Wijtmans,: search on Z-Library

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1

4,6-Diphenyl Pyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration With the Aid of Molecular Modeling

Trist, Iuni Margaret Laura, Nannetti, Giulio, Tintori, Cristina, Fallacara, Anna Lucia, Deodato, Davide, Mercorelli, Beatrice, Palù, Giorgio, Wijtmans, Maikel, Gospodova, Tzveta, Edink, Ewald, Verheij

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.76 MB

english, 2016

2

6-Amino-3-Pyridinols: Towards Diffusion-Controlled Chain-Breaking Antioxidants

Maikel Wijtmans, Derek A. Pratt, Luca Valgimigli, Gino A. DiLabio, Gian Franco Pedulli, Ned A. Porter

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 120 KB

english, 2003

3

Biological Relevance and Synthesis of C-Substituted Morpholine Derivatives

Wijtmans, Roel, Vink, Mandy K., Schoemaker, Hans E., van Delft, Floris L., Blaauw, Richard H., Rutjes, Floris P.

Journal:

Year:

2004

Language:

english

File:

PDF, 1.55 MB

english, 2004

4

6-Amino-3-Pyridinols: Towards Diffusion-Controlled Chain-Breaking Antioxidants

Maikel Wijtmans, Derek A. Pratt, Luca Valgimigli, Gino A. DiLabio, Gian Franco Pedulli, Ned A. Porter

Journal:

Angewandte Chemie International Edition

Year:

2003

File:

PDF, 29 KB

2003

5

Biological Relevance and Synthesis of C-Substituted Morpholine Derivatives

Roel Wijtmans, Mandy K. S. Vink, Hans E. Schoemaker, Floris L. van Delft, Richard H. Blaauw, Floris P. J. T. Rutjes

Journal:

Year:

2004

File:

PDF, 53 KB

2004

6

Targeted LC–MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA

Mark Eggink, Maikel Wijtmans, Ansgar Kretschmer, Jeroen Kool, Henk Lingeman, Iwan J. P. de Esch, Wilfried M. A. Niessen, Hubertus Irth

Journal:

Analytical and Bioanalytical Chemistry

Year:

2010

Language:

english

File:

PDF, 497 KB

english, 2010

7

Therapeutic targeting of chemokine receptors by small molecules

Maikel Wijtmans, Danny J. Scholten, Iwan J.P. de Esch, Martine J. Smit, Rob Leurs

Journal:

Drug Discovery Today: Technologies

Year:

2012

Language:

english

File:

PDF, 399 KB

english, 2012

8

Identification of Overlapping but Differential Binding Sites for the High-Affinity CXCR3 Antagonists NBI-74330 and VUF11211

Scholten, D. J., Roumen, L., Wijtmans, M., Verkade-Vreeker, M. C. A., Custers, H., Lai, M., de Hooge, D., Canals, M., de Esch, I. J. P., Smit, M. J., de Graaf, C., Leurs, R.

Journal:

Molecular Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.58 MB

english, 2013

9

Disentangling defects and sound modes in disordered solids

Wijtmans, Sven, Manning, M. Lisa

Journal:

Year:

2017

Language:

english

File:

PDF, 3.28 MB

english, 2017

10

Chemical Insights in the Concept of Hybrid Drugs: The Antitumor Effect of Nitric Oxide-Donating Aspirin Involves A Quinone Methide but Not Nitric Oxide nor Aspirin

Hulsman, Niels, Medema, Jan Paul, Bos, Carina, Jongejan, Aldo, Leurs, Rob, Smit, Martine J., de Esch, Iwan J. P., Richel, Dick, Wijtmans, Maikel

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 396 KB

english, 2007

11

Identification of Ligand Binding Hot Spots of the Histamine H 1 Receptor Following Structure-Based Fragment Optimization

Kuhne, Sebastiaan, Kooistra, Albert J., Bosma, Reggie, Bortolato, Andrea, Wijtmans, Maikel, Vischer, Henry F., Mason, Jonathan S., de Graaf, Chris, De Esch, Iwan J. P., Leurs, Rob

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 3.52 MB

english, 2016

12

Bromo-Cyclobutenaminones as New Covalent UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors

Hamilton, David J., ÃbrÃ¡nyi-Balogh, PÃ©ter, Keeley, Aaron, Petri, LÃ¡szlÃ³, Hrast, Martina, Imre, TÃmea, Wijtmans, Maikel, Gobec, Stanislav, Esch, Iwan J. P. de, KeserÅ±, GyÃ¶rgy MiklÃ³s

Journal:

Pharmaceuticals

Year:

2020

File:

PDF, 1.08 MB

2020

13

Lipid-Soluble 3-Pyridinol Antioxidants Spare α-Tocopherol and Do Not Efficiently Mediate Peroxidation of Cholesterol Esters in Human Low-Density Lipoprotein

Kim, Hye-Young, Pratt, Derek A., Seal, Jennifer R., Wijtmans, Maikel, Porter, Ned A.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 78 KB

english, 2005

14

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

Maikel Wijtmans, David Maussang, Francesco Sirci, Danny J. Scholten, Meritxell Canals, Azra Mujić-Delić, Milagros Chong, Kristell L.S. Chatalic, Hans Custers, Elwin Janssen, Chris de Graaf, Martine J.

