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1

Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial

Burmester, Gerd R, Blanco, Ricardo, Charles-Schoeman, Christina, Wollenhaupt, Jürgen, Zerbini, Cristiano, Benda, Birgitta, Gruben, David, Wallenstein, Gene, Krishnaswami, Sriram, Zwillich, Samuel H, K

Journal:

Year:

2013

Language:

english

File:

PDF, 344 KB

english, 2013

2

Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis

Kremer, Joel, Li, Zhan-Guo, Hall, Stephen, Fleischmann, Roy, Genovese, Mark, Martin-Mola, Emilio, Isaacs, John D., Gruben, David, Wallenstein, Gene, Krishnaswami, Sriram, Zwillich, Samuel H., Koncz, T

Journal:

Annals of Internal Medicine

Year:

2013

Language:

english

File:

PDF, 191 KB

english, 2013

3

Selective Inhibition of the Prothrombinase Complex: Factor Va Alters Macromolecular Recognition of a Tick Anticoagulant Peptide Mutant by Factor Xa †,‡

Betz, Andreas, Vlasuk, George P., Bergum, Peter W., Krishnaswamy, Sriram

Journal:

Year:

1997

Language:

english

File:

PDF, 209 KB

english, 1997

4

Single- and multiple-dose pharmacokinetics of tofacitinib in healthy Chinese volunteers

Krishnaswami, Sriram, Wang, Tao, Yuan, Yi, Alvey, Christine W., Checchio, Tina, Peterson, Mark, Shi, Haihong, Riese, Richard

Journal:

Clinical Pharmacology in Drug Development

Year:

2015

Language:

english

File:

PDF, 200 KB

english, 2015

5

A rapid pro-hemostatic approach to overcome direct oral anticoagulants

Thalji, Nabil K, Ivanciu, Lacramioara, Davidson, Robert, Gimotty, Phyllis A, Krishnaswamy, Sriram, Camire, Rodney M

Journal:

Nature Medicine

Year:

2016

Language:

english

File:

PDF, 1.54 MB

english, 2016

6

[IEEE 2018 International Wafer Level Packaging Conference (IWLPC) - San Jose, CA (2018.10.23-2018.10.25)] 2018 International Wafer Level Packaging Conference (IWLPC) - Degas Module Thermal Architecture, Variable Wafer Delays, and Throughput, Productivity, and Consistency in Fan-Out Packaging Barrier/Seed Layer PVD

Werbaneth, Paul, Runstadler, Billy, North, Sam, Kudriavtsev, Vladimir, Krishnaswami, Sriram, Danh, Luy, Bluck, Terry, Blonigan, Camron

Year:

2018

Language:

english

File:

PDF, 34 KB

english, 2018

7

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo

Joel M. Kremer, Bradley J. Bloom, Ferdinand C. Breedveld, John H. Coombs, Mark P. Fletcher, David Gruben, Sriram Krishnaswami, Rubén Burgos-Vargas, Bethanie Wilkinson, Cristiano A. F. Zerbini, Samuel

Journal:

Arthritis & Rheumatism

Year:

2009

Language:

english

File:

PDF, 279 KB

english, 2009

8

Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs

Roy Fleischmann, Maurizio Cutolo, Mark C. Genovese, Eun Bong Lee, Keith S. Kanik, Seth Sadis, Carol A. Connell, David Gruben, Sriram Krishnaswami, Gene Wallenstein, Bethanie E. Wilkinson, Samuel H. Zw

Journal:

Arthritis & Rheumatism

Year:

2012

Language:

english

File:

PDF, 424 KB

english, 2012

9

The utility of mixed-effects covariate analysis in rapid selection of doses in pediatric subjects: A case study with fexofenadine hydrochloride

Rajesh Krishna, Sriram Krishnaswami, Barbara Kittner, Abdul J. Sankoh, Bradford K. Jensen

Journal:

Biopharmaceutics & Drug Disposition

Year:

2004

Language:

english

File:

PDF, 352 KB

english, 2004

10

A sensitive LC–MS/MS method for the quantification of fluticasone propionate in human plasma

Sriram Krishnaswami, Helmut Möllmann, Hartmut Derendorf, Günther Hochhaus

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2000

Language:

english

File:

PDF, 130 KB

english, 2000

11

Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans

Bernhard X. Mayer, Christa Mensik, Sriram Krishnaswami, Hartmut Derendorf, Hans-Georg Eichler, Leopold Schmetterer, Michael Wolzt

Journal:

British Journal of Clinical Pharmacology

Year:

1999

Language:

english

File:

