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51

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado - ()] A108. HOW USEFUL ARE ANIMAL MODELS OF LUNG DISEASE? - Irreversible Elastase-Induced Emphysema And Its Correlation With Impaired Pulmonary Function In A Mouse Model

Bohla, Alexander, Kohse, Katrin, John, Gerrit, Königshoff, Melanie, Eickelberg, Oliver, Yildirim, Ali O.

Year:

2011

Language:

english

File:

PDF, 17 KB

english, 2011

52

BARD1 mediates TGF-β signaling in pulmonary fibrosis

André, Pierre-Alain, Prêle, Cecilia M., Vierkotten, Sarah, Carnesecchi, Stéphanie, Donati, Yves, Chambers, Rachel C., Pache, Jean-Claude, Crestani, Bruno, Barazzone-Argiroffo, Constance, Königshoff, M

Journal:

Respiratory Research

Year:

2015

Language:

english

File:

PDF, 2.08 MB

english, 2015

53

Systematic phenotyping and correlation of biomarkers with lung function and histology in lung fibrosis

Fernandez, Isis E., Amarie, Oana V., Mutze, Kathrin, Königshoff, Melanie, Yildirim, Ali Önder, Eickelberg, Oliver

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2016

Language:

english

File:

PDF, 896 KB

english, 2016

54

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] D28. DEVELOPMENTAL SIGNALING REBORN IN ADULT LUNG DISEASE - Sonic Hedgehog Mediates Epithelial/Mesenchymal Crosstalk In Lung Cancer

Bermudez, Olga M., Koch, Ina, Hennen, Elisabeth, Stein, Maria M., Lindner, Michael, Konigshoff, Melanie, Eickelberg, Oliver

Year:

2012

Language:

english

File:

PDF, 19 KB

english, 2012

55

No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice

Chen, Shanze, Yin, Renfu, Mutze, Kathrin, Yu, Youjia, Takenaka, Shinji, Königshoff, Melanie, Stoeger, Tobias

Journal:

Particle and Fibre Toxicology

Year:

2015

Language:

english

File:

PDF, 2.34 MB

english, 2015

56

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans - ()] B28. OXIDATIVE STRESS, SIGNAL TRANSDUCTION AND MECHANISMS OF LUNG INJURY - Microarray Analysis Reveals NFIB As A Potential Target Of The Matricellular Protein WISP1 In Alveolar Epithelial Cells In Idiopathic Pulmonary Fibrosis

Konigshoff, Melanie, Rensing, Nele, Wilhelm, Jochen, Balsara, Nisha, Eickelberg, Oliver

Year:

2010

Language:

english

File:

PDF, 18 KB

english, 2010

57

Age dictates a steroid resistant cascade of Wnt5a, transglutaminase-2 and leukotrienes in inflamed airways

Dietz, Katharina, Jiménez, Marta de los Reyes, Gollwitzer, Eva S., Chaker, Adam M., Zissler, Ulrich M., Rådmark, Olof P., Baarsma, Hoeke A., Königshoff, Melanie, Schmidt-Weber, Carsten B., Marsland, B

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 5.61 MB

english, 2016

58

Systematic Identification of Pharmacological Targets from Small-Molecule Phenotypic Screens

Liu, Xueping, Baarsma, Hoeke Abele, Thiam, Chung Hwee, Montrone, Corinna, Brauner, Barbara, Fobo, Gisela, Heier, Julia-Sophie, Duscha, Sven, Königshoff, Melanie, Angeli, Veronique, Ruepp, Andreas, Cam

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.87 MB

english, 2016

59

Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling

Ota, Chiharu, Baarsma, Hoeke A., Wagner, Darcy E., Hilgendorff, Anne, Königshoff, Melanie

Journal:

Molecular and Cellular Pediatrics

Year:

2016

Language:

english

File:

PDF, 1.07 MB

english, 2016

60

Cigarette smoke alters the secretome of lung epithelial cells

Mossina, Alessandra, Lukas, Christina, Merl-Pham, Juliane, Uhl, Franziska E., Mutze, Kathrin, Schamberger, Andrea, Staab-Weijnitz, Claudia, Jia, Jie, Yildirim, Ali Ö., Königshoff, Melanie, Hauck, Stef

Journal:

Year:

2016

Language:

english

File:

PDF, 943 KB

english, 2016

61

WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts

Klee, S., Lehmann, M., Wagner, D. E., Baarsma, H. A., Königshoff, M.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 641 KB

english, 2016

62

WNT Signaling in Lung Aging and Disease

Lehmann, Mareike, Baarsma, Hoeke A., Königshoff, Melanie

Journal:

Annals of the American Thoracic Society

Year:

2016

Language:

english

File:

PDF, 480 KB

english, 2016

63

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] D28. DEVELOPMENTAL SIGNALING REBORN IN ADULT LUNG DISEASE - Activation Of Wnt/Beta-Catenin Signaling Promotes Lung Epithelial Repair In Emphysema

Callegari, Jens, Kipp, Julia, Konigshoff, Melanie

Year:

2012

Language:

english

File:

PDF, 19 KB

english, 2012

64

An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices

Alsafadi, Hani N, Staab-Weijnitz, Claudia A, Lehmann, Mareike, Lindner, Michael, Peschel, Britta, Königshoff, Melanie, Wagner, Darcy Elizabeth

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2017

Language:

english

File:

PDF, 1.22 MB

english, 2017

65

Lung volumes predict survival in patients with chronic lung allograft dysfunction

Kneidinger, Nikolaus, Milger, Katrin, Janitza, Silke, Ceelen, Felix, Leuschner, Gabriela, Dinkel, Julien, Königshoff, Melanie, Weig, Thomas, Schramm, René, Winter, Hauke, Behr, Jürgen, Neurohr, Claus

Journal:

European Respiratory Journal

Year:

2017

Language:

english

File:

PDF, 412 KB

english, 2017

66

‘WNT-er is coming’ : WNT signalling in chronic lung diseases

Baarsma, H A, Königshoff, M

Journal:

Year:

2017

Language:

english

File:

PDF, 1.31 MB

english, 2017

67

An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis

Jenkins, R. Gisli, Moore, Bethany B., Chambers, Rachel C., Eickelberg, Oliver, Königshoff, Melanie, Kolb, Martin, Laurent, Geoffrey J., Nanthakumar, Carmel B., Olman, Mitchell A., Pardo, Annie, Selman

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2017

Language:

english

File:

PDF, 676 KB

english, 2017

68

Linking Wnt Signaling to Mucosal Inflammation

Costa, Rita, Königshoff, Melanie

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2017

Language:

english

File:

PDF, 430 KB

english, 2017

69

Pulmonary CCR2 + CD4 + T cells are immune regulatory and attenuate lung fibrosis development

Milger, Katrin, Yu, Yingyan, Brudy, Eva, Irmler, Martin, Skapenko, Alla, Mayinger, Michael, Lehmann, Mareike, Beckers, Johannes, Reichenberger, Frank, Behr, Jürgen, Eickelberg, Oliver, Königshoff, Mel

Journal:

Year:

2017

Language:

english

File:

PDF, 9.02 MB

english, 2017

70

Cell-specific expression of runt-related transcription factor 2 contributes to pulmonary fibrosis

Mümmler, Carlo, Burgy, Olivier, Hermann, Sarah, Mutze, Kathrin, Günther, Andreas, Königshoff, Melanie

Journal:

The FASEB Journal

Year:

2017

Language:

english

File:

PDF, 2.35 MB

english, 2017

71

Breaking the In Vitro Barrier in Respiratory Medicine: Engineered Microphysiological Systems for COPD and Beyond

Benam, Kambez H, Königshoff, Melanie, Eickelberg, Oliver

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2017

Language:

english

File:

PDF, 737 KB

english, 2017

72

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

Brandsma, Corry-Anke, de Vries, Maaike, Costa, Rita, Woldhuis, Roy R., Königshoff, Melanie, Timens, Wim

Journal:

European Respiratory Review

Year:

2017

Language:

english

File:

PDF, 580 KB

english, 2017

73

WNT receptor signalling in lung physiology and pathology

Skronska-Wasek, Wioletta, Gosens, Reinoud, Königshoff, Melanie, Baarsma, Hoeke Abele

Journal:

Pharmacology & Therapeutics

Year:

2018

Language:

english

File:

PDF, 2.02 MB

english, 2018

74

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans - ()] C61. GENE REGULATION DURING DEVELOPMENT AND IN INJURY - Expression Profiling Of Protein Arginine Methyltransferase (Prmt) Isoforms In Chronic Obstructive Pulmonary Disease (COPD)

Yildirim, Ali O., Konigshoff, Melanie, Wang, Qiongman, Eickelberg, Oliver

Year:

2010

Language:

english

File:

PDF, 16 KB

english, 2010

75

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

Königshoff, Melanie, Balsara, Nisha, Pfaff, Eva-Maria, Kramer, Monika, Chrobak, Izabella, Seeger, Werner, Eickelberg, Oliver, Schmidt, Harald H. H. W.

