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51

Mrvil, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1

Jr, John D Shaughnessy, Largaespada, David A, Tian, Erming, Fletcher, Colin F, Cho, Brian C, Vyas, Paresh, Jenkins, Nancy A, Copeland, Neal G

Journal:

Year:

1999

Language:

english

File:

PDF, 807 KB

english, 1999

52

Vav promoter-tTA conditional transgene expression system for hematopoietic cells drives high level expression in developing B and T cells

Won-Il Kim, Stephen M. Wiesner, David A. Largaespada

Journal:

Experimental Hematology

Year:

2007

Language:

english

File:

PDF, 609 KB

english, 2007

53

Assessing Sleeping Beauty Transpositions for T-Cell Immunotherapy by Supercomputer-Based High-Throughput Profiling of Integration Events

S.O. Ang, S.N. Maiti, B. Moriarity, K. Andrews, M. Ossowski, K. Tzeng, R. Talbot, D. Kellar, H. Huls, P. Kebriaei, S. Kelly, E. Shpall, D.A. Largaespada, R. Champlin, P.B. Hackett, L.J.N. Cooper

Journal:

Biology of Blood and Marrow Transplantation

Year:

2012

Language:

english

File:

PDF, 51 KB

english, 2012

54

A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis

Starr, T. K., Scott, P. M., Marsh, B. M., Zhao, L., Than, B. L. N., O'Sullivan, M. G., Sarver, A. L., Dupuy, A. J., Largaespada, D. A., Cormier, R. T.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 301 KB

english, 2011

55

Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML

Kurata, Morito, Rathe, Susan K., Bailey, Natashay J., Aumann, Natalie K., Jones, Justine M., Veldhuijzen, G. Willemijn, Moriarity, Branden S., Largaespada, David A.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.15 MB

english, 2016

56

Folate Deficiency Is Prevalent in Women of Childbearing Age in Belize and Is Negatively Affected by Coexisting Vitamin B-12 Deficiency: Belize National Micronutrient Survey 2011

Rosenthal, Jorge, Largaespada, Natalia, Bailey, Lynn B, Cannon, Michael, Alverson, CJ, Ortiz, Dayrin, Kauwell, Gail PA, Sniezek, Joe, Figueroa, Ramon, Daly, Robyn, Allen, Peter

Journal:

Journal of Nutrition

Year:

2017

Language:

english

File:

PDF, 821 KB

english, 2017

57

Efficient Non-Viral Integration and Stable Gene Expression in Multipotent Adult Progenitor Cells

Wilber, Andrew, Ulloa Montoya, Fernando, Hammer, Luke, Moriarity, Branden S., Geurts, Aron M., Largaespada, David A., Verfaillie, Catherine M., McIvor, R. Scott, Lakshmipathy, Uma

Journal:

Stem Cells International

Year:

2011

Language:

english

File:

PDF, 3.68 MB

english, 2011

58

Identification of a Novel GTPase, the Inducibly Expressed GTPase, That Accumulates in Response to Interferon

Taylor, G. A., Jeffers, M., Largaespada, D. A., Jenkins, N. A., Copeland, N. G., Woude, G. F. V.

Journal:

Journal of Biological Chemistry

Year:

1996

Language:

english

File:

PDF, 1.51 MB

english, 1996

59

[IEEE 2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences (ICCABS) - Orlando, FL, USA (2011.02.3-2011.02.5)] 2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences (ICCABS) - Poster: Assessing the content of active endogenous LINE1 retrotransposons in human colorectal cancer samples using high-throughput pyrosequencing

Fan, Danhua, Rahrmann, Eric P., Silverstein, Kevin A. T., Largaespada, David A.

Year:

2011

Language:

english

File:

PDF, 108 KB

english, 2011

60

Structure-based prediction of insertion-site preferences of transposons into chromosomes

Geurts, A. M., Hackett, C. S., Bell, J. B., Bergemann, T. L., Collier, L. S., Carlson, C. M., Largaespada, D. A., Hackett, P. B.

Journal:

Nucleic Acids Research

Year:

2006

Language:

english

File:

PDF, 506 KB

english, 2006

61

A Modified Sleeping Beauty Transposon System That Can Be Used to Model a Wide Variety of Human Cancers in Mice

Dupuy, A. J., Rogers, L. M., Kim, J., Nannapaneni, K., Starr, T. K., Liu, P., Largaespada, D. A., Scheetz, T. E., Jenkins, N. A., Copeland, N. G.

