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51

Systems biology of pro-angiogenic therapies targeting the VEGF system

Feilim Mac Gabhann, Amina A. Qutub, Brian H. Annex, Aleksander S. Popel

Journal:

Wiley Interdisciplinary Reviews: Systems Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 598 KB

english, 2010

52

Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows

Junfeng Zhang, Paul C. Johnson, Aleksander S. Popel

Journal:

Microvascular Research

Year:

2009

Language:

english

File:

PDF, 2.39 MB

english, 2009

53

Extracellular regulation of VEGF: Isoforms, proteolysis, and vascular patterning

Vempati, Prakash, Popel, Aleksander S., Mac Gabhann, Feilim

Journal:

Cytokine & Growth Factor Reviews

Year:

2014

Language:

english

File:

PDF, 2.56 MB

english, 2014

54

Estimating oxygen transport resistance of the microvascular wall

Vadapalli, Arjun, Pittman, Roland N., Popel, Aleksander S.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2000

Language:

english

File:

PDF, 275 KB

english, 2000

55

Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization

Kim, Jayoung, Lima e Silva, Raquel, Shmueli, Ron B., Mirando, Adam C., Tzeng, Stephany Y., Pandey, Niranjan B., Ben-Akiva, Elana, Popel, Aleksander S., Campochiaro, Peter A., Green, Jordan J.

Journal:

Acta Biomaterialia

Year:

2019

Language:

english

File:

PDF, 1.63 MB

english, 2019

56

Immunoactivating the tumor microenvironment enhances immunotherapy as predicted by integrative computational model

Popel, Aleksander S.

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

Language:

english

File:

PDF, 904 KB

english, 2020

57

Digital Pathology Analysis Quantifies Spatial Heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 Immune Markers in Triple-Negative Breast Cancer

Mi, Haoyang, Gong, Chang, Sulam, Jeremias, Fertig, Elana J., Szalay, Alexander S., Jaffee, Elizabeth M., Stearns, Vered, Emens, Leisha A., Cimino-Mathews, Ashley M., Popel, Aleksander S.

Journal:

Frontiers in Physiology

Year:

2020

File:

PDF, 10.59 MB

2020

58

A Computational Study of the Effect of Capillary Network Anastomoses and Tortuosity on Oxygen Transport

DANIEL GOLDMAN, ALEKSANDER S POPEL

Journal:

Journal of Theoretical Biology

Year:

2000

Language:

english

File:

PDF, 410 KB

english, 2000

59

Multi-scale Computational Models of Pro-angiogenic Treatments in Peripheral Arterial Disease

Feilim Mac Gabhann, James W. Ji, Aleksander S. Popel

Journal:

Annals of Biomedical Engineering

Year:

2007

Language:

english

File:

PDF, 651 KB

english, 2007

60

Serpin-Derived Peptides Are Antiangiogenic and Suppress Breast Tumor Xenograft Growth

Koskimaki, Jacob E., Rosca, Elena V., Rivera, Corban G., Lee, Esak, Chen, William, Pandey, Niranjan B., Popel, Aleksander S.

Journal:

Translational Oncology

Year:

2012

Language:

english

File:

PDF, 853 KB

english, 2012

61

Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide

Shmueli, Ron B., Ohnaka, Masayuki, Miki, Akiko, Pandey, Niranjan B., Lima e Silva, Raquel, Koskimaki, Jacob E., Kim, Jayoung, Popel, Aleksander S., Campochiaro, Peter A., Green, Jordan J.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.12 MB

english, 2013

62

Vasculature-specific MRI reveals differential anti-angiogenic effects of a biomimetic peptide in an orthotopic breast cancer model

Kim, Eugene, Lee, Esak, Plummer, Charlesa, Gil, Stacy, Popel, Aleksander S., Pathak, Arvind P.