Journal:

Year:

2008

Language:

english

File:

PDF, 585 KB

english, 2008

76

Age-Dependent Decline in Mouse Lung Regeneration with Loss of Lung Fibroblast Clonogenicity and Increased Myofibroblastic Differentiation

Paxson, Julia A., Gruntman, Alisha, Parkin, Christopher D., Mazan, Melissa R., Davis, Airiel, Ingenito, Edward P., Hoffman, Andrew M., Königshoff, Melanie

Journal:

Year:

2011

Language:

english

File:

PDF, 2.46 MB

english, 2011

77

Expression of B-RAF V600E in Type II Pneumocytes Causes Abnormalities in Alveolar Formation, Airspace Enlargement and Tumor Formation in Mice

Zanucco, Emanuele, Götz, Rudolf, Potapenko, Tamara, Carraretto, Irene, Ceteci, Semra, Ceteci, Fatih, Seeger, Werner, Savai, Rajkumar, Rapp, Ulf R., Königshoff, Melanie

Journal:

Year:

2011

Language:

english

File:

PDF, 12.32 MB

english, 2011

78

High Throughput Genomic Screen Identifies Multiple Factors That Promote Cooperative Wnt Signaling

Miller, Mayumi F., Cohen, Ethan David, Baggs, Julie E., Hogenesch, John B., Morrisey, Edward E., Königshoff, Melanie

Journal:

Year:

2013

Language:

english

File:

PDF, 567 KB

english, 2013

79

Canonical Wnt Signaling Activity in Early Stages of Chick Lung Development

Moura, Rute Silva, Carvalho-Correia, Eduarda, daMota, Paulo, Correia-Pinto, Jorge, Königshoff, Melanie

Journal:

Year:

2014

Language:

english

File:

PDF, 43.33 MB

english, 2014

80

Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling

Toruń, Anna, Szymańska, Ewelina, Castanon, Irinka, Wolińska-Nizioł, Lidia, Bartosik, Anna, Jastrzębski, Kamil, Miętkowska, Magdalena, González-Gaitán, Marcos, Miaczynska, Marta, Königshoff, Melanie

Journal:

Year:

2015

Language:

english

File:

PDF, 5.96 MB

english, 2015

81

S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis

Zhang, Wei, Ohno, Shinji, Steer, Beatrix, Klee, Stephan, Staab-Weijnitz, Claudia A., Wagner, Darcy, Lehmann, Mareike, Stoeger, Tobias, Königshoff, Melanie, Adler, Heiko

Journal:

Frontiers in Immunology

Year:

2018

Language:

english

File:

PDF, 4.49 MB

english, 2018

82

Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis

Heinzelmann, Katharina, Lehmann, Mareike, Gerckens, Michael, Noskovičová, Nina, Frankenberger, Marion, Lindner, Michael, Hatz, Rudolf, Behr, Jürgen, Hilgendorff, Anne, Königshoff, Melanie, Eickelberg,

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2018

Language:

english

File:

PDF, 1.77 MB

english, 2018

83

Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures

Burgstaller, Gerald, Sengupta, Arunima, Vierkotten, Sarah, Preissler, Gerhard, Lindner, Michael, Behr, Jürgen, Königshoff, Melanie, Eickelberg, Oliver

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2018

Language:

english

File:

PDF, 4.61 MB

english, 2018

84

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado - ()] C36. CRITICAL PATHWAYS IN ALLERGIC INFLAMMATION - Protein Arginine Methyltransferases (PRMT) Are Involved In Th17 Cell Differentiation

Kohse, Katrin, Wang, Qiongman, Stritzke, Sabine, Königshoff, Melanie, Eickelberg, Oliver, Yildirim, Ali O.

Year:

2011

Language:

english

File:

PDF, 18 KB

english, 2011

85

Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis

Lehmann, Mareike, Buhl, Lara, Alsafadi, Hani N., Klee, Stephan, Hermann, Sarah, Mutze, Kathrin, Ota, Chiharu, Lindner, Michael, Behr, Jürgen, Hilgendorff, Anne, Wagner, Darcy E., Königshoff, Melanie

Journal:

Respiratory Research

Year:

2018

Language:

english

File:

PDF, 3.46 MB

english, 2018

86

Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation

Ng-Blichfeldt, John-Poul, Schrik, Anneke, Kortekaas, Rosa K., Noordhoek, Jacobien A., Heijink, Irene H., Hiemstra, Pieter S., Stolk, Jan, Königshoff, Melanie, Gosens, Reinoud

Journal:

Year:

2018

Language:

english

File:

PDF, 4.23 MB

english, 2018

87

New players in chronic lung disease identified at the European Respiratory Society International Congress in Paris 2018: from microRNAs to extracellular vesicles

Burgy, Olivier, Fernandez Fernandez, Elena, Rolandsson Enes, Sara, Königshoff, Melanie, Greene, Catherine M., Bartel, Sabine

Journal:

Journal of Thoracic Disease

Year:

2018

Language:

english

File:

PDF, 155 KB

english, 2018

88

Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling

Gerckens, Michael, Alsafadi, Hani N., Wagner, Darcy E., Lindner, Michael, Burgstaller, Gerald, Königshoff, Melanie

Journal:

Journal of Visualized Experiments

Year:

2019

File:

PDF, 1.03 MB

2019

89

The oncogene ECT2 contributes to a hyperplastic, proliferative lung epithelial cell phenotype in IPF

Ulke, Henrik M, Mutze, Kathrin, Lehmann, Mareike, Wagner, Darcy E, Heinzelmann, Katharina, Günther, Andreas, Eickelberg, Oliver, Königshoff, Melanie

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2019

Language:

english

File:

PDF, 5.08 MB

english, 2019

90

Kurzlehrbuch Biochemie || 8 Hormone

Königshoff, Melanie, Brandenburger, Timo, Duszenko, Michael

Year:

2018

Language:

german

File:

PDF, 3.04 MB

german, 2018

91

Kurzlehrbuch Biochemie || 10 Stoffwechsel der einzelnen Organe

Königshoff, Melanie, Brandenburger, Timo, Duszenko, Michael

Year:

2018

Language:

german

File:

PDF, 4.27 MB

german, 2018

92

Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended ex vivo Culture

Bailey, Kolene E., Pino, Christopher, Lennon, Mallory L, Lyons, Anne, Jacot, Jeffrey G, Lammers, Steven R, Königshoff, Melanie, Magin, Chelsea M

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2019

Language:

english

File:

PDF, 1.11 MB

english, 2019

93

Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors

Wu,, van Dijk,, Ng-Blichfeldt,, Bos,, Ciminieri,, Königshoff,, Kistemaker,, Gosens,

Journal:

Year:

2019

Language:

english

File:

PDF, 2.78 MB

english, 2019

94

Shared and distinct mechanisms of fibrosis

Distler, Jörg H. W., Györfi, Andrea-Hermina, Ramanujam, Meera, Whitfield, Michael L., Königshoff, Melanie, Lafyatis, Robert

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2019

Language:

english

File:

PDF, 2.29 MB

english, 2019

95

Shared and distinct mechanisms of fibrosis

Distler, Jörg H. W., Györfi, Andrea-Hermina, Ramanujam, Meera, Whitfield, Michael L., Königshoff, Melanie, Lafyatis, Robert

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2019

File:

PDF, 2.29 MB

2019

96

[American Thoracic Society American Thoracic Society 2009 International Conference, May 15-20, 2009 â¢ San Diego, California - ()] D17. FIBROBLASTS, PROGENITOR CELLS, AND MODELS OF INTERSTITIAL FIBROSIS THAT REVEAL MECHANISMS OF DISEASE - Dimethylarginine Dimethylaminohydrolase 2 in Idiopathic Pulmonary Fibrosis.

Pullamsetti, SS, Savai, R, Dumitrascu, R, Konigshoff, M, Ghofrani, HA, Weissmann, N, Grimminger, F, Eickelberg, O, Guenther, A, Leiper, J, Seeger, W, Schermuly, RT

Year:

2009

File:

PDF, 117 KB

2009

97

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D28. DEVELOPMENTAL SIGNALING REBORN IN ADULT LUNG DISEASE - The Wnt/PCP Pathway Alters Bronchial Cell Morphology In Idiopathic Pulmonary Fibrosis

Srivastava, Barkha, Gegg, Moritz, Lickert, Heiko, Konigshoff, Melanie

Year:

2012

File:

PDF, 19 KB

2012

98

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D76. ALVEOLAR EPITHELIUM: NOVEL TOOLS AND PHENOTYPES - MicroRNA Profiling Of Murine Alveolar Epithelial Type II Cells Isolated By Two Different Procedures

Singer, Katharina, Callegari, Jens, Dehmel, Stefan, Imker, Rabea, Eickelberg, Oliver, Konigshoff, Melanie, Krauss-Etschmann, Susanne

Year:

2012

File:

PDF, 20 KB

2012

99

[American Thoracic Society American Thoracic Society 2009 International Conference, May 15-20, 2009 â¢ San Diego, California - ()] B29. TRANSLATIONAL INVESTIGATION INTO MECHANISMS OF LUNG FIBROSIS - Activation of Wnt/beta-Catenin Signalling during Experimental Lung Fibrosis In Vivo.

Konigshoff, M, Balsara, N, Eickelberg, O

Year:

2009

File:

PDF, 116 KB

2009

100

[American Thoracic Society American Thoracic Society 2009 International Conference, May 15-20, 2009 â¢ San Diego, California - ()] B60. PULMONARY FIBROSIS: THE FIBROBLAST - Dysregulation of the Wnt/beta-Catenin Pathway in Idiopathic Pulmonary Fibrosis: Epithelial-Derived Dickkopf Proteins Control Wnt-Induced Effects.

Konigshoff, M, Pfaff, EM, Balsara, N, Gunther, A, Eickelberg, O

Year:

2009

File:

PDF, 116 KB

2009