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51

Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity

Oxana Ryabtsova, Koen Jansen, Sebastiaan Van Goethem, Jurgen Joossens, Jonathan D. Cheng, Anne-Marie Lambeir, Ingrid De Meester, Koen Augustyns, Pieter Van der Veken

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 395 KB

english, 2012

52

The dipeptidyl peptidase IV (CD26, EC 3.4.14.5) inhibitor vildagliptin is a potent antihyperalgesic in rats by promoting endomorphin-2 generation in the spinal cord

Kornél Király, Anne-Marie Lambeir, Judit Szalai, Apolka Szentirmay, Walter Luyten, István Barna, Zita Puskár, Márk Kozsurek, András Z. Rónai

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 449 KB

english, 2011

53

In situ prolyl oligopeptidase activity assay in neural cell cultures

Linda Klimaviciusa, Rajeev Kumar Jain, Külli Jaako, Roos Van Elzen, Melanie Gerard, Pieter van Der Veken, Anne-Marie Lambeir, Alexander Zharkovsky

Journal:

Journal of Neuroscience Methods

Year:

2012

Language:

english

File:

PDF, 592 KB

english, 2012

54

A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro

Anne-Marie Lambeir, Paul Proost, Simon Scharpé, Ingrid De Meester

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

55

A prediction of DPP IV/CD26 domain structure from a physico-chemical investigation of dipeptidyl peptidase IV (CD26) from human seminal plasma

Anne-Marie Lambeir, José Fernando Dı́az Pereira, Pablo Chacón, Geert Vermeulen, Karel Heremans, Bart Devreese, Jozef Van Beeumen, Ingrid De Meester, Simon Scharpé

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1997

Language:

english

File:

PDF, 1.00 MB

english, 1997

56

A Quantitative Analysis of Tubulin-Colchicine Binding to Microtubules

Annemie LAMBEIR, Yves ENGELBORGHS

Journal:

Year:

1980

Language:

english

File:

PDF, 553 KB

english, 1980

57

A Quantitatiove Desdcription of Microtubule Formadtion in the Presence of Tubulin-Colchicine

Annemie LAMBEIR, Yves ENSGELBORGHS

Journal:

Year:

1983

Language:

english

File:

PDF, 535 KB

english, 1983

58

Oxygen binding to dithionite-reduced chloroperoxidase

Anne-Marie LAMBEIR, H. Brian DUNFORD

Journal:

Year:

1985

Language:

english

File:

PDF, 383 KB

english, 1985

59

Rapid-scan stopped-flow studies of the pH dependence of the reaction between mercuric reductase and NADPH

Lena SAHLMAN, Anne-Marie LAMBEIR, Sven LINDSKOG

Journal:

Year:

1986

Language:

english

File:

PDF, 922 KB

english, 1986

60

Glyceraldehyde-phosphate dehydrogenase from Trypanosoma brucei : Comparison of the glycosomal and cytosolic isoenzymes

Onno MISSET, Jozef VAN BEEUMEN, Anne-Marie LAMBEIR, Rob VAN DER MEER, Fred R. OPPERDOES

Journal:

Year:

1987

Language:

english

File:

PDF, 724 KB

english, 1987

61

Kinetics of the oxidation of ascorbic acid, ferrocyanide and p-phenolsulfonic acid by chloroperoxidase compounds I and II

Anne-Marie LAMBEIR, H. Brian DUNFORD, Michael A. PICKARD

Journal:

Year:

1987

Language:

english

File:

PDF, 574 KB

english, 1987

62

Kinetic properties of triose-phosphate isomerase from Trypanosoma brucei brucei : A comparison with the rabbit muscle and yeast enzymes

Anne-Marie LAMBEIR, Fred R. OPPERDOES, Rik K. WIERENGA

Journal:

Year:

1987

Language:

english

File:

PDF, 608 KB

english, 1987

63

Glucosephosphate isomerase from Trypanosoma brucei : Cloning and characterization of the gene and analysis of the enzyme

Martine MARCHAND, Ulco KOOYSTRA, Rik K. WIERENGA, Anne-Marie LAMBEIR, Jos Van BEEUMEN, Fred R. OPPERDOES, Paul A. M. MICHELS

Journal:

Year:

1989

Language:

english

File:

PDF, 1.23 MB

english, 1989

64

Kinetics of the reaction of compound II of horseradish peroxidase with hydrogen peroxide to form compound III

