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1

Carbonic anhydrase inhibitors: Sulfonamides as antitumor agents?

Claudiu T Supuran, Fabrizio Briganti, Silvia Tilli, W.Richard Chegwidden, Andrea Scozzafava

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 301 KB

english, 2001

2

Design of Zinc Binding Functions for Carbonic Anhydrase Inhibitors

Montero, Jean-Louis, Supuran, Claudiu, Scozzafava, Andrea, Winum, Jean-Yves

Journal:

Current Pharmaceutical Design

Year:

2008

Language:

english

File:

PDF, 165 KB

english, 2008

3

Sulfamates and Their Therapeutic Potential

Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran

Journal:

Year:

2005

File:

PDF, 8 KB

2005

4

Carbonic Anhydrase Inhibitors. Synthesis of Water-Soluble, Topically Effective, Intraocular Pressure-Lowering Aromatic/Heterocyclic Sulfonamides Containing Cationic or Anionic Moieties: Is the Tail More Important than the Ring?1

Scozzafava, Andrea, Menabuoni, Luca, Mincione, Francesco, Briganti, Fabrizio, Mincione, Giovanna, Supuran, Claudiu T.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 128 KB

english, 1999

5

Therapeutic applications of serine protease inhibitors

Ilies, Marc A, Supuran, Claudiu T, Scozzafava, Andrea

Journal:

Expert Opinion on Therapeutic Patents

Year:

2002

Language:

english

File:

PDF, 673 KB

english, 2002

6

Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity

Marc A Ilies, Bernard Masereel, Stéphanie Rolin, Andrea Scozzafava, Gheorghe Câmpeanu, Valentin Cı̂mpeanu, Claudiu T Supuran

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 347 KB

english, 2004

7

Fungal laccase, cellobiose dehydrogenase, and chemical mediators: Combined actions for the decolorization of different classes of textile dyes

Ilaria Ciullini, Silvia Tilli, Andrea Scozzafava, Fabrizio Briganti

Journal:

Bioresource Technology

Year:

2008

Language:

english

File:

PDF, 152 KB

english, 2008

8

Carbonic anhydrases as targets for medicinal chemistry

Claudiu T. Supuran, Andrea Scozzafava

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 637 KB

english, 2007

9

Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?

Peter Burghout, Daniela Vullo, Andrea Scozzafava, Peter W.M. Hermans, Claudiu T. Supuran

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 536 KB

english, 2011

10

Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids

Alessio Innocenti, Worraanong Leewattanapasuk, Gheorghe Manole, Andrea Scozzafava, Fritz A. Mühlschlegel, Claudiu T. Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 217 KB

english, 2010

11

Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I–XV

Alessio Innocenti, Ilhami Gülçin, Andrea Scozzafava, Claudiu T. Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 243 KB

english, 2010

12

Different behavior of sulfonamides with respect to copper-substituted bovine and human carbonic anhydrases

Ivano Bertini, Claudio Luchinat, Roberto Monnanni, Andrea Scozzafava

Journal:

Journal of Inorganic Biochemistry

Year:

1982

Language:

english

File:

PDF, 385 KB

english, 1982

13

Direct micellar systems as a tool to improve the efficiency of aromatic substrate conversion for fine chemicals production

Debora Berti, Demetrio Randazzo, Fabrizio Briganti, Piero Baglioni, Andrea Scozzafava, Patrizia Di Gennaro, Enrica Galli, Giuseppina Bestetti

Journal:

Journal of Inorganic Biochemistry

Year:

2000

Language:

english

File:

PDF, 154 KB

english, 2000

14

Protease inhibitors – Part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido- glycine hydroxamate inhibitors of Clostridium histolyticum collagenase

Andrea Scozzafava, Claudiu T Supuran

Journal:

European Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 134 KB

english, 2000

15

Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties

Francesco Mincione, Michele Starnotti, Luca Menabuoni, Andrea Scozzafava, Angela Casini, Claudiu T. Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 126 KB

english, 2001

16

Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV

Angela Casini, Jochen Antel, Francesco Abbate, Andrea Scozzafava, Samuel David, Harald Waldeck, Siegfried Schäfer, Claudiu T Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 179 KB

english, 2003

17

Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions

Monica Ilies, Claudiu T. Supuran, Andrea Scozzafava, Angela Casini, Francesco Mincione, Luca Menabuoni, Miron T. Caproiu, Maria Maganu, Mircea D. Banciu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 242 KB

english, 2000

18

Sulfonamides: a patent review (2008 – 2012)

Carta, Fabrizio, Scozzafava, Andrea, Supuran, Claudiu T

Journal:

Expert Opinion on Therapeutic Patents

Year:

2012

Language:

english

File:

PDF, 431 KB

english, 2012

19

Carbonic Anhydrase Inhibitors: Aromatic Sulfonamides and Disulfonamides Act as Efficient Tumor Growth Inhibitors

Supuran, Claudiu T., Scozzafava, Andrea

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 785 KB

english, 2000

20

Carbonic anhydrase inhibitors and their therapeutic potential

Supuran, Claudiu T, Scozzafava, Andrea

Journal:

Expert Opinion on Therapeutic Patents

Year:

2000

Language:

english

File:

PDF, 369 KB

english, 2000

21

Carbonic Anhydrase Inhibitors: Hypoxia-Activatable Sulfonamides Incorporating Disulfide Bonds that Target the Tumor-Associated Isoform IX †

De Simone, Giuseppina, Vitale, Rosa Maria, Di Fiore, Anna, Pedone, Carlo, Scozzafava, Andrea, Montero, Jean-Louis, Winum, Jean-Yves, Supuran, Claudiu T.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 160 KB

english, 2006

22

Applications of carbonic anhydrase inhibitors and activators in therapy

Supuran, Claudiu T, Scozzafava, Andrea

Journal:

Expert Opinion on Therapeutic Patents

Year:

2002

Language:

english

File:

PDF, 1.13 MB

english, 2002

23

Synthesis of Biologically Active Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Symmetrically 1,1′‐Disubstituted Ferrocene‐Derived Compounds

Chohan, Zahid H., Scozzafava, Andrea, Supuran, Claudiu T.

Journal:

Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry

Year:

2003

Language:

english

File:

PDF, 284 KB

english, 2003

24

Protein tyrosine kinase inhibitors as anticancer agents

Supuran, Claudiu T, Scozzafava, Andrea

Journal:

Expert Opinion on Therapeutic Patents

Year:

2004

Language:

english

File:

PDF, 273 KB

english, 2004

25

Synthesis and inhibition potency of novel ureido benzenesulfonamides incorporating GABA as tumor-associated carbonic anhydrase IX and XII inhibitors

Ceruso, Mariangela, Antel, Sabrina, Scozzafava, Andrea, Supuran, Claudiu T.

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 438 KB

english, 2015

26

Development and ex vivo evaluation of 5-aminolevulinic acid-loaded niosomal formulations for topical photodynamic therapy

Bragagni, Marco, Scozzafava, Andrea, Mastrolorenzo, Antonio, Supuran, Claudiu T., Mura, Paola

Journal:

International Journal of Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 555 KB

english, 2015

27

Carbonic Anhydrase Inhibitors

Supuran, Claudiu, Scozzafava, Andrea

Journal:

Current Medicinal Chemistry - Immunology Endocrine & Metabolic Agents

Year:

2001

Language:

english

File:

PDF, 699 KB

english, 2001

28

Carbonic Anhydrase Inhibitors. Part 551 Metal Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In Vitro Inhibition Studies With Carbonic Anhydrase Isozymes I, II and IV

Supuran, Claudiu T., Scozzafava, Andrea, Briganti, Fabrizio, Ilies, Marc A., Jitianu, Andrei

