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1

The p38α mitogen-activated protein kinase as a central nervous system drug discovery target

Aaron S Borders, Lucia de Almeida, Linda J Van Eldik, D Martin Watterson

Journal:

BMC Neuroscience

Year:

2008

Language:

english

File:

PDF, 1.37 MB

english, 2008

2

Organization of the genetic locus for chicken myosin light chain kinase is complex: Multiple proteins are encoded and exhibit differential expression and localization

Konstantin G. Birukov, James P. Schavocky, Vladimir P. Shirinsky, Margarita V. Chibalina, Linda J. Van Eldik, D. Martin Watterson

Journal:

Journal of Cellular Biochemistry

Year:

1998

Language:

english

File:

PDF, 767 KB

english, 1998

3

Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: Organization, expression, alternative splicing, and polymorphic marker

D. Martin Watterson, James P. Schavocky, Ling Guo, Curtis Weiss, Alexandre Chlenski, Vladimir P. Shirinsky, Linda J. Van Eldik, Jacques Haiech

Journal:

Journal of Cellular Biochemistry

Year:

1999

Language:

english

File:

PDF, 461 KB

english, 1999

4

Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia

Mark S. Wainwright, Jeffrey M. Craft, W. Sue T. Griffin, Alexander Marks, Jose Pineda, Kyle R. Padgett, Linda J. Van Eldik

Journal:

Annals of Neurology

Year:

2004

Language:

english

File:

PDF, 266 KB

english, 2004

5

Calmodulin and calbindin localization in retina from six vertebrate species

Roland Pochet, Brigitte Pasteels, Akiko Seto-ohshima, Enrico Bastianelli, Satoko Kitajima, Linda J. Van Eldik

Journal:

The Journal of Comparative Neurology

Year:

1991

Language:

english

File:

PDF, 1.63 MB

english, 1991

6

Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38

Zhong Xie, Carolyn J. Smith, Linda J. Van Eldik

Journal:

Year:

2004

Language:

english

File:

PDF, 766 KB

english, 2004

7

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human β-amyloid

Jeffrey M. Craft, D. Martin Watterson, Alexander Marks, Linda J. Van Eldik

Journal:

Year:

2005

Language:

english

File:

PDF, 400 KB

english, 2005

8

Human amyloid β-induced neuroinflammation is an early event in neurodegeneration

Jeffrey M. Craft, D. Martin Watterson, Linda J. Van Eldik

Journal:

Year:

2006

Language:

english

File:

PDF, 301 KB

english, 2006

9

Differential regulation of S100β and mRNAS coding for S100-like proteins (42A and 42C) during development and after lesion of rat sciatic nerve

M. De León, Dr. Linda J. Van Eldik, E. M. Shooter

Journal:

Journal of Neuroscience Research

Year:

1991

Language:

english

File:

PDF, 875 KB

english, 1991

10

S100β Induces Neuronal Cell Death Through Nitric Oxide Release from Astrocytes

Jingru Hu, Adriana Ferreira, Linda J. Van Eldik

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 1.10 MB

english, 1997

11

S100β Increases Levels of β-Amyloid Precursor Protein and Its Encoding mRNA in Rat Neuronal Cultures

Yuekui Li, Jianzhong Wang, Jin G. Sheng, Ling Liu, Steven W. Barger, Richard A. Jones, Linda J. Van Eldik, Robert E. Mrak, W. Sue T. Griffin

Journal:

Journal of Neurochemistry

Year:

1998

Language:

english

File:

PDF, 1.46 MB

english, 1998

12

Apolipoprotein E Attenuates β-Amyloid-Induced Astrocyte Activation

Jingru Hu, Mary Jo LaDu, Linda J. Van Eldik

Journal:

Journal of Neurochemistry

Year:

1998

Language:

english

File:

PDF, 1.20 MB

english, 1998

13

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

Adam D Bachstetter, Bin Xing, Lucia de Almeida, Edgardo R Dimayuga, D Martin Watterson, Linda J Van Eldik

Journal:

Journal of Neuroinflammation

Year:

2011

Language:

english

File:

PDF, 634 KB

english, 2011

14

Identification of the binding site on S100B protein for the actin capping protein CapZ

Peter M. Kilby, GORDON C. K. Roberts, Linda J. Van Eldik

Journal:

Protein Science

Year:

1997

Language:

english

File:

PDF, 3.74 MB

english, 1997

15

Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies

Peter T. Nelson, Elizabeth Head, Frederick A. Schmitt, Paulina R. Davis, Janna H. Neltner, Gregory A. Jicha, Erin L. Abner, Charles D. Smith, Linda J. Van Eldik, Richard J. Kryscio, Stephen W. Scheff

Journal:

Acta Neuropathologica

Year:

2011

Language:

english

File:

PDF, 1.07 MB

english, 2011

16

Association between male gender and cortical Lewy body pathology in large autopsy series

