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1

Breast cancer: T-DM1 — an important agent in the history of breast cancer management

Metzger-Filho, Otto, Winer, Eric P.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2017

Language:

english

File:

PDF, 145 KB

english, 2017

2

Surgical Options and Locoregional Recurrence in Patients Diagnosed with Invasive Lobular Carcinoma of the Breast

Sagara, Yasuaki, Barry, William T., Mallory, Melissa Anne, Vaz-Luis, Ines, Aydogan, Fatih, Brock, Jane E., Winer, Eric P., Golshan, Mehra, Metzger-Filho, Otto

Journal:

Annals of Surgical Oncology

Year:

2015

Language:

english

File:

PDF, 452 KB

english, 2015

3

Breast Conservation After Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer

Golshan, Mehra, Loibl, Sibylle, Wong, Stephanie M., Houber, Jens Bodo, O’Shaughnessy, Joyce, Rugo, Hope S., Wolmark, Norman, McKee, Mark D., Maag, David, Sullivan, Danielle M., Metzger-Filho, Otto, Vo

Journal:

Year:

2020

File:

PDF, 304 KB

2020

4

Pregnancy occurring during or following adjuvant trastuzumab in patients enrolled in the HERA trial (BIG 01-01)

Hatem A. Azim, Otto Metzger-Filho, Evandro de Azambuja, Sibylle Loibl, Florine Focant, Ekaterina Gresko, Mounir Arfi, Martine Piccart-Gebhart

Journal:

Breast Cancer Research and Treatment

Year:

2012

Language:

english

File:

PDF, 179 KB

english, 2012

5

Beyond trastuzumab: New treatment options for HER2-positive breast cancer

Kamal S. Saini, Hatem A. Azim Jr, Otto Metzger-Filho, Sherene Loi, Christos Sotiriou, Evandro de Azambuja, Martine Piccart

Journal:

Year:

2011

Language:

english

File:

PDF, 255 KB

english, 2011

6

Dissecting the Heterogeneity of Triple-Negative Breast Cancer

Metzger-Filho, O., Tutt, A., de Azambuja, E., Saini, K. S., Viale, G., Loi, S., Bradbury, I., Bliss, J. M., Azim, H. A., Ellis, P., Di Leo, A., Baselga, J., Sotiriou, C., Piccart-Gebhart, M.

Journal:

Journal of Clinical Oncology

Year:

2012

Language:

english

File:

PDF, 138 KB

english, 2012

7

Clinical development of insulin-like growth factor receptor—1 (IGF-1R) inhibitors: At the crossroad?

Andrea Gombos, Otto Metzger-Filho, Lissandra Dal Lago, Ahmad Awada-Hussein

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 365 KB

english, 2012

8

Targeted therapies in breast cancer: are heart and vessels also being targeted?

Carmen Criscitiello, Otto Metzger-Filho, Kamal S Saini, Gilberto de Castro Jr, Marie Diaz, André La Gerche, Evandro de Azambuja, Martine J Piccart-Gebhart

Journal:

Breast Cancer Research

Year:

2012

Language:

english

File:

PDF, 714 KB

english, 2012

9

Benefit-Risk Assessment of Bevacizumab in the Treatment of Breast Cancer

Rodrigo Dienstmann, Felipe Ades, Kamal S. Saini, Otto Metzger-Filho

Journal:

Year:

2012

Language:

english

File:

PDF, 143 KB

english, 2012

10

Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer

Saini, Kamal S., Loi, Sherene, de Azambuja, Evandro, Metzger-Filho, Otto, Saini, Monika Lamba, Ignatiadis, Michail, Dancey, Janet E., Piccart-Gebhart, Martine J.

Journal:

Cancer Treatment Reviews

Year:

2013

Language:

english

File:

PDF, 924 KB

english, 2013

11

Clinicopathological Features Among Patients With Advanced Human Epidermal Growth Factor–2-Positive Breast Cancer With Prolonged Clinical Benefit to First-Line Trastuzumab-Based Therapy: A Retrospective Cohort Study

Vaz-Luis, Ines, Seah, Davinia, Olson, Erin M., Wagle, Nikhil, Metzger-Filho, Otto, Sohl, Jessica, Litsas, Georgia, Burstein, Harold J., Krop, Ian E., Winer, Eric P., Lin, Nancy U.