PDF, 125 KB

english, 1999

12

Estimating transformations for repeated measures modeling of continuous bounded outcome data

Matthew M. Hutmacher, Jonathan L. French, Sriram Krishnaswami, Sujatha Menon

Journal:

Statistics in Medicine

Year:

2011

Language:

english

File:

PDF, 475 KB

english, 2011

13

Three-dimensional solution structure ofTropidechis carinatusvenom extract trocarin: a structural homologue of Xa and prothrombin activator

Divi Venkateswarlu, Sriram Krishnaswamy, Thomas A. Darden, Lee G. Pedersen

Journal:

Journal of Molecular Modeling

Year:

2002

Language:

english

File:

PDF, 598 KB

english, 2002

14

Exposure-response modeling using latent variables for the efficacy of a JAK3 inhibitor administered to rheumatoid arthritis patients

Matthew M. Hutmacher, Sriram Krishnaswami, Kenneth G. Kowalski

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2008

Language:

english

File:

PDF, 491 KB

english, 2008

15

Theory versus practice

SRIRAM, RADHA, KUMAR, KRISHNASWAMY S.

Journal:

Year:

1989

File:

PDF, 142 KB

1989

16

An interactive algorithm for the assessment of cumulative cortisol suppression during inhaled corticosteroid therapy

Sriram Krishnaswami, Guenther Hochhaus, Hartmut Derendorf

Journal:

The AAPS Journal

Year:

2000

Language:

english

File:

PDF, 421 KB

english, 2000

17

A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone

Joel M. Kremer, Stanley Cohen, Bethanie E. Wilkinson, Carol A. Connell, Jonathan L. French, Juan Gomez-Reino, David Gruben, Keith S. Kanik, Sriram Krishnaswami, Virginia Pascual-Ramos, Gene Wallenstei

Journal:

Arthritis & Rheumatism

Year:

2012

Language:

english

File:

PDF, 338 KB

english, 2012

18

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo

Joel M. Kremer, Bradley J. Bloom, Ferdinand C. Breedveld, John H. Coombs, Mark P. Fletcher, David Gruben, Sriram Krishnaswami, Rubén Burgos-Vargas, Bethanie Wilkinson, Cristiano A. F. Zerbini, Samuel

Journal:

Arthritis & Rheumatism

Year:

2012

Language:

english

File:

PDF, 33 KB

english, 2012

19

Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes

Richard J. Riese, Sriram Krishnaswami, Joel Kremer

Journal:

Best Practice & Research Clinical Rheumatology

Year:

2010

Language:

english

File:

PDF, 308 KB

english, 2010

20

Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data

Pankaj Gupta, Christine Alvey, Rong Wang, Martin E. Dowty, Odette A. Fahmi, Robert L. Walsky, Richard J. Riese, Sriram Krishnaswami

Journal:

British Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 927 KB

english, 2012

21

Characterization of ligand-induced states of maize homoserine dehydrogenase

Sriram Krishnaswamy, John K. Bryan

Journal:

Archives of Biochemistry and Biophysics

Year:

1983

Language:

english

File:

PDF, 1.30 MB

english, 1983

22

Ligand-induced interconversions of maize homoserine dehydrogenase among different states

Sriram Krishnaswamy, John K. Bryan

Journal:

Archives of Biochemistry and Biophysics

Year:

1983

Language:

english

File:

PDF, 1.25 MB

english, 1983

23

Use of monoclonal antibodies for the purification and characterization of the threonine-sensitive isozyme of maize homoserine dehydrogenase

Sriram Krishnaswamy, John K. Bryan

Journal:

Archives of Biochemistry and Biophysics

Year:

1986

Language:

english

File:

PDF, 1.53 MB

english, 1986

24

Analgesic efficacy of celecoxib in postoperative oral surgery pain: A single-dose, two-center, randomized, double-blind, active- and placebo-controlled study

Raymond Cheung, Sriram Krishnaswami, Ken Kowalski

Journal:

Clinical Therapeutics

Year:

2007

Language:

english

File:

PDF, 930 KB

english, 2007

25

Na+ Site in Blood Coagulation Factor IXa: Effect on Catalysis and Factor VIIIa Binding

Amy E. Schmidt, Jonathan E. Stewart, Akash Mathur, Sriram Krishnaswamy, S. Paul Bajaj

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 671 KB

english, 2005

26

Imaging coagulation reactions in vivo

Lacramioara Ivanciu, Sriram Krishnaswamy, Rodney M. Camire

Journal:

Thrombosis Research

Year:

2012

Language:

english

File:

PDF, 362 KB

english, 2012

27

Enhanced transgene expression in rat brain cell cultures with a disulfide-containing cationic lipid

Preeti S Ajmani, Fuxing Tang, Sriram Krishnaswami, Edwin M Meyer, Colin Sumners, Jeffrey A Hughes

Journal:

Neuroscience Letters

Year:

1999

Language:

english

File:

PDF, 147 KB

english, 1999

28

Surface-Dependent Reactions in the Propagation Phase of Blood Coagulation

KENNETH G. MANN, EDWIN G. BOVILL, SRIRAM KRISHNASWAMY

Journal:

Annals of the New York Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 731 KB

english, 1991

29

[Methods in Enzymology] Proteolytic Enzymes in Coagulation, Fibrinolysis, and Complement Activation Part A: Mammalian Blood Coagulation Factors and Inhibitors Volume 222 || [15] Assembly of prothrombinase complex

Krishnaswamy, Sriram

Year:

1993

Language:

english

File:

PDF, 1.10 MB

english, 1993

30

Evaluation of the potential interaction between tofacitinib and drugs that undergo renal tubular secretion using metformin, an in vivo marker of renal organic cation transporter 2

Klamerus, Karen J., Alvey, Christine, Li, Lei, Feng, Bo, Wang, Rong, Kaplan, Irina, Shi, Haihong, Dowty, Martin E., Krishnaswami, Sriram

Journal:

Clinical Pharmacology in Drug Development

Year:

2014

Language:

english

File:

PDF, 359 KB

english, 2014

31

Yield of continuous fiber composites under axisymmetric loading

Zhang, Hongyan, Krishnaswami, Sriram, Anderson, Peter M., Daehn, Glenn S.

Journal:

Scripta Metallurgica et Materialia

Year:

1993

Language:

english

File:

PDF, 448 KB

english, 1993

32

Su2090 A Population Pharmacokinetic Model From a Phase 2 Study of Tofacitinib (CP-690,550), an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

Gao, Xiang, Krishnaswami, Sriram, Mukherjee, Arnab

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 150 KB

english, 2012

33

Structural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium

Vadivel, Kanagasabai, Agah, Sayeh, Messer, Amanda S., Cascio, Duilio, Bajaj, Madhu S., Krishnaswamy, Sriram, Esmon, Charles T., Padmanabhan, Kaillathe, Bajaj, S. Paul

Journal:

Journal of Molecular Biology

Year:

2013

Language:

english

File:

PDF, 3.30 MB

english, 2013

34

Contribution of the Prothrombin Fragment 2 Domain to the Function of Factor Va in the Prothrombinase Complex †

Krishnaswamy, Sriram, Walker, Randall K.

Journal:

Year:

1997

Language:

english

File:

PDF, 272 KB

english, 1997

35

Assembly of the Prothrombinase Complex Enhances the Inhibition of Bovine Factor Xa by Tick Anticoagulant Peptide

Krishnaswamy, Sriram, Vlasuk, George P., Bergum, Peter W.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.47 MB

english, 1994

36

Exosites Determine Macromolecular Substrate Recognition by Prothrombinase †

Krishnaswamy, Sriram, Betz, Andreas

Journal:

Year:

1997

Language:

english

File:

PDF, 159 KB

english, 1997

37

A Supratherapeutic Dose of the Janus Kinase Inhibitor Tasocitinib (CP-690,550) Does Not Prolong QTc Interval in Healthy Participants

Krishnaswami, Sriram, Kudlacz, Elizabeth, Wang, Rong, Chan, Gary

Journal:

Journal of Clinical Pharmacology

Year:

2011

Language:

english

File:

PDF, 323 KB

english, 2011

38

A Semi-Mechanistic Model of CP-690,550-Induced Reduction in Neutrophil Counts in Patients With Rheumatoid Arthritis

Gupta, Pankaj, Friberg, Lena E., Karlsson, Mats O., Krishnaswami, Sriram, French, Jonathan

Journal:

Journal of Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 395 KB

english, 2010

39

Single-Dose and Steady-State Pharmacokinetic and Pharmacodynamic Evaluation of Therapeutically Clinically Equivalent Doses of Inhaled Fluticasone Propionate and Budesonide, Given as Diskus® or Turbohaler® Dry-Powder Inhalers to Healthy Subjects

Möllmann, Helmut, Wagner, Melanie, Krishnaswami, Sriram, Dimova, Hristina, Tang, Yufei, Falcoz, Christine, Daley-Yates, Peter T., Krieg, Michael, Stöckmann, Ricarda, Barth, Jürgen, Lawlor, Ms. Carolin

Journal:

Journal of Clinical Pharmacology

Year:

2001

Language:

english

File:

PDF, 140 KB

english, 2001

40

Dosing Celecoxib in Pediatric Patients With Juvenile Rheumatoid Arthritis

Krishnaswami, Sriram, Hutmacher, Matt M., Robbins, Jeffery L., Bello, Akintunde, West, Christine, Bloom, Bradley J.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.35 MB

english, 2012

41

Pharmacokinetics of tofacitinib, a janus kinase inhibitor, in patients with impaired renal function and end-stage renal disease

Krishnaswami, Sriram, Chow, Vincent, Boy, Mary, Wang, Cunshan, Chan, Gary

Journal:

Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 250 KB

english, 2014

42

Effect of CP-690,550, an Orally Active Janus Kinase Inhibitor, on Renal Function in Healthy Adult Volunteers

Lawendy, Nervin, Krishnaswami, Sriram, Wang, Rong, Gruben, David, Cannon, Courtney, Swan, Suzanne, Chan, Gary

Journal:

Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 205 KB

english, 2009

43

Evaluation of the effect of fluconazole and ketoconazole on the pharmacokinetics of tofacitinib in healthy adult subjects

Gupta, Pankaj, Chow, Vincent, Wang, Ronnie, Kaplan, Irina, Chan, Gary, Alvey, Christine, Ni, Grace, Ndongo, Marie-Noella, LaBadie, Robert R., Krishnaswami, Sriram

Journal:

Clinical Pharmacology in Drug Development

Year:

2014

Language:

english

File:

PDF, 275 KB

english, 2014

44

Herpes Zoster and Tofacitinib Therapy in Patients With Rheumatoid Arthritis

Winthrop, Kevin L., Yamanaka, Hisashi, Valdez, Hernan, Mortensen, Eric, Chew, Robert, Krishnaswami, Sriram, Kawabata, Thomas, Riese, Richard

Journal:

Arthritis & Rheumatology

Year:

2014

Language:

english

File:

PDF, 171 KB

english, 2014

45

Regulated Cleavage of Prothrombin by Prothrombinase

Bradford, Harlan N., Micucci, Joseph A., Krishnaswamy, Sriram

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 1.63 MB

english, 2010

46

Analysis of Infections and All-Cause Mortality in Phase II, Phase III, and Long-Term Extension Studies of Tofacitinib in Patients With Rheumatoid Arthritis

Cohen, Stanley, Radominski, Sebastião C., Gomez-Reino, Juan J., Wang, Lisy, Krishnaswami, Sriram, Wood, Susan P., Soma, Koshika, Nduaka, Chudi I., Kwok, Kenneth, Valdez, Hernan, Benda, Birgitta, Riese

Journal:

Arthritis & Rheumatology

Year:

2014

Language:

english

File:

PDF, 212 KB

english, 2014

47

Safety, tolerability, and pharmacokinetics of single oral doses of tofacitinib, a Janus kinase inhibitor, in healthy volunteers

Krishnaswami, Sriram, Boy, Mary, Chow, Vincent, Chan, Gary

Journal:

Clinical Pharmacology in Drug Development

Year:

2015

Language:

english

File:

PDF, 274 KB

english, 2015

48

A Prospective Study Comparing Celecoxib with Naproxen in Children with Juvenile Rheumatoid Arthritis

Foeldvari, Ivan, Szer, Ilona S., Zemel, Lawrence S., Lovell, Daniel J., Giannini, Edward H., Robbins, Jeffery L., West, Christine R., Steidle, Gina, Krishnaswami, Sriram, Bloom, Bradley J.

Journal:

The Journal of Rheumatology

Year:

2008

Language:

english

File:

PDF, 278 KB

english, 2008

49

Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials

Strand, Vibeke, Ahadieh, Sima, French, Jonathan, Geier, Jamie, Krishnaswami, Sriram, Menon, Sujatha, Checchio, Tina, Tensfeldt, Thomas G., Hoffman, Elaine, Riese, Richard, Boy, Mary, Gómez-Reino, Juan

Journal:

Arthritis Research & Therapy

Year:

2015

Language:

english

File:

PDF, 916 KB

english, 2015

50

The effect of mild and moderate hepatic impairment on the pharmacokinetics of tofacitinib, an orally active Janus kinase inhibitor

Lawendy, Nervin, Lamba, Manisha, Chan, Gary, Wang, Rong, Alvey, Christine W., Krishnaswami, Sriram

Journal:

Clinical Pharmacology in Drug Development

Year:

2014

Language:

english

File:

PDF, 261 KB

english, 2014