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1

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signaling

Kayagaki, Nobuhiko, Stowe, Irma B., Lee, Bettina L., O’Rourke, Karen, Anderson, Keith, Warming, Søren, Cuellar, Trinna, Haley, Benjamin, Roose-Girma, Merone, Phung, Qui T., Liu, Peter S., Lill, Jennie

Journal:

Year:

2015

Language:

english

File:

PDF, 5.50 MB

english, 2015

2

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

Rutz, Sascha, Kayagaki, Nobuhiko, Phung, Qui T., Eidenschenk, Celine, Noubade, Rajkumar, Wang, Xiaoting, Lesch, Justin, Lu, Rongze, Newton, Kim, Huang, Oscar W., Cochran, Andrea G., Vasser, Mark, Faub

Journal:

Year:

2014

Language:

english

File:

PDF, 2.60 MB

english, 2014

3

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

Kayagaki, N., Wong, M. T., Stowe, I. B., Ramani, S. R., Gonzalez, L. C., Akashi-Takamura, S., Miyake, K., Zhang, J., Lee, W. P., Muszynski, A., Forsberg, L. S., Carlson, R. W., Dixit, V. M.

Journal:

Year:

2013

Language:

english

File:

PDF, 480 KB

english, 2013

4

Apoptosis of pancreatic β-cells detected in accelerated diabetes of NOD mice: no role of Fas-Fas ligand interaction in autoimmune diabetes

Yun-Hee Kim, Sunshin Kim, Kyung-Ah Kim, Hideo Yagita, Nobuhiko Kayagaki, Kwang-Won Kim, Myung-Shik Lee

Journal:

European Journal of Immunology

Year:

1999

Language:

english

File:

PDF, 242 KB

english, 1999

5

Antiviral response by natural killer cells through TRAIL gene induction by IFN–α/β

Kojiro Sato, Shigeaki Hida, Hiroshi Takayanagi, Taeko Yokochi, Nobuhiko Kayagaki, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Nobuyuki Tanaka, Tadatsugu Taniguchi, Kouetsu Ogasawara

Journal:

European Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 148 KB

english, 2001

6

Reply

K. Nozawa, N. Kayagaki, Y. Tokano, H. Yagita, K. Okumura, H. Hashimoto

Journal:

Arthritis & Rheumatism

Year:

1998

Language:

english

File:

PDF, 131 KB

english, 1998

7

Requirement of Cell–Cell Contact in the Induction of Jurkat T Cell Apoptosis: The Membrane-Anchored but Not Soluble Form of FasL Can Trigger Anti-CD3-Induced Apoptosis in Jurkat T Cells

Naoki Oyaizu, Nobuhiko Kayagaki, Hideo Yagita, Savita Pahwa, Yoji Ikawa

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 131 KB

english, 1997

8

Caspase-1-Independent, Fas/Fas Ligand–Mediated IL-18 Secretion from Macrophages Causes Acute Liver Injury in Mice

Hiroko Tsutsui, Nobuhiko Kayagaki, Keisuke Kuida, Hiroki Nakano, Nobuki Hayashi, Kiyoshi Takeda, Kiyoshi Matsui, Shin-Ichiro Kashiwamura, Toshikazu Hada, Shizuo Akira, Hideo Yagita, Haruki Okamura, Ke

Journal:

Year:

1999

Language:

english

File:

PDF, 177 KB

english, 1999

9

A metalloproteinase inhibitor prevents acute graft-versus-host disease in mice after bone marrow transplantation

Hattori, K, Hirano, T, Ushiyama, C, Miyajima, H, Yamakawa, N, Ikeda, S, Yoshino, K, Tateno, M, Oshimi, K, Kayagaki, N

Journal:

Bone Marrow Transplantation

Year:

1999

Language:

english

File:

PDF, 145 KB

english, 1999

10

Antitumor effect of locally produced CD95 ligand

Seino, Ken-Ichiro, Kayagaki, Nobuhiko, Okumura, Ko, Yagita, Hideo

Journal:

Nature Medicine

Year:

1997

File:

PDF, 838 KB

1997

11

Type I Interferons (IFNs) Regulate Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

Kayagaki, N., Yamaguchi, N., Nakayama, M., Eto, H., Okumura, K., Yagita, H.

