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1

IL-12 and IL-23: master regulators of innate and adaptive immunity

Claire L. Langrish, Brent S. McKenzie, Nicholas J. Wilson, Rene De Waal Malefyt, Robert A. Kastelein, Daniel J. Cua

Journal:

Immunological Reviews

Year:

2004

Language:

english

File:

PDF, 670 KB

english, 2004

2

Understanding the IL-23–IL-17 immune pathway

Brent S. McKenzie, Robert A. Kastelein, Daniel J. Cua

Journal:

Trends in Immunology

Year:

2006

Language:

english

File:

PDF, 164 KB

english, 2006

3

Review of first 5 years of screening for familial hypercholesterolaemia in the Netherlands

Marina AW Umans-Eckenhausen, Joep C Defesche, Eric JG Sijbrands, Robert LJM Scheerder, John JP Kastelein

Journal:

Year:

2001

Language:

english

File:

PDF, 521 KB

english, 2001

4

HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial

Paul M Ridker, Jacques Genest, S Matthijs Boekholdt, Peter Libby, Antonio M Gotto, Børge G Nordestgaard, Samia Mora, Jean G MacFadyen, Robert J Glynn, John JP Kastelein

Journal:

Year:

2010

Language:

english

File:

PDF, 144 KB

english, 2010

5

Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: Results of a 24week, double-blind, randomized Phase 3 trial

Roth, Eli M., Taskinen, Marja-Riitta, Ginsberg, Henry N., Kastelein, John J.P., Colhoun, Helen M., Robinson, Jennifer G., Merlet, Laurence, Pordy, Robert, Baccara-Dinet, Marie T.

Journal:

International Journal of Cardiology

Year:

2014

Language:

english

File:

PDF, 586 KB

english, 2014

6

IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-γ when combined with IL-18

Guifang Cai, Robert A. Kastelein, Christopher A. Hunter

Journal:

European Journal of Immunology

Year:

1999

Language:

english

File:

PDF, 143 KB

english, 1999

7

Comparison of the effects of interleukin-1α, interleukin-lβ and interferon-γ-inducing factor on the production of interferon-γ by natural killer

Christopher A. Hunter, Jackie Timans, Paul Pisacane, Satish Menon, Guifang Cai, William Walker, Miguel Aste-Amezaga, Richard Chizzonite, J. Fernando Bazan, Robert A. Kastelein

Journal:

European Journal of Immunology

Year:

1997

Language:

english

File:

PDF, 676 KB

english, 1997

8

Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis

Ivo Sonderegger, Till A. Röhn, Michael O. Kurrer, Giandomenica Iezzi, Yu Zou, Robert A. Kastelein, Martin F. Bachmann, Manfred Kopf

Journal:

European Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 332 KB

english, 2006

9

Uncovered: the family relationship of a T-cell-membrane protein and bacterial toxins

Friedrieh Koch-Nolte, Friedrich Haag, Robert Kastelein, Fernando Bazan

Journal:

Immunology Today

Year:

1996

Language:

english

File:

PDF, 660 KB

english, 1996

10

Cytoplasmic and periplasmic expression of a highly basic protein, human interleukin 4, inEscherichia coli

Daniel Lundell, Robert Greenberg, Yair Alroy, Russell Condon, James D. Fossetta, Keith Gewain, Rob Kastelein, Charles A. Lunn, Richard Reim, Chandravadan Shah, Anita van Kimmenade, Satwant K. Narula

Journal:

Journal of Industrial Microbiology & Biotechnology

Year:

1990

Language:

english

File:

PDF, 1.73 MB

english, 1990

11

Expression of biologically active, mature human granulocyte-macrophage colony stimulating factor with anE. colisecretory expression system

Robert Greenberg, Daniel Lundell, Yair Alroy, Susan Bonitz, Russell Condon, James Fossetta, Beth Frommer, Keith Gewain, Mitchell Katz, Paul J. Leibowitz, satwant K. Narula, Robert Kastelein, Anita Van

