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1

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Gaoquan Li, Lisa A. Hasvold, Zhi-Fu Tao, Gary T. Wang, Stephen L. Gwaltney II, Jyoti Patel, Peter Kovar, Robert B. Credo, Zehan Chen, Haiying Zhang, Chang Park, Hing L. Sham, Thomas Sowin, Saul H. Ros

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 203 KB

english, 2006

2

Synthesis of 2-Substituted (±)-(2 R, 3 R, 5 R )-Tetrahydrofuran-3,5-dicarboxylic Acid Derivatives †

Wang, Gary T., Wang, Sheldon, Chen, Yuanwei, Gentles, Robert, Sowin, Thomas

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 63 KB

english, 2001

3

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

Yunsong Tong, Kent D. Stewart, Sheela Thomas, Magdalena Przytulinska, Eric F. Johnson, Vered Klinghofer, Joel Leverson, Owen McCall, Niru B. Soni, Yan Luo, Nan-horng Lin, Thomas J. Sowin, Vincent L. G

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 490 KB

english, 2008

4

Structure-Based Design, Synthesis, and Biological Evaluation of Potent and Selective Macrocyclic Checkpoint Kinase 1 Inhibitors

Tao, Zhi-Fu, Wang, Le, Stewart, Kent D., Chen, Zehan, Gu, Wendy, Bui, Mai-Ha, Merta, Philip, Zhang, Haiying, Kovar, Peter, Johnson, Eric, Park, Chang, Judge, Russell, Rosenberg, Saul, Sowin, Thomas, L

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 463 KB

english, 2007

5

Aeromedical Decision Making and Seizure Risk After Traumatic Brain Injury: Longitudinal Outcome

McGuire, Stephen A., Marsh, Royden W., Sowin, Timothy W., Robinson, Andrew Y.

Journal:

Aviation Space and Environmental Medicine

Year:

2012

Language:

english

File:

PDF, 607 KB

english, 2012

6

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Lisa A. Hasvold, Le Wang, Magdalena Przytulinska, Zhan Xiao, Zehan Chen, Wen-Zhen Gu, Philip J. Merta, John Xue, Peter Kovar, Haiying Zhang, Chang Park, Thomas J. Sowin, Saul H. Rosenberg, Nan-Horng L

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 150 KB

english, 2008

7

Macrocyclic ureas as potent and selective Chk1 inhibitors: An improved synthesis, kinome profiling, structure–activity relationships, and preliminary pharmacokinetics

Zhi-Fu Tao, Zehan Chen, Mai-Ha Bui, Peter Kovar, Eric Johnson, Jennifer Bouska, Haiying Zhang, Saul Rosenberg, Thomas Sowin, Nan-Horng Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 304 KB

english, 2007

8

Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors

Gaoquan Li, Zhi-Fu Tao, Yunsong Tong, Magdalena K. Przytulinska, Peter Kovar, Philip Merta, Zehan Chen, Haiying Zhang, Thomas Sowin, Saul H. Rosenberg, Nan-Horng Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 181 KB

english, 2007

9

Synthesis of α-amino and α-alkoxy aldehydes via oxoammonium oxidation

M. Robert Leanna, Thomas J. Sowin, Howard E. Morton

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 280 KB

english, 1992

10

Solid-Phase Synthesis of Benzoxazoles from 3-Nitrotyrosine

Beebe, Xenia, Wodka, Dariusz, Sowin, Thomas J.

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 80 KB

english, 2001

11

ChemInform Abstract: A Facile Synthesis of Chiral Bicyclic Lactams Utilized in the Formation of Chiral Quaternary Carbon Compounds.

MEYERS, A. I., LEFKER, B. A., SOWIN, T. J., WESTRUM, L. J.

Journal:

Year:

1990

File:

PDF, 97 KB

1990

12

Enantioselective synthesis of the 1.beta.-methylcarbapenems via cycloaddition of 3-siloxypentadiene and 4-acetoxyazetidinone

Sowin, Thomas J., Meyers, A. I.

