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51

Using the Pummerer Cyclization−Deprotonation−Cycloaddition Cascade of Imidosulfoxides for Alkaloid Synthesis

Padwa, Albert, Heidelbaugh, Todd M., Kuethe, Jeffrey T.

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 159 KB

english, 2000

52

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen, Hong, Qingmei, Lai, Zhong, Wu, Zhicai, Yu, Yang, Kim, David W., Ting, Pauline C., Kuethe, Jeffrey T., Yang, Ginger X., Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Spe

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 373 KB

english, 2013

53

Synthesis of Novel KDR Kinase Inhibitors through Catalytic Reductive Cyclization of o -Nitrobenzylcarbonyl Compounds

Wong, Audrey, Kuethe, Jeffrey T., Davies, Ian W., Hughes, David L.

Journal:

Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 85 KB

english, 2004

54

A Concise Synthesis of ( S )- N -Ethoxycarbonyl-α-methylvaline

Kuethe, Jeffrey T., Gauthier, Donald R., Beutner, Gregory L., Yasuda, Nobuyoshi

Journal:

Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 69 KB

english, 2007

55

Rapid and Efficient Synthesis of 1 H -Indol-2-yl-1 H -quinolin-2-ones

Kuethe, Jeffrey T., Wong, Audrey, Davies, Ian W.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 79 KB

english, 2003

56

Development of a Practical, Asymmetric Synthesis of the Hepatitis C Virus Protease Inhibitor MK-5172

Kuethe, Jeffrey, Zhong, Yong-Li, Yasuda, Nobuyoshi, Beutner, Gregory, Linn, Katherine, Kim, Mary, Marcune, Benjamin, Dreher, Spencer Douglas, Humphrey, Guy, Pei, Tao

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 420 KB

english, 2013

57

New Application of the Pummerer Reaction of Imidosulfoxides for the Generation of Mesoionic Dipoles †

Kuethe, Jeffrey T., Padwa, Albert

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 103 KB

english, 1997

58

A Rapid Synthesis of 2-Aryl-5-substituted-2,3-dihydrobenzofurans

Kuethe, Jeffrey T., Wong, Audrey, Journet, Michel, Davies, Ian W.

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 110 KB

english, 2005

59

Vinylogous Pummerer Reaction of Amido-Substituted Sulfoxides as a Method for Preparing Oxindoles and Tetrahydroisoquinolones

Kuethe, Jeffrey T., Cochran, John E., Padwa, Albert

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 223 KB

english, 1995

60

Heterocyclic Synthesis via the Tandem Thionium/ N -Acyliminium Ion Cascade

Padwa, Albert, Heidelbaugh, Todd M., Kuethe, Jeffrey T., McClure, Michael S.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 45 KB

english, 1998

61

Tandem Pummerer/Mannich Cyclization Cascade of α-Sulfinylamides as a Method To Prepare Aza-Heterocycles ‡

Padwa, Albert, Heidelbaugh, Todd M., Kuethe, Jeffrey T., McClure, Michael S., Wang, Qiu

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 204 KB

english, 2002

62

Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes

Biftu, Tesfaye, Sinha-Roy, Ranabir, Chen, Ping, Qian, Xiaoxia, Feng, Dennis, Kuethe, Jeffrey T., Scapin, Giovanna, Gao, Ying Duo, Yan, Youwei, Krueger, Davida, Bak, Annette, Eiermann, George, He, Jiaf

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 353 KB

english, 2014

63

Diastereoselective Addition of Prochiral Metallo Enolates to Chiral 1-Acylpyridinium Salts

Comins, Daniel L., Kuethe, Jeffrey T., Hong, Hao, Lakner, Frederick J., Concolino, Thomas E., Rheingold, Arnold L.

