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1

User information-seeking behavior in a medical Web portal environment: A preliminary study

Dongming Zhang, Caroline Zambrowicz, Hong Zhou, Nancy K. Roderer

Journal:

Journal of the American Society for Information Science and Technology

Year:

2004

Language:

english

File:

PDF, 1.53 MB

english, 2004

2

Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor

Lapuerta, P., Zambrowicz, B., Strumph, P., Sands, A.

Journal:

Diabetes and Vascular Disease Research

Year:

2015

Language:

english

File:

PDF, 872 KB

english, 2015

3

Production and Identification of Biologically Active Peptides Derived from By-product of Hen Egg-Yolk Phospholipid Extraction

Eckert, Ewelina, Zambrowicz, Aleksandra, Bobak, Łukasz, Zabłocka, Agnieszka, Chrzanowska, Józefa, Trziszka, Tadeusz

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2018

Language:

english

File:

PDF, 2.52 MB

english, 2018

4

Trypsin inhibitor, antioxidant and antimicrobial activities as well as chemical composition of potato sprouts originating from yellow- and colored-fleshed varieties

Miedzianka, Joanna, Pęksa, Anna, Nemś, Agnieszka, Drzymała, Katarzyna, Zambrowicz, Aleksandra, Kowalczewski, Przemysław

Journal:

Journal of Environmental Science and Health Part B

Year:

2019

Language:

english

File:

PDF, 1.70 MB

english, 2019

5

Effects of yolkin on the immune response of mice and its plausible mechanism of action

Obmińska-Mrukowicz, Bożena, Szczypka, Marianna, Lis, Magdalena, Pawlak, Aleksandra, Suszko-Pawłowska, Agnieszka, Sysak, Angelika, Zambrowicz, Aleksandra, Burster, Timo, Kocięba, Maja, Artym, Jolanta,

Journal:

Immunology Letters

Year:

2020

Language:

english

File:

PDF, 2.59 MB

english, 2020

6

In vivo drug target discovery: identifying the best targets from the genome

D.Wade Walke, Chunsheng Han, Joseph Shaw, Elisabeth Wann, Brian Zambrowicz, Arthur Sands

Journal:

Current Opinion in Biotechnology

Year:

2001

Language:

english

File:

PDF, 81 KB

english, 2001

7

10.1038/33423

Zambrowicz, Brian P., Friedrich, Glenn A., Buxton, Eric C., Lilleberg, Stan L., Person, Christophe, Sands, Arthur T.

Journal:

Year:

1998

Language:

english

File:

PDF, 298 KB

english, 1998

8

Knockouts model the 100 best-selling drugs—will they model the next 100?

Zambrowicz, Brian P., Sands, Arthur T.

Journal:

Nature Reviews Drug Discovery

Year:

2003

Language:

english

File:

PDF, 456 KB

english, 2003

9

Postsynaptic diacylglycerol lipase α mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex

Hiroki Yoshino, Takeaki Miyamae, Gwenn Hansen, Brian Zambrowicz, Michael Flynn, Donna Pedicord, Yuval Blat, Ryan S. Westphal, Robert Zaczek, David A. Lewis, Guillermo Gonzalez-Burgos

Journal:

The Journal of Physiology

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

10

Full-speed mammalian genetics: in vivo target validation in the drug discovery process

Alejandro Abuin, Kathleen H Holt, Kenneth A Platt, Arthur T Sands, Brian P Zambrowicz

Journal:

Trends in Biotechnology

Year:

2002

Language:

english

File:

PDF, 132 KB

english, 2002

11

Characterization of the Murine Zfy1 and Zfy2 Promoters

Brian P. Zambrowicz, Seth D. Finalley, Elizabeth M. Simpson, David C. Page, Richard D. Palmiter

Journal:

Year:

1994

File:

PDF, 155 KB

1994

12

Significance and redox state of SH groups in pyruvate carrier isolated from bovine heart mitochondria

Katarzyna Anna Nałȩcz, Michele Müller, Ewa Brygida Zambrowicz, Lech Wojtczak, Angelo Azzi

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

1990

Language:

english

File:

PDF, 784 KB

english, 1990

13

Lack of interaction of serotonin levels and bone mass in LRP5 and TPH1 knockout mice and following pharmacological reduction of intestinal serotonin content

