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51

Expression of Rat Liver Cytochrome P-450MC cDNA in Saccharomyces cerevisiae

OEDA, KENJI, SAKAKI, TOSHIYUKI, OHKAWA, HIDEO

Journal:

Year:

1985

Language:

english

File:

PDF, 480 KB

english, 1985

52

Metabolism of Polychlorinated Dibenzo- p -dioxins (PCDDs) by Human Cytochrome P450-Dependent Monooxygenase Systems

Inouye, Kuniyo, Shinkyo, Raku, Takita, Teisuke, Ohta, Miho, Sakaki, Toshiyuki

Journal:

Journal of Agricultural and Food Chemistry

Year:

2002

Language:

english

File:

PDF, 224 KB

english, 2002

53

Rotation and interactions of genetically expressed cytochrome P-450IA1 and NADPH-cytochrome P-450 reductase in yeast microsomes

Iwase, Tadashi, Sakaki, Toshiyuki, Yabusaki, Yoshiyasu, Ohkawa, Hideo, Ohta, Yoshihiro, Kawato, Suguru

Journal:

Year:

1991

Language:

english

File:

PDF, 639 KB

english, 1991

54

Genetically Engineered Modification of P450 Monooxygenases: Functional Analysis of the Amino-Terminal Hydrophobic Region and Hinge Region of the P450/Reductase Fused Enzyme

YABUSAKI, YOSHIYASU, MURAKAMI, HIROKO, SAKAKI, TOSHIYUKI, SHIBATA, MEGUMI, OHKAWA, HIDEO

Journal:

Year:

1988

Language:

english

File:

PDF, 5.56 MB

english, 1988

55

Expression of Bovine Cytochrome P450c17 cDNA in Saccharomyces cerevisiae

SAKAKI, TOSHIYUKI, SHIBATA, MEGUMI, YABUSAKI, YOSHIYASU, MURAKAMI, HIROKO, OHKAWA, HIDEO

Journal:

Year:

1989

Language:

english

File:

PDF, 4.69 MB

english, 1989

56

A Genetically Engineered P450 Monooxygenase: Construction of the Functional Fused Enzyme between Rat Cytochrome P450c and NADPH-Cytochrome P450 Reductase

MURAKAMI, HIROKO, YABUSAKI, YOSHIYASU, SAKAKI, TOSHIYUKI, SHIBATA, MEGUMI, OHKAWA, HIDEO

Journal:

Year:

1987

Language:

english

File:

PDF, 3.72 MB

english, 1987

57

Coexpression of Genetically Engineered Fused Enzyme between Yeast NADPH–P450 Reductase and Human Cytochrome P450 3A4 and Human Cytochrome b5 in Yeast

Koji Hayashi, Toshiyuki Sakaki, Shiro Kominami, Kuniyo Inouye, Yoshiyasu Yabusaki

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 90 KB

english, 2000

58

Conversion of vitamin D3 to 1α,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1

Natsumi Sawada, Toshiyuki Sakaki, Sachiyo Yoneda, Tatsuya Kusudo, Raku Shinkyo, Miho Ohta, Kuniyo Inouye

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 231 KB

english, 2004

59

Structural determinants of the position of 2,3′,4,4′,5-pentachlorobiphenyl (CB118) hydroxylation by mammalian cytochrome P450 monooxygenases

Mise, Shintaro, Haga, Yuki, Itoh, Toshimasa, Kato, Akira, Fukuda, Itsuko, Goto, Erika, Yamamoto, Keiko, Yabu, Miku, Matsumura, Chisato, Nakano, Takeshi, Sakaki, Toshiyuki, Inui, Hideyuki

Journal:

Toxicological Sciences

Year:

2016

Language:

english

File:

PDF, 792 KB

english, 2016

60

Synthesis of the CYP24A1 major metabolite of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3

Takano, Masashi, Yasuda, Kaori, Tohyama, Eri, Higuchi, Erika, Sakaki, Toshiyuki, Kittaka, Atsushi

