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1

Protein tyrosine phosphatase: enzymatic assays

Jacqueline Montalibet, Kathryn I. Skorey, Brian P. Kennedy

Journal:

Year:

2005

Language:

english

File:

PDF, 209 KB

english, 2005

2

Direct O-acylation of small molecules containing CO2----HN .rarw. HO units by a distorted amide: enhancement of amine basicity by a pendant carboxylate in a serine protease mimic

Skorey, K. I., Somayaji, V., Brown, R. S.

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 1014 KB

english, 1989

3

Correction. Biomimetic Models for Cysteine Proteases. 3. Acylation of Imidazolium-Thiolate Zwitterions by p -Nitrophenylacetates as a Model for the Acylation Step and Demonstration of Intramolecular General-Base-Catalyzed Delivery of H 2 O by Imidazole to Thiol Esters as a Model for the Deacylation Step

Street, J P., Skorey, K I., Brown, R S., Ball, R G.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 94 KB

english, 1986

4

Biomimetic models for cysteine proteases. 3. Acylation of imidazolium-thiolate zwitterions by p-nitrophenylacetate as a model for the acylation step and demonstration of intramolecular general-base-catalyzed delivery of water by imidazole to thiol esters as a model for the deacylation step

Street, J. P., Skorey, K. I., Brown, R. S., Ball, R. G.

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 1.34 MB

english, 1985

5

Discovery of Novel P2Y14 Agonist and Antagonist Using Conventional and Nonconventional Methods

Hamel, M., Henault, M., Hyjazie, H., Morin, N., Bayly, C., Skorey, K., Therien, A. G., Mancini, J., Brideau, C., Kargman, S.

Journal:

Journal of Biomolecular Screening

Year:

2011

Language:

english

File:

PDF, 409 KB

english, 2011

6

A Two-Component Affinity Chromatography Purification ofHelix pomatiaArylsulfatase by Tyrosine Vanadate

Kathryn I. Skorey, Nathalie A. Johnson, Gregory Huyer, Michael J. Gresser

Journal:

Protein Expression and Purification

Year:

1999

Language:

english

File:

PDF, 153 KB

english, 1999

7

Characterization of the non-heme iron center of human 5-lipoxygenase by electron paramagnetic resonance, fluorescence, and ultraviolet-visible spectroscopy: Redox cycling between ferrous and ferric states

Chasteen, N. Dennis, Grady, John K., Skorey, Kathryn I., Neden, Kevin J., Riendeau, Denis, Percival, M. David

Journal:

Year:

1993

Language:

english

File:

PDF, 1.11 MB

english, 1993

8

Development of a Robust Scintillation Proximity Assay for Protein Tyrosine Phosphatase 1B Using the Catalytically Inactive (C215S) Mutant

Kathryn I. Skorey, Brian P. Kennedy, Richard W. Friesen, Chidambaram Ramachandran

Journal:

Analytical Biochemistry

Year:

2001

Language:

english

File:

PDF, 128 KB

english, 2001

9

ChemInform Abstract: Influence of a Carboxylate Group on the Rate of O-Acylation of 2-Hydroxymethylimidazoles by a Strained Amide.

SKOREY, K. I., SOMAYAJI, V., BROWN, R. S.

Journal:

Year:

1988

File:

PDF, 84 KB

1988

10

Martin–Bell syndrome segregating in a large kindred with normal transmitting males: Clinical, cytogenetic, and linkage study

Virginia P. Johnson, Nancy J. Carpenter, Patricia A. Skorey

Journal:

American Journal of Medical Genetics Part A

Year:

1991

Language:

english

File:

PDF, 1.42 MB

english, 1991

11

Correction. Biomimetic Models for Cysteine Proteases. 2. Nucleophilic Thiolate-Containing Zwitterions Produced from Imidazole-Thiol Pairs. A Model for the Acylation Step in Papain-Mediated Hydrolyses

Skorey, K I., Brown, R S.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 112 KB

english, 1986

12

The development of potent non-peptidic PTP-1B inhibitors

Claude Dufresne, Patrick Roy, Zhaoyin Wang, Ernest Asante-Appiah, Wanda Cromlish, Yves Boie, Farnaz Forghani, Sylvie Desmarais, Qingping Wang, Kathryn Skorey, Deena Waddleton, Chidambaram Ramachandran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 169 KB

english, 2004

13

Biomimetic models for cysteine proteases. 2. Nucleophilic thiolate-containing zwitterions produced from imidazole-thiol pairs. A model for the acylation step in papain

Skorey, K. I., Brown, R. S.