Journal:

Clinical Breast Cancer

Year:

2013

Language:

english

File:

PDF, 652 KB

english, 2013

12

Patterns of Recurrence and Outcome According to Breast Cancer Subtypes in Lymph Node-Negative Disease: Results From International Breast Cancer Study Group Trials VIII and IX

Metzger-Filho, O., Sun, Z., Viale, G., Price, K. N., Crivellari, D., Snyder, R. D., Gelber, R. D., Castiglione-Gertsch, M., Coates, A. S., Goldhirsch, A., Cardoso, F.

Journal:

Journal of Clinical Oncology

Year:

2013

Language:

english

File:

PDF, 181 KB

english, 2013

13

CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01)

Pestalozzi, Bernhard C, Holmes, Eileen, de Azambuja, Evandro, Metzger-Filho, Otto, Hogge, Laurence, Scullion, Matt, Láng, István, Wardley, Andrew, Lichinitser, Mikhail, Sanchez, Roberto I Lopez, Mülle

Journal:

The Lancet Oncology

Year:

2013

Language:

english

File:

PDF, 198 KB

english, 2013

14

Trastuzumab-Associated Cardiac Events at 8 Years of Median Follow-Up in the Herceptin Adjuvant Trial (BIG 1-01)

de Azambuja, E., Procter, M. J., van Veldhuisen, D. J., Agbor-Tarh, D., Metzger-Filho, O., Steinseifer, J., Untch, M., Smith, I. E., Gianni, L., Baselga, J., Jackisch, C., Cameron, D. A., Bell, R., Le

Journal:

Journal of Clinical Oncology

Year:

2014

Language:

english

File:

PDF, 187 KB

english, 2014

15

Larotaxel: broadening the road with new taxanes

Metzger-Filho, Otto, Moulin, Camilo, de Azambuja, Evandro, Ahmad, Awada

Journal:

Expert Opinion on Investigational Drugs

Year:

2009

Language:

english

File:

PDF, 604 KB

english, 2009

16

Management of metastatic HER2-positive breast cancer progression after adjuvant trastuzumab therapy – current evidence and future trends

Metzger-Filho, Otto, Vora, Tushar, Awada, Ahmad

Journal:

Expert Opinion on Investigational Drugs

Year:

2010

Language:

english

File:

PDF, 235 KB

english, 2010

17

Magnitude of Trastuzumab Benefit in Patients With HER2-Positive, Invasive Lobular Breast Carcinoma: Results From the HERA Trial

Metzger-Filho, O., Procter, M., de Azambuja, E., Leyland-Jones, B., Gelber, R. D., Dowsett, M., Loi, S., Saini, K. S., Cameron, D., Untch, M., Smith, I., Gianni, L., Baselga, J., Jackisch, C., Bell, R

Journal:

Journal of Clinical Oncology

Year:

2013

Language:

english

File:

PDF, 227 KB

english, 2013

18

Pertuzumab: Optimizing HER2 Blockade

Metzger-Filho, O., Winer, E. P., Krop, I.

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 376 KB

english, 2013

19

Analysis of Regional Timelines To Set Up a Global Phase III Clinical Trial in Breast Cancer: The Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Experience

Metzger-Filho, O., de Azambuja, E., Bradbury, I., Saini, K. S., Bines, J., Simon, S. D., Dooren, V. V., Aktan, G., Pritchard, K. I., Wolff, A. C., Smith, I., Jackisch, C., Lang, I., Untch, M., Boyle,

Journal:

Year:

2013

Language:

english

File:

PDF, 936 KB

english, 2013

20

Neoadjuvant Chemotherapy and Targeted Therapies: a Promising Strategy

Metzger-Filho, O., de Azambuja, E.