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 544 KB

english, 2016

61

In vivo absorption and metabolism of leptosperin and methyl syringate, abundantly present in manuka honey

Ishisaka, Akari, Ikushiro, Shinichi, Takeuchi, Mie, Araki, Yukako, Juri, Maki, Yoshiki, Yui, Kawai, Yoshichika, Niwa, Toshio, Kitamoto, Noritoshi, Sakaki, Toshiyuki, Ishikawa, Hirohito, Kato, Yoji

Journal:

Molecular Nutrition & Food Research

Year:

2017

Language:

english

File:

PDF, 1.02 MB

english, 2017

62

Introduction of fluorine atoms to vitamin D3 side-chain and synthesis of 24,24-difluoro-25-hydroxyvitamin D3 　

Kawagoe, Fumihiro, Mototani, Sayuri, Yasuda, Kaori, Nagasawa, Kazuo, Uesugi, Motonari, Sakaki, Toshiyuki, Kittaka, Atsushi

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2019

Language:

english

File:

PDF, 460 KB

english, 2019

63

ChemInform Abstract: Studies on the Synthesis and Metabolism of 14-epi-2α-(3-Hydroxypropyl)-19-norvitamin D3 (Ia) and Its 2β-Isomer.

Toshiyuki Sakaki, et al. et al.

Journal:

Year:

2011

File:

PDF, 25 KB

2011

64

Bioconversion of vitamin D to its active form by bacterial or mammalian cytochrome P450

Toshiyuki Sakaki, Hiroshi Sugimoto, Keiko Hayashi, Kaori Yasuda, Eiji Munetsuna, Masaki Kamakura, Shinichi Ikushiro, Yoshitsugu Shiro

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2011

Language:

english

File:

PDF, 1.01 MB

english, 2011

65

Metabolism of 26,26,26,27,27,27-F6-1α,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats

Toshiyuki Sakaki, Natsumi Sawada, Daisuke Abe, Koichiro Komai, Shunichi Shiozawa, Yasuki Nonaka, Kimie Nakagawa, Toshio Okano, Miho Ohta, Kuniyo Inouye

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 286 KB

english, 2003

66

Further Oxidation of Hydroxycalcidiol by Calcidiol 24-Hydroxylase : A Study with the Mature Enzyme Expressed in Escherichia coli

Megumi Akiyoshi-Shibata, Toshiyuki Sakaki, Yoshihiko Ohyama, Mitsuhide Noshiro, Kyuichiro Okuda, Yoshiyasu Yabusaki

Journal:

Year:

1994

Language:

english

File:

PDF, 898 KB

english, 1994

67

Structure-Based Design of a Highly Active Vitamin D Hydroxylase from Streptomyces griseolus CYP105A1 †‡

Hayashi, Keiko, Sugimoto, Hiroshi, Shinkyo, Raku, Yamada, Masato, Ikeda, Shinnosuke, Ikushiro, Shinichi, Kamakura, Masaki, Shiro, Yoshitsugu, Sakaki, Toshiyuki

Journal:

Year:

2008

Language:

english

File:

PDF, 3.99 MB

english, 2008

68

An integrativein silicoapproach for discovering candidates for drug-targetable protein-protein interactions in interactome data

Nobuyoshi Sugaya, Kazuyoshi Ikeda, Toshiyuki Tashiro, Shizu Takeda, Jun Otomo, Yoshiko Ishida, Akiko Shiratori, Atsushi Toyoda, Hideki Noguchi, Tadayuki Takeda, Satoru Kuhara, Yoshiyuki Sakaki, Takao

Journal:

BMC Pharmacology

Year:

2007

Language:

english

File:

PDF, 1.46 MB

english, 2007

69

Label-Free Amperometric Detection of Albumin with an Oil/Water-type Flow Cell for Urine Protein Analysis

Risa Matsui, Toru Sakaki, Toshiyuki Osakai

Journal:

Electroanalysis

Year:

2012

Language:

english

File:

PDF, 594 KB

english, 2012

70

Multiple forms of human P450 expressed in Saccharomyces cerevisiae: Systematic characterization and comparison with those of the rat