Journal:

Cancer Research

Year:

2009

Language:

english

File:

PDF, 375 KB

english, 2009

62

A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma

Mirabello, L., Koster, R., Moriarity, B. S., Spector, L. G., Meltzer, P. S., Gary, J., Machiela, M. J., Pankratz, N., Panagiotou, O. A., Largaespada, D., Wang, Z., Gastier-Foster, J. M., Gorlick, R.,

Journal:

Cancer Discovery

Year:

2015

File:

PDF, 1.84 MB

2015

63

Mammalian germ-line transgenesis by transposition

Dupuy, A. J., Clark, K., Carlson, C. M., Fritz, S., Davidson, A. E., Markley, K. M., Finley, K., Fletcher, C. F., Ekker, S. C., Hackett, P. B., Horn, S., Largaespada, D. A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 399 KB

english, 2002

64

Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen

Ho, Yen-Yi, Starr, Timothy K., LaRue, Rebecca S., Largaespada, David A.

Journal:

BMC Medical Genomics

Year:

2016

Language:

english

File:

PDF, 1.64 MB

english, 2016

65

Transforming science: cancer gene identification

Lara S Collier, David A Largaespada

Journal:

Current Opinion in Genetics & Development

Year:

2006

Language:

english

File:

PDF, 280 KB

english, 2006

66

385. Tol2 Transposon as a Gene Therapy Vector: Characterization, Optimization and Correction of Hereditary Tyrosinemia Type 1 in Mouse

Balciunas, Darius, Wilber, Andrew, Wangensteen, Kirk, Bell, Jason, Geurts, Aron, Hackett, Perry B., Largaespada, David A., McIvor, R. Scott, Ekker, Stephen C.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 82 KB

english, 2006

67

Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

Carlson, C. M., Frandsen, J. L., Kirchhof, N., McIvor, R. S., Largaespada, D. A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 627 KB

english, 2005

68

An shRNA screen identifies MEIS1 as a driver of malignant peripheral nerve sheath tumors

Patel, Ami V., Chaney, Katherine E., Choi, Kwangmin, Largaespada, David A., Kumar, Ashish R., Ratner, Nancy

Journal:

Year:

2016

Language:

english

File:

PDF, 905 KB

english, 2016

69

Deoxycytidine kinase is downregulated in Ara-C-resistant acute myeloid leukemia murine cell lines

Rathe, S K, Largaespada, D A

Journal:

Year:

2010

Language:

english

File:

PDF, 199 KB

english, 2010

70

Testing a Teaching Appointment and Geragogy-Based Approach to Medication Knowledge at Discharge

Sharon Kimball, Gail Buck, Debora Goldstein, Elena Largaespada, Lauren Logan, Diane Stebbins, Lisa Halvorsen, Kris Kalman-Yearout

Journal:

Rehabilitation Nursing

Year:

2010

Language:

english

File:

PDF, 190 KB

english, 2010

71

Epidemiology of childhood leukemia: a transdisciplinary approach

J. Ross, K.J. Johnson, D.A. Largaespada, L.G. Spector, S. Ognjanovic

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 92 KB

english, 2008

72

Sleeping Beauty-Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

Bender, A. M., Collier, L. S., Rodriguez, F. J., Tieu, C., Larson, J. D., Halder, C., Mahlum, E., Kollmeyer, T. M., Akagi, K., Sarkar, G., Largaespada, D. A., Jenkins, R. B.

Journal:

Cancer Research

Year:

2010

Language:

english

File:

PDF, 2.08 MB

english, 2010

73

Identification of PDE4D as a Proliferation Promoting Factor in Prostate Cancer Using a Sleeping Beauty Transposon-Based Somatic Mutagenesis Screen

Rahrmann, E. P., Collier, L. S., Knutson, T. P., Doyal, M. E., Kuslak, S. L., Green, L. E., Malinowski, R. L., Roethe, L., Akagi, K., Waknitz, M., Huang, W., Largaespada, D. A., Marker, P. C.

Journal:

Cancer Research

Year:

2009

Language:

english

File:

PDF, 661 KB

english, 2009

74

Modular assembly of transposon integratable multigene vectors using RecWay assembly

Moriarity, B. S., Rahrmann, E. P., Keng, V. W., Manlove, L. S., Beckmann, D. A., Wolf, N. K., Khurshid, T., Bell, J. B., Largaespada, D. A.