Journal:

Journal of the American Chemical Society

Year:

1999

Language:

english

File:

PDF, 114 KB

english, 1999

64

A biocatalytic/reductive etherification approach to substituted piperidinyl ethers

Kuethe, Jeffrey T., Janey, Jacob M., Truppo, Matthew, Arredondo, Juan, Li, Tao, Yong, Kelvin, He, Shuwen

Journal:

Year:

2014

Language:

english

File:

PDF, 1.44 MB

english, 2014

65

Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors

Debenham, John S., Graham, Thomas H., Verras, Andreas, Zhang, Yong, Clements, Matthew J., Kuethe, Jeffrey T., Madsen-Duggan, Christina, Liu, Wensheng, Bhatt, Urmi R., Chen, Dunlu, Chen, Qing, Garcia-C

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.40 MB

english, 2013

66

Medical Diary for the ensuing Week.

Debenham, John S., Graham, Thomas H., Verras, Andreas, Zhang, Yong, Clements, Matthew J., Kuethe, Jeffrey T., Madsen-Duggan, Christina, Liu, Wensheng, Bhatt, Urmi R., Chen, Dunlu, Chen, Qing, Garcia-C

Journal:

Year:

1906

Language:

english

File:

PDF, 391 KB

english, 1906

67

HUNTERIAN SOCIETY.

Debenham, John S., Graham, Thomas H., Verras, Andreas, Zhang, Yong, Clements, Matthew J., Kuethe, Jeffrey T., Madsen-Duggan, Christina, Liu, Wensheng, Bhatt, Urmi R., Chen, Dunlu, Chen, Qing, Garcia-C

Journal:

Year:

1891

Language:

english

File:

PDF, 400 KB

english, 1891

68

Magnetically Driven Agitation in a Tube Mixer Affords Clog-Resistant Fast Mixing Independent of Linear Velocity

Dolman, Sarah J., Nyrop, Jason L., Kuethe, Jeffrey T.

Journal:

Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 1.91 MB

english, 2011

69

Diels−Alder Reactions of N -Acyl-2-alkyl(aryl)-5-vinyl-2,3-dihydro-4-pyridones

Comins, Daniel L., Kuethe, Jeffrey T., Miller, Teresa M., Février, Florence C., Brooks, Clinton A.

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 338 KB

english, 2005

70

Addition of Indolyl and Pyrrolyl Grignard Reagents to 1-Acylpyridinium Salts

Kuethe, Jeffrey T., Comins, Daniel L.

Journal:

Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 93 KB

english, 2004

71

A Practical Method for Preparation of 4-Hydroxyquinolinone Esters

Beutner, Gregory L., Kuethe, Jeffrey T., Yasuda, Nobuyoshi

Journal:

Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 116 KB

english, 2007

72

Efficient and Practical Synthesis of ( R )-2-Methylpyrrolidine

Zhao, Dalian, Kuethe, Jeffrey T., Journet, Michel, Peng, Zhihui, Humphrey, Guy R.

Journal:

Journal of Organic Chemistry

Year:

2006

Language:

english

File:

PDF, 58 KB

english, 2006

73

A Rapid, Large-Scale Synthesis of a Potent Cholecystokinin (CCK) 1R Receptor Agonist

Kuethe, Jeffrey T., Childers, Karla G., Humphrey, Guy R., Journet, Michel, Peng, Zhihui

Journal:

Organic Process Research & Development

Year:

2008

Language:

english

File:

PDF, 181 KB

english, 2008

74

Asymmetric Diels−Alder Reactions of Chiral Cyclopropylidene Imide Dienophiles: Preparation of gem -Dimethyl- and Spirocyclopropane Norbornyl Carboxylic Acids

Kuethe, Jeffrey T., Zhao, Dalian, Humphrey, Guy R., Journet, Michel, McKeown, Arlene E.

Journal:

Journal of Organic Chemistry

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

75

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen, Hong, Qingmei, Lai, Zhong, Yang, David X., Ting, Pauline C., Kuethe, Jeffrey T., Cernak, Timothy A., Dykstra, Kevin D., Sperbeck, Donald M., Wu, Zhicai, Yu, Yang, Yang, Ginger X., Jian, Ti

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 615 KB

english, 2014

76

Additive and Vinylogous Pummerer Reactions of Amido Sulfoxides and Their Use in the Preparation of Nitrogen Containing Heterocycles