Peter T. Nelson, Frederick A. Schmitt, Gregory A. Jicha, Richard J. Kryscio, Erin L. Abner, Charles D. Smith, Linda J. Van Eldik, William R. Markesbery

Journal:

Journal of Neurology

Year:

2010

Language:

english

File:

PDF, 263 KB

english, 2010

17

Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses

D. Martin Watterson, Jacques Haiech, Linda J. Van Eldik

Journal:

Journal of Molecular Neuroscience

Year:

2002

Language:

english

File:

PDF, 93 KB

english, 2002

18

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits

Wenhui Hu, Hantamalala Ralay Ranaivo, Saktimayee M. Roy, Heather A. Behanna, Laura K. Wing, Lenka Munoz, Ling Guo, Linda J. Van Eldik, D. Martin Watterson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 183 KB

english, 2007

19

Levels and Distribution of the Calcium-Modulated Proteins S100 and Calmodulin in Rat C6 Glioma Cells

Danna B. Zimmer, Linda J. Van Eldik

Journal:

Journal of Neurochemistry

Year:

1988

Language:

english

File:

PDF, 1.53 MB

english, 1988

20

S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors

Ling Liu, Yuekui Li, Linda J. Van Eldik, W. Sue T. Griffin, Steven W. Barger

Journal:

Journal of Neurochemistry

Year:

2005

Language:

english

File:

PDF, 257 KB

english, 2005

21

Glial Activation Links Early-Life Seizures and Long-Term Neurologic Dysfunction: Evidence Using a Small Molecule Inhibitor of Proinflammatory Cytokine Upregulation

Kathleen C. Somera-Molina, Beverley Robin, Cherie Ann Somera, Christopher Anderson, Christy Stine, Sookyong Koh, Heather A. Behanna, Linda J. Van Eldik, D. Martin Watterson, Mark S. Wainwright

Journal:

Year:

2007

Language:

english

File:

PDF, 855 KB

english, 2007

22

Lipoproteins in the Central Nervous System

MARY JO LADU, CATHERINE REARDON, LINDA VAN ELDIK, ANNE M. FAGAN, GUOJUN BU, DAVID HOLTZMAN, GODFREY S. GETZ

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 936 KB

english, 2000

23

Targeting protein kinases in central nervous system disorders

Chico, Laura K., Van Eldik, Linda J., Watterson, D. Martin

Journal:

Nature Reviews Drug Discovery

Year:

2009

Language:

english

File:

PDF, 582 KB

english, 2009

24

Dance of the dimers

Krebs, Joachim, Quadroni, Manfredo, Van Eldik, Linda J.

Journal:

Natural Structural Biology

Year:

1995

File:

PDF, 483 KB

1995

25

Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against β-amyloid induced injury

D. Martin Watterson, Anastasia V. Velentza, Magdalena Zasadzki, Jeffrey M. Craft, Jacques Haiech, Linda J. Van Eldik

Journal:

Journal of Molecular Neuroscience

Year:

2003

Language:

english

File:

PDF, 717 KB

english, 2003

26

A dual role for apolipoprotein E in neuroinflammation

Ling Guo, Mary Jo LaDu, Linda J. Van Eldik

Journal:

Journal of Molecular Neuroscience

Year:

2004

Language:

english

File:

PDF, 190 KB

english, 2004

27

ApoE and Aβ1–42 interactions

Arlene M. Manelli, W. Blaine Stine, Linda J. Van Eldik, Mary Jo LaDu

Journal:

Journal of Molecular Neuroscience

Year:

2004

Language:

english

File:

PDF, 434 KB

english, 2004

28

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human β-amyloid in a murine model of neuroinflammation

Jeffrey M. Craft, Linda J. Van Eldik, Magdalena Zasadzki, Wenhui Hu, D. Martin Watterson

Journal:

Journal of Molecular Neuroscience

Year:

2004

Language:

english

File:

PDF, 98 KB

english, 2004

29

Distribution of calmodulin and calmodulin-binding proteins in membranes from bovine epididymal spermatozoa

Thomas D. Noland, Linda J. Van Eldik, David L. Garbers, Wilson H. Burgess

Journal:

Molecular Reproduction and Development

Year:

1985

Language:

english

File:

PDF, 497 KB

english, 1985

30

S100β protects hippocampal neurons from damage induced by glucose deprivation

Steven W. Barger, Linda J. Van Eldik, Mark P. Mattson

Journal:

Year:

1995

Language:

english

File:

PDF, 376 KB

english, 1995

31

Disulfide-linked S100β dimers and signal transduction

Steven W. Barger, Sandra R. Wolchok, Linda J. Van Eldik

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1992

Language:

english

File:

PDF, 889 KB

english, 1992

32

Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’ seizure model

Kathleen C. Somera-Molina, Sangeetha Nair, Linda J. Van Eldik, D. Martin Watterson, Mark S. Wainwright