Journal:

Journal of Experimental Medicine

Year:

1999

Language:

english

File:

PDF, 159 KB

english, 1999

12

Metalloproteinase-mediated release of human Fas ligand

Journal:

Journal of Experimental Medicine

Year:

1995

Language:

english

File:

PDF, 750 KB

english, 1995

13

Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL)

Nobuhiko Kayagaki, Noriko Yamaguchi, Masaaki Abe, Sachiko Hirose, Toshikazu Shirai, Ko Okumura, Hideo Yagita

Journal:

Cellular Immunology

Year:

2002

Language:

english

File:

PDF, 399 KB

english, 2002

14

Treatment of Lupus in NZB/W F1 Mice with Monoclonal Antibody Against Fas Ligand

Atsuo Nakajima, Hiroshi Hirai, Nobuhiko Kayagaki, Shinichi Yoshino, Sachiko Hirose, Hideo Yagita, Ko Okumura

Journal:

Journal of Autoimmunity

Year:

2000

Language:

english

File:

PDF, 121 KB

english, 2000

15

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

Meunier, Etienne, Dick, Mathias S., Dreier, Roland F., Schürmann, Nura, Broz, Daniela Kenzelmann, Warming, Søren, Roose-Girma, Merone, Bumann, Dirk, Kayagaki, Nobuhiko, Takeda, Kiyoshi, Yamamoto, Masa

Journal:

Year:

2014

Language:

english

File:

PDF, 7.24 MB

english, 2014

16

Th1 and Th2 subsets equally undergo Fas-dependent and -independent activation-induced cell death

Norihiko Watanabe, Hisashi Arase, Kazuhiro Kurasawa, Itsuo Iwamoto, Nobuhiko Kayagaki, Hideo Yagita, Ko Okumura, Shoichiro Miyatake, Takashi Saito

Journal:

European Journal of Immunology

Year:

1997

Language:

english

File:

PDF, 778 KB

english, 1997

17

Protection of islet allografts transplanted together with Fas ligand expressing testicular allografts

Y. Takeda, M. Gotoh, K. Dono, M. Nishihara, T. Grochowiecki, F. Kimura, T. Yoshida, Y. Ohta, H. Ota, H. Ohzato, K. Umeshita, T. Takeda, N. Matsuura, M. Sakon, N. Kayagaki, H. Yagita, K. Okumura, M. Mi

Journal:

Year:

1998

Language:

english

File:

PDF, 3.01 MB

english, 1998

18

Phosphorylation of NLRC4 is critical for inflammasome activation

Qu, Yan, Misaghi, Shahram, Izrael-Tomasevic, Anita, Newton, Kim, Gilmour, Laurie L., Lamkanfi, Mohamed, Louie, Salina, Kayagaki, Nobuhiko, Liu, Jinfeng, Kömüves, László, Cupp, James E., Arnott, David,

Journal:

Year:

2012

Language:

english

File:

PDF, 844 KB

english, 2012

19

Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection

Muñoz, Melba, Eidenschenk, Celine, Ota, Naruhisa, Wong, Kit, Lohmann, Uwe, Kühl, Anja A., Wang, Xiaoting, Manzanillo, Paolo, Li, Yun, Rutz, Sascha, Zheng, Yan, Diehl, Lauri, Kayagaki, Nobuhiko, van Lo

Journal:

Year:

2015

Language:

english

File:

PDF, 2.02 MB

english, 2015

20

Inhibition of Autoimmune Diabetes by Fas Ligand: The Paradox Is Solved

Kim, S., Kim, K.-A., Hwang, D.-Y., Lee, T. H., Kayagaki, N., Yagita, H., Lee, M.-S.