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 412 KB

english, 1985

14

Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors

Jean-Philippe Leclerc, Jean-Pierre Falgueyret, Mélina Girardin, Jocelyne Guay, Sébastien Guiral, Zheng Huang, Chun Sing Li, Renata Oballa, Yeeman K. Ramtohul, Kathryn Skorey, Paul Tawa, Hao Wang, Lei

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 903 KB

english, 2011

15

The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B †

Scapin, Giovanna, Patel, Sangita B., Becker, Joseph W., Wang, Qingping, Desponts, Caroline, Waddleton, Deena, Skorey, Kathryn, Cromlish, Wanda, Bayly, Christopher, Therien, Michel, Gauthier, Jacques Y

Journal:

Year:

2003

Language:

english

File:

PDF, 353 KB

english, 2003

16

ChemInform Abstract: Direct O-Acylation of Small Molecules Containing CO- 2---HN··←HO Units by a Distorted Amide: Enhancement of Amine Basicity by a Pendant Carboxylate in a Serine Protease Mimic.

SKOREY, K. I., SOMAYAJI, V., BROWN, R. S.

Journal:

Year:

1989

File:

PDF, 187 KB

1989

17

Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells

E. Wong, C. DeLuca, C. Boily, S. Charleson, W. Cromlish, D. Denis, S. Kargman, B.P. Kennedy, M. Ouellet, K. Skorey, G.P. O'Neill, P.J. Vickers, D. Riendeau

Journal:

Inflammation Research

Year:

1997

Language:

english

File:

PDF, 390 KB

english, 1997

18

High-Throughput Scintillation Proximity Assay for Stearoyl-CoA Desaturase-1

Tawa, P., Falgueyret, J.-P., Guiral, S., Isabel, E., Powell, D. A., Zuck, P., Skorey, K.

Journal:

Journal of Biomolecular Screening

Year:

2011

Language:

english

File:

PDF, 706 KB

english, 2011

19

From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors

W.C. Black, C. Bayly, M. Belley, C.-C. Chan, S. Charleson, D. Denis, J.Y. Gauthier, R. Gordon, D. Guay, S. Kargman, C.K. Lau, Y. Leblanc, J. Mancini, M. Ouellet, D. Percival, P. Roy, K. Skorey, P. Tag

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 307 KB

english, 1996

20

Molecular structure of 3,4,5-trihydro-2-oxo-1,5-ethanobenzazepine and its reaction with .beta.-amino alcohols as a model for the acylation step of the serine proteases

Somayaji, V., Skorey, K. I., Brown, R. S., Ball, R. G.

Journal:

Journal of Organic Chemistry

Year:

1986

Language:

english

File:

PDF, 931 KB

english, 1986

21

Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme

Michel Thérien, Kathryn Skorey, Robert Zamboni, Chun Sing Li, Cheuk K Lau, Tammy LeRiche, Vouy Linh Truong, Deena Waddleton, Chidambaram Ramachandran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 274 KB

english, 2004

22

Using mass spectrometry to study the photo-affinity labeling of protein tyrosine phosphatase 1B

Tammy LeRiche, Kathryn Skorey, Patrick Roy, Dan McKay, Kevin P. Bateman

Journal:

International Journal of Mass Spectrometry

Year:

2004

Language:

english

File:

PDF, 208 KB

english, 2004

23

[Society of Petroleum Engineers SPE Kuwait International Petroleum Conference and Exhibition - Kuwait City, Kuwait (2012-12-10)] SPE Kuwait International Petroleum Conference and Exhibition - Evaluation of the Effect of Asphaltene Deposition in the Reservoir for the Development of the Magwa Marrat Reservoir

Blunt, Martin Julian, Al-Jadi, Manayer, Al-Qattan, Abrar, Al-Kanderi, Jasem M., Gharbi, Oussama, Badamchizadeh, Amin, Dashti, Hameeda Hussain, Chimmalgi, Vishvanath Shivappa, Bond, Deryck John, Skorey