Journal:

Current Microbiology

Year:

1988

Language:

english

File:

PDF, 1.30 MB

english, 1988

12

Inhibition of Secretory Phospholipase A2in Patients with Acute Coronary Syndromes: Rationale and Design of the Vascular Inflammation Suppression to Treat Acute Coronary Syndrome for 16 Weeks (VISTA-16) Trial

Stephen J. Nicholls, Matthew A. Cavender, John J. P. Kastelein, Gregory Schwartz, David D. Waters, Robert S. Rosenson, Dianna Bash, Colin Hislop

Journal:

Cardiovascular Drugs and Therapy

Year:

2012

Language:

english

File:

PDF, 119 KB

english, 2012

13

Borrelia burgdorferi potently activates bone marrow-derived conventional dendritic cells for production of IL-23 required for IL-17 release by T cells

Jens Knauer, Sabine Siegemund, Uwe Müller, Samiya Al-Robaiy, Robert A. Kastelein, Gottfried Alber, Reinhard K. Straubinger

Journal:

FEMS Immunology & Medical Microbiology

Year:

2007

Language:

english

File:

PDF, 276 KB

english, 2007

14

New paradigms in inflammation: where to next?

Christopher A. Hunter, Robert Kastelein

Journal:

Immunological Reviews

Year:

2008

Language:

english

File:

PDF, 54 KB

english, 2008

15

A newly defined interleukin-1?

Bazan, J. Fernando, Timans, Jackie C., Kastelein, Robert A.

Journal:

Year:

1996

File:

PDF, 375 KB

1996

16

IL-23 promotes tumour incidence and growth

Langowski, John L., Zhang, Xueqing, Wu, Lingling, Mattson, Jeanine D., Chen, Taiying, Smith, Kathy, Basham, Beth, McClanahan, Terrill, Kastelein, Robert A., Oft, Martin

Journal:

Year:

2006

Language:

english

File:

PDF, 492 KB

english, 2006

17

IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

Saenz, Steven A., Siracusa, Mark C., Perrigoue, Jacqueline G., Spencer, Sean P., Urban Jr, Joseph F., Tocker, Joel E., Budelsky, Alison L., Kleinschek, Melanie A., Kastelein, Robert A., Kambayashi, Ta

Journal:

Year:

2010

Language:

english

File:

PDF, 706 KB

english, 2010

18

TGF-β, a 'double agent' in the immune pathology war

Cua, Daniel J, Kastelein, Robert A

Journal:

Nature Immunology

Year:

2006

Language:

english

File:

PDF, 1.23 MB

english, 2006

19

Evaluation of murine interleukin 4 (IL-4) receptor expression using anti-receptor monoclonal antibodies and S1 nuclease protection analyses

Hiroshi Ishida, Gloria Yang, Nobuyuki Harada, Robin L. Hastings, Brian E. Castle, Robert Kastelein, Atsushi Miyajima, Maureen Howard

Journal:

Cellular Immunology

Year:

1991

Language:

english

File:

PDF, 1.98 MB

english, 1991

20

Evidence for a Role of the Interleukin-23 Pathway in the Pathogenesis of Psoriasis

Frank Nestle, Francesca Capon, Jonathan Barker, Robert Kastelein, Richard Trembath, Giulia Tonel, Paola Di Meglio, Elizabeth Oldham, Jerry Lanchbury

Journal:

Clinical Immunology

Year:

2007

Language:

english

File:

PDF, 51 KB

english, 2007

21

Circulating and Gut-resident Human Th17 Cells Express CD161 and Promote Intestinal Inflammation

Melanie Kleinschek, Katia Boniface, Svetlana Sadekova, William Faubion, Rene de Waal Malefyt, Robert Pierce, Terrill McClanahan, Robert Kastelein

Journal:

Clinical Immunology

Year:

2009

Language:

english

File:

PDF, 152 KB

english, 2009

22

Genetic Structure and Chromosomal Mapping of MyD88

Gary Hardiman, Nancy A. Jenkins, Neal G. Copeland, Debra J. Gilbert, Dawn K. Garcia, Susan L. Naylor, Robert A. Kastelein, J.Fernando Bazan

Journal:

Year:

1997

Language:

english

File:

PDF, 513 KB

english, 1997

23

Computational Identification, Cloning, and Characterization of IL-1R9, a Novel Interleukin-1 Receptor-like Gene Encoded over an Unusually Large Interval of Human Chromosome Xq22.2–q22.3

Theodore R. Sana, Reno Debets, Jackie C. Timans, J.Fernando Bazan, Robert A. Kastelein

Journal:

Year:

2000

Language:

english

File:

PDF, 727 KB

english, 2000

24

Expression and Purification of a Synthetic Human Obese Gene Product

Scott W. Altmann, Jackie C. Timans, Fernando L. Rock, J.Fernando Bazan, Robert A. Kastelein

Journal:

Protein Expression and Purification

Year:

1995

Language:

english

File:

PDF, 127 KB

english, 1995

25

32 IL-27P28 Protects Mice From EAE

Caroline Diveu, Mandy J. McGeachy, Manjiri Sathe, Barbara Joyce-Shaikh, Terrill McClanahan, Daniel M. Gorman, Daniel J. Cua, Robert A. Kastelein

Journal:

Year:

2007

Language:

english

File:

PDF, 48 KB

english, 2007

26

Swords into plowshares: IL-23 repurposes tumor immune surveillance

John L. Langowski, Robert A. Kastelein, Martin Oft

Journal:

Trends in Immunology

Year:

2007

Language:

english

File:

PDF, 349 KB

english, 2007

27

The IL-12 Family of Heterodimeric Cytokines: New Players in the Regulation of T Cell Responses

Giorgio Trinchieri, Stefan Pflanz, Robert A Kastelein

Journal:

Year:

2003

Language:

english

File:

PDF, 167 KB

english, 2003

28

The IL-27R (WSX-1) Is Required to Suppress T Cell Hyperactivity during Infection

Alejandro Villarino, Linda Hibbert, Linda Lieberman, Emma Wilson, Tak Mak, Hiroki Yoshida, Robert A. Kastelein, Christiaan Saris, Christopher A. Hunter

Journal:

Year:

2003

Language:

english

File:

PDF, 819 KB

english, 2003

29

A new nomenclature for IL-1-family genes

John E Sims, Yang Pan, Dirk E Smith, Martin J.H Nicklin, Jenny L Barton, J.Fernando Bazan, Robert A Kastelein, Samantha J Busfield, John E Ford, Haishan Lin, Julio J Mulero, Sanjay Kumar, James (Guohu

Journal:

Trends in Immunology

Year:

2001

Language:

english

File:

PDF, 23 KB

english, 2001

30

Novel IL-12 family members shed light on the orchestration of Th1 responses

Frank Brombacher, Robert A. Kastelein, Gottfried Alber

Journal:

Trends in Immunology

Year:

2003

Language:

english

File:

PDF, 1.12 MB

english, 2003

31

C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: The EPIC-Norfolk prospective population study 1993–2003

S. Matthijs Boekholdt, C. Erik Hack, Manjinder S. Sandhu, Robert Luben, Sheila A. Bingham, Nicholas J. Wareham, Ron J.G. Peters, J. Wouter Jukema, Nicholas E. Day, John J.P. Kastelein, Kay-Tee Khaw

Journal:

Atherosclerosis

Year:

2006

Language:

english

File:

PDF, 131 KB

english, 2006

32

Cloning and overexpression of the colicin E1 immunity gene

Armen B. Shanafelt, Kenneth M. Goldman, Robert A. Kastelein, Celik Kayalar

Journal:

Year:

1987

Language:

english

File:

PDF, 401 KB

english, 1987

33

Serum Myeloperoxidase Levels Are Associated With the Future Risk of Coronary Artery Disease in Apparently Healthy Individuals: The EPIC-Norfolk Prospective Population Study

Marijn C. Meuwese, Erik S.G. Stroes, Stanley L. Hazen, Joram N. van Miert, Jan Albert Kuivenhoven, Robert G. Schaub, Nicholas J. Wareham, Robert Luben, John J.P. Kastelein, Kay-Tee Khaw, S. Matthijs B

Journal:

Journal of the American College of Cardiology

Year:

2007

Language:

english

File:

PDF, 121 KB

english, 2007

34

On-Treatment Non–High-Density Lipoprotein Cholesterol, Apolipoprotein B, Triglycerides, and Lipid Ratios in Relation to Residual Vascular Risk After Treatment With Potent Statin Therapy: JUPITER (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin)

Samia Mora, Robert J. Glynn, S. Matthijs Boekholdt, Børge G. Nordestgaard, John J.P. Kastelein, Paul M. Ridker

Journal:

Journal of the American College of Cardiology

Year:

2012

Language:

english

File:

PDF, 273 KB

english, 2012

35

407: Dose-dependent Reductions in LDL-C with ISIS 301012, an Antisense Inhibitor of Apolipoprotein B

Mark Karl Wedel, Diane L. Tribble, Brenda Baker, Evan Stein, J. Wouter Jukema, Eric Sijbrands, Mieke Trip, Frank Visseren, Robert Weiss, Fatima Akdim, John J.P. Kastelein, Rainard Fuhr

Journal:

Journal of Clinical Lipidology

Year:

2007

Language:

english

File:

PDF, 39 KB

english, 2007

36

Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

Charles O. Elson, Yingzi Cong, Casey T. Weaver, Trenton R. Schoeb, Terrill K. McClanahan, Robert B. Fick, Robert A. Kastelein

Journal:

Gastroenterology

Year:

2007

Language:

english

File:

PDF, 1.58 MB

english, 2007

37

Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation

Kastelein, Robert A., Hunter, Christopher A., Cua, Daniel J.

Journal:

Annual Review of Immunology

Year:

2007

Language:

english

File:

PDF, 222 KB

english, 2007

38

A 24-WEEK STUDY OF ALIROCUMAB AS MONOTHERAPY VERSUS EZETIMIBE: THE FIRST PHASE 3 DATA OF A PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 INHIBITOR

Roth, Eli M., Taskinen, Marja-Riitta, Ginsberg, Henry, Kastelein, John, Colhoun, Helen M., Merlet, Laurence, Pordy, Robert, Baccara-Dinet, Marie T.

Journal:

Journal of the American College of Cardiology

Year:

2014

Language:

english

File:

PDF, 180 KB

english, 2014

39

EFFICACY AND SAFETY OF EZETIMIBE MONOTHERAPY IN CHILDREN SIX TO TEN YEARS OF AGE WITH HETEROZYGOUS FAMILIAL OR NON-FAMILIAL HYPERCHOLESTEROLEMIA

Kastelein, John J.P., Kusters, Meeike, Caceres, Maria, Coll, Mauricio, Cuffie, Cynthia, Gagné, Claude, Jacobson, Marc, Kwiterovich, Peter, Lee, Raymond, Lowe, Robert, Massaad, Rachid, McCrindle, Brian

Journal:

Journal of the American College of Cardiology

Year:

2013

Language:

english

File:

PDF, 149 KB

english, 2013

40

Identification of Critical Regions in Mouse Granulocyte--Macrophage Colony-Stimulating Factor by Scanning-Deletion Analysis

Armen B. Shanafelt and Robert A. Kastelein

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 1.49 MB

english, 1989

41

Identification of a Novel selD Homolog from Eukaryotes, Bacteria, and Archaea: Is there an Autoregulatory Mechanism in Selenocysteine Metabolism?