Padwa, Albert, Kuethe, Jeffrey T.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 172 KB

english, 1998

77

Correction to Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle

Song, Zhiguo J., Tellers, David M., Journet, Michel, Kuethe, Jeffrey T., Lieberman, David, Humphrey, Guy, Zhang, Fei, Peng, Zhihui, Waters, Marjorie S., Zewge, Daniel, Nolting, Andrew, Zhao, Dalian, R

Journal:

Journal of Organic Chemistry

Year:

2011

File:

PDF, 76 KB

2011

78

Asymmetric Synthesis of 1,2,3-Trisubstituted Cyclopentanes and Cyclohexanes as Key Components of Substance P Antagonists

Kuethe, Jeffrey T., Wong, Audrey, Wu, Jimmy, Davies, Ian W., Dormer, Peter G., Welch, Christopher J., Hillier, Michael C., Hughes, David L., Reider, Paul J.

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 162 KB

english, 2002

79

Diels−Alder Reactions of 5-Vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones: Regio- and Stereoselective Synthesis of Octahydroquinolines

Kuethe, Jeffrey T., Brooks, Clinton A., Comins, Daniel L.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 63 KB

english, 2003

80

Addition of Metallo Enolates to Chiral 1-Acylpyridinium Salts: Total Synthesis of (+)-Cannabisativine

Kuethe, Jeffrey T., Comins, Daniel L.

Journal:

Organic Letters

Year:

2000

Language:

english

File:

PDF, 61 KB

english, 2000

81

Addition of Indolyl and Pyrrolyl Grignard Reagents to 1-Acylpyridinium Salts.

Kuethe, Jeffrey T., Comins, Daniel L.

Journal:

Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 21 KB

english, 2004

82

The Mukaiyama-Michael Reaction of N -Acyl-2,3-dihydro-4-pyridones: Regio- and Stereoselective Synthesis of cis -2,6-Disubstituted 1,2,5,6-Tetrahydropyridines

Kuethe, Jeffrey T., Comins, Daniel L.

Journal:

Organic Letters

Year:

1999

Language:

english

File:

PDF, 46 KB

english, 1999

83

Reactive resin facilitated preparation of an enantiopure fluorobicycloketone

Wong, Audrey, Welch, Christopher J., Kuethe, Jeffrey T., Vazquez, Enrique, Shaimi, Mohamed, Henderson, Derek, Davies, Ian W., Hughes, David L.

Journal:

Organic & Biomolecular Chemistry

Year:

2004

Language:

english

File:

PDF, 245 KB

english, 2004

84

Development of a Palladium-Catalyzed α-Arylation of Cyclopropyl Nitriles

McCabe Dunn, Jamie M., Kuethe, Jeffrey T., Orr, Robert K., Tudge, Matthew, Campeau, Louis-Charles

Journal:

Organic Letters

Year:

2014

Language:

english

File:

PDF, 1.12 MB

english, 2014

85

A General Approach to Indoles: Practical Applications for the Synthesis of Highly Functionalized Pharmacophores

Kuethe, Jeffrey T.

Journal:

CHIMIA International Journal for Chemistry

Year:

2006

Language:

english

File:

PDF, 1.59 MB

english, 2006

86

Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin

Chen, Ping, Feng, Dennis, Qian, Xiaoxia, Apgar, James, Wilkening, Robert, Kuethe, Jeffrey T., Gao, Ying-Duo, Scapin, Giovanna, Cox, Jason, Doss, George, Eiermann, George, He, Huaibing, Li, Xiaohua, Ly

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.35 MB

english, 2015

87

Development of a Multi-kilogram Scale Synthesis of a TRPV1 Antagonist

Kuethe, Jeffrey T, Journet, Michel, Peng, zhihui, Zhao, Dalian, McKeown, Arlene E, Humphrey, Guy

Journal:

Organic Process Research & Development

Year:

2016

Language:

english

File:

PDF, 415 KB

english, 2016

88

The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors

Cox, Jason M., Chu, Hong D., Kuethe, Jeffrey T., Gao, Ying-Duo, Scapin, Giovanna, Eiermann, George, He, Huaibing, Li, Xiaohua, Lyons, Kathryn A., Metzger, Joseph, Petrov, Aleksandr, Wu, Joseph K., Xu,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 543 KB

english, 2016

89

ChemInform Abstract: Development of a Palladium-Catalyzed α-Arylation of Cyclopropyl Nitriles.

