Niedernhofer, L: search on Z-Library

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1

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Robbins, Paul D., Jurk, Diana, Khosla, Sundeep, Kirkland, James L., LeBrasseur, Nathan K., Miller, Jordan D., Passos, JoÃ£o F., Pignolo, Robert J., Tchkonia, Tamar, Niedernhofer, Laura J.

Journal:

Annual Review of Pharmacology

Year:

2021

File:

PDF, 2.05 MB

2021

2

The Clinical Potential of Senolytic Drugs

Kirkland, James L., Tchkonia, Tamara, Zhu, Yi, Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Journal of the American Geriatrics Society

Year:

2017

Language:

english

File:

PDF, 64 KB

english, 2017

3

Hsp90 inhibitors as senolytic drugs to extend healthy aging

Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.36 MB

english, 2018

4

Senotherapeutics for healthy ageing

Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Nature Reviews Drug Discovery

Year:

2018

Language:

english

File:

PDF, 121 KB

english, 2018

5

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

Yousefzadeh, Matthew J., Wilkinson, John E., Hughes, Brian, Gadela, Namrata, Ladiges, Warren C., Vo, Nam, Niedernhofer, Laura J., Huffman, Derek M., Robbins, Paul D.

Journal:

Year:

2020

File:

PDF, 1.11 MB

2020

6

Nuclear Genomic Instability and Aging

Niedernhofer, Laura J., Gurkar, Aditi U., Wang, Yinsheng, Vijg, Jan, Hoeijmakers, Jan H.J., Robbins, Paul D.

Journal:

Annual Review of Biochemistry

Year:

2018

Language:

english

File:

PDF, 391 KB

english, 2018

7

Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system

Dong Wang, Nam V. Vo, Gwendolyn A. Sowa, Robert A. Hartman, Kevin Ngo, So Ra Choe, William T. Witt, Qing Dong, Joon Y. Lee, Laura J. Niedernhofer, James D. Kang

Journal:

The Spine Journal

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

8

26. Treatment Using a Therapeutic Peptide Inhibitor Against the Stress Mediator NFkB Delayed Age-Dependent Spinal Degeneration in an Accelerated Aging Mouse Model

Nam Vo, Jeremy Tilstra, Andria Robison, Arydas Usas, Gwendolyn Sowa, Rebecca Studer, Joon Lee, Laura Niedernhofer, James Kang

Journal:

The Spine Journal

Year:

2009

Language:

english

File:

PDF, 133 KB

english, 2009

9

The Role of Cancer Therapy Agents in Intervertebral Disc Degeneration

Luigi A. Nasto, Dong Wang, Cheryl Clauson, Qing Dong, Gwendolyn A. Sowa, Peter Roughley, Paul D. Robbins, Laura Niedernhofer, James D. Kang, Nam Vo

Journal:

The Spine Journal

Year:

2012

Language:

english

File:

PDF, 48 KB

english, 2012

10

Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

Nasto, Luigi A., Ngo, Kevin, Leme, Adriana S., Robinson, Andria R., Dong, Qing, Roughley, Peter, Usas, Arvydas, Sowa, Gwendolyn A., Pola, Enrico, Kang, James, Niedernhofer, Laura J., Shapiro, Steven,

Journal:

The Spine Journal

Year:

2014

Language:

english

File:

PDF, 996 KB

english, 2014

11

Hyper telomere recombination accelerates replicative senescence and may promote premature aging

R. Tanner Hagelstrom, Krastan B. Blagoev, Laura J. Niedernhofer, Edwin H. Goodwin, Susan M. Bailey and José N. Onuchic

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.44 MB

english, 2010

12

ISSLS Prize Winner

Nasto, Luigi A., Seo, Hyoung-Yeon, Robinson, Andria R., Tilstra, Jeremy S., Clauson, Cheryl L., Sowa, Gwendolyn A., Ngo, Kevin, Dong, Qing, Pola, Enrico, Lee, Joon Y., Niedernhofer, Laura J., Kang, Ja

Journal:

Year:

2012

Language:

english

File:

PDF, 2.70 MB

english, 2012

13

Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2 nd Scripps Symposium on the Biology of Aging

Robbins, Paul D., Niedernhofer, Laura J.

