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1

Highly specific and sensitive detection of malignancy in urine samples from patients with urothelial cancer by CD44v8–10/CD44v10 competitive RT-PCR

Hideaki Miyake, Isamu Okamoto, Isao Hara, Kazuo Gohji, Kazuki Yamanaka, Soichi Arakawa, Sadao Kamidono, Hideyuki Saya

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 112 KB

english, 1998

2

Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence

Ohtani, Naoko, Yamakoshi, Kimi, Iida, Shin-ichi, Tahara, Hidetoshi, Nakayama, Keiko, Nakayama, Keiichi I., Ide, Toshinori, Saya, Hideyuki, Hara, Eiji, Takahashi, Akiko

Journal:

Nature Cell Biology

Year:

2006

Language:

english

File:

PDF, 1.99 MB

english, 2006

3

Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell – cell contacts

Ito, Kiyoharu, Okamoto, Isamu, Araki, Norie, Kawano, Yoshiaki, Nakao, Mitsuyoshi, Fujiyama, Shigetoshi, Tomita, Kimio, Mimori, Tatsuyuki, Saya, Hideyuki

Journal:

Year:

1999

Language:

english

File:

PDF, 739 KB

english, 1999

4

Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase

Ichiro Izawa, Norihiko Tamaki, Hideyuki Saya

Journal:

Year:

1996

Language:

english

File:

PDF, 694 KB

english, 1996

5

PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin

Liping Feng, Shunji Yunoue, Hiroshi Tokuo, Tatsuya Ozawa, Dongwei Zhang, Siriporn Patrakitkomjorn, Toru Ichimura, Hideyuki Saya, Norie Araki

Journal:

Year:

2004

Language:

english

File:

PDF, 369 KB

english, 2004

6

Phosphorylation of neurofibromin by cAMP-dependent protein kinase is regulated via a cellular association of NG,NG-dimethylarginine dimethylaminohydrolase

Hiroshi Tokuo, Shunji Yunoue, Liping Feng, Masumi Kimoto, Hideaki Tsuji, Tomomichi Ono, Hideyuki Saya, Norie Araki

Journal:

Year:

2001

Language:

english

File:

PDF, 281 KB

english, 2001

7

Therapeutic strategies targeting cancer stem cells

Yoshida, Go J., Saya, Hideyuki

Journal:

Year:

2016

Language:

english

File:

PDF, 1.13 MB

english, 2016

8

[Advances in Bioethics] Taking Life and Death Seriously - Bioethics from Japan Volume 8 || Cell Death: Its Style and Significance

Year:

2005

Language:

english

File:

PDF, 308 KB

english, 2005

9

Endothelium-induced three-dimensional invasion of heterogeneous glioma initiating cells in a microfluidic coculture platform

Chonan, Yuta, Taki, Sotaro, Sampetrean, Oltea, Saya, Hideyuki, Sudo, Ryo

Journal:

Integrative Biology

Year:

2017

Language:

english

File:

PDF, 6.03 MB

english, 2017

10

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

Shibao, Shunsuke, Minami, Noriaki, Koike, Naoyoshi, Fukui, Nobuyuki, Yoshida, Kazunari, Saya, Hideyuki, Sampetrean, Oltea

Journal:

Year:

2017

Language:

english

File:

PDF, 1.75 MB

english, 2017

11

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Fujimori, Koki, Ishikawa, Mitsuru, Otomo, Asako, Atsuta, Naoki, Nakamura, Ryoichi, Akiyama, Tetsuya, Hadano, Shinji, Aoki, Masashi, Saya, Hideyuki, Sobue, Gen, Okano, Hideyuki

Journal:

Nature Medicine

Year:

2018

Language:

english

File:

PDF, 8.79 MB

english, 2018

12

Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx

Atsushi Obata, Masao Eura, Jiichiro Sasaki, Hideyuki Saya, Kazuaki Chikamatsu, Mitsuhiro Tada, Richard D. Iggo, Eiji Yumoto

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 277 KB

english, 2000

13

NE-dlg, a mammalian homolog of drosophila dlg tumor suppressor, induces growth suppression and impairment of cell adhesion: possible involvement of down-regulation of β-catenin by NE-dlg expression

Norihisa Hanada, Keishi Makino, Hisashi Koga, Tetsuro Morisaki, Hiroaki Kuwahara, Norio Masuko, Yoichi Tabira, Takehisa Hiraoka, Nobuo Kitamura, Akira Kikuchi, Hideyuki Saya