Journal:

Metal-Based Drugs

Year:

1998

Language:

english

File:

PDF, 1.91 MB

english, 1998

29

Efficient polycyclic aromatic hydrocarbons dihydroxylation in direct micellar systems

Demetrio Randazzo, Debora Berti, Fabrizio Briganti, Piero Baglioni, Andrea Scozzafava, Patrizia Di Gennaro, Enrica Galli, Giuseppina Bestetti

Journal:

Biotechnology and Bioengineering

Year:

2001

Language:

english

File:

PDF, 177 KB

english, 2001

30

Density Functional Characterization of the Chemoselective Oxidation of Catechol by using Molecular Oxygen: Thermodynamics of the Reaction between [(triphos)Ir(dtbc)]+ and O2

Alessandro Bencini, Eckhard Bill, Andrea Scozzafava, Federico Totti

Journal:

Chemistry - A European Journal

Year:

2003

Language:

english

File:

PDF, 304 KB

english, 2003

31

Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, VA, VII, and XIV with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton-Transfer Processes within the Active Site of an Enzyme

Claudia Temperini, Andrea Scozzafava, Daniela Vullo, Claudiu T. Supuran

Journal:

Chemistry - A European Journal

Year:

2006

Language:

english

File:

PDF, 445 KB

english, 2006

32

ChemInform Abstract: The Antifungal Activity of Sulfonylamido Derivatives of 2-Aminophenoxathiin and Related Compounds.

Claudiu T. Supuran, Andrea Scozzafava, Fabrizio Briganti, George Loloiu, Ovidiu Maior

Journal:

Year:

1999

File:

PDF, 26 KB

1999

33

ChemInform Abstract: Novel Carbonic Anhydrase Isozymes I, II, and IV Activators Incorporating Sulfonyl-Histamino Moieties.

Fabrizio Briganti, Andrea Scozzafava, Claudiu T. Supuran

Journal:

Year:

1999

File:

PDF, 30 KB

1999

34

ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 70. Synthesis and Ocular Pharmacology of a New Class of Water-Soluble, Topically Effective Intraocular Pressure Lowering Agents Derived from Nicotinic Acid and Aromatic/Heterocyclic Sulfonamides

Claudiu T. Supuran, Andrea Scozzafava, Luca Menabuoni, Francesco Mincione, Fabrizio Briganti, Giovanna Mincione

Journal:

Year:

2000

File:

PDF, 30 KB

2000

35

ChemInform Abstract: Protease Inhibitors. Part 3. Synthesis of Non-basic Thrombin Inhibitors Incorporating Pyridinium-Sulfanilylguanidine Moieties at the P1 Site.

Andrea Scozzafava, Fabrizio Briganti, Claudiu T. Supuran

Journal:

Year:

2000

File:

PDF, 30 KB

2000

36

ChemInform Abstract: Carbonic Anhydrase Activators. Part 21. Novel Activators of Isozymes I, II, and IV Incorporating Carboxamido and Ureido Histamine Moieties.

Andrea Scozzafava, Claudiu T. Supuran

Journal:

Year:

2000

File:

PDF, 28 KB

2000

37

ChemInform Abstract: Carbonic Anhydrase Inhibitors: Topical Sulfonamide Antiglaucoma Agents Incorporating Secondary Amine Moieties

Giovanni Renzi, Andrea Scozzafava, Claudiu T. Supuran

Journal:

Year:

2000

File:

PDF, 27 KB

2000

38

ChemInform Abstract: Protease Inhibitors: Synthesis of Clostridium histolyticum Collagenase Inhibitors Incorporating Sulfonyl-L-alanine Hydroxamate Moieties.

Andrea Scozzafava, Claudiu T. Supuran

Journal:

Year:

2000

File:

PDF, 28 KB

2000

39

ChemInform Abstract: Protease Inhibitors. Part 5. Alkyl/Arylsulfonyl- and Arylsulfonylureido-/Arylureido- Glycine Hydroxamate Inhibitors of Clostridium histolyticum Collagenase.

