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1

Double-strand DNA end-binding and sliding of the toroidal CRISPR-associated protein Csn2

Arslan, Z., Wurm, R., Brener, O., Ellinger, P., Nagel-Steger, L., Oesterhelt, F., Schmitt, L., Willbold, D., Wagner, R., Gohlke, H., Smits, S. H. J., Pul, U.

Journal:

Nucleic Acids Research

Year:

2013

Language:

english

File:

PDF, 15.40 MB

english, 2013

2

Reduction of Alzheimer’s Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-Enantiomeric Peptide Identified by Mirror Image Phage Display

Thomas van Groen, Katja Wiesehan, Susanne A. Funke, Inga Kadish, Luitgard Nagel-Steger, Dieter Willbold

Journal:

Year:

2008

Language:

english

File:

PDF, 493 KB

english, 2008

3

Modulation of aggregate size- and shape-distributions of the amyloid-β peptide by a designed β-sheet breaker

Luitgard Nagel-Steger, Borries Demeler, Wolfgang Meyer-Zaika, Katrin Hochdörffer, Thomas Schrader, Dieter Willbold

Journal:

European Biophysics Journal

Year:

2010

Language:

english

File:

PDF, 566 KB

english, 2010

4

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex

Hauske, Patrick, Nagel-Steger, Luitgard, Clarke, Anthony R, Kaiser, Markus, Merdanovic, Melisa, Mamant, Nicolette, Meltzer, Michael, Poepsel, Simon, Auckenthaler, Alexandra, Melgaard, Rie

Journal:

Nature Structural and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 981 KB

english, 2010

5

The Structural Transition of the Prion Protein into its Pathogenic Conformation is Induced by Unmasking Hydrophobic Sites

K.-W. Leffers, J. Schell, K. Jansen, R. Lucassen, T. Kaimann, L. Nagel-Steger, J. Tatzelt, D. Riesner

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 542 KB

english, 2004

6

O1-06-06: Improved memory capacity of amyloid precursor protein transgenic mice through passive administration of a monoclonal antibody inducing a conformational shift of amyloid-beta

Andreas Muhs, Sophie Lohmann, David Hickman, Maria Pihlgren, Luitgard Nagel-Steger, Gia Machaidze, James Mason, Burkhard Bechinger, Andrea Pfeifer, Claude Nicolau*

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 21.81 MB

english, 2006

7

Oral treatment with an Aβ42 oligomer modulating D-amino acid peptide improves cognitive behavior of APP/ PS1 double transgenic mice

Dieter Willbold, Thomas van Groen, Inga Kadish, Dirk Bartnik, Luitgard Nagel-Steger, Olexandr Brener, Andreas Schiffmann, Carsten Korth, Katja Wiesehan, Susanne A. Funke

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 45 KB

english, 2009

8

Rational Design of β-Sheet Ligands Against Aβ 42 -Induced Toxicity

Hochdörffer, Katrin, März-Berberich, Julia, Nagel-Steger, Luitgard, Epple, Matthias, Meyer-Zaika, Wolfgang, Horn, Anselm H.C., Sticht, Heinrich, Sinha, Sharmistha, Bitan, Gal, Schrader, Thomas

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 4.28 MB

english, 2011

9

Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins

Kotter, S., Unger, A., Hamdani, N., Lang, P., Vorgerd, M., Nagel-Steger, L., Linke, W. A.

Journal:

The Journal of Cell Biology

Year:

2014

Language:

english

File:

PDF, 3.74 MB

english, 2014

10

The Off-rate of Monomers Dissociating from Amyloid- Protofibrils

Gruning, C. S. R., Klinker, S., Wolff, M., Schneider, M., Toksoz, K., Klein, A. N., Nagel-Steger, L., Willbold, D., Hoyer, W.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 2.10 MB

english, 2013

11

Small Heat Shock Proteins Associate under Stress Conditions with Elastic Titin Filaments and Provide Protection from Aggregation

Kötter, Sebastian, Nagel-Steger, Luitgard, Lang, Patrick, Linke, Wolfgang A.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 107 KB

english, 2012

12

Small Heat Shock Proteins Prevent Titin Aggregation-Induced Stiffening in Human Myocytes

Kötter, Sebastian, Unger, Andreas, Hamdani, Nazha, Nagel-Steger, Luitgard, Linke, Wolfgang A.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 42 KB

english, 2014

13

Investigation of low molecular weight D-enantiomeric peptides for diagnosis and therapy of Alzheimer's disease