Journal:

Nucleic Acids Research

Year:

2013

Language:

english

File:

PDF, 8.17 MB

english, 2013

75

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia

Heltemes-Harris, L M, Larson, J D, Starr, T K, Hubbard, G K, Sarver, A L, Largaespada, D A, Farrar, M A

Journal:

Year:

2015

Language:

english

File:

PDF, 1005 KB

english, 2015

76

TMOD-43. A PORCINE MODEL OF NEUROFIBROMATOSIS TYPE I-ASSOCIATED NERVOUS SYSTEM TUMORS

Isakson, Sara, Coutts, Alex, Largaespada, David, Watson, Adrienne

Journal:

Year:

2017

Language:

english

File:

PDF, 59 KB

english, 2017

77

Overexpression of HGF/MET axis along with p53 inhibition induces de novo glioma formation in mice

Qin, Yuan, Musket, Anna, Kou, Jianqun, Preiszner, Johanna, Tschida, Barbara R, Qin, Anna, Land, Craig A, Staal, Ben, Kang, Liang, Tanner, Kirk, Jiang, Yong, Schweitzer, John B, Largaespada, David A, X

Journal:

Neuro-Oncology Advances

Year:

2020

File:

PDF, 1.44 MB

2020

78

Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia

Bin Yin, Scott C. Kogan, Ross A. Dickins, Scott W. Lowe, David A. Largaespada

Journal:

Experimental Hematology

Year:

2006

Language:

english

File:

PDF, 348 KB

english, 2006

79

Cost-effectiveness of HPV vaccination in Belize

Walwyn, Leslie, Janusz, Cara Bess, Clark, Andrew David, Prieto, Elise, Waight, Eufemia, Largaespada, Natalia

Journal:

Year:

2015

Language:

english

File:

PDF, 1.22 MB

english, 2015

80

Evi9 Encodes a Novel Zinc Finger Protein That Physically Interacts with BCL6, a Known Human B-Cell Proto-Oncogene Product

Nakamura, T., Yamazaki, Y., Saiki, Y., Moriyama, M., Largaespada, D. A., Jenkins, N. A., Copeland, N. G.

Journal:

Molecular and Cellular Biology

Year:

2000

Language:

english

File:

PDF, 1.82 MB

english, 2000

81

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Pomeroy, E J, Lee, L A, Lee, R D W, Schirm, D K, Temiz, N A, Ma, J, Gruber, T A, Diaz-Flores, E, Moriarity, B S, Downing, J R, Shannon, K M, Largaespada, D A, Eckfeldt, C E

Journal:

Year:

2016

Language:

english

File:

PDF, 1.99 MB

english, 2016

82

Increased follicle recruitment and testosterone-related adiposity contribute to granulosa cell dysfunction in lean polycystic ovary syndrome (PCOS) women

Guedikian, A., Lee, A.Y., Grogan, T.R., Abbott, D.H., Largaespada, K., Chazenbalk, G.D., Dumesic, D.A.

Journal:

Fertility and Sterility

Year:

2017

Language:

english

File:

PDF, 137 KB

english, 2017

83

Transposon Insertion Mutagenesis in Mice for Modeling Human Cancers: Critical Insights Gained and New Opportunities

Beckmann, Pauline J., Largaespada, David A.

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 1.22 MB

2020

84

Explaining sex differences in dental caries prevalence: Saliva, hormones, and “life-history” etiologies

John R. Lukacs, Leah L. Largaespada

Journal:

American Journal of Human Biology

Year:

2006

Language:

english

File:

PDF, 203 KB

english, 2006

85

High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene

G. Maroteaux, M. Loos, S. van der Sluis, B. Koopmans, E. Aarts, K. van Gassen, A. Geurts, The NeuroBSIK Mouse Phenomics Consortium, D. A. Largaespada, B. M. Spruijt, O. Stiedl, A. B. Smit, M. Verhage

Journal:

Genes, Brain and Behavior

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

86

Developmental Origins of Cancer

Johnson, K. J., Springer, N. M., Bielinsky, A.-K., Largaespada, D. A., Ross, J. A.

Journal:

Cancer Research

Year:

2009

Language:

english

File:

PDF, 180 KB

english, 2009

87

CADD-14. TARGETING THE CD200 CHECKPOINT FOR THE FIGHT AGAINST CENTRAL NERVOUS SYSTEM TUMORS

Olin, Michael, Ampudia-Mesias, Elisabet, Pennell, Christopher A, Xiong, Zhengming, Rathe, Susan K, Largaespada, David A, Moertel, Christopher L, Pluhar, G Elizabeth

Journal:

Year:

2018

Language:

english

File:

PDF, 113 KB

english, 2018

88

New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors

Williams, Kyle B., Largaespada, David A.