Journal:

Year:

2015

Language:

english

File:

PDF, 3.78 MB

english, 2015

63

Collagen IV and CXC chemokine-derived antiangiogenic peptides suppress glioma xenograft growth

Rosca, Elena Victoria, Lal, Bachchu, Koskimaki, Jacob E., Popel, Aleksander S., Laterra, John

Journal:

Anti-Cancer Drugs

Year:

2012

Language:

english

File:

PDF, 547 KB

english, 2012

64

An agent-based model of triple-negative breast cancer: the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia

Norton, Kerri-Ann, Wallace, Travis, Pandey, Niranjan B., Popel, Aleksander S.

Journal:

BMC Systems Biology

Year:

2017

Language:

english

File:

PDF, 2.25 MB

english, 2017

65

Quantitative Systems Pharmacology Modeling of PBMC-Humanized Mouse to Facilitate Preclinical Immuno-oncology Drug Development

Ma, Huilin, Pilvankar, Minu, Wang, Jun, Giragossian, Craig, Popel, Aleksander S.

Journal:

ACS Pharmacology & Translational Science

Year:

2020

File:

PDF, 2.85 MB

2020

66

Diffusion in tissue slices with metabolism obeying Michaelis-Menten kinetics

Aleksander S. Popel

Journal:

Journal of Theoretical Biology

Year:

1979

Language:

english

File:

PDF, 325 KB

english, 1979

67

Three autocrine feedback loops determine HIF1α expression in chronic hypoxia

Amina A. Qutub, Aleksander S. Popel

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2007

Language:

english

File:

PDF, 1021 KB

english, 2007

68

A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries

William J. Federspiel, Aleksander S. Popel

Journal:

Microvascular Research

Year:

1986

Language:

english

File:

PDF, 1.83 MB

english, 1986

69

A Computer-Based Method for Determination of the Cell-Free Layer Width in Microcirculation

SANGHO KIM, ROBERT L. KONG, ALEKSANDER S. POPEL, MARCOS INTAGLIETTA, PAUL C. JOHNSON

Journal:

Microcirculation

Year:

2006

Language:

english

File:

PDF, 473 KB

english, 2006

70

Computational systems biology approaches to anti-angiogenic cancer therapeutics

Finley, Stacey D., Chu, Liang-Hui, Popel, Aleksander S.

Journal:

Drug Discovery Today

Year:

2015

Language:

english

File:

PDF, 833 KB

english, 2015

71

Simultaneous blockade of IL-6 and CCL5 signaling for synergistic inhibition of triple-negative breast cancer growth and metastasis

Jin, Kideok, Pandey, Niranjan B., Popel, Aleksander S.

Journal:

Breast Cancer Research

Year:

2018

Language:

english

File:

PDF, 2.93 MB

english, 2018

72

Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection

Zhang, Yu, Bazzazi, Hojjat, Lima e Silva, Raquel, Pandey, Niranjan B., Green, Jordan J., Campochiaro, Peter A., Popel, Aleksander S.

Journal:

Investigative Opthalmology & Visual Science

Year:

2018

Language:

english

File:

PDF, 2.68 MB

english, 2018

73

Diameter changes in skeletal muscle venules during arterial pressure reduction

Bishop, Jeffrey J., Nance, Patricia R., Popel, Aleksander S., Intaglietta, Marcos, Johnson, Paul C.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2000

Language:

english

File:

PDF, 446 KB

english, 2000

74

Parametric Analysis of the Relationship between End-capillary and Mean Tissue PO2as Predicted by a Mathematical Model

Maithili Sharan, Suman Gupta, Aleksander S. Popel

Journal:

Journal of Theoretical Biology

Year:

1998

Language:

english

File:

PDF, 214 KB

english, 1998

75

Blood–plasma separation in Y-shaped bifurcating microfluidic channels: a dissipative particle dynamics simulation study

Li, Xuejin, Popel, Aleksander S, Karniadakis, George Em

Journal:

Physical Biology

Year:

2012

Language:

english

File:

PDF, 2.00 MB

english, 2012

76

Peptides Derived from Type IV Collagen, CXC Chemokines, and Thrombospondin-1 Domain-Containing Proteins Inhibit Neovascularization and Suppress Tumor Growth in MDA-MB-231 Breast Cancer Xenografts

Koskimaki, Jacob E., Karagiannis, Emmanouil D., Rosca, Elena V., Vesuna, Farhad, Winnard, Paul T., Raman, Venu, Bhujwalla, Zaver M., Popel, Aleksander S.