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 668 KB

english, 2012

15

N,N-Acetals as N-Acyliminium Ion Precursors: Synthesis and Absolute Stereochemistry of Epiquinamide

Wijdeven, Marloes A., Wijtmans, Roel, van den Berg, Rutger J. F., Noorduin, Wim, Schoemaker, Hans E., Sonke, Theo, van Delft, Floris L., Blaauw, Richard H., Fitch, Richard W., Spande, Thomas F.

Journal:

Organic Letters

Year:

2008

Language:

english

File:

PDF, 123 KB

english, 2008

16

Visible Light Excitation of CdSe Nanocrystals Triggers the Release of Coumarin from Cinnamate Surface Ligands

Wijtmans, Maikel, Rosenthal, Sandra J., Zwanenburg, Binne, Porter, Ned A.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 211 KB

english, 2006

17

Self-cleavage of the Pseudomonas aeruginosa Cell-surface Signaling Anti-sigma Factor FoxR Occurs through an N-O Acyl Rearrangement

Bastiaansen, Karlijn C., van Ulsen, Peter, Wijtmans, Maikel, Bitter, Wilbert, Llamas, María A.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 1.48 MB

english, 2015

18

A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light

Gómez-Santacana, Xavier, de Munnik, Sabrina M, Mocking, Tamara A M, Hauwert, Niels J, Sun, Shanliang, Vijayachandran, Prashanna, de Esch, Iwan J P, Vischer, Henry F, Wijtmans, Maikel, Leurs, Rob

Journal:

Beilstein Journal of Organic Chemistry

Year:

2019

Language:

english

File:

PDF, 3.86 MB

english, 2019

19

Erratum to “En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family” [Trends Pharmacol. Sci. 32 (4) (2011) 250–257]

Rob Leurs, Henry F. Vischer, Maikel Wijtmans, Iwan J.P. de Esch

Journal:

Trends in Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 55 KB

english, 2012

20

4-Benzyl-1 H -imidazoles with Oxazoline Termini as Histamine H 3 Receptor Agonists

Wijtmans, Maikel, Celanire, Sylvain, Snip, Erwin, Gillard, Michel R., Gelens, Edith, Collart, Philippe P., Venhuis, Bastiaan J., Christophe, Bernard, Hulscher, Saskia, Goot, Henk van der, Lebon, Flore

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 720 KB

english, 2008

21

Histamine H3 receptor ligands with a 3-cyclobutoxy motif: a novel and versatile constraint of the classical 3-propoxy linker

Wijtmans, Maikel, Denonne, Frédéric, Célanire, Sylvain, Gillard, Michel, Hulscher, Saskia, Delaunoy, Christel, Van houtvin, Nathalie, Bakker, Remko A., Defays, Sabine, Gérard, Julien, Grooters, Luc, H

Journal:

Year:

2010

Language:

english

File:

PDF, 193 KB

english, 2010

22

A Photoswitchable Agonist for the Histamine H3 Receptor, a prototypic family A G protein-coupled receptor

Hauwert, Niels J., Mocking, Tamara A.M., Da Costa Pereira, Daniel, Lion, Ken, Huppelschoten, Yara, Vischer, Henry F., De Esch, Iwan J.P., Wijtmans, Maikel, Leurs, Rob

Journal:

Angewandte Chemie

Year:

2019

Language:

english

File:

PDF, 1.61 MB

english, 2019

23

Enzymatic synthesis of optically pure cyanohydrins in microchannels using a crude cell lysate

Kaspar Koch, Rutger J.F. van den Berg, Pieter J. Nieuwland, Roel Wijtmans, Marcel G. Wubbolts, Hans E. Schoemaker, Floris P.J.T. Rutjes, Jan C.M. van Hest

Journal:

Chemical Engineering Journal

Year:

2008

Language:

english

File:

PDF, 164 KB

english, 2008

24

Pharmacological modulation of chemokine receptor function

DJ Scholten, M Canals, D Maussang, L Roumen, MJ Smit, M Wijtmans, C de Graaf, HF Vischer, R Leurs