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 679 KB

english, 2000

14

A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis

Hiromasa Tsuiki, Masayuki Nitta, Akiko Furuya, Nobuo Hanai, Toshiyoshi Fujiwara, Masaki Inagaki, Masato Kochi, Yukitaka Ushio, Hideyuki Saya, Hideo Nakamura

Journal:

Journal of Cellular Biochemistry

Year:

2000

Language:

english

File:

PDF, 456 KB

english, 2000

15

Evidence that HLA class II-restricted human CD4+ T cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms

Hiroshi Fujita, Satoru Senju, Hiroshi Yokomizo, Hideyuki Saya, Michio Ogawa, Sho Matsushita, Yasuharu Nishimura

Journal:

European Journal of Immunology

Year:

1998

Language:

english

File:

PDF, 229 KB

english, 1998

16

Comparative analysis of brain proteins from p53-deficient mice by two-dimensional electrophoresis

Norie Araki, Tadaomi Morimasa, Tomoko Sakai, Hiroshi Tokuoh, Shunji Yunoue, Masaharu Kamo, Kenji Miyazaki, Koji Abe, Hideyuki Saya, Akira Tsugita

Journal:

ELECTROPHORESIS

Year:

2000

Language:

english

File:

PDF, 456 KB

english, 2000

17

Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas : A novel hypothesis of tumorigenesis

Takuro Kaneko, Tetsumori Yamashima, Yasuo Tohma, Motohiro Nomura, Shinobu Imajoh-Ohmi, Takaomi C. Saido, Mitsuyoshi Nakao, Hideyuki Saya, Hiroshi Yamamoto, Junkoh Yamashita

Journal:

Year:

2001

Language:

english

File:

PDF, 410 KB

english, 2001

18

Molecularly targeted therapies for glioma

Ryuya Yamanaka, Hideyuki Saya

Journal:

Annals of Neurology

Year:

2009

Language:

english

File:

PDF, 538 KB

english, 2009

19

Influence of p53 mutations on prognosis of patients with glioblastoma

Shoji Shiraishi, Kenji Tada, Hideo Nakamura, Keishi Makino, Masato Kochi, Hideyuki Saya, Jun-ichi Kuratsu, Yukitaka Ushio

Journal:

Year:

2002

Language:

english

File:

PDF, 114 KB

english, 2002

20

Expression profiles of carcinosarcoma of the uterine corpus—are these similar to carcinoma or sarcoma?

Tatsuyuki Chiyoda, Hiroshi Tsuda, Hideo Tanaka, Fumio Kataoka, Hiroyuki Nomura, Sadako Nishimura, Masashi Takano, Nobuyuki Susumu, Hideyuki Saya, Daisuke Aoki

Journal:

Genes, Chromosomes and Cancer

Year:

2012

Language:

english

File:

PDF, 1.71 MB

english, 2012

21

Restoration of endogenous wild-type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis

Jun Ikeda, Mitsuhiro Tada, Nobuaki Ishii, Hideyuki Saya, Kazuhiko Tsuchiya, Kumio Okaichi, Kazuhiko Mishima, Yutaka Sawamura, Giulia Fulci, Ta-Jen Liu, Erwin G. Van Meir

Journal:

International Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 434 KB

english, 2001

22

PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma

Watcharin Loilome, Sirinun Juntana, Nisana Namwat, Vajarabhongsa Bhudhisawasdi, Anucha Puapairoj, Banchob Sripa, Masanao Miwa, Hideyuki Saya, Gregory J. Riggins, Puangrat Yongvanit

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 1.93 MB

english, 2011

23

Antigen common to several species, recognized by a rat monoclonal antibody raised against syngeneic rat bladder tumor

Hiroshi Eto, Hideyuki Saya, Motomi Nakata, Akira Mizoguchi, Sadao Kamidono

Journal:

International Journal of Cancer

Year:

1989

Language:

english

File:

PDF, 1.02 MB

english, 1989

24

Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell-carcinoma cell lines of the oral cavity

Jose Juarez, Gary Clayman, Motowo Nakajima, Kenneth K. Tanabe, Hideyuki Saya, Garth L. Nicolson, Douglas Boyd

Journal:

International Journal of Cancer

Year:

1993

Language:

english

File:

PDF, 1.12 MB

english, 1993

25

Polyclonal uses of T-cell receptor (TCR)α and β genes for cytotoxic T lymphocytes in human metastatic melanoma: possible involvement of TCRα in tumor-cell recognition