Journal:

Year:

2020

File:

PDF, 3.19 MB

2020

89

A bad rap: Rap1 signaling and oncogenesis

David A Largaespada

Journal:

Year:

2003

Language:

english

File:

PDF, 62 KB

english, 2003

90

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

Rawlings, D., Saffran, D., Tsukada, S, Largaespada, D., Grimaldi, J., Cohen, L, Mohr, R., Bazan, J., Howard, M, Copeland, N., et, al.

Journal:

Year:

1993

Language:

english

File:

PDF, 1.37 MB

english, 1993

91

RNA as a Source of Transposase for Sleeping Beauty-Mediated Gene Insertion and Expression in Somatic Cells and Tissues

WILBER, A, FRANDSEN, J, GEURTS, J, LARGAESPADA, D, HACKETT, P, MCIVOR, R

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 344 KB

english, 2006

92

Understanding the Osteosarcoma Pathobiology: A Comparative Oncology Approach

Varshney, Jyotika, Scott, Milcah, Largaespada, David, Subramanian, Subbaya

Journal:

Veterinary Sciences

Year:

2016

Language:

english

File:

PDF, 223 KB

english, 2016

93

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma

Diessner, Brandon J., Marko, Tracy A., Scott, Ruth M., Eckert, Andrea L., Stuebner, Kathleen M., Hohenhaus, Ann E., Selting, Kim A., Largaespada, David A., Modiano, Jaime F., Spector, Logan G.

Journal:

Cancer Medicine

Year:

2019

File:

PDF, 219 KB

2019

94

IMMU-23. TARGETING THE CD200 CHECKPOINT TO ENHANCE IMMUNOTHERAPY FOR CNS TUMORS

Moertel, Christopher, Pluhar, G Elizabeth, Ampudia-Mesias, Elisabet, Xiong, Zhengming, Pennell, Christopher A, Rathe, Susan K, Largaespada, David A, Olin, Michael R

Journal:

Year:

2019

File:

PDF, 161 KB

2019

95

Modeling hepatitis B virus X–induced hepatocellular carcinoma in mice with the sleeping beauty transposon system

Vincent W. Keng, Barbara R. Tschida, Jason B. Bell, David A. Largaespada

Journal:

Year:

2011

Language:

english

File:

PDF, 835 KB

english, 2011

96

Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes

Takashi Fujino, Yukari Yamazaki, David A Largaespada, Nancy A Jenkins, Neal G Copeland, Katsuiku Hirokawa, Takuro Nakamura

Journal:

Experimental Hematology

Year:

2001

Language:

english

File:

PDF, 899 KB

english, 2001

97

Interweaving the Strands: β-Catenin, an HIV Co-Receptor, and Schwann Cell Tumors

Largaespada, David, Ratner, Nancy

Journal:

Year:

2013

Language:

english

File:

PDF, 200 KB

english, 2013

98

193. Direct Comparison of Integration Efficiency and Stable Gene Expression Mediated by the Transposon System and by the PhiC31 Phage Integrase System in Cultured Human Fibroblasts and in Various Stem Cell Targets

WILBER, A, MONTOYA, F, GEURTS, A, LARGAESPADA, D, LAKSHMIPATHY, U, MCIVOR, R

Journal:

Molecular Therapy

Year:

2005

Language:

english

File:

PDF, 78 KB

english, 2005

99

Activation of Clg , a Novel Dbl Family Guanine Nucleotide Exchange Factor Gene, by Proviral Insertion at Evi24 , a Common Integration Site in B Cell and Myeloid Leukemias

Himmel, Karen L., Bi, Feng, Shen, Haifa, Jenkins, Nancy A., Copeland, Neal G., Zheng, Yi, Largaespada, David A.

Journal:

Journal of Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 1.21 MB

english, 2002

100

De novo Induction of Genetically Engineered Brain Tumors in Mice Using Plasmid DNA

Wiesner, S. M., Decker, S. A., Larson, J. D., Ericson, K., Forster, C., Gallardo, J. L., Long, C., Demorest, Z. L., Zamora, E. A., Low, W. C., SantaCruz, K., Largaespada, D. A., Ohlfest, J. R.

Journal:

Cancer Research

Year:

2009

Language:

english

File:

PDF, 802 KB

english, 2009

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