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 439 KB

english, 1988

13

Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Sandra Leitza, Edward B. Reilly, Thomas W. von Geldern

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 317 KB

english, 2005

14

Synthesis of Macrocyclic Urea Kinase Inhibitors

Tao, Zhi-Fu, Sowin, Thomas, Lin, Nan-Horng

Journal:

Year:

2007

Language:

english

File:

PDF, 97 KB

english, 2007

15

Computer application to vibronic spectra including dd transitions

J. Myrczek, A. Bartecki, M. Sowin̂ska

Journal:

Journal of Molecular Structure

Year:

1984

Language:

english

File:

PDF, 204 KB

english, 1984

16

Purification of HTOS Libraries by Supercritical Fluid Chromatography

Hochlowski, Jill, Olson, Jeff, Pan, Jeff, Sauer, Daryl, Searle, Philip, Sowin, Thomas

Journal:

Journal of Liquid Chromatography & Related Technologies

Year:

2003

Language:

english

File:

PDF, 731 KB

english, 2003

17

Encyclopedia of Reagents for Organic Synthesis || Crotonaldehyde

Sowin, Thomas J.

Year:

2001

Language:

english

File:

PDF, 114 KB

english, 2001

18

NEO PI-R normative personality data that distinguish U.S. Air Force female pilots.

Chappelle, Wayne L., Novy, Major Pamela L., Sowin, Colonel Timothy W., Thompson, William T.

Journal:

Military Psychology

Year:

2010

Language:

english

File:

PDF, 100 KB

english, 2010

19

Synthesis of Substituted Quinolines Using the Dianion Addition of N-Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones.

Rolf E. Swenson, Thomas J. Sowin, Henry Q. Zhang

Journal:

Year:

2003

File:

PDF, 218 KB

2003

20

Discovery of 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors

Zhi-Fu Tao, Gaoquan Li, Yunsong Tong, Kent D. Stewart, Zehan Chen, Mai-Ha Bui, Philip Merta, Chang Park, Peter Kovar, Haiying Zhang, Hing L. Sham, Saul H. Rosenberg, Thomas J. Sowin, Nan-Horng Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 330 KB

english, 2007

21

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyano- pyrazi-2-yl)ureas as Potent and Selective Inhibitors of Chk1 Kinase: Synthesis, Preliminary SAR, and Biological Activities

Wang, Gary T., Li, Gaoquan, Mantei, Robert A., Chen, Zehan, Kovar, Peter, Gu, Wendy, Xiao, Zhan, Zhang, Haiying, Sham, Hing L., Sowin, Thomas, Rosenberg, Saul H., Lin, Nan-Horng

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 269 KB

english, 2005

22

A facile synthesis of chiral bicyclic lactams utilized in the formation of chiral quaternary carbon compounds

Meyers, A. I., Lefker, Bruce A., Sowin, Thomas J., Westrum, Larry J.

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 572 KB

english, 1989

23

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics

Zehan Chen, Zhan Xiao, Wen-zhen Gu, John Xue, Mai H. Bui, Peter Kovar, Gaoquan Li, Gary Wang, Zhi-Fu Tao, Yunsong Tong, Nan-Horng Lin, Hing L. Sham, Jean Y. J. Wang, Thomas J. Sowin, Saul H. Rosenberg

Journal:

International Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 1.69 MB

english, 2006

24

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase

Gary T. Wang, Xilu Wang, Weibo Wang, Lisa A. Hasvold, Gerry Sullivan, Charles W. Hutchins, Steve O’Conner, Robert Gentiles, Thomas Sowin, Jerry Cohen, Wen-Zhen Gu, Haiying Zhang, Saul H. Rosenberg, Hi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 327 KB

english, 2005

25

Design, preparation and performance of a phthalide-based chiral stationary phase

William H. Pirkle, Thomas J. Sowin

Journal:

Journal of Chromatography A

Year:

1987

Language:

english

File:

PDF, 663 KB

english, 1987

26

Preparative separation of enantiomers by flash chromatography

William H. Pirkle, Athanasios Tsipouras, Thomas J. Sowin

Journal:

Journal of Chromatography A

Year:

1985

Language:

english

File:

PDF, 204 KB

english, 1985

27

Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors

Xiao, Zhan, Xue, John, Gu, Wen-Zhen, Bui, Mai, Li, Gaoquan, Tao, Zhi-Fu, Lin, Nan-Horng, Sowin, Thomas J., Zhang, Haiying

Journal:

Year:

2008

Language:

english

File:

PDF, 882 KB

english, 2008

28

Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

Irini Akritopoulou-Zanze, Daniel H. Albert, Peter F. Bousquet, George A. Cunha, Christopher M. Harris, Maria Moskey, Jurgen Dinges, Kent D. Stewart, Thomas J. Sowin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 281 KB

english, 2007

29

Synthesis of Substituted Quinolines Using the Dianion Addition of N -Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones

Swenson, Rolf E., Sowin, Thomas J., Zhang, Henry Q.

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 77 KB

english, 2002

30

Discovery of 3 H -Benzo[4,5]thieno[3,2- d ]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Tao, Zhi-Fu, Hasvold, Lisa A., Leverson, Joel D., Han, Edward K., Guan, Ran, Johnson, Eric F., Stoll, Vincent S., Stewart, Kent D., Stamper, Geoff, Soni, Nirupama, Bouska, Jennifer J., Luo, Yan, Sowin

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.89 MB

english, 2009

31

Amino-Substituted Heterocycles as Isosteres of trans-Cinnamides: Design and Synthesis of Heterocyclic Biaryl Sulfides as Potent Antagonists of LFA-1/ICAM-1 Binding.

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Sandra Leitza, Edward B. Reilly, Thomas W. von Geldern

Journal:

Year:

2005

File:

PDF, 17 KB

2005

32

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core

Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Clarence J. Maring, Dale J. Kempf, Warren M. Kati, Vincent Stoll, Kent D. Stewart, Graeme Laver

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 308 KB

english, 2005

33

A facile synthesis of antitumoral indeno[1,2-c]pyrazole-4-one by mild oxidation with molecular oxygen

Zhi-Fu Tao, Thomas J. Sowin, Nan-Horng Lin

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 105 KB

english, 2005

34

Correlation of the circular dichroic spectra of 3-arylphthalides with absolute configuration and conformation

Pirkle, William H., Sowin, Thomas J., Salvadori, Piero, Rosini, Carlo

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 536 KB

english, 1988

35

Aerobic Acyloxylation of Allylic C–H Bonds Initiated by a Pd0 Precatalyst with 4,5‐Diazafluoren‐9‐one as an Ancillary Ligand

Kozack, Caitlin V., Sowin, Jennifer A., Jaworski, Jonathan N., Iosub, Andrei V., Stahl, Shannon S

Journal:

Year:

2019

Language:

english

File:

PDF, 1.27 MB

english, 2019

36

Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics

Zhan Xiao, John Xue, Dimitri Semizarov, Thomas J. Sowin, Saul H. Rosenberg, Haiying Zhang

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 985 KB

english, 2005

37

Solid-Phase Organic Synthesis. Volume 1 Edited by Anthony W. Czarnik. John Wiley & Sons, New York. 2001. viii + 164 pp. 16 × 23.5 cm. ISBN 0-471-31484-6. $69.95.

Sowin, Thomas J.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 14 KB

english, 2001

38

A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

Xiao, Zhan, Xue, John, Sowin, Thomas J, Rosenberg, Saul H, Zhang, Haiying

Journal:

Year:

2004

Language:

english

File:

PDF, 359 KB

english, 2004

39

Microcircuit Hardening Study

Sowin, D. C., Kells, K. E., Wicklein, H. W., Hunter, L. T.