Journal:

Year:

2009

Language:

english

File:

PDF, 2.22 MB

english, 2009

77

A systems biology view of blood vessel growth and remodelling

Logsdon, Elizabeth A., Finley, Stacey D., Popel, Aleksander S., Gabhann, Feilim Mac

Journal:

Journal of Cellular and Molecular Medicine

Year:

2014

Language:

english

File:

PDF, 504 KB

english, 2014

78

A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition

Gong, Chang, Milberg, Oleg, Wang, Bing, Vicini, Paolo, Narwal, Rajesh, Roskos, Lorin, Popel, Aleksander S.

Journal:

Journal of The Royal Society Interface

Year:

2017

Language:

english

File:

PDF, 4.11 MB

english, 2017

79

A Peptide Derived from Type 1 Thrombospondin Repeat–Containing Protein WISP-1 Inhibits Corneal and Choroidal Neovascularization

Cano, Marisol del Valle, Karagiannis, Emmanouil D., Soliman, Mohamed, Bakir, Belal, Zhuang, Wenjuan, Popel, Aleksander S., Gehlbach, Peter L.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2009

Language:

english

File:

PDF, 472 KB

english, 2009

80

Erythrocyte consumption of nitric oxide in presence and absence of plasma-based hemoglobin

Tsoukias, Nikolaos M., Popel, Aleksander S.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2002

Language:

english

File:

PDF, 319 KB

english, 2002

81

A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade

Milberg, Oleg, Gong, Chang, Jafarnejad, Mohammad, Bartelink, Imke H., Wang, Bing, Vicini, Paolo, Narwal, Rajesh, Roskos, Lorin, Popel, Aleksander S.

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 7.20 MB

english, 2019

82

Rate of oxygen loss from arterioles is an order of magnitude higher than expected

Popel, Aleksander S., Pittman, Roland N., Ellsworth, Mary L.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1991

Language:

english

File:

PDF, 119 KB

english, 1991

83

Mechanosensitive Channels in the Lateral Wall Can Enhance the Cochlear Outer Hair Cell Frequency Response

Alexander A. Spector, Aleksander S. Popel, Ruth Anne Eatock, William E. Brownell

Journal:

Annals of Biomedical Engineering

Year:

2005

Language:

english

File:

PDF, 471 KB

english, 2005

84

Augmentation of pressure in a vessel indenting the surface of the lung

Joshua E. Tsitlik, Henry R. Halperin, Alan D. Guerci, Lisa S. Dvorine, Aleksander S. Popel, Cynthia O. Siu, Frank C. P. Yin, Myron L. Weisfeldt

Journal:

Annals of Biomedical Engineering

Year:

1987

Language:

english

File:

PDF, 1.49 MB

english, 1987

85

Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes

Kejing Chen, Barbora Piknova, Roland N. Pittman, Alan N. Schechter, Aleksander S. Popel

Journal:

Year:

2008

Language:

english

File:

PDF, 1.48 MB

english, 2008

86

Novel Peptide-Specific Quantitative Structure–Activity Relationship (QSAR) Analysis Applied to Collagen IV Peptides with Antiangiogenic Activity

Rivera, Corban G., Rosca, Elena V., Pandey, Niranjan B., Koskimaki, Jacob E., Bader, Joel S., Popel, Aleksander S.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.05 MB

english, 2011

87

Inhibition of Lymphangiogenesis and Angiogenesis in Breast Tumor Xenografts and Lymph Nodes by a Peptide Derived from Transmembrane Protein 45A

Lee, Esak, Koskimaki, Jacob E., Pandey, Niranjan B., Popel, Aleksander S.