Bartnik, Dirk, Funke, Susanne A., Cinar, Yeliz, Brener, Oleksandr, Nagel-Steger, Luitgard, Wiesehan, Katja, Willbold, Dieter

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 40 KB

english, 2009

14

Oligomeric Aβ-targeting D-peptides and peptide-aminopyrazole-hybrids for treatment of Alzheimer's disease

Bartnik, Dirk, van Groen, Thomas, Kadish, Inga, Nagel-Steger, Luitgard, Maerz-Berberich, Julia, Müller-Schiffmann, Andreas, Brener, Oleksandr, Horn, Anselm H., Reymann, Klaus, Gottmann, Kurt, Schrader

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 56 KB

english, 2011

15

Oral treatment with the amyloid-beta oligomer precipitating substance D3 improves pathology of Alzheimer's transgenic mice

Willbold, Dieter, van Groen, Thomas, Kadish, Inga, Bartnik, Dirk, Brener, Oleksandr, Nagel-Steger, Luitgard, Funke, Susanne A.

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 44 KB

english, 2010

16

Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division

Thakur, Harish C., Singh, Madhurendra, Nagel-Steger, Luitgard, Prumbaum, Daniel, Fansa, Eyad Kalawy, Gremer, Lothar, Ezzahoini, Hakima, Abts, André, Schmitt, Lutz, Raunser, Stefan, Ahmadian, Mohammad

Journal:

Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 2.55 MB

english, 2013

17

Oral Treatment with the d -Enantiomeric Peptide D3 Improves the Pathology and Behavior of Alzheimer’s Disease Transgenic Mice

Aileen Funke, Susanne, van Groen, Thomas, Kadish, Inga, Bartnik, Dirk, Nagel-Steger, Luitgard, Brener, Oleksandr, Sehl, Torsten, Batra-Safferling, Renu, Moriscot, Christine, Schoehn, Guy, Horn, Anselm

Journal:

ACS Chemical Neuroscience

Year:

2010

Language:

english

File:

PDF, 3.29 MB

english, 2010

18

Rho-kinase: regulation, (dys)function, and inhibition

Amin, Ehsan, Dubey, Badri Nath, Zhang, Si-Cai, Gremer, Lothar, Dvorsky, Radovan, Moll, Jens M., Taha, Mohamed S., Nagel-Steger, Luitgard, Piekorz, Roland P., Somlyo, Avril V., Ahmadian, Mohammad R.

Journal:

Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 1015 KB

english, 2013

19

Inhibition of cytotoxicity and amyloid fibril formation by a D-amino acid peptide that specifically binds to Alzheimer's disease amyloid peptide

Wiesehan, K., Stohr, J., Nagel-Steger, L., van Groen, T., Riesner, D., Willbold, D.

Journal:

Protein Engineering Design and Selection

Year:

2008

Language:

english

File:

PDF, 355 KB

english, 2008

20

Prevention of Alzheimer's Disease-associated A Aggregation by Rationally Designed Nonpeptidic -Sheet Ligands

Rzepecki, P., Nagel-Steger, L., Feuerstein, S., Linne, U., Molt, O., Zadmard, R., Aschermann, K., Wehner, M., Schrader, T., Riesner, D.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 385 KB

english, 2004

21

Mechanisms of prion protein assembly into amyloid

Stohr, J., Weinmann, N., Wille, H., Kaimann, T., Nagel-Steger, L., Birkmann, E., Panza, G., Prusiner, S. B., Eigen, M., Riesner, D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 969 KB

english, 2008

22

Sequence-independent Control of Peptide Conformation in Liposomal Vaccines for Targeting Protein Misfolding Diseases

Hickman, D. T., Lopez-Deber, M. P., Ndao, D. M., Silva, A. B., Nand, D., Pihlgren, M., Giriens, V., Madani, R., St-Pierre, A., Karastaneva, H., Nagel-Steger, L., Willbold, D., Riesner, D., Nicolau, C.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 2.48 MB

english, 2011

23

Interaction of the cellular prion protein with raft-like lipid membranes

Elfrink, Kerstin, Nagel-Steger, Luitgard, Riesner, Detlev

Journal:

Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 264 KB

english, 2007

24

A Novel, Enzymatically Active Conformation of theEscherichia coli NADH:Ubiquinone Oxidoreductase (Complex I)

Bottcher, B., Scheide, D., Hesterberg, M., Nagel-Steger, L., Friedrich, T.