Journal:

IEEE Transactions on Nuclear Science

Year:

1966

Language:

english

File:

PDF, 1.13 MB

english, 1966

40

Major Depressive Disorder in Military Aviators: A Retrospective Study of Prevalence

Lollis, Blake D., Marsh, Royden W., Sowin, Timothy W., Thompson, William T.

Journal:

Aviation Space and Environmental Medicine

Year:

2009

Language:

english

File:

PDF, 472 KB

english, 2009

41

Application of Base Cleavable Safety Catch Linkers to Solid Phase Library Production

Wade, Warren S., Yang, Fan, Sowin, Thomas J.

Journal:

Journal of Combinatorial Chemistry

Year:

2000

Language:

english

File:

PDF, 121 KB

english, 2000

42

Use of 99Tcm-MIBI scintigraphy in the evaluation of perfusion improvement after myocardial revascularization with the use of the left internal thoracic artery

JEMIELITY, M., KWINECKI, P., BASZKO, A., CZEPCZYN´SKI, R., RUCHAŁA, M., PONIŻYN´SKI, A., CIES´LIN´SKI, A., SOWIN´SKI, J., GEMBICKI, M.

Journal:

Nuclear Medicine Communications

Year:

2001

Language:

english

File:

PDF, 107 KB

english, 2001

43

Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores

Wang, Gary T., Chen, Yuanwei, Wang, Sheldon, Gentles, Robert, Sowin, Thomas, Kati, Warren, Muchmore, Steve, Giranda, Vincent, Stewart, Kent, Sham, Hing, Kempf, Dale, Laver, W. Graeme

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 457 KB

english, 2001

44

ChemInform Abstract: Synthesis and Separation of Diastereomeric Imino Alcohol Derivatives of Chiral Phthalides: A Method for Assignment of Phthalide Absolute Configurations.

PIRKLE, W. H., SOWIN, T. J.

Journal:

Year:

1987

File:

PDF, 198 KB

1987

45

Encoding of Combinatorial Chemistry Libraries by Fluorine-19 NMR

Hochlowski, Jill E., Whittern, David N., Sowin, Thomas J.

Journal:

Journal of Combinatorial Chemistry

Year:

1999

Language:

english

File:

PDF, 57 KB

english, 1999

46

Reagents for High-Throughput Solid-Phase and Solution-Phase Organic Synthesis Edited by Peter Wipf. John Wiley & Sons, Chichester, West Sussex, England. 2005. xi + 380 pp. 22 × 29 cm. ISBN 0-470-86298-X. $140.00.

Sowin, Thomas J.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 26 KB

english, 2005

47

Direct liquid chromatographic separation of phthalide enantiomers

William H. Pirkle, Thomas J. Sowin

Journal:

Journal of Chromatography A

Year:

1987

Language:

english

File:

PDF, 686 KB

english, 1987

48

Kinase Drug Discovery by Affinity Selection/Mass Spectrometry (ASMS): Application to DNA Damage Checkpoint Kinase Chk1

Comess, K. M., Trumbull, J. D., Park, C., Chen, Z., Judge, R. A., Voorbach, M. J., Coen, M., Gao, L., Tang, H., Kovar, P., Cheng, X., Schurdak, M. E., Zhang, H., Sowin, T., Burns, D. J.

Journal:

Journal of Biomolecular Screening

Year:

2006

Language:

english

File:

PDF, 266 KB

english, 2006

49

Encyclopedia of Reagents for Organic Synthesis || Acetaldehyde

Sowin, Thomas J.

Year:

2001

Language:

english

File:

PDF, 65 KB

english, 2001

50

ChemInform Abstract: A Novel and Expeditious Route to A-81988: An Angiotensin II Receptor Antagonist.

F. A. J. KERDESKY, T. J. SOWIN

Journal:

Year:

1996

File:

PDF, 28 KB

1996

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