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1

β-Catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation

Gabriel Mbalaviele, Sharmin Sheikh, Joseph P. Stains, Valerie S. Salazar, Su-Li Cheng, Di Chen, Roberto Civitelli

Journal:

Journal of Cellular Biochemistry

Year:

2005

Language:

english

File:

PDF, 764 KB

english, 2005

2

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis

Stephen J. Mnich, Patrick M. Blanner, Liangbiao G. Hu, Alexander F. Shaffer, Fernando A. Happa, Shawn O'Neil, Okechukwu Ukairo, Dave Weiss, Eric Welsh, Chad Storer, Gabriel Mbalaviele, Hidenori Ichijo

Journal:

International Immunopharmacology

Year:

2010

Language:

english

File:

PDF, 848 KB

english, 2010

3

Expression, purification and functional characterization of IκB kinase-2 (IKK-2) mutants

Sumathy Mathialagan, Gennadiy I. Poda, Ravi G. Kurumbail, Shaun R. Selness, Troii Hall, Beverly A. Reitz, Robin A. Weinberg, Nandini Kishore, Gabriel Mbalaviele

Journal:

Protein Expression and Purification

Year:

2010

Language:

english

File:

PDF, 635 KB

english, 2010

4

PARP1 hinders histone H2B occupancy at the NFATc1 promoter to restrain osteoclast differentiation

Wang, Chun, Xiao, Jianqiu, Nowak, Kathrin, Gunasekera, Kapila, Alippe, Yael, Speckman, Sheree, Yang, Tong, Kress, Dustin, Abu‐Amer, Yousef, Hottiger, Michael O., Mbalaviele, Gabriel

Journal:

Journal of Bone and Mineral Research

Year:

2019

Language:

english

File:

PDF, 2.79 MB

english, 2019

5

PARP1 hinders histone H2B occupancy at the NFATc1 promoter to restrain osteoclast differentiation

Wang, Chun, Xiao, Jianqiu, Nowak, Kathrin, Gunasekera, Kapila, Alippe, Yael, Speckman, Sheree, Yang, Tong, Kress, Dustin, Abu‐Amer, Yousef, Hottiger, Michael O., Mbalaviele, Gabriel

Journal:

Journal of Bone and Mineral Research

Year:

2019

File:

PDF, 2.79 MB

2019

6

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

Arra, Manoj, Swarnkar, Gaurav, Ke, Ke, Otero, Jesse E., Ying, Jun, Duan, Xin, Maruyama, Takashi, Rai, Muhammad Farooq, OâKeefe, Regis J., Mbalaviele, Gabriel, Shen, Jie, Abu-Amer, Yousef

Journal:

Nature Communications

Year:

2020

File:

PDF, 2.95 MB

2020

7

Renal effects induced by prolonged mPGES1 inhibition

Salazar, F., Vazquez, M. L., Masferrer, J. L., Mbalaviele, G., Llinas, M. T., Saez, F., Arhancet, G., Salazar, F. J.

Journal:

AJP: Renal Physiology

Year:

2014

Language:

english

File:

PDF, 199 KB

english, 2014

8

Smad4 mediates critical interactions between BMP and canonical Wnt signaling in osteoblasts

V. Salazar⁎, L. Huang, J. Norris, G. Mbalaviele, R. Civitelli

Journal:

Year:

2012

Language:

english

File:

PDF, 64 KB

english, 2012

9

Attenuation of NF‐κB in intestinal epithelial cells is sufficient to mitigate the bone loss co‐morbidity of experimental mouse colitis

Ke, Ke, Chen, Tim(Hung‐Po), Arra, Manoj, Mbalaviele, Gabriel, Swarnkar, Gaurav, Abu‐Amer, Yousef

Journal:

Journal of Bone and Mineral Research

Year:

2019

File:

PDF, 1.66 MB

2019

10

Human Mesenchymal Stem Cells Promote Human Osteoclast Differentiation from CD34 + Bone Marrow Hematopoietic Progenitors 1

Mbalaviele, Gabriel, Jaiswal, Neelam, Meng, Alice, Cheng, Linzhao, Van Den Bos, Christian, Thiede, Mark

Journal:

Year:

1999

Language:

english

File:

PDF, 1.68 MB

english, 1999

11

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

Alippe, Yael, Wang, Chun, Ricci, Biancamaria, Xiao, Jianqiu, Qu, Chao, Zou, Wei, Novack, Deborah V., Abu-Amer, Yousef, Civitelli, Roberto, Mbalaviele, Gabriel

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 8.13 MB

english, 2017

12

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor

Gabriel Mbalaviele, Adele M. Pauley, Alexander F. Shaffer, Ben S. Zweifel, Sumathy Mathialagan, Stephen J. Mnich, Olga V. Nemirovskiy, Jeff Carter, James K. Gierse, Jane L. Wang, Michael L. Vazquez, W

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 609 KB

english, 2010

13

Activation of Peroxisome Proliferator-activated Receptor-gamma Pathway Inhibits Osteoclast Differentiation

Journal:

Journal of Biological Chemistry

Year:

2000

Language:

english

File:

PDF, 978 KB

english, 2000

14

Inhibition of p38 Mitogen-Activated Protein Kinase Prevents Inflammatory Bone Destruction

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2006

Language:

english

File:

PDF, 656 KB

english, 2006

15

Short-term local injections of transforming growth factor-β1 decrease ovariectomy-stimulated osteoclastic resorption in vivo in rats

Johann Beaudreuil, Gabriel Mbalaviele, Martine Cohen-Solal, Caroline Morieux, Marie Christine de Vernejoul, Philippe Orcel

Journal:

Journal of Bone and Mineral Research

Year:

1995

Language:

english

File:

PDF, 721 KB

english, 1995

16

Cadherin-6 Mediates the Heterotypic Interactions between the Hemopoietic Osteoclast Cell Lineage and Stromal Cells in a Murine Model of Osteoclast Differentiation

Gabriel Mbalaviele, Riko Nishimura, Akira Myoi, Maria Niewolna, Sakamuri V. Reddy, Di Chen, Jian Feng, David Roodman, Gregory R. Mundy and Toshiyuki Yoneda

Journal:

The Journal of Cell Biology

Year:

1998

Language:

english

File:

PDF, 1.15 MB

english, 1998

17

Osteoclast formation from human cord blood mononuclear cells co-cultured with mice embryonic metatarsals in the presence of M-CSF

Mbalaviele, G., Orcel, P., Morieux, C., Nijweide, P.J., De Vernejoul, M.C.

Journal:

Year:

1995

Language:

english

File:

PDF, 934 KB

english, 1995

18

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice

Xiao, Jianqiu, Wang, Chun, Yao, Juo-Chin, Alippe, Yael, Xu, Canxin, Kress, Dustin, Civitelli, Roberto, Abu-Amer, Yousef, Kanneganti, Thirumala-Devi, Link, Daniel C., Mbalaviele, Gabriel, Bhandoola, Av

Journal:

Year:

2018

Language:

english

File:

PDF, 10.80 MB

english, 2018

19

Anti-Inflammatory Properties of a Novel N-Phenyl Pyridinone Inhibitor of p38 Mitogen-Activated Protein Kinase: Preclinical-to-Clinical Translation

Hope, H. R., Anderson, G. D., Burnette, B. L., Compton, R. P., Devraj, R. V., Hirsch, J. L., Keith, R. H., Li, X., Mbalaviele, G., Messing, D. M., Saabye, M. J., Schindler, J. F., Selness, S. R., Stil

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2009

Language:

english

File:

PDF, 719 KB

english, 2009

20

N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms

Di Benedetto, A., Watkins, M., Grimston, S., Salazar, V., Donsante, C., Mbalaviele, G., Radice, G. L., Civitelli, R.

