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1

Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA

Campbell, Nancy H., Smith, Daniel L., Reszka, Anthony P., Neidle, Stephen, O'Hagan, David

Journal:

Organic & Biomolecular Chemistry

Year:

2011

Language:

english

File:

PDF, 719 KB

english, 2011

2

G-quadruplexes as therapeutic targets

Stephen Neidle, Martin A. Read

Journal:

Year:

2000

Language:

english

File:

PDF, 818 KB

english, 2000

3

ChemInform Abstract: A New Class of Symmetric Bisbenzimidazole-Based DNA Minor Groove-Binding Agents Showing Antitumor Activity.

John Mann, Anne Baron, Yaw Opoku-Boahen, Eric Johannsson, Gary Parkinson, Lloyd R. Kelland, Stephen Neidle

Journal:

Year:

2001

File:

PDF, 28 KB

2001

4

Human telomerase inhibition by substituted acridine derivatives

R. John Harrison, Sharon M. Gowan, Lloyd R. Kelland, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 348 KB

english, 1999

5

New insights into sequence-dependent DNA structure

Neidle, Stephen

Journal:

Natural Structural Biology

Year:

1998

Language:

english

File:

PDF, 168 KB

english, 1998

6

10.1038/19701

Neidle, Stephen

Journal:

Year:

1999

Language:

english

File:

PDF, 372 KB

english, 1999

7

10.1038/19699

Neidle, Stephen

Journal:

Year:

1999

Language:

english

File:

PDF, 372 KB

english, 1999

8

Highly structured water network in crystals of a deoxydinucleoside–drug complex

Neidle, Stephen, Berman, Helen M., Shieh, H. S.

Journal:

Year:

1980

File:

PDF, 548 KB

1980

9

Rational Design of Acridine-Based Ligands with Selectivity for Human Telomeric Quadruplexes

Sparapani, Silvia, Haider, Shozeb M., Doria, Filippo, Gunaratnam, Mekala, Neidle, Stephen

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 2.69 MB

english, 2010

10

Sequence-Dependent Drug Binding to the Minor Groove of DNA: Crystal Structure of the DNA Dodecamer d(CGCAAATTTGCG)2 Complexed with Propamidine

Nunn, Christine M., Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 2.99 MB

english, 1995

11

The structures of quadruplex nucleic acids and their drug complexes

Journal:

Current Opinion in Structural Biology

Year:

2009

Language:

english

File:

PDF, 666 KB

english, 2009

12

Stabilization of DNA triple helices by a series of mono- and disubstituted amidoanthraquinones

Melanie D. Keppler, Martin A. Read, Philip J. Perry, John O. Trent, Terence C. Jenkins, Anthony P. Reszka, Stephen Neidle, Keith R. Fox

Journal:

Year:

1999

Language:

english

File:

PDF, 937 KB

english, 1999

13

Quadruplex Nucleic Acids Volume 733 || DNA Quadruplex?Ligand Recognition: Structure and Dynamics

Neidle, Stephen, Balasubramanian, Shankar

Year:

2006

Language:

english

File:

PDF, 12.75 MB

english, 2006

14

A New Class of Symmetric Bisbenzimidazole-Based DNA Minor Groove-Binding Agents Showing Antitumor Activity

Mann, John, Baron, Anne, Opoku-Boahen, Yaw, Johansson, Eric, Parkinson, Gary, Kelland, Lloyd R., Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 259 KB

english, 2001

15

Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2 An examination of propeller twist and minor-groove water structure at 2·2Åresolution

Karen J. Edwards, David G. Brown, Neil Spink, Jane V. Skelly, Stephen Neidle

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 1.22 MB

english, 1992

16

Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes

Campbell, Nancy H., Karim, Nurul H. Abd, Parkinson, Gary N., Gunaratnam, Mekala, Petrucci, Vanessa, Todd, Alan K., Vilar, Ramon, Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 4.46 MB

english, 2012

17

Molecular Modeling Studies on G-Quadruplex Complexes of Telomerase Inhibitors: Structure−Activity Relationships

Read, Martin A., Wood, Alexis A., Harrison, John R., Gowan, Sharon M., Kelland, Lloyd R., Dosanjh, Harvinder S., Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 581 KB

english, 1999

18

Synthesis, G-Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2- b ]quinolines with One, Two, or Three Basic Side Chains

Lavrado, João, Borralho, Pedro M., Ohnmacht, Stephan A., Castro, Rui E., Rodrigues, Cecília M. P., Moreira, Rui, Santos, Daniel J. V. A. dos, Neidle, Stephen, Paulo, Alexandra