Andrea Scozzafava, Claudiu T. Supuran

Journal:

Year:

2000

File:

PDF, 28 KB

2000

40

ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 78. Synthesis of Water-Soluble Sulfonamides Incorporating β-Alanyl Moieties, Possessing Long Lasting-Intraocular Pressure Lowering Properties via the Topical Route.

Claudiu T. Supuran, Fabrizio Briganti, Luca Menabuoni, Giovanna Mincione, Francesco Mincione, Andrea Scozzafava

Journal:

Year:

2000

File:

PDF, 30 KB

2000

41

ChemInform Abstract: Arylsulfonyl-N,N-diethyl-dithiocarbamates: A Novel Class of Antitumor Agents.

Andrea Scozzafava, Antonio Mastrolorenzo, Claudiu T. Supuran

Journal:

Year:

2000

File:

PDF, 26 KB

2000

42

ChemInform Abstract: Carbonic Anhydrase Inhibitors: Synthesis of Sulfonamides Incorporating dtpa Tails and of Their Zinc Complexes with Powerful Topical Antiglaucoma Properties.

Andrea Scozzafava, Luca Menabuoni, Francesco Mincione, Giovanna Mincione, Claudiu T. Supuran

Journal:

Year:

2001

File:

PDF, 24 KB

2001

43

ChemInform Abstract: Antimycobacterial Activity of 9-Sulfonylated/Sulfenylated-6-mercaptopurine Derivatives.

Andrea Scozzafava, Antonio Mastrolorenzo, Claudiu T. Supuran

Journal:

Year:

2001

File:

PDF, 27 KB

2001

44

ChemInform Abstract: Carbonic Anhydrase Inhibitors: 4-Sulfamoyl-benzenecarboxamides and 4-Chloro-3-sulfamoyl-benzenecarboxamides with Strong Topical Antiglaucoma Properties.

Francesco Mincione, Michele Starnotti, Luca Menabuoni, Andrea Scozzafava, Angela Casini, Claudiu T. Supuran

Journal:

Year:

2001

File:

PDF, 27 KB

2001

45

ChemInform Abstract: Bacterial Protease Inhibitors

Claudio T. Supuran, Andrea Scozzafava, Brian W. Clare

Journal:

Year:

2002

File:

PDF, 23 KB

2002

46

Carbonic Anhydrase Inhibitors. Preparation of Potent Sulfonamides Inhibitors Incorporating Bile Acid Tails

Andrea Scozzafava, Claudiu T. Supuran

Journal:

Year:

2002

File:

PDF, 27 KB

2002

47

Protease Inhibitors: Synthesis of Matrix Metalloproteinase and Bacterial Collagenase Inhibitors Incorporating 5-Amino-2-mercapto-1,3,4-thiadiazole Zinc Binding Functions.

Andrea Scozzafava, Claudiu T. Supuran

Journal:

Year:

2002

File:

PDF, 27 KB

2002

48

Carbonic Anhydrase Inhibitors

Claudiu T. Supuran, Andrea Scozzafava, Angela Casini

Journal:

Year:

2003

File:

PDF, 53 KB

2003

49

Carbonic Anhydrase Inhibitors: Inhibition of Cytosolic Isozymes I and II with Sulfamide Derivatives.

Angela Casini, Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, Claudiu T. Supuran

Journal:

Year:

2003

File:

PDF, 67 KB

2003

50

Carbonic Anhydrase Inhibitors: Topically Acting Antiglaucoma Sulfonamides Incorporating Esters and Amides of 3- and 4-Carboxybenzolamide.

Angela Casini, Andrea Scozzafava, Francesco Mincione, Luca Menabuoni, Michele Starnotti, Claudiu T. Supuran

Journal:

Year:

2003

File:

PDF, 73 KB

2003