Journal:

The Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 684 KB

english, 2000

21

A metalloproteinase inhibitor prevents acute graft-versus-host disease while preserving the graft-versus-leukaemia effect of allogeneic bone marrow transplantation

Hattori, Koichi, Hirano, Takao, Miyajima, Hiroaki, Yamakawa, Norifumi, Ikeda, Shoji, Yoshino, Kohichiro, Tateno, Masatoshi, Oshimi, Kazuo, Kayagaki, Nobuhiko, Yagita, Hideo, Okumura, Ko

Journal:

British Journal of Haematology

Year:

1999

Language:

english

File:

PDF, 603 KB

english, 1999

22

Soluble Fas molecule in the serum of patients with systemic lupus erythematosus

Yoshiaki Tokano, Sachiko Miyake, Nobuhiko Kayagaki, Kazuhisa Nozawa, Shinji Morimoto, Miyuki Azuma, Hideo Yagita, Yoshinari Takasaki, Ko Okumura, Hiroshi Hashimoto

Journal:

Journal of Clinical Immunology

Year:

1996

Language:

english

File:

PDF, 429 KB

english, 1996

23

Phosphorylation-dependent activity of the deubiquitinase DUBA

Huang, Oscar W, Ma, Xiaolei, Yin, JianPing, Flinders, Jeremy, Maurer, Till, Kayagaki, Nobuhiko, Phung, Qui, Bosanac, Ivan, Arnott, David, Dixit, Vishva M

Journal:

Nature Structural and Molecular Biology

Year:

2012

Language:

english

File:

PDF, 799 KB

english, 2012

24

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

Jonathan W. Jones, Nobuhiko Kayagaki, Petr Broz, Thomas Henry, Kim Newton, Karen O'Rourke, Salina Chan, Jennifer Dong, Yan Qu, Meron Roose-Girma, Vishva M. Dixit, Denise M. Monack and Stanley Falkow

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.64 MB

english, 2010

25

DUBA: A Deubiquitinase That Regulates Type I Interferon Production

Kayagaki, N., Phung, Q., Chan, S., Chaudhari, R., Quan, C., O'Rourke, K. M., Eby, M., Pietras, E., Cheng, G., Bazan, J. F.

Journal:

Year:

2007

Language:

english

File:

PDF, 417 KB

english, 2007

26

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Eugene Varfolomeev, John W. Blankenship, Sarah M. Wayson, Anna V. Fedorova, Nobuhiko Kayagaki, Parie Garg, Kerry Zobel, Jasmin N. Dynek, Linda O. Elliott, Heidi J.A. Wallweber, John A. Flygare, Wayne

Journal:

Year:

2007

Language:

english

File:

PDF, 1.11 MB

english, 2007

27

024 Expression of the Fas and Fas ligand in cutaneous lupus

Nakajimal, M., Nakajima, A., Kayagaki, N., Okumura, K., Hondal, M.

Journal:

Journal of Dermatological Science

Year:

1996

Language:

english

File:

PDF, 112 KB

english, 1996

28

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

Broz, Petr, Ruby, Thomas, Belhocine, Kamila, Bouley, Donna M., Kayagaki, Nobuhiko, Dixit, Vishva M., Monack, Denise M.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.18 MB

english, 2012

29

Does caspase-12 suppress inflammasome activation?

Vande Walle, Lieselotte, Jiménez Fernández, Daniel, Demon, Dieter, Van Laethem, Naomi, Van Hauwermeiren, Filip, Van Gorp, Hanne, Van Opdenbosch, Nina, Kayagaki, Nobuhiko, Lamkanfi, Mohamed

Journal:

Year:

2015

Language:

english

File:

PDF, 4.56 MB

english, 2015

30

Serum soluble Fas/APO-1 is increased in patients with primary Sjögren's syndrome

T. Fujihara, T. Takeuchi, K. Tsubota, N. Kayagaki, H. Yagita, K. Okumura, T. Abe

Journal:

Clinical Rheumatology

Year:

1998

Language:

english

File:

PDF, 462 KB

english, 1998

31

Skin-Specific Caspase-1-Transgenic Mice Show Cutaneous Apoptosis and Pre-Endotoxin Shock Condition with a High Serum Level of IL-18

Yamanaka, K.-i., Tanaka, M., Tsutsui, H., Kupper, T. S., Asahi, K., Okamura, H., Nakanishi, K., Suzuki, M., Kayagaki, N., Black, R. A., Miller, D. K., Nakashima, K., Shimizu, M., Mizutani, H.