Journal:

Year:

2013

Language:

english

File:

PDF, 1018 KB

english, 2013

19

A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus

Shiu, Winnie K.P., Malkinson, John P., Rahman, M. Mukhlesur, Curry, Jonathan, Stapleton, Paul, Gunaratnam, Mekala, Neidle, Stephen, Mushtaq, Shazad, Warner, Marina, Livermore, David M., Evangelopoulos

Journal:

International Journal of Antimicrobial Agents

Year:

2013

Language:

english

File:

PDF, 509 KB

english, 2013

20

Structure of the First Parallel DNA Quadruplex-Drug Complex

Clark, George R., Pytel, Patrycja D., Squire, Christopher J., Neidle, Stephen

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 108 KB

english, 2003

21

A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines

Lombardo, Caterina M., Welsh, Sarah J., Strauss, Sandra J., Dale, Aaron G., Todd, Alan K., Nanjunda, Rupesh, Wilson, W. David, Neidle, Stephen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 494 KB

english, 2012

22

Principles of Nucleic Acid Structure || Principles of Small Molecule-DNA Recognition

Neidle, Stephen

Year:

2008

Language:

english

File:

PDF, 4.83 MB

english, 2008

23

A Molecular Anchor for Stabilizing Triple-Helical DNA

Keith R. Fox, Paolo Polucci, Terence C. Jenkins and Stephen Neidle

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.06 MB

english, 1995

24

Quadruplex Nucleic Acids as Novel Therapeutic Targets

Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.97 MB

english, 2016

25

Induced-fit recognition of CCG trinucleotide repeats by a nickel chromomycin complex results in large-scale DNA deformation

Tseng, Wen-Hsuan, Chang, Chung-Ke, Wu, Pei-Ching, Hu, Nien-Jen, Lee, Gene-Hsiang, Tzeng, Ching-Cherng, Neidle, Stephen, Hou, Ming-Hon

Journal:

Angewandte Chemie International Edition

Year:

2017

Language:

english

File:

PDF, 1.64 MB

english, 2017

26

Induced-Fit Recognition of CCG Trinucleotide Repeats by a Nickel-Chromomycin Complex Resulting in Large-Scale DNA Deformation

Tseng, Wen-Hsuan, Chang, Chung-ke, Wu, Pei-Ching, Hu, Nien-Jen, Lee, Gene-Hsiang, Tzeng, Ching-Cherng, Neidle, Stephen, Hou, Ming-Hon

Journal:

Angewandte Chemie

Year:

2017

Language:

english

File:

PDF, 1.66 MB

english, 2017

27

Principles of Nucleic Acid Structure || Nonstandard and Higher-Order DNA Structures: DNA–DNA Recognition

Neidle, Stephen

Year:

2008

Language:

english

File:

PDF, 3.18 MB

english, 2008

28

Principles of Nucleic Acid Structure || DNA Structure as Observed in Fibers and Crystals

Neidle, Stephen

Year:

2008

Language:

english

File:

PDF, 1.81 MB

english, 2008

29

Principles of Nucleic Acid Structure || RNA Structures and Their Diversity

Neidle, Stephen

Year:

2008

Language:

english

File:

PDF, 5.35 MB

english, 2008

30

Principles of Nucleic Acid Structure || Principles of Protein-DNA Recognition

Neidle, Stephen

Year:

2008

Language:

english

File:

PDF, 3.86 MB

english, 2008

31

Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation

Satange, Roshan, Chuang, Chien-Ying, Neidle, Stephen, Hou, Ming-Hon

Journal:

Nucleic Acids Research

Year:

2019

Language:

english

File:

PDF, 6.99 MB

english, 2019

32

Principles of Nucleic Acid Structure || Methods for Studying Nucleic Acid Structure

Neidle, Stephen

Year:

2008

File:

PDF, 1.06 MB

2008

33

[Annual Reports in Medicinal Chemistry] Quadruplex Nucleic Acids As Targets For Medicinal Chemistry Volume 54 || Preface

Neidle, Stephen

Year:

2020

File:

PDF, 16 KB

2020

34

Crystallographic insights into DNA minor groove recognition by drugs

Journal:

Year:

1997

Language:

english

File:

PDF, 385 KB

english, 1997

35

Conformations of the sugar-phosphate backbone in helical DNA crystal structures

Bohdan Schneider, Stephen Neidle, Helen M. Berman

Journal:

Year:

1997

Language:

english

File:

PDF, 274 KB

english, 1997

36

Chemical Variation of Natural-Product-Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives

Lech-Gustav Milroy, Giovanna Zinzalla, Giuseppe Prencipe, Patrick Michel, Steven V. Ley, Mekala Gunaratnam, Monica Beltran, Stephen Neidle

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 166 KB

english, 2007

37

Chemical Variation of Natural-Product-Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives

Lech-Gustav Milroy, Giovanna Zinzalla, Giuseppe Prencipe, Patrick Michel, Steven V. Ley, Mekala Gunaratnam, Monica Beltran, Stephen Neidle

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

38

ChemInform Abstract: Symmetric Bis-benzimidazoles: New Sequence-Selective DNA-Binding Molecules.