Language:

english

File:

PDF, 938 KB

english

24

2-Aryl benzimidazoles: Human SCD1-specific stearoyl coenzyme-A desaturase inhibitors

David A. Powell, Yeeman Ramtohul, Marie-Eve Lebrun, Renata Oballa, Sathesh Bhat, Jean-Pierre Falgueyret, Sebastien Guiral, Zheng Huang, Kathryn Skorey, Paul Tawa, Lei Zhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 434 KB

english, 2010

25

Calcium Is Not Required for 5-Lipoxygenase Activity at High Phosphatidyl Choline Vesicle Concentrations

Skorey, Kathryn I., Gresser, Michael J.

Journal:

Year:

1998

Language:

english

File:

PDF, 238 KB

english, 1998

26

Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors

Elise Isabel, David A. Powell, W. Cameron Black, Chi-Chung Chan, Sheldon Crane, Robert Gordon, Jocelyne Guay, Sebastien Guiral, Zheng Huang, Joël Robichaud, Kathryn Skorey, Paul Tawa, Lijing Xu, Lei Z

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 408 KB

english, 2011

27

Enzyme occupancy measurement of intracellular protein tyrosine phosphatase 1B using photoaffinity probes

Kathryn Skorey, Deena Waddleton, Michel Therien, Tammy Leriche

Journal:

Analytical Biochemistry

Year:

2006

Language:

english

File:

PDF, 504 KB

english, 2006

28

The influence of a carboxylate group on the rate of O-acylation of 2-hydroxymethylimidazoles by a strained amide

Skorey, K. I., Somayaji, V., Brown, R. S.

Journal:

Journal of the American Chemical Society

Year:

1988

Language:

english

File:

PDF, 279 KB

english, 1988

29

How Does Alendronate Inhibit Protein-tyrosine Phosphatases?

Skorey, K., Ly, H. D., Kelly, J., Hammond, M., Ramachandran, C., Huang, Z., Gresser, M. J., Wang, Q.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 806 KB

english, 1997

30

ChemInform Abstract: Molecular Structure of 2,3,4,5-Tetrahydro-2-oxo-1,5-ethanobenzazepine (I) and Its Reaction with β-Amino Alcohols as a Model for the Acylation Step of the Serine Proteases.

SOMAYAJI, V., SKOREY, K. I., BROWN, R. S., BALL, R. G.

Journal:

Year:

1987

File:

PDF, 85 KB

1987

31

14. BURNOUT IN PEDIATRIC RESIDENTS: WHEN IS BURNOUT MOST LIKELY TO OCCUR DURING AN INPATIENT SERVICE MONTH AND WHAT ARE ITS ASSOCIATED FACTORS

Skorey, Maria J., Rinehart, Valerie H., Hsu, Hao, McCauley, Kortany, High, Robin, Greenwood, Katie

Journal:

Academic Pediatrics

Year:

2019

Language:

english

File:

PDF, 33 KB

english, 2019

32

ChemInform Abstract: Biomimetic Models for Cysteine Proteases. Part 3. Acylation of Imidazolium-Thiolate Zwitterions by p-Nitrophenylacetate as a Model for the Acylation Step and Demonstration of Intramolecular General-Base-Catalyzed Delivery of H2O by Im

STREET, J. P., SKOREY, K. I., BROWN, R. S., BALL, R. G.

Journal:

Chemischer Informationsdienst

Year:

1986

File:

PDF, 202 KB

1986

33

Residues Distant from the Active Site Influence Protein-tyrosine Phosphatase 1B Inhibitor Binding

Montalibet, J., Skorey, K., McKay, D., Scapin, G., Asante-Appiah, E., Kennedy, B. P.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.05 MB

english, 2006

34

Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor

Yongxin Han, Michel Belley, Christopher I. Bayly, John Colucci, Claude Dufresne, Andre Giroux, Cheuk K. Lau, Yves Leblanc, Daniel McKay, Michel Therien, Marie-Claire Wilson, Kathryn Skorey, Chi-Chung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 299 KB

english, 2008

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