Dai Seito, Tatsuo Morita, Kazuhiro Masuoka, Tomoyuki Maeda, Hideyuki Saya, Kyogo Itoh

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 675 KB

english, 1994

26

Direct sequencing analysis of transmembrane region of human neu gene by polymerase chain reaction

Hideyuki Saya, Seiji Ara, Polly S. Y. Lee, Jungsil Ro, Mien-Chie Hung

Journal:

Molecular Carcinogenesis

Year:

1990

Language:

english

File:

PDF, 413 KB

english, 1990

27

Detection of loss of heterozygosity in the p53 gene in renal cell carcinoma and bladder cancer using the polymerase chain reaction

Koji Oka, Jiro Ishikawa, Janet M. Bruner, Rei Takahashi, Hideyuki Saya

Journal:

Molecular Carcinogenesis

Year:

1991

Language:

english

File:

PDF, 407 KB

english, 1991

28

Alternative splicing of neurofibromatosis type 1 gene transcript in malignant brain tumors: PCR analysis of frozen-section mRNA

Hiroshi Mochizuki, Toru Nishi, Janet M. Bruner, Polly S. Y. Lee, Victor A. Levin, Hideyuki Saya

Journal:

Molecular Carcinogenesis

Year:

1992

Language:

english

File:

PDF, 496 KB

english, 1992

29

Novel variants of CD44 arising from alternative splicing: Changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase

Kenneth K. Tanabe, Toru Nishi, Hideyuki Saya

Journal:

Molecular Carcinogenesis

Year:

1993

Language:

english

File:

PDF, 942 KB

english, 1993

30

A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2

Kumio Okaichi, Li-Hong Wang, Ji-ichiro Sasaki, Hideyuki Saya, Mitsuhiro Tada, Yutaka Okumura

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1999

Language:

english

File:

PDF, 216 KB

english, 1999

31

Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability

Masayuki Nitta, Hiromasa Tsuiki, Yoshimi Arima, Kei Harada, Takahumi Nishizaki, Kousuke Sasaki, Tatsuyuki Mimori, Yukitaka Ushio, Hideyuki Saya

Journal:

Year:

2002

Language:

english

File:

PDF, 835 KB

english, 2002

32

Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes

Tadashi Anan, Yoichi Nagata, Hisashi Koga, Yoshiomi Honda, Nami Yabuki, Chikara Miyamoto, Akira Kuwano, Ichiro Matsuda, Fumio Endo, Hideyuki Saya, Mitsuyoshi Nakao

Journal:

Year:

1998

Language:

english

File:

PDF, 710 KB

english, 1998

33

Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma

Takeshi Kino, Hideo Takeshima, Mitsuyoshi Nakao, Toru Nishi, Keizo Yamamoto, Takahiro Kimura, Yoshiki Saito, Masato Kochi, Jun-ichi Kuratsu, Hideyuki Saya, Yukitaka Ushio

Journal:

Year:

2001

Language:

english

File:

PDF, 512 KB

english, 2001

34

PML-nuclear bodies are involved in cellular serum response

Kazuhito Matsuzaki, Takeshi Minami, Masahide Tojo, Yoshiomi Honda, Noriko Saitoh, Shinji Nagahiro, Hideyuki Saya, Mitsuyoshi Nakao

Journal:

Year:

2003

Language:

english

File:

PDF, 783 KB

english, 2003

35

Calpain-dependent proteolysis of NF2 protein: Involvement in schwannomas and meningiomas

Yoriyoshi Kimura, Hideyuki Saya, Mitsuyoshi Nakao

Journal:

Year:

2000

Language:

english

File:

PDF, 281 KB

english, 2000

36

Tissue culture methods to study neurological disorders: Establishment of immortalized Schwann cells from murine disease models

Kazuhiko Watabe, Tsuyoshi Sakamoto, Yoko Kawazoe, Makoto Michikawa, Katsuichi Miyamoto, Takashi Yamamura, Hideyuki Saya, Norie Araki

Journal:

Year:

2003

Language:

english

File:

PDF, 445 KB

english, 2003

37

Proteome profiling reveals gender differences in the composition of human serum

Koichiro Miike, Masashi Aoki, Ryo Yamashita, Yumiko Takegawa, Hideyuki Saya, Teruhisa Miike, Ken-ichi Yamamura

Journal:

Year:

2010

Language:

english

File:

PDF, 624 KB

english, 2010

38

Proteome profiling reveals gender differences in the composition of human serum

Koichiro Miike, Masashi Aoki, Ryo Yamashita, Yumiko Takegawa, Hideyuki Saya, Teruhisa Miike, Ken-ichi Yamamura

Journal:

PROTEOMICS - Clinical Applications

Year:

2010

Language:

english

File:

PDF, 523 KB

english, 2010

39

Neurofibromatosis type 1 (NF1) gene: Implication in neuroectodermal differentiation and genesis of brain tumors

Toru Nishi, Hideyuki Saya

Journal:

Cancer and Metastasis Reviews

Year:

1991

Language:

english

File:

PDF, 887 KB

english, 1991

40

Detection ofp53alterations in human astrocytomas using frozen tissue sections for the polymerase chain reaction

Koji Aka, Janet M. Bruner, Melissa L. Bondy, Keith Ligon, Toru Nishi, Auro del Giglio, Richard P. Moser, Victor A. Levin, Hideyuki Saya

Journal:

Journal of Neuro-Oncology

Year:

1993

Language:

english

File:

PDF, 1.20 MB

english, 1993

41

Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas

Richard S. Morrison, Fumio Yamaguchi, Hideyuki Saya, Janet M. Bruner, Alan M. Yahanda, Lawrence A. Donehower, Mitchel Berger

Journal:

Journal of Neuro-Oncology

Year:

1994

Language:

english

File:

PDF, 947 KB

english, 1994

42

Pineoblastoma with neuronal differentiation — Immunohistochemical and immunocytochemical studies

Yasuhiro Okuda, Katsushi Taomoto, Hideyuki Saya, Akihiro Ijichi, Takashi Kokunai, Norihiko Tamaki, Satoshi Matsumoto

Journal:

Journal of Neuro-Oncology

Year:

1988

Language:

english

File:

PDF, 1.15 MB

english, 1988

43

C-terminal processing of tyrosinase is responsible for activation ofPholiota microsporaproenzyme

Yasuko Kawamura-Konishi, Saya Maekawa, Mariko Tsuji, Hideyuki Goto

Journal:

Applied Microbiology and Biotechnology

Year:

2011

Language:

english

File:

PDF, 312 KB

english, 2011

44

ADAM-17 associated with CD44 cleavage and metastasis in oral squamous cell carcinoma

Yasuo Takamune, Tetsuro Ikebe, Osamu Nagano, Hideki Nakayama, Kazutoshi Ota, Takehisa Obayashi, Hideyuki Saya, Masanori Shinohara

Journal:

Virchows Archiv

Year:

2007

Language:

english

File:

PDF, 363 KB

english, 2007

45

Breast cancer stem cells

Kazuharu Kai, Yoshimi Arima, Toshio Kamiya, Hideyuki Saya

Journal:

Year:

2010

Language:

english

File:

PDF, 400 KB

english, 2010

46

Significant Correlation of Nitric Oxide Synthase Activity and p53 Gene Mutation in Stage I Lung Adenocarcinoma

Hisao Fujimoto, Ji-ichiro Sasaki, Mitsuhiro Matsumoto, Moritaka Suga, Yukio Ando, Richard Iggo, Mitsuhiro Tada, Hideyuki Saya, Masayuki Ando

Journal:

Year:

1998

Language:

english

File:

PDF, 81 KB

english, 1998

47

Mechanism and biological significance of CD44 cleavage

Osamu Nagano, Hideyuki Saya

Journal:

Year:

2004

Language:

english

File:

PDF, 240 KB

english, 2004

48

Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells

Takayuki Nitta, Masayuki Kanai, Eiji Sugihara, Masakazu Tanaka, Binlian Sun, Toshiro Nagasawa, Shunro Sonoda, Hideyuki Saya, Masanao Miwa

Journal:

Year:

2006

Language:

english

File:

PDF, 232 KB

english, 2006

49

Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model

Kazuharu Kai, Osamu Nagano, Eiji Sugihara, Yoshimi Arima, Oltea Sampetrean, Takatsugu Ishimoto, Masaya Nakanishi, Naoto T. Ueno, Hirotaka Iwase, Hideyuki Saya

Journal:

Year:

2009

Language:

english

File:

PDF, 645 KB

english, 2009

50

Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway

Anchalee Techasen, Watcharin Loilome, Nisana Namwat, Eri Takahashi, Eiji Sugihara, Anucha Puapairoj, Masanao Miwa, Hideyuki Saya, Puangrat Yongvanit

Journal:

Year:

2010

Language:

english

File:

PDF, 799 KB

english, 2010