Journal:

Year:

2013

Language:

english

File:

PDF, 3.83 MB

english, 2013

88

Computational Model of Vascular Endothelial Growth Factor Spatial Distribution in Muscle and Pro-Angiogenic Cell Therapy

Mac Gabhann, Feilim, Ji, James W., Popel, Aleksander S.

Journal:

PLoS Computational Biology

Year:

2006

Language:

english

File:

PDF, 780 KB

english, 2006

89

Computational fluid dynamics of aggregating red blood cells in postcapillary venules

Chung, Bong, Kim, Sangho, Johnson, Paul C., Popel, Aleksander S.

Journal:

Computer Methods in Biomechanics & Biomedical Engineering

Year:

2009

Language:

english

File:

PDF, 1.96 MB

english, 2009

90

Inhibition of breast cancer growth and metastasis by a biomimetic peptide

Lee, Esak, Lee, Seung Jae, Koskimaki, Jacob E., Han, Zheyi, Pandey, Niranjan B., Popel, Aleksander S.

Journal:

Scientific Reports

Year:

2014

Language:

english

File:

PDF, 11.15 MB

english, 2014

91

Gene delivery nanoparticles to modulate angiogenesis

Kim, Jayoung, Mirando, Adam C., Popel, Aleksander S., Green, Jordan J.

Journal:

Advanced Drug Delivery Reviews

Year:

2016

Language:

english

File:

PDF, 1.30 MB

english, 2016

92

The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts

Dore-Savard, Louis, Lee, Esak, Kakkad, Samata, Popel, Aleksander S., Bhujwalla, Zaver M.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.09 MB

english, 2016

93

A Model of Nitric Oxide Capillary Exchange

TSOUKIAS, NIKOLAOS M., POPEL, ALEKSANDER S.

Journal:

Microcirculation

Year:

2003

Language:

english

File:

PDF, 698 KB

english, 2003

94

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells

Bazzazi, Hojjat, Popel, Aleksander S., Diamond, Scott L

Journal:

PLoS Computational Biology

Year:

2017

Language:

english

File:

PDF, 2.16 MB

english, 2017

95

Computer Simulation of TSP1 Inhibition of VEGF–Akt–eNOS: An Angiogenesis Triple Threat

Bazzazi, Hojjat, Zhang, Yu, Jafarnejad, Mohammad, Isenberg, Jeffrey S., Annex, Brian H., Popel, Aleksander S.

Journal:

Frontiers in Physiology

Year:

2018

Language:

english

File:

PDF, 6.85 MB

english, 2018

96

Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide

Mirando, Adam C., Patil, Akash, Rafie, Christine I., Christmas, Brian J., Pandey, Niranjan B., Stearns, Vered, Jaffee, Elizabeth M., Roussos Torres, Evanthia T., Popel, Aleksander S.

Journal:

Year:

2020

File:

PDF, 4.04 MB

2020

97

Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model

Jacob E Koskimaki, Emmanouil D Karagiannis, Benjamin C Tang, Hans Hammers, D Neil Watkins, Roberto Pili, Aleksander S Popel

Journal:

Year:

2010

Language:

english

File:

PDF, 1.24 MB

english, 2010

98

Effects of erythrocyte aggregation and venous network geometry on red blood cell axial migration

Bishop, Jeffrey J., Popel, Aleksander S., Intaglietta, Marcos, Johnson, Paul C.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2001

Language:

english

File:

PDF, 942 KB

english, 2001

99

Angiogenesis-Associated Crosstalk Between Collagens, CXC Chemokines, and Thrombospondin Domain-Containing Proteins

Corban G. Rivera, Joel S. Bader, Aleksander S. Popel

Journal:

Annals of Biomedical Engineering

Year:

2011

Language:

english

File:

PDF, 574 KB

english, 2011

100

The cost of departure from optimal radii in microvascular networks

Thomas F. Sherman, Aleksander S. Popel, Akos Koller, Paul C. Johnson

Journal:

Journal of Theoretical Biology

Year:

1989

Language:

english

File:

PDF, 934 KB

english, 1989

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