Journal:

Journal of Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 848 KB

english, 2002

25

The Centrosomal Adaptor TACC3 and the Microtubule Polymerase chTOG Interact via Defined C-terminal Subdomains in an Aurora-A Kinase-independent Manner

Thakur, H. C., Singh, M., Nagel-Steger, L., Kremer, J., Prumbaum, D., Fansa, E. K., Ezzahoini, H., Nouri, K., Gremer, L., Abts, A., Schmitt, L., Raunser, S., Ahmadian, M. R., Piekorz, R. P.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 4.65 MB

english, 2014

26

The mammalian autophagy initiator complex contains two HORMA domain proteins

Michel, Max, Schwarten, Melanie, Decker, Christina, Nagel-Steger, Luitgard, Willbold, Dieter, Weiergräber, Oliver H.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.11 MB

english, 2015

27

An Account of Amyloid Oligomers: Facts and Figures Obtained from Experiments and Simulations

Nagel-Steger, Luitgard, Owen, Michael C., Strodel, Birgit

Journal:

Year:

2016

Language:

english

File:

PDF, 1.61 MB

english, 2016

28

Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation

Streich, Carmen, Akkari, Laura, Decker, Christina, Bormann, Jenny, Rehbock, Christoph, Müller-Schiffmann, Andreas, Niemeyer, Felix Carlsson, Nagel-Steger, Luitgard, Willbold, Dieter, Sacca, Barbara, K

Journal:

Year:

2016

Language:

english

File:

PDF, 2.76 MB

english, 2016

29

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d -Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species

Ziehm, Tamar, Brener, Oleksandr, van Groen, Thomas, Kadish, Inga, Frenzel, Daniel, Tusche, Markus, Kutzsche, Janine, Reiß, Kerstin, Gremer, Lothar, Nagel-Steger, Luitgard, Willbold, Dieter

Journal:

ACS Chemical Neuroscience

Year:

2016

Language:

english

File:

PDF, 3.31 MB

english, 2016

30

The Chlamydia pneumoniae Adhesin Pmp21 forms Oligomers with Adhesive Properties

Luczak, Sören E.T., Smits, Sander H.J., Decker, Christina, Nagel-Steger, Luitgard, Schmitt, Lutz, Hegemann, Johannes H.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.59 MB

english, 2016

31

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations

Yerabham, Antony S. K., Mas, Philippe J., Decker, Christina, Soares, Dinesh C., Weiergräber, Oliver H., Nagel-Steger, Luitgard, Willbold, Dieter, Hart, Darren J., Bradshaw, Nicholas J., Korth, Carsten

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 3.69 MB

english, 2017

32

An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure

Bradshaw, Nicholas J., Yerabham, Antony S. K., Marreiros, Rita, Zhang, Tao, Nagel-Steger, Luitgard, Korth, Carsten

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 4.12 MB

english, 2017

33

Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution

Wolff, Martin, Zhang-Haagen, Bo, Decker, Christina, Barz, Bogdan, Schneider, Mario, Biehl, Ralf, Radulescu, Aurel, Strodel, Birgit, Willbold, Dieter, Nagel-Steger, Luitgard

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 4.37 MB

english, 2017

34

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

van Groen, Thomas, Schemmert, Sarah, Brener, Oleksandr, Gremer, Lothar, Ziehm, Tamar, Tusche, Markus, Nagel-Steger, Luitgard, Kadish, Inga, Schartmann, Elena, Elfgen, Anne, Jürgens, Dagmar, Willuweit,

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.29 MB

english, 2017

35

Stoichiometric Zn 2+ interferes with the self-association of Aβ42: Insights from size distribution analysis

Zhang, Tao, Pauly, Thomas, Nagel-Steger, Luitgard

Journal:

International Journal of Biological Macromolecules

Year:

2018

Language:

english

File:

PDF, 1.28 MB

english, 2018

36

Inhibition of Amyloid Aβ Aggregation by High Pressures or Specific D-Enantiomeric Peptides

Cavini, Italo A., Munte, Claudia E., Beck Erlach, Markus, van Groen, Thomas, Kadish, Inga, Zhang, Tao, Ziehm, Tamar, Nagel-Steger, Luitgard, Kutzsche, Janine, Kremer, Werner, Willbold, Dieter, Kalbitz

Journal:

Chemical Communications

Year:

2018

Language:

english

File:

PDF, 734 KB

english, 2018

37

Amyloid β Oligomeric Species Present in the Lag Phase of Amyloid Formation

Wolff, Martin, Unuchek, Dmitry, Zhang, Bo, Gordeliy, Valentin, Willbold, Dieter, Nagel-Steger, Luitgard, Gomes, Aldrin V.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.89 MB

english, 2015

38

Seeded Fibrillation as Molecular Basis of the Species Barrier in Human Prion Diseases

Luers, Lars, Bannach, Oliver, Stöhr, Jan, Wördehoff, Michael Marius, Wolff, Martin, Nagel-Steger, Luitgard, Riesner, Detlev, Willbold, Dieter, Birkmann, Eva, Zabel, Mark D.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.43 MB

english, 2013

39

Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11

Nouri, Kazem, Moll, Jens M., Milroy, Lech-Gustav, Hain, Anika, Dvorsky, Radovan, Amin, Ehsan, Lenders, Michael, Nagel-Steger, Luitgard, Howe, Sebastian, Smits, Sander H. J., Hengel, Hartmut, Schmitt,

Journal:

Year:

2015

Language:

english

File:

PDF, 2.41 MB

english, 2015

40

Monomeric Amyloid Beta Peptide in Hexafluoroisopropanol Detected by Small Angle Neutron Scattering

Zhang-Haagen, Bo, Biehl, Ralf, Nagel-Steger, Luitgard, Radulescu, Aurel, Richter, Dieter, Willbold, Dieter, Zheng, Jie

Journal:

Year:

2016

Language:

english

File:

PDF, 577 KB

english, 2016

41

Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association

Kukuk, Laura, Dingley, Andrew J., Granzin, Joachim, Nagel-Steger, Luitgard, Thiagarajan-Rosenkranz, Pallavi, Ciupka, Daniel, Hänel, Karen, Batra-Safferling, Renu, Pacheco, Victor, Stoldt, Matthias, Pf

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 4.17 MB

english, 2019

42

Interference with Amyloid-β Nucleation by Transient Ligand Interaction

Zhang,, Loschwitz,, Strodel,, Nagel-Steger,, Willbold,

Journal:

Year:

2019

Language:

english

File:

PDF, 2.78 MB

english, 2019

43

Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses

Alvarez, Clarisa E., Bovdilova, Anastasiia, Höppner, Astrid, Wolff, Christian-Claus, Saigo, Mariana, Trajtenberg, Felipe, Zhang, Tao, Buschiazzo, Alejandro, Nagel-Steger, Luitgard, Drincovich, Maria F

Journal:

Year:

2019

Language:

english

File:

PDF, 2.34 MB

english, 2019

44

Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses

Alvarez, Clarisa E., Bovdilova, Anastasiia, Höppner, Astrid, Wolff, Christian-Claus, Saigo, Mariana, Trajtenberg, Felipe, Zhang, Tao, Buschiazzo, Alejandro, Nagel-Steger, Luitgard, Drincovich, Maria F

Journal:

Year:

2019

File:

PDF, 2.34 MB

2019

45

Posttranslational modification of the NADP-malic enzyme involved in C4 photosynthesis fine-tunes the enzymatic activity during the day

Bovdilova, Anastasiia, Alexandre, Bruno M., Höppner, Astrid, Matias Luís, Inês, Alvarez, Clarisa E, Bickel, David, Gohlke, Holger, Decker, Christina, Nagel-Steger, Luitgard, Alseekh, Saleh, Fernie, Al

Journal:

Year:

2019

Language:

english

File:

PDF, 1.68 MB

english, 2019

46

Solution-Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies

Zhang, Tao, Nagel-Steger, Luitgard, Willbold, Dieter

Journal:

Year:

2019

Language:

english

File:

PDF, 701 KB

english, 2019

47

Towards the mode of action of the clinical stage all-D-enantiomeric peptide RD2 on Aβ42 aggregation

Zhang, Tao, Gering, Ian, Kutzsche, Janine, Nagel-Steger, Luitgard, Willbold, Dieter

Journal:

ACS Chemical Neuroscience

Year:

2019

Language:

english

File:

PDF, 1.01 MB

english, 2019

48

Towards the mode of action of the clinical stage all-D-enantiomeric peptide RD2 on Aβ42 aggregation

Zhang, Tao, Gering, Ian, Kutzsche, Janine, Nagel-Steger, Luitgard, Willbold, Dieter

Journal:

ACS Chemical Neuroscience

Year:

2019

File:

PDF, 1.01 MB

2019

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