McCabe Dunn, Jamie M., Kuethe, Jeffrey T., Orr, Robert K., Tudge, Matthew, Campeau, Louis-Charles

Journal:

Year:

2015

File:

PDF, 31 KB

2015

90

ChemInform Abstract: A Concise Synthesis of 3,4-Fused Spiro[isobenzofuran-3-ones], Spiro[furo[3,4-b]pyridin-5(7H)-ones], 3-Aryl-, and Alkylphthalides.

Kuethe, Jeffrey T., Maloney, Kevin M.

Journal:

Year:

2013

File:

PDF, 40 KB

2013

91

ChemInform Abstract: A Biocatalytic/Reductive Etherification Approach to Substituted Piperidinyl Ethers.

Kuethe, Jeffrey T., Janey, Jacob M., Truppo, Matthew, Arredondo, Juan, Li, Tao, Yong, Kelvin, He, Shuwen

Journal:

Year:

2014

File:

PDF, 22 KB

2014

92

Asymmetric Synthesis of a Potent HIV-1 Integrase Inhibitor

Kuethe, Jeffrey T, Humphrey, Guy R., Journet, Michel, Peng, Zhihui, Childers, Karla Glaser

Journal:

Journal of Organic Chemistry

Year:

2016

Language:

english

File:

PDF, 497 KB

english, 2016

93

A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives

Gilbert, Eric J., Brunskill, Andrew, Cai, Jiaqiang, Cai, Yaxian, Chu, Xin-Jie, Dai, Xing, Hao, Jinsong, Kuethe, Jeffrey T., Lai, Zhong, Liu, Hong, Mu, Cuizhi, Qi, Yan, Scott, Jack D., Taoka, Brandon,

Journal:

Year:

2016

Language:

english

File:

PDF, 1.40 MB

english, 2016

94

Discovery of N -[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617) an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1−3 (HIF PHD1−3) for the Treatment of Anemia.

Debenham, John S, Madsen-Duggan, Christina B., Clements, Matthew J., Walsh, Thomas F., Kuethe, Jeffrey T, Reibarkh, Mikhail, Salowe, Scott P., Sonatore, Lisa M., Hajdu, Richard, Milligan, James A., Vi

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.47 MB

english, 2016

95

Chemoselective Reduction of α-Cyano Carbonyl Compounds: Application to the Preparation of Heterocycles

Pollack, Scott R., Kuethe, Jeffrey T.

Journal:

Organic Letters

Year:

2016

Language:

english

File:

PDF, 1.38 MB

english, 2016

96

Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen, Lai, Zhong, Hong, Qingmei, Shang, Jackie, Reibarkh, Mikhail, Kuethe, Jeffrey T., Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Cernak, Timothy A., Dykstra, Kevin D., Sperbeck, Donald M

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 2.92 MB

english, 2019

97

A concise synthesis of functionalized 2,3-dihydrofuro[3,2-b], [3,2-c], and [2,3-b]pyridines

Kuethe, Jeffrey T.

Journal:

Year:

2019

Language:

english

File:

PDF, 628 KB

english, 2019

98

A concise synthesis of functionalized 2,3-dihydrofuro[3,2-b], [3,2-c], and [2,3-b]pyridines

Kuethe, Jeffrey T.

Journal:

Year:

2019

File:

PDF, 628 KB

2019

99

The Impact of a Comprehensive Resident Curriculum and Required Participation in “This Week in SCORE” on General Surgery ABSITE Performance and Well-Being

Winer, Leah K., Cortez, Alex R., Kassam, Al-Faraaz, Quillin, Ralph C., Goodman, Michael D., Makley, Amy T., Sussman, Jeffrey J., Kuethe, Joshua W.

Journal:

Journal of Surgical Education

Year:

2019

Language:

english

File:

PDF, 705 KB

english, 2019