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 3.61 MB

english, 2012

25

Keynote review: Histamine H3 receptor antagonists reach out for the clinic

Sylvain Celanire, Maikel Wijtmans, Patrice Talaga, Rob Leurs, Iwan J.P. de Esch

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 353 KB

english, 2005

26

Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy

Maikel Wijtmans, Dennis Verzijl, Cindy M.E. van Dam, Leontien Bosch, Martine J. Smit, Rob Leurs, Iwan J.P. de Esch

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 2.66 MB

english, 2009

27

Development of an on-line weak-cation exchange liquid chromatography–tandem mass spectrometric method for screening aldehyde products in biological matrices

Mark Eggink, Ségolène Charret, Maikel Wijtmans, Henk Lingeman, Jeroen Kool, Wilfried M.A. Niessen, Hubertus Irth

Journal:

Journal of Chromatography B

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

28

Triazole Ligands Reveal Distinct Molecular Features That Induce Histamine H4 Receptor Affinity and Subtly Govern H4/H3 Subtype Selectivity

Istyastono, Enade P., Smit, Judith, Lim, Herman, Boonnak, Ratchanok, Nijmeijer, Saskia, Smits, Rogier A., Jongejan, Aldo, Wijtmans, Maikel, de Graaf, Chris, de Kloe, Gerdien

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.54 MB

english, 2011

29

Online Fluorescence Enhancement Assay for the Acetylcholine Binding Protein with Parallel Mass Spectrometric Identification

Kool, Jeroen, de Kloe, Gerdien E., Bruyneel, Ben, de Vlieger, Jon S., Retra, Kim, Wijtmans, Maikel, van Elk, Rene, Smit, August B., Leurs, Rob, Lingeman, Henk, de Esch, Iwan J.P., Irth, Hubertus

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.29 MB

english, 2010

30

Development of a Selective ESI-MS Derivatization Reagent: Synthesis and Optimization for the Analysis of Aldehydes in Biological Mixtures

Eggink, Mark, Wijtmans, Maikel, Ekkebus, Reggy, Lingeman, Henk, Esch, Iwan J. P. de, Kool, Jeroen, Niessen, Wilfried M. A., Irth, Hubertus

Journal:

Analytical Chemistry

Year:

2008

Language:

english

File:

PDF, 1.74 MB

english, 2008

31

4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as high-affinity non-imidazole histamine H3 receptor agonists with in vivo central nervous system activity

Wágner, Gábor, Mocking, Tamara, Arimont, Marta, Provensi, Gustavo, Rani, Barbara, Silva-Marques, Bruna, Latacz, Gniewomir, Da Costa Pereira, Daniel, Karatzidou, Christina, Vischer, Henry F., Wijtmans,

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 2.66 MB

english, 2019

32

Enzyme-Promoted Desymmetrisation of Prochiral Bis(cyanomethyl) Sulfoxide

Piotr Kiełbasiński, Michał Rachwalski, Marian Mikołajczyk, Małgorzata Szyrej, Michał W. Wieczorek, Roel Wijtmans, Floris P. J. T. Rutjes

Journal:

Advanced Synthesis & Catalysis

Year:

2007

Language:

english

File:

PDF, 88 KB

english, 2007

33

Synthesis of N–H vinylaziridines: a comparative study

Berit Olofsson, Roel Wijtmans, Peter Somfai

Journal:

Year:

2002

Language:

english

File:

PDF, 99 KB

english, 2002

34

Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase

Oscar P.J. van Linden, Carine Farenc, Willem H. Zoutman, Liesbeth Hameetman, Maikel Wijtmans, Rob Leurs, Cornelis P. Tensen, Gregg Siegal, Iwan J.P. de Esch

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.48 MB

english, 2012

35

Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3

DJ Scholten, M Canals, M Wijtmans, S de Munnik, P Nguyen, D Verzijl, IJP de Esch, HF Vischer, MJ Smit, R Leurs

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.90 MB

english, 2012

36

Activating Students’ Interest and Participation in Lectures and Practical Courses Using Their Electronic Devices

Wijtmans, Maikel, van Rens, Lisette, van Muijlwijk-Koezen, Jacqueline E.

Journal:

Journal of Chemical Education

Year:

2014

Language:

english

File:

PDF, 1.39 MB

english, 2014

37

Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment

Mladic, Marija, Scholten, Danny J., Wijtmans, Maikel, Falck, David, Leurs, Rob, Niessen, Wilfried M. A., Smit, Martine J., Kool, Jeroen

Journal:

Analytical and Bioanalytical Chemistry

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

38

Photoswitching the efficacy of a small-molecule ligand for a peptidergic GPCR: from antagonism to agonism

Leurs, Rob, Gómez-Santacana, Xavier, de Munnik, Sabrina M., Vijayachandran, Prashanna, Da Costa Pereira, Daniel, Bebelman, Jan Paul M., de Esch, Iwan J. P., Vischer, Henry F., Wijtmans, Maikel