Journal:

JNCI Monographs

Year:

2011

Language:

english

File:

PDF, 186 KB

english, 2011

21

Role of the multidisciplinary team in breast cancer management: results from a large international survey involving 39 countries

Saini, K. S., Taylor, C., Ramirez, A.- J., Palmieri, C., Gunnarsson, U., Schmoll, H. J., Dolci, S. M., Ghenne, C., Metzger-Filho, O., Skrzypski, M., Paesmans, M., Ameye, L., Piccart-Gebhart, M. J., de

Journal:

Annals of Oncology

Year:

2012

Language:

english

File:

PDF, 123 KB

english, 2012

22

Genomic grade adds prognostic value in invasive lobular carcinoma

Metzger-Filho, O., Michiels, S., Bertucci, F., Catteau, A., Salgado, R., Galant, C., Fumagalli, D., Singhal, S. K., Desmedt, C., Ignatiadis, M., Haussy, S., Finetti, P., Birnbaum, D., Saini, K. S., Be

Journal:

Annals of Oncology

Year:

2013

Language:

english

File:

PDF, 196 KB

english, 2013

23

Changing the clinical picture of challenging tumors: tales becoming reality?

Moulin, Camilo, Metzger-Filho, Otto, Awada, Ahmad

Journal:

Future Oncology

Year:

2009

Language:

english

File:

PDF, 1.23 MB

english, 2009

24

Trastuzumab re-treatment following adjuvant trastuzumab and the importance of distant disease-free interval: the HERA trial experience

Metzger-Filho, Otto, de Azambuja, Evandro, Procter, Marion, Krieguer, Magalie, Smith, Ian, Baselga, Jose, Cameron, David, Untch, Michael, Jackisch, Christian, Bell, Richard, Gianni, Luca, Goldhirsch,

Journal:

Breast Cancer Research and Treatment

Year:

2016

Language:

english

File:

PDF, 536 KB

english, 2016

25

Differences between invasive lobular and invasive ductal carcinoma of the breast: results and therapeutic implications

Barroso-Sousa, R., Metzger-Filho, O.

Journal:

Therapeutic Advances in Medical Oncology

Year:

2016

Language:

english

File:

PDF, 732 KB

english, 2016

26

1965 Patterns of care and relative effectiveness of aromatase inhibitors compared to tamoxifen in patients with early breast cancer: A multi-institutional study

Ferreira, A., Palha, A., Correia, L., Filipe, P., Rodrigues, V., Costa, L., Miranda, A., André, R., Fernandes, J., Gouveia, J., Passos Coelho, J.L., Moreira, A., Brito, M., Ribeiro, J., Metzger-Filho,

Journal:

European Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 60 KB

english, 2015

27

Time trends in incidence rates and survival of newly diagnosed stage IV breast cancer by tumor histology: a population-based analysis

Di Meglio, Antonio, Freedman, Rachel A., Lin, Nancy U., Barry, William T., Metzger-Filho, Otto, Keating, Nancy L., King, Tari A., Sertoli, Mario Roberto, Boccardo, Francesco, Winer, Eric P., Vaz-Luis,

Journal:

Breast Cancer Research and Treatment

Year:

2016

Language:

english

File:

PDF, 783 KB

english, 2016

28

Molecular Targeted Therapy in Prevalent Tumors: Learning from the Past and Future Perspectives

Metzger-Filho, Otto, Moulin, Camilo, Awada, Ahmad

Journal:

Current Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 368 KB

english, 2010

29

First-line systemic treatment of ovarian cancer: a critical review of available evidence and expectations for future directions

Metzger-Filho, Otto, Moulin, Camilo, DʼHondt, Veronique

Journal:

Current Opinion in Oncology

Year:

2010

Language:

english

File:

PDF, 195 KB

english, 2010

30

Variation in the use of granulocyte-colony stimulating factor for dose dense paclitaxel: A single institution retrospective study

Barroso-Sousa, Romualdo, Paes, Flavia Rocha, Vaz-Luis, Ines, Batista, Rafael Borges, Costa, Rafael Brant, Losk, Katya, Camuso, Kristen, Metzger-Filho, Otto, Hughes, Melissa E., Bunnell, Craig A., Gols

Journal:

Year:

2016

Language:

english

File:

PDF, 318 KB

english, 2016

31

Novel Strategies in Hormone Receptor-Positive Advanced Breast Cancer: Overcoming Endocrine Resistance

Garrido-Castro, A. C., Metzger-Filho, O.

