi, P. Gómez, C. Arriagada, J. Montiel, F. Aboitiz, J. Segura-Aguilar

Journal:

Pharmacology Biochemistry and Behavior

Year:

2002

Language:

english

File:

PDF, 239 KB

english, 2002

47

DT-Diaphorase Maintains the Reduced State of Ubiquinones in Lipid Vesicles thereby Promoting their Antioxidant Function

Laura Landi, Diana Fiorentini, M.Cristina Galli, Juan Segura-Aguilar, Robert E Beyer

Journal:

Free Radical Biology and Medicine

Year:

1997

Language:

english

File:

PDF, 373 KB

english, 1997

48

Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product

Diana Metodiewa, Anil K. Jaiswal, Narimantas Cenas, Egle Dickancaité, Juan Segura-Aguilar

Journal:

Free Radical Biology and Medicine

Year:

1999

Language:

english

File:

PDF, 225 KB

english, 1999

49

Stable Expression of Short Interfering RNA for DT-Diaphorase Induces Neurotoxicity

Lozano, Jorge, Muñoz, Patricia, Nore, Beston F., LeDoux, Susan, Segura-Aguilar, Juan

Journal:

Chemical Research in Toxicology

Year:

2010

Language:

english

File:

PDF, 177 KB

english, 2010

50

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

Vidal, R. L., Figueroa, A., Court, F. A., Thielen, P., Molina, C., Wirth, C., Caballero, B., Kiffin, R., Segura-Aguilar, J., Cuervo, A. M.

Journal:

Human Molecular Genetics

Year:

2012

Language:

english

File:

PDF, 4.63 MB

english, 2012