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 1.62 MB

english, 2018

39

Discovery of a New Class of Non-imidazole Oxazoline-Based Histamine H3 Receptor (H3R) Inverse Agonists

Sylvain Célanire, Maikel Wijtmans, Bernard Christophe, Philippe Collart, Iwan de Esch, Donald Dassesse, Christel Delaunoy, Frédéric Denonne, Véronique Durieu, Edith Gelens, Michel Gillard, Bénédicte L

Journal:

Year:

2009

Language:

english

File:

PDF, 428 KB

english, 2009

40

Synthesis and Reactivity of Some 6-Substituted-2,4-dimethyl-3-pyridinols, a Novel Class of Chain-Breaking Antioxidants

Wijtmans, Maikel, Pratt, Derek A., Brinkhorst, Johan, Serwa, Remigiusz, Valgimigli, Luca, Pedulli, Gian Franco, Porter, Ned A.

Journal:

Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 171 KB

english, 2004

41

A Photoswitchable Agonist for the Histamine H3 Receptor, a prototypic family A G protein-coupled receptor

Hauwert, Niels J., Mocking, Tamara A.M., Da Costa Pereira, Daniel, Lion, Ken, Huppelschoten, Yara, Vischer, Henry F., De Esch, Iwan J.P., Wijtmans, Maikel, Leurs, Rob

Journal:

Angewandte Chemie International Edition

Year:

2019

Language:

english

File:

PDF, 1.61 MB

english, 2019

42

Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI–MS(/MS) applied for the analysis of prostanoids and NSAID in urine

A. Kretschmer, M. Giera, M. Wijtmans, L. de Vries, H. Lingeman, H. Irth, W.M.A. Niessen

Journal:

Journal of Chromatography B

Year:

2011

Language:

english

File:

PDF, 512 KB

english, 2011

43

En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family

Rob Leurs, Henry F. Vischer, Maikel Wijtmans, Iwan J.P. de Esch

Journal:

Trends in Pharmacological Sciences

Year:

2011

Language:

english

File:

PDF, 325 KB

english, 2011

44

Total Synthesis of (+)-Epiquinamide

Wijdeven, Marloes A., Botman, Peter N. M., Wijtmans, Roel, Schoemaker, Hans E., Rutjes, Floris P. J. T., Blaauw, Richard H.

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 76 KB

english, 2005

45

6-Amino-3-Pyridinols: Towards Diffusion-Controlled Chain-Breaking Antioxidants

Maikel Wijtmans, Derek A. Pratt, Luca Valgimigli, Gino A. DiLabio, Gian Franco Pedulli, Ned A. Porter

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

46

Towards Small-Molecule CXCR3 Ligands with Clinical Potential

Maikel Wijtmans, Dennis Verzijl, Rob Leurs, Iwan J. P. de Esch, Martine J. Smit

Journal:

Year:

2008

Language:

english

File:

PDF, 539 KB

english, 2008

47

Chemical Subtleties in Small-Molecule Modulation of Peptide Receptor Function: The Case of CXCR3 Biaryl-Type Ligands

Wijtmans, Maikel, Scholten, Danny J., Roumen, Luc, Canals, Meritxell, Custers, Hans, Glas, Marjolein, Vreeker, Marlies C. A., de Kanter, Frans J. J., de Graaf, Chris, Smit, Martine J., de Esch, Iwan J

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.37 MB

english, 2012

48

Regiochemistry of the Condensation of 2-Aroyl-cyclohexanones and 2-Cyanoacetamide: 13 C-Labeling Studies and Semiempirical MO Calculations

van Linden, Oscar P. J., Wijtmans, Maikel, Roumen, Luc, Rotteveel, Lonneke, Leurs, Rob, de Esch, Iwan. J. P.

Journal:

Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 1.78 MB

english, 2012

49

Nitrile hydrolysis activity of Rhodococcus erythropolis NCIMB 11540 whole cells

Mandy K. S Vink, Roel Wijtmans, Christoph Reisinger, Rutger J. F. van den Berg, Christien A. Schortinghuis, Helmut Schwab, Hans E. Schoemaker, Floris P. J. T. Rutjes

Journal:

Biotechnology Journal

Year:

2006

Language:

english

File:

PDF, 430 KB

english, 2006

50

Structure-based exploration and pharmacological evaluation of N-Substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists

Adlere, I., Sun, S., Zarca, A., Roumen, L., Gozelle, M., Viciano, C. Perpiñá, Caspar, B., Arimont, M., Bebelman, J.P., Briddon, S.J., Hoffmann, C., Hill, S.J., Smit, M.J., Vischer, H.F., Wijtmans, M.,

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 5.57 MB

english, 2018

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