Journal:

The Journal of Immunology

Year:

2000

Language:

english

File:

PDF, 926 KB

english, 2000

32

A Metalloproteinase Inhibitor Prevents Lethal Acute Graft-Versus-Host Disease in Mice

Hattori, Koichi, Hirano, Takao, Ushiyama, Chifuyu, Miyajima, Hiroaki, Yamakawa, Norifumi, Ebata, Tomohiko, Wada, Yukihisa, Ikeda, Shoji, Yoshino, Kohichiro, Tateno, Masatoshi, Oshimi, Kazuo, Kayagaki,

Journal:

Year:

1997

File:

PDF, 6.35 MB

1997

33

Subcellular localization and characterization of interleukin-1α produced by rat bladder cancer cells

H. Hojo, A. Kaneko, N. Kayagaki, M. Saki, Y. Hashimoto

Journal:

Immunology Letters

Year:

1994

Language:

english

File:

PDF, 473 KB

english, 1994

34

Fas/Fas ligand-mediated elimination of antigen-bearing Langerhans cells in draining lymph nodes

Kawamura, Azuma, Kayagaki, Shimada, Yagita, Okumura

Journal:

British Journal of Dermatology

Year:

1999

Language:

english

File:

PDF, 253 KB

english, 1999

35

Accumulation of soluble fas in inflamed joints of patients with rheumatoid arthritis

Tomoko Hasunuma, Nobuhiko Kayagaki, Hiroshi Asahara, Satoru Motokawa, Tetsuji Kobata, Hideo Yagita, Hiroyuki Aono, Takayuki Sumida, Ko Okumura, Kusuki Nishioka

Journal:

Arthritis & Rheumatism

Year:

1997

Language:

english

File:

PDF, 603 KB

english, 1997

36

Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-κB inhibitors

Chinatsu Kasuga, Tomohiko Ebata, Nobuhiko Kayagaki, Hideo Yagita, Makoto Hishii, Hajime Aral, Kiyoshi Sato, Ko Okumura

Journal:

Year:

2004

Language:

english

File:

PDF, 1.34 MB

english, 2004

37

Polymorphism of Murine Fas Ligand that Affects the Biological Activity

Nobuhiko Kayagaki, Noriko Yamaguchi, Fumiko Nagao, Seishi Matsuo, Hiroaki Maeda, Ko Okumura and Hideo Yagita

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.69 MB

english, 1997

38

Expression of Fas ligand mRNA in germinal centres of the human tonsil

Kondo, Eisaku, Yoshino, Tadashi, Nishiuchi, Ritsuo, Sakuma, Isao, Nishizaki, Kazunori, Kayagaki, Nobuhiko, Yagita, Hideo, Akagi, Tadaatsu

Journal:

The Journal of Pathology

Year:

1997

Language:

english

File:

PDF, 423 KB

english, 1997

39

Humanization and Epitope Mapping of Neutralizing Anti-Human Fas Ligand Monoclonal Antibodies: Structural Insights into Fas/Fas Ligand Interaction

Nisihara, T., Ushio, Y., Higuchi, H., Kayagaki, N., Yamaguchi, N., Soejima, K., Matsuo, S., Maeda, H., Eda, Y., Okumura, K., Yagita, H.

Journal:

The Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 2.40 MB

english, 2001

40

IRF2 transcriptionally induces GSDMD expression for pyroptosis

Kayagaki, Nobuhiko, Lee, Bettina L., Stowe, Irma B., Kornfeld, Opher S., O'Rourke, Karen, Mirrashidi, Kathleen M., Haley, Benjamin, Watanabe, Colin, Roose-Girma, Merone, Modrusan, Zora, Kummerfeld, Sa

Journal:

Science Signaling

Year:

2019

File:

PDF, 3.98 MB

2019

41

Elevated serum levels of soluble Fas/APO-1 (CD95) in patients with hepatocellular carcinoma

Jodo, Kobayashi, Nakajima, Matsunaga, Nakayama, Ogura, Kayagaki, Okumura, Koike

Journal:

Clinical & Experimental Immunology

Year:

1998

Language:

english

File:

PDF, 236 KB

english, 1998

42

Selective Upregulation of Fibroblast Fas Ligand Expression, and Prolongation of Fas/Fas Ligand-Mediated Skin Allograft Survival, by Retinoic Acid: the Skin as a Retinoide-Inducible Immune Privilege Site

Saitoh, Atsushi, Kawanabe, Takeshi, Weidong, He, Kayagaki, Nobuhiko, Kawamura, Tatsuyoshi, Yagita, Hideo, Okumura, Ko, Shimada, Shinji

Journal:

The Journal of Investigative Dermatology

Year:

2000

Language:

english

File:

PDF, 892 KB

english, 2000

43

TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice

Cretney, Erika, McQualter, Jonathan L, Kayagaki, Nobuhiko, Yagita, Hideo, Bernard, Claude CA, Grewal, Iqbal S, Ashkenazi, Avi, Smyth, Mark J

Journal:

Immunology & Cell Biology

Year:

2005

Language:

english

File:

PDF, 469 KB

english, 2005

44

10.1038/83416

Takeda, Kazuyoshi, Hayakawa, Yoshihiro, Smyth, Mark J., Kayagaki, Nobuhiko, Yamaguchi, Noriko, Kakuta, Shigeru, Iwakura, Yoichiro, Yagita, Hideo, Okumura, Ko

Journal:

Nature Medicine

Year:

2001

Language:

english

File:

PDF, 1.06 MB

english, 2001

45

Protection Against Fas-Mediated and Tumor Necrosis Factor Receptor 1-Mediated Liver Injury by Blockade of FADD Without Loss of Nuclear Factor-κB Activation

Seino, Ken-ichiro, Setoguchi, Yasuhiro, Ogino, Takashi, Kayagaki, Nobuhiko, Akiba, Hisaya, Nakano, Hiroyasu, Taniguchi, Hideki, Takada, Yasutsugu, Yuzawa, Kenji, Todoroki, Takeshi, Fukuchi, Yoshinosuk

Journal:

Annals of Surgery

Year:

2001

Language:

english

File:

PDF, 816 KB

english, 2001

46

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

Lee, Bettina L., Stowe, Irma B., Gupta, Aaron, Kornfeld, Opher S., Roose-Girma, Merone, Anderson, Keith, Warming, Søren, Zhang, Juan, Lee, Wyne P., Kayagaki, Nobuhiko

Journal:

Journal of Experimental Medicine

Year:

2018

Language:

english

File:

PDF, 1.52 MB

english, 2018

47

Characterization of the in vivo function of TNF-α-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice

Lisa M. Sedger, Moira B. Glaccum, JoAnn C. L. Schuh, Suzanne T. Kanaly, Eilidh Williamson, Nobuhiko Kayagaki, Theordore Yun, Pam Smolak, Tiep Le, Ray Goodwin, Brian Gliniak

Journal:

European Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 227 KB

english, 2002

48

A Protective Role of PKCϵ against TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis in Glioma Cells

Hisaaki Shinohara, Nobuhiko Kayagaki, Hideo Yagita, Naoki Oyaizu, Motoi Ohba, Toshio Kuroki, Yoji Ikawa

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 222 KB

english, 2001

49

Rejection of Fas Ligand-expressing grafts

K. Seino, N. Kayagaki, K. Fukao, K. Okumura, H. Yagita

Journal:

Transplantation Proceedings

Year:

1997

Language:

english

File:

PDF, 199 KB

english, 1997

50

Non-canonical inflammasome activation targets caspase-11

Kayagaki, Nobuhiko, Warming, Søren, Lamkanfi, Mohamed, Walle, Lieselotte Vande, Louie, Salina, Dong, Jennifer, Newton, Kim, Qu, Yan, Liu, Jinfeng, Heldens, Sherry, Zhang, Juan, Lee, Wyne P., Roose-Gir

Journal:

Year:

2011

Language:

english

File:

PDF, 1.18 MB

english, 2011

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