M. Jorge Guimaraes, David Peterson, Alain Vicari, Benjamin G. Cocks, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, David A. Ferrick, Robert A. Kastelein, J. Fernando Bazan and Albert Zlotnik

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.66 MB

english, 1996

42

A Family of Human Receptors Structurally Related to Drosophila Toll

Fernando L. Rock, Gary Hardiman, Jackie C. Timans, Robert A. Kastelein and J. Fernando Bazan

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 2.15 MB

english, 1998

43

IL-27 and IFN- α Signal via Stat1 and Stat3 and Induce T-Bet and IL-12R β 2 in Naive T Cells

Hibbert, Linda, Pflanz, Stefan, de Waal Malefyt, Rene, Kastelein, Robert A.

Journal:

Journal of Interferon & Cytokine Research

Year:

2003

Language:

english

File:

PDF, 367 KB

english, 2003

44

Molecular cloning of a cDNA encoding the human interleukin 4 receptor

Galizzl, Jean-Pierre, Zuber, Caroline E., Harada, Nobuyuki, Gorman, Daniel M., Djossou, Odile, Kastelein, Robert, Banchereau, Jacques, Howard, Maureen, Miyajima, Atsushi

Journal:

International Immunology

Year:

1990

Language:

english

File:

PDF, 5.30 MB

english, 1990

45

Involvement of the Fourth α-Helix of Mouse Granulocyte-Macrophage Colony-Stimulating Factor in Binding to the α-Subunit of the Receptor Complex

Altmann, Scott W., Patel, Neela, Kastelein, Robert A.

Journal:

Year:

1995

Language:

english

File:

PDF, 1006 KB

english, 1995

46

Mouse IL-17: A Cytokine Preferentially Expressed by αβTCR+CD4—CD8— T Cells

KENNEDY, JACQUELINE, ROSSI, DEVORA L., ZURAWSKI, SANDRA M., VEGA, FELIX, KASTELEIN, ROBERT A., WAGNER, JANET L., HANNUM, CHARLES H., ZLOTNIK, ALBERT

Journal:

Journal of Interferon & Cytokine Research

Year:

1996

Language:

english

File:

PDF, 2.23 MB

english, 1996

47

A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism

Glynn, Robert J., Danielson, Eleanor, Fonseca, Francisco A.H., Genest, Jacques, Gotto, Antonio M., Kastelein, John J.P., Koenig, Wolfgang, Libby, Peter, Lorenzatti, Alberto J., MacFadyen, Jean G., Nor

Journal:

Boston Medical and Surgical Journal

Year:

2009

Language:

english

File:

PDF, 332 KB

english, 2009

48

IL-23 drives the expansion of pathogenic ThIL-17cells required for autoimmune inflammation

Langrish, Claire L., Chen, Yi, Blumenschein, Wendy M., Mattson, Jeanine, Basham, Beth, Sedgwick, Jonathan D., McClanahan, Terrill, Kastelein, Robert A., Cua, Daniel J.

Journal:

Inflammation Research

Year:

2005

File:

PDF, 370 KB

2005

49

Recent failures in antiatherosclerotic drug development

Stoekenbroek, Robert M., Kastelein, John J.P., Hovingh, G. Kees

Journal:

Current Opinion in Lipidology

Year:

2013

Language:

english

File:

PDF, 242 KB

english, 2013

50

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study

Saleheen, Danish, Scott, Robert, Javad, Sundas, Zhao, Wei, Rodrigues, Amrith, Picataggi, Antonino, Lukmanova, Daniya, Mucksavage, Megan L, Luben, Robert, Billheimer, Jeffery, Kastelein, John J P, Boek

Journal:

The Lancet Diabetes & Endocrinology

Year:

2015

Language:

english

File:

PDF, 367 KB

english, 2015