Stephen Neidle, John Mann, Emma L. Rayner, Anne Baron, Yaw Opoku-Boahen, Ian J. Simpson, Nicola J. Smith, Keith R. Fox, John A. Hartley, Lloyd R. Kelland

Journal:

Year:

1999

File:

PDF, 32 KB

1999

39

ChemInform Abstract: Chemoenzymatic Preparation of the Novel Antifolate Thymidylate Synthase Inhibitor N-(4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta [g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoyl)-L-glutamic Acid (Ia) and Its Glutamyl Cleavage Product (Ib).

Jonathan H. Marriott, Stephen Neidle, Zbigniew Matusiak, Vassilios Bavetsias, Ann L. Jackman, Camille Melin, F. Thomas Boyle

Journal:

Year:

1999

File:

PDF, 31 KB

1999

40

ChemInform Abstract: A Novel Inhibitor of Human Telomerase Derived from 10H-Indolo[3,2-b]quinoline.

Vittorio Caprio, Berengere Guyen, Yaw Opoku-Boahen, John Mann, Sharon M. Gowan, Lloyd M. Kelland, Martin A. Read, Stephen Neidle

Journal:

Year:

2000

File:

PDF, 30 KB

2000

41

ChemInform Abstract: Synthesis of the Farnesyl Ether 2,3,5-Trifluoro-6-hydroxy-4- [(E,E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yloxy]nitrobenzene, and Related Compounds Containing a Substituted Hydroxytrifluorophenyl Residue: Novel Inhibitors of Protein Farnesyltransferase, Geranylgeranyltransferase I and Squalene Synthase.

Jonathan H. Marriott, Amelia M. Moreno Barber, Ian R. Hardcastle, Martin G. Rowlands, Rachel M. Grimshaw, Stephen Neidle, Michael Jarman

Journal:

Year:

2001

Language:

english

File:

PDF, 49 KB

english, 2001

42

ChemInform Abstract: DNA Minor-Groove Recognition by Small Molecules

Journal:

Year:

2001

File:

PDF, 24 KB

2001

43

Truncated Azinomycin Analogues Intercalate into DNA.

Maxwell A. Casely-Hayford, Klaus Pors, Laurence H. Patterson, Clive Gerner, Stephen Neidle, Mark Searcey

Journal:

Year:

2005

File:

PDF, 9 KB

2005

44

Oxidative ring contraction of benzeneselenenate adducts of glycal ethers. synthesis of showdomycin analogues

Andrew Kaye, Stephen Neidle, Colin B. Reese

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 216 KB

english, 1988

45

The antitumor complex ethylenediamine platinum (II) malonate: X-ray structure analysis, and studies of its stability in solution

Shirley D. Cutbush, Reiko Kuroda, Stephen Neidle, A.Brian Robins

Journal:

Journal of Inorganic Biochemistry

Year:

1983

Language:

english

File:

PDF, 439 KB

english, 1983

46

The use of molecular modeling in anticancer drug design

Journal:

Journal of Molecular Graphics

Year:

1989

Language:

english

File:

PDF, 125 KB

english, 1989

47

Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells

Francisco Cuenca, Michael J.B. Moore, Karin Johnson, Bérangère Guyen, Anne De Cian, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 497 KB

english, 2009

48

Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase

David F. Burke, Charles A. Laughton, Chris F. Snook, Stephen Neidle, Gerard A. Potter, Michael Jarman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 228 KB

english, 1995

49

Conformational flexibility and its potential influence on metabolic reactions for the anti-tumour compound a-ammine-bd-bis(butyrato)-cf-dichloro-e-cyclohexylamine platinum(IV)

Stephen Neidle, Barry A Murrer, Christopher Fj Barnard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 255 KB

english, 1996

50

Perturbations in DNA structure upon interaction with porphyrins revealed by chemical probes, DNA footprinting and molecular modelling

Kevin G. Ford, Stephen Neidle

Journal:

Bioorganic & Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 668 KB

english, 1995