Journal:

Current Breast Cancer Reports

Year:

2016

Language:

english

File:

PDF, 2.85 MB

english, 2016

32

CDK4/6 inhibition triggers anti-tumour immunity

Goel, Shom, DeCristo, Molly J., Watt, April C., BrinJones, Haley, Sceneay, Jaclyn, Li, Ben B., Khan, Naveed, Ubellacker, Jessalyn M., Xie, Shaozhen, Metzger-Filho, Otto, Hoog, Jeremy, Ellis, Matthew J

Journal:

Year:

2017

Language:

english

File:

PDF, 8.34 MB

english, 2017

33

Genomic Grade Index (GGI): Feasibility in Routine Practice and Impact on Treatment Decisions in Early Breast Cancer

Metzger-Filho, Otto, Catteau, Aurélie, Michiels, Stefan, Buyse, Marc, Ignatiadis, Michail, Saini, Kamal S., de Azambuja, Evandro, Fasolo, Virginie, Naji, Sihem, Canon, Jean Luc, Delrée, Paul, Coibion,

Journal:

Year:

2013

Language:

english

File:

PDF, 277 KB

english, 2013

34

Targeting the Cellular Signaling: BRAF Inhibition and Beyond for the Treatment of Metastatic Malignant Melanoma

Ades, Felipe, Metzger-Filho, Otto

Journal:

Dermatology Research and Practice

Year:

2012

Language:

english

File:

PDF, 1.32 MB

english, 2012

35

Bevacizumab and Breast Cancer: A Meta-Analysis of First-Line Phase III Studies and a Critical Reappraisal of Available Evidence

Rossari, José R., Metzger-Filho, Otto, Paesmans, Marianne, Saini, Kamal S., Gennari, Alessandra, de Azambuja, Evandro, Piccart-Gebhart, Martine

Journal:

Journal of Oncology

Year:

2012

Language:

english

File:

PDF, 1.39 MB

english, 2012

36

Neoadjuvant Treatment of Stage IIB/III Triple Negative Breast Cancer with Cyclophosphamide, Doxorubicin, and Cisplatin (CAP Regimen): A Single Arm, Single Center Phase II Study (GBECAM 2008/02)

Ferreira, Arlindo R., Metzger-Filho, Otto, Sarmento, Roberta M. B., Bines, José

Journal:

Frontiers in Oncology

Year:

2018

Language:

english

File:

PDF, 1.39 MB

english, 2018

37

Magnetic resonance imaging for prediction of pathologic response to neoadjuvant chemotherapy in triple-negative breast cancer

Golshan, M., Wong, S., Loibl, S., Huober, J.B., O'Shaughnessy, J., Rugo, H.S., Wolmark, N., McKee, M.D., Maag, D., Sullivan, D.M., Metzger-Filho, O., Von Minckwitz, G., Geyer, C.E., Sikov, W.M., Untch

Journal:

European Journal of Surgical Oncology (EJSO)

Year:

2019

Language:

english

File:

PDF, 78 KB

english, 2019

38

CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity

Watt, April C., Cejas, Paloma, DeCristo, Molly J., Metzger-Filho, Otto, Lam, Enid Y. N., Qiu, Xintao, BrinJones, Haley, Kesten, Nikolas, Coulson, Rhiannon, Font-Tello, Alba, Lim, Klothilda, Vadhi, Rag

Journal:

Year:

2020

File:

PDF, 22.35 MB

2020

39

Prognostic role of distant disease-free interval from completion of adjuvant trastuzumab in HER2-positive early breast cancer: analysis from the ALTTO (BIG 2-06) trial

Lambertini, Matteo, Agbor-Tarh, Dominique, Metzger-Filho, Otto, Ponde, Noam F, Poggio, Francesca, Hilbers, Florentine S, Korde, Larissa A, Chumsri, Saranya, Werner, Olena, Del Mastro, Lucia, Caparica,

Journal:

Year:

2020

File:

PDF, 1.52 MB

2020

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