Journal:

Year:

2017

Language:

english

File:

PDF, 82 KB

english, 2017

14

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Yi, Doornebal, Ewald J., Pirtskhalava, Tamar, Giorgadze, Nino, Wentworth, Mark, Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D., Tchkonia, Tamara, Kirkland, James L.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.38 MB

english, 2017

15

Heterochronic Parabiosis Approach: is it Possible to Interrupt the Aging Process of the Intervertebral Disc Degeneration? An in vivo Experimental Study

Colangelo, Debora, Robbins, Paul, Nasto, Luigi Aurelio, Niedernhofer, Laura, Pola, Enrico

Journal:

Global Spine Journal

Year:

2016

File:

PDF, 81 KB

2016

16

Development of clinical trials to extend healthy lifespan

Justice, Jamie N., Niedernhofer, Laura, Robbins, Paul D., Aroda, Vanita R., Espeland, Mark A., Kritchevsky, Stephen B., Kuchel, George A., Barzilai, Nir

Journal:

Cardiovascular Endocrinology & Metabolism

Year:

2018

File:

PDF, 119 KB

2018

17

Genetics of extreme human longevity to guide drug discovery for healthy ageing

Zhang, Zhengdong D., Milman, Sofiya, Lin, Jhih-Rong, Wierbowski, Shayne, Yu, Haiyuan, Barzilai, Nir, Gorbunova, Vera, Ladiges, Warren C., Niedernhofer, Laura J., Suh, Yousin, Robbins, Paul D., Vijg, J

Journal:

Nature Metabolism

Year:

2020

File:

PDF, 2.05 MB

2020

18

Genome instability and accelerated aging: The relevance for normal aging and life span extension

Jan H.J. Hoeijmakers, George Garinis, Ingrid van der Pluijm, Jay Mitchell, Jaan-Olle Andressoo, Karin Diderich, Astrid Lalai, Harm de Waard, Dolf Beems, Harry van Steeg, Laura Niedernhofer, Bert van d

Journal:

Year:

2006

Language:

english

File:

PDF, 70 KB

english, 2006

19

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Niedernhofer, Laura J., Garinis, George A., Raams, Anja, Lalai, Astrid S., Robinson, Andria Rasile, Appeldoorn, Esther, Odijk, Hanny, Oostendorp, Roos, Ahmad, Anwaar, van Leeuwen, Wibeke

Journal:

Year:

2006

Language:

english

File:

PDF, 1002 KB

english, 2006

20

Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1−/− mice

Prasher, Joanna M, Lalai, Astrid S, Heijmans-Antonissen, Claudia, Ploemacher, Robert E, Hoeijmakers, Jan H J, Touw, Ivo P, Niedernhofer, Laura J

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 613 KB

english, 2005

21

The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells

Niedernhofer, L. J.

Journal:

The EMBO Journal

Year:

2001

Language:

english

File:

PDF, 272 KB

english, 2001

22

Multiple DNA Binding Domains Mediate the Function of the ERCC1-XPF Protein in Nucleotide Excision Repair

Su, Y., Orelli, B., Madireddy, A., Niedernhofer, L. J., Scharer, O. D.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 1.81 MB

english, 2012

23

Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model

Derek J. Matoka, Veronica Yao, Diana S. Harya, Jennifer L. Gregg, Andria R. Robinson, Laura J. Niedernhofer, Anil V. Parwani, Christoph Maier, Dean J. Bacich

Journal:

Year:

2012

Language:

english

File:

PDF, 1.21 MB

english, 2012

24

Nucleotide excision repair deficient mouse models and neurological disease

Laura J. Niedernhofer

Journal:

Year:

2008

Language:

english

File:

PDF, 820 KB

english, 2008

25

DNA repair is crucial for maintaining hematopoietic stem cell function

Laura J. Niedernhofer

Journal:

Year:

2008

Language:

english

File:

PDF, 438 KB

english, 2008

26

Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease

Siobhán Q. Gregg, Andria Rasile Robinson, Laura J. Niedernhofer

Journal:

Year:

2011

Language:

english

File:

PDF, 714 KB

english, 2011

27

Ercc1 Deficient Mice Show Segmental Progeria

M. Dollé, R. Kuiper, M. Roodbergen, J. Robinson, S. de Vlugt, S. Wijnhoven, D. Beems, L. de la Fonteyne, P. de With, L. Niedernhofer, P. Hasty, J. Vijg, J. Hoeijmakers, H. van Steeg

Journal:

Journal of Comparative Pathology

Year:

2012

Language:

english

File:

PDF, 57 KB

english, 2012

28

Spine degeneration in a murine model of chronic human tobacco smokers

D. Wang, L.A. Nasto, P. Roughley, A.S. Leme, A.M. Houghton, A. Usas, G. Sowa, J. Lee, L. Niedernhofer, S. Shapiro, J. Kang, N. Vo

Journal:

Osteoarthritis and Cartilage

Year:

2012

Language:

english

File:

PDF, 1.39 MB

english, 2012

29

Tissue-specific accelerated aging in nucleotide excision repair deficiency

Laura J. Niedernhofer

Journal:

Mechanisms of Ageing and Development

Year:

2008

Language:

english

File:

PDF, 419 KB

english, 2008

30

Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: Molecules to patients

Laura J. Niedernhofer, Vilhelm A. Bohr, Miriam Sander, Kenneth H. Kraemer

Journal:

Mechanisms of Ageing and Development

Year:

2011

Language:

english

File:

PDF, 610 KB

english, 2011

31

Premature aging-related peripheral neuropathy in a mouse model of progeria

James R. Goss, Donna Beer Stolz, Andria Rasile Robinson, Mingdi Zhang, Norma Arbujas, Paul D. Robbins, Joseph C. Glorioso, Laura J. Niedernhofer

Journal:

Mechanisms of Ageing and Development

Year:

2011

Language:

english

File:

PDF, 844 KB

english, 2011

32

Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice

Martijn E.T. Dollé, Rita A. Busuttil, Ana Maria Garcia, Susan Wijnhoven, Ellen van Drunen, Laura J. Niedernhofer, Gijsbertus van der Horst, Jan H.J. Hoeijmakers, Harry van Steeg, Jan Vijg

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2006

Language:

english

File:

PDF, 1.19 MB

english, 2006

33

Fanconi anemia: A paradigm of discovering molecular pathways from patients

Paul R. Andreassen, Laura J. Niedernhofer

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2009

Language:

english

File:

PDF, 101 KB

english, 2009

34

Mouse models of Fanconi anemia

Kalindi Parmar, Alan D’Andrea, Laura J. Niedernhofer

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2009

Language:

english

File:

PDF, 203 KB

english, 2009

35

Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice

Scott C. Smith, Andria R. Robinson, Laura J. Niedernhofer, Michal Hetman

Journal:

Neurobiology of Disease

Year:

2012

Language:

english

File:

PDF, 752 KB

english, 2012

36

Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: A gynecologic oncology group study

Jennifer M. Rubatt, Kathleen M. Darcy, Chunqiao Tian, Franco Muggia, Rajiv Dhir, Deborah K. Armstrong, Michael A. Bookman, Laura J. Niedernhofer, Julie Deloia, Michael Birrer, Thomas Carl Krivak

Journal:

Gynecologic Oncology

Year:

2012

Language:

english

File:

PDF, 716 KB

english, 2012

37

Divide and conquer: nucleotide excision repair battles cancer and ageing

James R Mitchell, Jan HJ Hoeijmakers, Laura J Niedernhofer

Journal:

Current Opinion in Cell Biology

Year:

2003

Language:

english

File:

PDF, 650 KB

english, 2003

38

The oxidative DNA lesions 8,5′-cyclopurines accumulate with aging in a tissue-specific manner

Jin Wang, Cheryl L. Clauson, Paul D. Robbins, Laura J. Niedernhofer, Yinsheng Wang

Journal:

Year:

2012

Language:

english

File:

PDF, 146 KB

english, 2012

39

Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan

Laura J. Niedernhofer, Paul D. Robbins

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2008

Language:

english

File:

PDF, 342 KB

english, 2008

40

Fanconi Anemia (Cross)linked to DNA Repair

Laura J. Niedernhofer, Astrid S. Lalai, Jan H.J. Hoeijmakers

Journal:

Year:

2005

Language:

english

File:

PDF, 736 KB

english, 2005

41

The Fanconi Anemia Signalosome Anchor

Laura J. Niedernhofer

Journal:

Year:

2007

Language:

english

File:

PDF, 505 KB

english, 2007

42

ERCC1/XPF Removes the 3′ Overhang from Uncapped Telomeres and Represses Formation of Telomeric DNA-Containing Double Minute Chromosomes

Xu-Dong Zhu, Laura Niedernhofer, Bernhard Kuster, Matthias Mann, Jan H.J Hoeijmakers, Titia de Lange

Journal:

Year:

2003

Language:

english

File:

PDF, 634 KB

english, 2003

43

First Reported Patient with Human ERCC1 Deficiency Has Cerebro-Oculo-Facio-Skeletal Syndrome with a Mild Defect in Nucleotide Excision Repair and Severe Developmental Failure

Nicolaas G.J. Jaspers, Anja Raams, Margherita Cirillo Silengo, Nils Wijgers, Laura J. Niedernhofer, Andria Rasile Robinson, Giuseppina Giglia-Mari, Deborah Hoogstraten, Wim J. Kleijer, Jan H.J. Hoeijm

Journal:

The American Journal of Human Genetics

Year:

2007

Language:

english

File:

PDF, 2.32 MB

english, 2007

44

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

Lavasani, Mitra, Robinson, Andria R., Lu, Aiping, Song, Minjung, Feduska, Joseph M., Ahani, Bahar, Tilstra, Jeremy S., Feldman, Chelsea H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny

Journal:

Nature Communications

Year:

2012

Language:

english

File:

PDF, 2.87 MB

english, 2012

45

Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease

Zhiyin Xun, Sulay Rivera-Sánchez, Sylvette Ayala-Peña, James Lim, Helen Budworth, Erin M. Skoda, Paul D. Robbins, Laura J. Niedernhofer, Peter Wipf, Cynthia T. McMurray

Journal:

Year:

2012

Language:

english

File:

PDF, 700 KB

english, 2012

46

Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum

Julie A. DeLoia, Nikhil R. Bhagwat, Kathleen M. Darcy, Mary Strange, Chunquio Tian, Kevin Nuttall, Thomas C. Krivak, Laura J. Niedernhofer

Journal:

Gynecologic Oncology

Year:

2012

Language:

english

File:

PDF, 817 KB

english, 2012

47

A quantitative assay for assessing the effects of DNA lesions on transcription

You, Changjun, Dai, Xiaoxia, Yuan, Bifeng, Wang, Jin, Wang, Jianshuang, Brooks, Philip J, Niedernhofer, Laura J, Wang, Yinsheng

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 617 KB

english, 2012

48

DNA damage and repair: from premature aging and cancer to longevity

J.H.J. Hoeijmakers, G. Garinis, B. Schumacher, J. Pothof, I. van der Pluijm, L.L. Niedernhofer, K. Diderich, J. Mitchell, R.B. Beems, H. van Steeg, G.T.J. van der Horst

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 85 KB

english, 2008

49

Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole

Basu, Ashis K., Wood, Michael L., Niedernhofer, Laura J., Ramos, Leilani A., Essigmann, John M.

Journal:

Year:

1993

Language:

english

File:

PDF, 2.11 MB

english, 1993

50

Cell Autonomous and Nonautonomous Mechanisms Drive Hematopoietic Stem/progenitor Cell Loss in the Absence of DNA Repair

Cho, Joon Seok, Kook, Sung Ho, Robinson, Andria Rasile, Niedernhofer, Laura J., Lee, Byeong-Chel

Journal:

Year:

2013

Language:

english

File:

PDF, 1.57 MB

english, 2013

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