Journal:

Journal of Cell Science

Year:

2010

Language:

english

File:

PDF, 863 KB

english, 2010

21

NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis

Swarnkar, Gaurav, Chen, Tim Hung-Po, Arra, Manoj, Nasir, Amjad M., Mbalaviele, Gabriel, Abu-Amer, Yousef

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.83 MB

english, 2017

22

Omnipresence of inflammasome activities in inflammatory bone diseases

Alippe, Yael, Mbalaviele, Gabriel

Journal:

Seminars in Immunopathology

Year:

2019

File:

PDF, 1.58 MB

2019

23

Transforming growth factor-β enhances calcitonin-induced cyclic AMP production and the number of calcitonin receptors in long-term cultures of human umbilical cord blood monocytes in the presence of 1,25-dihydroxycholecalciferol

Gabriel Mbalaviele, Philippe Orcel, Zhor Bouizar, Annick Jullienne, Marie Christine De Vernejoul

Journal:

Journal of Cellular Physiology

Year:

1992

Language:

english

File:

PDF, 837 KB

english, 1992

24

Accentuated Ovariectomy-Induced Bone Loss and Altered Osteogenesis in Heterozygous N-Cadherin Null Mice

Chung Fang Lai, Su-Li Cheng, Gabriel Mbalaviele, Christine Donsante, Marcus Watkins, Glenn L Radice, Roberto Civitelli

Journal:

Journal of Bone and Mineral Research

Year:

2006

Language:

english

File:

PDF, 2.62 MB

english, 2006

25

Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with -catenin

Salazar, V. S., Zarkadis, N., Huang, L., Watkins, M., Kading, J., Bonar, S., Norris, J., Mbalaviele, G., Civitelli, R.

Journal:

Journal of Cell Science

Year:

2013

Language:

english

File:

PDF, 1.72 MB

english, 2013

26

Cadherin-6 Mediates the Heterotypic Interactions between the Hemopoietic Osteoclast Cell Lineage and Stromal Cells in a Murine Model of Osteoclast Differentiation

Journal:

The Journal of Cell Biology

Year:

1998

Language:

english

File:

PDF, 631 KB

english, 1998

27

OsteoclastsâKey Players in Skeletal Health and Disease

Novack, Deborah Veis, Mbalaviele, Gabriel

Journal:

Microbiology Spectrum

Year:

2016

Language:

english

File:

PDF, 789 KB

english, 2016

28

Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice

Chen, T H-P, Swarnkar, G, Mbalaviele, G, Abu-Amer, Y

Journal:

Cell Death and Disease

Year:

2015

Language:

english

File:

PDF, 3.77 MB

english, 2015

29

Radiation causes tissue damage by dysregulating inflammasomeâgasdermin D signaling in both host and transplanted cells

Xiao, Jianqiu, Wang, Chun, Yao, Juo-Chin, Alippe, Yael, Yang, Tong, Kress, Dustin, Sun, Kai, Kostecki, Kourtney L., Monahan, Joseph B., Veis, Deborah J., Abu-Amer, Yousef, Link, Daniel C., Mbalaviele,

Journal:

Year:

2020

File:

PDF, 15.47 MB

2020

30

Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems

Maximova, Natalia, Zennaro, Floriana, Gregori, Massimo, Boz, Giulia, Zanon, Davide, Mbalaviele, Gabriel

Journal:

Year:

2020

Language:

english

File:

PDF, 7.31 MB

english, 2020

31

ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β

Robaszkiewicz, Agnieszka, Qu, Chao, Wisnik, Ewelina, Ploszaj, Tomasz, Mirsaidi, Ali, Kunze, Friedrich A., Richards, Peter J., Cinelli, Paolo, Mbalaviele, Gabriel, Hottiger, Michael O.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.70 MB

english, 2016

32

The pro-osteogenic action of β-catenin requires interaction with BMP signaling, but not Tcf/Lef transcriptional activity

Valerie S. Salazar, Gabriel Mbalaviele, Roberto Civitelli

Journal:

Journal of Cellular Biochemistry

Year:

2008

Language:

english

File:

PDF, 372 KB

english, 2008

33

Support of human CD34+ cell engraftment in nod/scid mice: Dependence on mode of delivery of human mesenchymal stem cells

JD Mosca, G Mbalaviele, L Liu, K Lee, EM Novelli, CI Civin, R Deans

Journal:

Experimental Hematology

Year:

2000

Language:

english

File:

PDF, 16 KB

english, 2000

34

Role of APD-Ribosylation in Bone Health and Disease

Wang,, Mbalaviele,

Journal:

Year:

2019

Language:

english

File:

PDF, 515 KB

english, 2019

35

Perspective: Cell–Cell Adhesion and Signaling Through Cadherins: Connecting Bone Cells in Their Microenvironment