Susumu Imaoka, Takao Yamada, Toyoko Hiroi, Koji Hayashi, Toshiyuki Sakaki, Yoshiyasu Yabusaki, Yoshihiko Funae

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.13 MB

english, 1996

71

Enzymatic synthesis of novel oligosaccharides from N -acetylsucrosamine and melibiose using Aspergillus niger α-galactosidase, and properties of the products

Sakaki, Yohei, Tashiro, Mitsuru, Katou, Moe, Sakuma, Chiseko, Hirano, Takako, Hakamata, Wataru, Nishio, Toshiyuki

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2016

Language:

english

File:

PDF, 919 KB

english, 2016

72

Synthesis of 25-Hydroxy-19-norvitamin D3 Analogs and Their Antiproliferative Activities on Prostate Cells

Kittaka, Atsushi, A. Arai, Midori, Tsutsumi, Ryuji, Hara, Hideki, C. Chen, Tai, Sakaki, Toshiyuki, Urushino, Naoko, Inouye, Kuniyo

Journal:

Year:

2005

Language:

english

File:

PDF, 680 KB

english, 2005

73

Avian Cytochrome P450 (CYP) 1-3 Family Genes: Isoforms, Evolutionary Relationships, and mRNA Expression in Chicken Liver

Watanabe, Kensuke P., Kawai, Yusuke K., Ikenaka, Yoshinori, Kawata, Minami, Ikushiro, Shin-Ichi, Sakaki, Toshiyuki, Ishizuka, Mayumi, Rotter, Varda

Journal:

Year:

2013

Language:

english

File:

PDF, 1.84 MB

english, 2013

74

Concise Synthesis of 23-Hydroxylated Vitamin D3 Metabolites

Kawagoe, Fumihiro, Sugiyama, Toru, Yasuda, Kaori, Uesugi, Motonari, Sakaki, Toshiyuki, Kittaka, Atsushi

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2018

Language:

english

File:

PDF, 1.17 MB

english, 2018

75

cDNA cloning and characterization of feline CYP1A1 and CYP1A2

Nagako Tanaka, Taku Miyasho, Raku Shinkyo, Toshiyuki Sakaki, Hiroshi Yokota

Journal:

Year:

2006

Language:

english

File:

PDF, 644 KB

english, 2006

76

Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D3 analogs

Kaori Yasuda, Shinichi Ikushiro, Masaki Kamakura, Masashi Takano, Nozomi Saito, Atsushi Kittaka, Tai C. Chen, Miho Ohta, Toshiyuki Sakaki

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 879 KB

english, 2013

77

Sophisticated Design of PVC Membrane Ion-Selective Electrodes Based on the Mixed Potential Theory

Imoto, Maya, Sakaki, Toru, Osakai, Toshiyuki

Journal:

Analytical Chemistry

Year:

2013

Language:

english

File:

PDF, 1.35 MB

english, 2013

78

Expression of Bovine Cytochrome P450c21 and Its Fused Enzymes with Yeast NADPH-Cytochrome P450 Reductase in Saccharomyces cerevisiae

SAKAKI, TOSHIYUKI, SHIBATA, MEGUMI, YABUSAKI, YOSHIYASU, MURAKAMI, HIROKO, OHKAWA, HIDEO

Journal:

DNA and Cell Biology

Year:

1990

Language:

english

File:

PDF, 4.51 MB

english, 1990

79

Production of an active form of vitamin D 2 by genetically engineered CYP105A1

Yasuda, Kaori, Yogo, Yuya, Sugimoto, Hiroshi, Mano, Hiroki, Takita, Teisuke, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Yasukawa, Kiyoshi, Shiro, Yoshitsugu, Sakaki, Toshiyuki

Journal:

Biochemical and Biophysical Research Communications

Year:

2017

Language:

english

File:

PDF, 891 KB

english, 2017

80

Microbial production of novel sulphated alkaloids for drug discovery

Matsumura, Eitaro, Nakagawa, Akira, Tomabechi, Yusuke, Ikushiro, Shinichi, Sakaki, Toshiyuki, Katayama, Takane, Yamamoto, Kenji, Kumagai, Hidehiko, Sato, Fumihiko, Minami, Hiromichi

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 2.33 MB

english, 2018

81

Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells

Munetsuna, Eiji, Kawanami, Rie, Nishikawa, Miyu, Ikeda, Shinnosuke, Nakabayashi, Sachie, Yasuda, Kaori, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Sakaki, Toshiyuki

Journal:

Molecular and Cellular Endocrinology

Year:

2014

Language:

english

File:

PDF, 930 KB

english, 2014

82

The roles of cytochrome P450 enzymes in prostate cancer development and treatment

Chen, Tai C., Sakaki, Toshiyuki, Yamamoto, Keiko, Kittaka, Atsushi

Journal:

Anticancer research

Year:

2012

Language:

english

File:

PDF, 237 KB

english, 2012

83

Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator

Mano, Hiroki, Takano, Masashi, Ikushiro, Shinichi, Kittaka, Atsushi, Sakaki, Toshiyuki

Journal:

Biochemical and Biophysical Research Communications

Year:

2018

Language:

english

File:

PDF, 934 KB

english, 2018

84

Sulfate conjugates are the major metabolites in rats administrated with sesamin

Yasuda, Kaori, Okamoto, Kairi, Ueno, Sera, Itoh, Kasumi, Nishikawa, Miyu, Ikushiro, Shinichi, Sakaki, Toshiyuki

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2018

Language:

english

File:

PDF, 891 KB

english, 2018

85

Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1 : Enzymes and catalysis

Keiko Hayashi, Kaori Yasuda, Hiroshi Sugimoto, Shinichi Ikushiro, Masaki Kamakura, Atsushi Kittaka, Ronald L. Horst, Tai C. Chen, Miho Ohta, Yoshitsugu Shiro, Toshiyuki Sakaki

Journal:

Year:

2010

Language:

english

File:

PDF, 841 KB

english, 2010

86

Cloning and expression in Escherichia coli and Saccharomyces cerevisiae of a novel tobacco cytochrome P-450-like cDNA

Miwa Sugiura, Toshiyuki Sakaki, Yoshiyasu Yabusaki, Hideo Ohkawa

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1996

Language:

english

File:

PDF, 1.04 MB

english, 1996

87

Measurement and characterization of C-3 epimerization activity toward vitamin D3

Maya Kamao, Susumi Hatakeyama, Toshiyuki Sakaki, Natsumi Sawada, Kuniyo Inouye, Noboru Kubodera, G. Satyanarayana Reddy, Toshio Okano

Journal:

Archives of Biochemistry and Biophysics

Year:

2005

Language:

english

File:

PDF, 366 KB

english, 2005

88

Development of novel bioluminescent sensor to detect and discriminate between vitamin D receptor agonists and antagonists in living cells

Mano, Hiroki, Nishikawa, Miyu, Yasuda, Kaori, Ikushiro, Shinichi, Saito, Nozomi, Takano, Masashi, Kittaka, Atsushi, Sakaki, Toshiyuki

Journal:

Bioconjugate Chemistry

Year:

2015

Language:

english

File:

PDF, 1.45 MB

english, 2015

89

Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D2 Derivatives Modified at the Side Chain and the A-Ring

Milczarek, Magdalena, Chodyński, Michał, Pietraszek, Anita, Stachowicz-Suhs, Martyna, Yasuda, Kaori, Sakaki, Toshiyuki, Wietrzyk, Joanna, Kutner, Andrzej

Journal:

International Journal of Molecular Sciences

Year:

2020

Language:

english

File:

PDF, 1.20 MB

english, 2020

90

Insight into functional diversity of cytochrome P450 in the white-rot basidiomycete Phanerochaete chrysosporium: Involvement of versatile monooxygenase