Journal:

Year:

2009

Language:

english

File:

PDF, 1.64 MB

english, 2009

33

Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NFκB and MAPK dependent pathways in rat astrocytes

Wendy L. Thompson, Linda J. Van Eldik

Journal:

Year:

2009

Language:

english

File:

PDF, 1.16 MB

english, 2009

34

Corrigendum to “Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NFκB and MAPK dependent pathways in rat astrocytes” [Brain Res. 1287 (2009) 47–57]

Wendy L. Thompson, Linda J. Van Eldik

Journal:

Year:

2009

Language:

english

File:

PDF, 77 KB

english, 2009

35

Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug

William J. Karpus, Nathaneal Reynolds, Heather A. Behanna, Linda J. Van Eldik, D. Martin Watterson

Journal:

Journal of Neuroimmunology

Year:

2008

Language:

english

File:

PDF, 623 KB

english, 2008

36

Cognitive impairment in humanized APP × PS1 mice is linked to Aβ1–42 and NOX activation

Annadora J. Bruce-Keller, Sunita Gupta, Alecia G. Knight, Tina L. Beckett, Jessica M. McMullen, Paulina R. Davis, M. Paul Murphy, Linda J. Van Eldik, Daret St Clair, Jeffrey N. Keller

Journal:

Neurobiology of Disease

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

37

Cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells

Tanuja Koppal, Tatiana V Petrova, Linda J Van Eldik

Journal:

Year:

2000

Language:

english

File:

PDF, 692 KB

english, 2000

38

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

Jingru Hu, Keith T Akama, Grant A Krafft, Brett A Chromy, Linda J Van Eldik

Journal:

Year:

1998

Language:

english

File:

PDF, 1.81 MB

english, 1998

39

S100B, a neurotropic protein that modulates neuronal protein phosphorylation, is upregulated during lesion-induced collateral sprouting and reactive synaptogenesis

Brenda S McAdory, Linda J Van Eldik, Jeanette J Norden

Journal:

Year:

1998

Language:

english

File:

PDF, 2.63 MB

english, 1998

40

Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation

Jingru Hu, Linda J Van Eldik

Journal:

Year:

1999

Language:

english

File:

PDF, 486 KB

english, 1999

41

Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets

Salida Mirzoeva, Tanuja Koppal, Tatiana V Petrova, Thomas J Lukas, D.Martin Watterson, Linda J Van Eldik

Journal:

Year:

1999

Language:

english

File:

PDF, 281 KB

english, 1999

42

Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures

Tatiana V. Petrova, Jingru Hu, Linda J. Van Eldik

Journal:

Year:

2000

Language:

english

File:

PDF, 175 KB

english, 2000

43

Ion-binding properties of recombinant S100β and two derivatives with either an inactivated Ca2+ site II or a normalized Ca2+ site I

Isabelle Durussel, Linda J. Van Eldik, Jos A. Cox

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1997

Language:

english

File:

PDF, 141 KB

english, 1997

44

The solution structure of the bovine S100B protein dimer in the calcium-free state

Peter M Kilby, Linda J Van Eldik, Gordon CK Roberts

Journal:

Year:

1996

Language:

english

File:

PDF, 1.38 MB

english, 1996

45

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

Bin Xing, Adam D Bachstetter, Linda J Van Eldik

Journal:

Molecular Neurodegeneration

Year:

2011

Language:

english

File:

PDF, 721 KB

english, 2011

46

Copper-Dependent Formation of Disulfide-Linked Dimer of S100B Protein

In Sook Matsui Lee, Masami Suzuki, Nobuhiro Hayashi, Jingru Hu, Linda J. Van Eldik, Koiti Titani, Morimitsu Nishikimi

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 330 KB

english, 2000

47

Elucidation of a minimal immunoreactive site of vertebrate calmodulin

Linda J. Van Eldik, D.Martin Watterson, Kam-Fook Fok, Bruce W. Erickson

Journal:

Archives of Biochemistry and Biophysics

Year:

1983

Language:

english

File:

PDF, 1005 KB

english, 1983

48

Calmodulin and rat vitamin D-dependent calcium-binding proteins: Biochemical and immunochemical comparison

Sylvia Christakos, M. Elizabeth, H. Bruns, Aruna S. Mehra, William B. Rhoten, Linda J. Van Eldik

Journal:

Archives of Biochemistry and Biophysics

Year:

1984

Language:

english

File:

PDF, 4.02 MB

english, 1984

49

Conditions for reproducible detection of calmodulin and S100β in immunoblots

Linda J. Van Eldik, Sandra R. Wolchok

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 468 KB

english, 1984

50

Interaction of calmodulin and other calcium-modulated proteins with mammalian and arthropod junctional membrane proteins

Linda J. Van Eldik, Elliot L. Hertzberg, Robert C. Berdan, Norton B. Gilula

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 1.26 MB

english, 1985

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