Suara A. ADEDIRAN, Anne-Marie LAMBEIR

Journal:

Year:

1989

Language:

english

File:

PDF, 625 KB

english, 1989

65

The cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei : Kinetic properties and comparison with homologous enzymes

Anne-Marie LAMBEIR, Ann M. LOISEAU, Douglas A. KUNTZ, Frederic M. VELLIEUX, Paul A. M. MICHELS, F. R. OPPERDOES

Journal:

Year:

1991

Language:

english

File:

PDF, 750 KB

english, 1991

66

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

TT Myöhänen, MJ Hannula, R Van Elzen, M Gerard, P Van Der Veken, JA García-Horsman, V Baekelandt, PT Männistö, AM Lambeir

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 6.59 MB

english, 2012

67

γ-Amino-Substituted Analogues of 1-[(S)-2,4-Diaminobutanoyl]piperidine as Highly Potent and Selective Dipeptidyl Peptidase II Inhibitors

Senten, Kristel, Van der Veken, Pieter, De Meester, Ingrid, Lambeir, Anne-Marie, Scharpé, Simon, Haemers, Achiel, Augustyns, Koen

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 208 KB

english, 2004

68

Translational research on prolyl oligopeptidase inhibitors: the long road ahead

Lambeir, Anne-Marie

Journal:

Expert Opinion on Therapeutic Patents

Year:

2011

Language:

english

File:

PDF, 191 KB

english, 2011

69

Structure–Activity Relationship Studies on Isoindoline Inhibitors of Dipeptidyl Peptidases 8 and 9 (DPP8, DPP9): Is DPP8-Selectivity an Attainable Goal?

Van Goethem, Sebastiaan, Matheeussen, Veerle, Joossens, Jurgen, Lambeir, Anne-Marie, Chen, Xin, De Meester, Ingrid, Haemers, Achiel, Augustyns, Koen, Van der Veken, Pieter

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.90 MB

english, 2011

70

A kinetic and spectral study of the alkaline transitions of chloroperoxidase

Anne-Marie Lambeir, H.Brian Dunford

Journal:

Archives of Biochemistry and Biophysics

Year:

1983

Language:

english

File:

PDF, 639 KB

english, 1983

71

A rapid-scan spectrometric and stopped-flow study of Compound I and Compound II of Pseudomonas cytochrome c peroxidase

Marjaana Rönnberg, Anne-Marie Lambeir, Nils Ellfolk, H.Brian Dunford

Journal:

Archives of Biochemistry and Biophysics

Year:

1985

Language:

english

File:

PDF, 547 KB

english, 1985

72

On the mechanism of chlorination by chloroperoxidase

H.Brian Dunford, Anne-Marie Lambeir, Mohammed A. Kashem, Michael Pickard

Journal:

Archives of Biochemistry and Biophysics

Year:

1987

Language:

english

File:

PDF, 819 KB

english, 1987

73

Dipeptide-derived diphenyl phosphonate esters: mechanism-based inhibitors of dipeptidyl peptidase IV

Anne-Marie Lambeir, Marianne Borloo, Ingrid De Meester, Alexander Belyaev, Koen Augustyns, Dirk Hendriks, Simon Scharpé, Achiel Haemers

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1996

Language:

english

File:

PDF, 653 KB

english, 1996

74

Suggested functions for prolyl oligopeptidase: A puzzling paradox

Inger Brandt, Simon Scharpé, Anne-Marie Lambeir

Journal:

Clinica Chimica Acta

Year:

2007

Language:

english

File:

PDF, 320 KB

english, 2007

75

Carboxypeptidase M: Multiple alliances and unknown partners

Kathleen Deiteren, Dirk Hendriks, Simon Scharpé, Anne Marie Lambeir

Journal:

Clinica Chimica Acta

Year:

2009

Language:

english

File:

PDF, 980 KB

english, 2009

76

Method comparison of dipeptidyl peptidase IV activity assays and their application in biological samples containing reversible inhibitors

Veerle Matheeussen, Anne-Marie Lambeir, Wolfgang Jungraithmayr, Nelson Gomez, Kathleen Mc Entee, Pieter Van der Veken, Simon Scharpé, Ingrid De Meester

Journal:

Clinica Chimica Acta

Year:

2012

Language:

english

File:

PDF, 364 KB

english, 2012

77

ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain

S. Sercu, A.M. Lambeir, E. Steenackers, A. El Ghalbzouri, K. Geentjens, T. Sasaki, N. Oyama, J. Merregaert

Journal:

Year:

2009

Language:

english

File:

PDF, 2.94 MB

english, 2009

78

The effect of prolyl oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum

Aaro J. Jalkanen, T. Petteri Piepponen, Jenni J. Hakkarainen, Ingrid De Meester, Anne-Marie Lambeir, Markus M. Forsberg

Journal:

Neurochemistry International

Year:

2012

Language:

english

File:

PDF, 490 KB

english, 2012

79

Search for substrates for prolyl oligopeptidase in porcine brain

Inger Brandt, Kris De Vriendt, Bart Devreese, Jozef Van Beeumen, Walter Van Dongen, Koen Augustyns, Ingrid De Meester, Simon Scharpé, Anne-Marie Lambeir

Journal:

Year:

2005

Language:

english

File:

PDF, 281 KB

english, 2005

80

Prolyl oligopeptidase stimulates the aggregation of α-synuclein

Inger Brandt, Melanie Gérard, Kjell Sergeant, Bart Devreese, Veerle Baekelandt, Koen Augustyns, Simon Scharpé, Yves Engelborghs, Anne-Marie Lambeir

Journal:

Year:

2008

Language:

english

File:

PDF, 278 KB

english, 2008

81

Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion

Anne-Marie Lambeir, Christine Durinx, Paul Proost, Jo Van Damme, Simon Scharpé, Ingrid De Meester

Journal:

Year:

2001

Language:

english

File:

PDF, 93 KB

english, 2001

82

Corrigendum to: Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion (FEBS 25376): [FEBS Letters 507 (2001) 327–330]

Anne-Marie Lambeir, Christine Durinx, Paul Proost, Jo Van Damme, Simon Scharpé, Ingrid De Meester

Journal:

Year:

2002

Language:

english

File:

PDF, 26 KB

english, 2002

83

The importance of the conserved Arg191–Asp227 salt bridge of triosephosphate isomerase for folding, stability, and catalysis

Inari Kursula, Sanna Partanen, Anne-Marie Lambeir, Rik K. Wierenga

Journal:

Year:

2002

Language:

english

File:

PDF, 392 KB

english, 2002

84

The effects of CD26/DPP IV-targeted therapy on acute allograft rejection

S. Korom, I. De Meester, K. Onodera, T.H.W. Stadlbauer, M. Borloo, A.M. Lambeir, J.W. Kupiec-Weglinski

Journal:

Transplantation Proceedings

Year:

1997

Language:

english

File:

PDF, 152 KB

english, 1997

85

Presence and release of SR-17 (chromogranin B586–602) in the porcine splenic nerve and its enzymatic degradation by CD26/dipeptidyl peptidase IV

Jan Depreitere, Christine Durinx, Zesheng Wang, Edmond Coen, Anne-Marie Lambeir, Simon Scharpé, Werner De Potter, Etienne J. Nouwen

Journal:

Regulatory Peptides

Year:

2002

Language:

english

File:

PDF, 411 KB

english, 2002

86

P2-Substituted N -Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy

Van der Veken, Pieter, Fülöp, Vilmos, Rea, Dean, Gerard, Melanie, Van Elzen, Roos, Joossens, Jurgen, Cheng, Jonathan D., Baekelandt, Veerle, De Meester, Ingrid, Lambeir, Anne-Marie, Augustyns, Koen

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.37 MB

english, 2012

87

Development of Irreversible Diphenyl Phosphonate Inhibitors for Urokinase Plasminogen Activator

Joossens, J., Van der Veken, P., Lambeir, A.-M., Augustyns, K., Haemers, A.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 63 KB

english, 2004

88

Arginine residues as stabilizing elements in proteins

Mrabet, Nadir T., Van den Broeck, Annemie, Van den Brande, Ilse, Stanssens, Patrick, Laroche, Yves, Lambeir, Anne Marie, Matthijssens, Gaston, Jenkins, John, Chiadmi, Mohamed

Journal:

Year:

1992

Language:

english

File:

PDF, 3.03 MB

english, 1992

89

Carboxypeptidase M in apoptosis, adipogenesis and cancer

Catherine J. Denis, Kathleen Deiteren, Dirk Hendriks, Paul Proost, Anne-Marie Lambeir

Journal:

Clinica Chimica Acta

Year:

2013

Language:

english

File:

PDF, 1016 KB

english, 2013

90

248 Acid stable amylolytic enzymes and lipase as components of pancreatic enzyme replacement in Cystic Fibrosis

S. Scharpé, A.M. Lambeir, M. Van Caillie-Bertrand, L. Van Schil, S. Van Biervliet, E. Robberecht

Journal:

Journal of Cystic Fibrosis

Year:

2006

Language:

english

File:

PDF, 129 KB

english, 2006

91

Preliminary crystallographic studies of glycosomal glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei

R.J. Read, R.K. Wierenga, H. Groendijk, W.G.J. Hol, A. Lambeir, F.R. Opperdoes

Journal:

Journal of Molecular Biology

Year:

1987

Language:

english

File:

PDF, 316 KB

english, 1987

92

In vivo inhibition of dipeptidyl peptidase IV activity by pro-pro-diphenyl-phosphonate (prodipine)

Ingrid De Meester, Alexander Belyaev, Anne-Marie Lambeir, Guido R.Y. De Meyer, Nancy Van Osselaer, Achiel Haemers, Simon Scharpé

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 938 KB

english, 1997

93

Carboxypeptidase M Expressed by Human Bone Marrow Cells Cleaves the C-Terminal Lysine of Stromal Cell-Derived Factor-1α: Another Player in Hematopoietic Stem/Progenitor Cell Mobilization?

Leah Marquez-Curtis, Ali Jalili, Kathleen Deiteren, Neeta Shirvaikar, Anne-Marie Lambeir, Anna Janowska-Wieczorek

Journal:

Year:

2008

Language:

english

File:

PDF, 1.70 MB

english, 2008

94

Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold

Jansen, Koen, Heirbaut, Leen, Cheng, Jonathan D., Joossens, Jurgen, Ryabtsova, Oxana, Cos, Paul, Maes, Louis, Lambeir, Anne-Marie, De Meester, Ingrid, Augustyns, Koen, Van der Veken, Pieter

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 946 KB

english, 2013

95

Fluoro-Olefins as Peptidomimetic Inhibitors of Dipeptidyl Peptidases

Van der Veken, Pieter, Senten, Kristel, Kertèsz, István, De Meester, Ingrid, Lambeir, Anne-Marie, Maes, Marie-Berthe, Scharpé, Simon, Haemers, Achiel, Augustyns, Koen

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 264 KB

english, 2005

96

Rapid Parallel Synthesis of Dipeptide Diphenyl Phosphonate Esters as Inhibitors of Dipeptidyl Peptidases

Senten, Kristel, Daniëls, Liesbeth, Van der Veken, Pieter, De Meester, Ingrid, Lambeir, Anne-Marie, Scharpé, Simon, Haemers, Achiel, Augustyns, Koen

Journal:

Journal of Combinatorial Chemistry

Year:

2003

Language:

english

File:

PDF, 121 KB

english, 2003

97

Diphenyl Phosphonate Inhibitors for the Urokinase-Type Plasminogen Activator: Optimization of the P4 Position

Joossens, Jurgen, Van der Veken, Pieter, Surpateanu, Georgiana, Lambeir, Anne-Marie, El-Sayed, Ibrahim, Ali, Omar M., Augustyns, Koen, Haemers, Achiel

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 356 KB

english, 2006

98

Validation of a specific prolylcarboxypeptidase activity assay and its suitability for plasma and serum measurements

Kehoe, Kaat, Verkerk, Robert, Sim, Yani, Waumans, Yannick, Van der Veken, Pieter, Lambeir, Anne-Marie, De Meester, Ingrid

Journal:

Analytical Biochemistry

Year:

2013

Language:

english

File:

PDF, 730 KB

english, 2013

99

Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

Jansen, Koen, Heirbaut, Leen, Verkerk, Robert, Cheng, Jonathan D., Joossens, Jurgen, Cos, Paul, Maes, Louis, Lambeir, Anne-Marie, De Meester, Ingrid, Augustyns, Koen, Van der Veken, Pieter

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

100

Protein engineering of xylose (glucose) isomerase from Actinoplanes missouriensis. 3. Changing metal specificity and the pH profile by site-directed mutagenesis

Van Tilbeurgh, Herman, Jenkins, John, Chiadmi, Mohammed, Janin, Joel, Wodak, Shoshana J., Mrabet, Nadir T., Lambeir, Anne marie

Journal:

Year:

1992

Language:

english

File:

PDF, 1.34 MB

english, 1992