Shinji Hirosue, Masahiro Tazaki, Nobuhiro Hiratsuka, Satoshi Yanai, Hiroki Kabumoto, Raku Shinkyo, Akira Arisawa, Toshiyuki Sakaki, Hiroshi Tsunekawa, Osamu Johdo, Hirofumi Ichinose, Hiroyuki Wariishi

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 636 KB

english, 2011

91

Increase of AMPA receptor glutamate receptor 1 subunit and B-cell receptor-associated protein 31 gene expression in hippocampus of fatigued mice

Masaki Kamakura, Keisuke Tamaki, Toshiyuki Sakaki, Yukio Yoneda

Journal:

Neuroscience Letters

Year:

2005

Language:

english

File:

PDF, 145 KB

english, 2005

92

Whole-cell dependent biosynthesis of N- and S-oxides using human flavin containing monooxygenases expressing budding yeast

Masuyama, Yuuka, Nishikawa, Miyu, Yasuda, Kaori, Sakaki, Toshiyuki, Ikushiro, Shinichi

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2020

File:

PDF, 1.02 MB

2020

93

Metabolism of polychlorinated dibenzo-p-dioxins by cytochrome P450 BM-3 and its mutant

Woro Triarsi Sulistyaningdyah, Jun Ogawa, Qing-Shan Li, Raku Shinkyo, Toshiyuki Sakaki, Kuniyo Inouye, Rolf D. Schmid, Sakayu Shimizu

Journal:

Biotechnology Letters

Year:

2004

Language:

english

File:

PDF, 90 KB

english, 2004

94

Metabolism of 20-epimer of 1α,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats

Tatsuya Kusudo, Toshiyuki Sakaki, Daisuke Abe, Toshie Fujishima, Atsushi Kittaka, Hiroaki Takayama, Miho Ohta, Kuniyo Inouye

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 220 KB

english, 2003

95

Homology modeling of human 25-hydroxyvitamin D3 1α-hydroxylase (CYP27B1) based on the crystal structure of rabbit CYP2C5

Keiko Yamamoto, Hiroyuki Masuno, Natsumi Sawada, Toshiyuki Sakaki, Kuniyo Inouye, Masaji Ishiguro, Sachiko Yamada

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 370 KB

english, 2004

96

Cell specificity and properties of the C-3 epimerization of Vitamin D3 metabolites

Maya Kamao, Syuichiro Tatematsu, Natsumi Sawada, Toshiyuki Sakaki, Susumi Hatakeyama, Noboru Kubodera, Toshio Okano

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 92 KB

english, 2004

97

Magnitude of CD8+ T-cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection

Hiroyoshi Doi, Kazumasa Hiroishi, Tomoe Shimazaki, Junichi Eguchi, Toshiyuki Baba, Takayoshi Ito, Takuya Matsumura, Hisako Nozawa, Kenichi Morikawa, Shigeaki Ishii, Ayako Hiraide, Masashi Sakaki, Mich

Journal:

Hepatology Research

Year:

2009

Language:

english

File:

PDF, 209 KB

english, 2009

98

Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor

Mano, Hiroki, Nishikawa, Miyu, Yasuda, Kaori, Ikushiro, Shinichi, Saito, Nozomi, Sawada, Daisuke, Honzawa, Shinobu, Takano, Masashi, Kittaka, Atsushi, Sakaki, Toshiyuki

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 758 KB

english, 2016

99

Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1

Nozomi Saito, Yoshitomo Suhara, Daisuke Abe, Tatsuya Kusudo, Miho Ohta, Kaori Yasuda, Toshiyuki Sakaki, Shinobu Honzawa, Toshie Fujishima, Atsushi Kittaka

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 423 KB

english, 2009

100

Inhibitory Effects of Detergents on Rat CYP1A1-Dependent Monooxygenase: Comparison of Mixed and Fused Systems Consisting of Rat CYP 1A1 and Yeast NADPH-P450 Reductase

Kuniyo Inouye, Shunya Kondo, Masaki Yamamura, Dai Nakanishi, Toshiyuki Sakaki

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 87 KB

english, 2001

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