Gabriel Mbalaviele, Chan Soo Shin, Roberto Civitelli

Journal:

Journal of Bone and Mineral Research

Year:

2006

Language:

english

File:

PDF, 1.83 MB

english, 2006

36

Mechanisms of the joint-protective effects of p38 MAPK inhibitors in rodent arthritis

Mbalaviele, Gabriel, Monahan, Joseph B

Journal:

Expert Opinion on Drug Discovery

Year:

2008

Language:

english

File:

PDF, 174 KB

english, 2008

37

N-cadherin Restrains PTH Activation of Lrp6/β-catenin Signaling and Osteoanabolic Action

Revollo, Leila, Kading, Jacqueline, Jeong, Sung Yeop, Li, Jiemin, Salazar, Valerie, Mbalaviele, Gabriel, Civitelli, Roberto

Journal:

Journal of Bone and Mineral Research

Year:

2015

Language:

english

File:

PDF, 3.45 MB

english, 2015

38

Attenuation of NF‐κB in intestinal epithelial cells is sufficient to mitigate the bone loss co‐morbidity of experimental mouse colitis

Ke, Ke, Chen, Tim(Hung‐Po), Arra, Manoj, Mbalaviele, Gabriel, Swarnkar, Gaurav, Abu‐Amer, Yousef

Journal:

Journal of Bone and Mineral Research

Year:

2019

Language:

english

File:

PDF, 1.66 MB

english, 2019

39

Human Umbilical Cord Blood Monocytes Express Calcitonin Receptors in Culture in the Presence of 1,25 Dihydroxyvitamin D

MBALAVIELE, GABRIEL, JULLIENNE, ANNICK, VERNEJOUL, MARIE CHRISTINE DE

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1991

Language:

english

File:

PDF, 861 KB

english, 1991

40

Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation

Wang, C, Qu, C, Alippe, Y, Bonar, S L, Civitelli, R, Abu-Amer, Y, Hottiger, M O, Mbalaviele, G

Journal:

Cell Death and Disease

Year:

2016

Language:

english

File:

PDF, 2.98 MB

english, 2016

41

Myeloid Deletion of Nemo Causes Osteopetrosis in Mice Owing to Upregulation of Transcriptional Repressors

Swarnkar, Gaurav, Shim, Kyuhwan, Nasir, Amjad M., Seehra, Kuljeet, Chen, Hung-Po, Mbalaviele, Gabriel, Abu-Amer, Yousef

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.73 MB

english, 2016

42

Selective inducible microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from an oxicam template

Jane Wang, David Limburg, Jeff Carter, Gabriel Mbalaviele, James Gierse, Michael Vazquez

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 757 KB

english, 2010

43

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling

Swarnkar, Gaurav, Karuppaiah, Kannan, Mbalaviele, Gabriel, Chen, Tim (Hung-Po), Abu-Amer, Yousef

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.37 MB

english, 2015

44

Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype

Salazar, V. S., Zarkadis, N., Huang, L., Norris, J., Grimston, S. K., Mbalaviele, G., Civitelli, R.

Journal:

Journal of Cell Science

Year:

2013

Language:

english

File:

PDF, 3.96 MB

english, 2013

45

Omnipresence of inflammasome activities in inflammatory bone diseases

Alippe, Yael, Mbalaviele, Gabriel

Journal:

Seminars in Immunopathology

Year:

2019

Language:

english

File:

PDF, 1.58 MB

english, 2019

46

A Novel, Highly Selective, Tight Binding I B Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor- B Pathway in Arthritis-Relevant Cells and Animal Models

Mbalaviele, G., Sommers, C. D., Bonar, S. L., Mathialagan, S., Schindler, J. F., Guzova, J. A., Shaffer, A. F., Melton, M. A., Christine, L. J., Tripp, C. S., Chiang, P.-C., Thompson, D. C., Hu, Y., K

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2009

Language:

english

File:

PDF, 513 KB

english, 2009

47

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells

Wang, Chun, Xu, Can-Xin, Alippe, Yael, Qu, Chao, Xiao, Jianqiu, Schipani, Ernestina, Civitelli, Roberto, Abu-Amer, Yousef, Mbalaviele, Gabriel

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 9.25 MB

english, 2017

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