R. Brommage, Q. Yang, J. Liu, F. Mseeh, W. Yu, S. Jeter-Jones, Z.-C. Shi, B. Zambrowicz, Q. Liu, D.R. Powell

Journal:

Year:

2011

Language:

english

File:

PDF, 62 KB

english, 2011

14

Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry

Brian P Zambrowicz, C Alexander Turner, Arthur T Sands

Journal:

Current Opinion in Pharmacology

Year:

2003

Language:

english

File:

PDF, 139 KB

english, 2003

15

Modeling drug action in the mouse with knockouts and RNA interference

Brian P. Zambrowicz, Arthur T. Sands

Journal:

Drug Discovery Today: TARGETS

Year:

2004

Language:

english

File:

PDF, 742 KB

english, 2004

16

Zero-current potentials in a large membrane channel: a simple theory accounts for complex behavior

Zambrowicz, E.B., Colombini, M.

Journal:

Biophysical Journal

Year:

1993

Language:

english

File:

PDF, 791 KB

english, 1993

17

907 LX1031, a Novel Locally-Acting Inhibitor of Serotonin (5-HT) Synthesis Significantly Improves Symptoms in Patients With IBS

Philip Brown, Dennis S. Riff, Jessica Jackson, Kenneth Frazier, Elaine Clark, Qi M. Yang, Wade Walke, Joel Freiman, Alan J. Main, Brian Zambrowicz, Arthur Sands

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 47 KB

english, 2010

18

S1053 Serotonin Biomarker Levels Correlate With Clinical Response in Phase 2 Trial of LX1031, a Novel Serotonin Synthesis Inhibitor for Non-Constipating IBS

Brian Zambrowicz, Philip Brown, Jessica Jackson, Kenneth Frazier, Elaine Clark, Qi M. Yang, Wade Walke, Joel Freiman, David Powell, Alan J. Main, Arthur Sands

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 99 KB

english, 2010

19

The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome

Philip M. Brown, Douglas A. Drossman, Alastair J.J. Wood, Gary A. Cline, Kenny S. Frazier, Jessica I. Jackson, Johanna Bronner, Joel Freiman, Brian Zambrowicz, Arthur Sands, Michael D. Gershon

Journal:

Gastroenterology

Year:

2011

Language:

english

File:

PDF, 1.55 MB

english, 2011

20

Effects of LX4211, a Dual SGLT1/SGLT2 Inhibitor, Plus Sitagliptin on Postprandial Active GLP-1 and Glycemic Control in Type 2 Diabetes

Zambrowicz, Brian, Ding, Zhi-Ming, Ogbaa, Ike, Frazier, Kenny, Banks, Phillip, Turnage, Anne, Freiman, Joel, Smith, Melinda, Ruff, Dennis, Sands, Arthur, Powell, David

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.38 MB

english, 2013

21

Manufacturing of peptides exhibiting biological activity

Zambrowicz, Aleksandra, Timmer, Monika, Polanowski, Antoni, Lubec, Gert, Trziszka, Tadeusz

Journal:

Year:

2013

Language:

english

File:

PDF, 196 KB

english, 2013

22

Induction of a New Metallothionein Isoform (MT-IV) Occurs during Differentiation of Stratified Squamous Epithelia

Quaife, Carol J., Findley, Seth D., Erickson, Jay C., Froelick, Glenda J., Kelly, Edward J., Zambrowicz, Brian P., Palmiter, Richard D.

Journal:

Year:

1994

Language:

english

File:

PDF, 5.23 MB

english, 1994

23

Effects of LX4211, a Dual Sodium-Dependent Glucose Cotransporters 1 and 2 Inhibitor, on Postprandial Glucose, Insulin, Glucagon-like Peptide 1, and Peptide Tyrosine Tyrosine in a Dose-Timing Study in Healthy Subjects

Zambrowicz, Brian, Ogbaa, Ike, Frazier, Kenny, Banks, Phillip, Turnage, Anne, Freiman, Joel, Boehm, Kristi A., Ruff, Dennis, Powell, David, Sands, Arthur

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 427 KB

english, 2013

24

LX4211 Increases Serum Glucagon-Like Peptide 1 and Peptide YY Levels by Reducing Sodium/Glucose Cotransporter 1 (SGLT1)-Mediated Absorption of Intestinal Glucose

Powell, D. R., Smith, M., Greer, J., Harris, A., Zhao, S., DaCosta, C., Mseeh, F., Shadoan, M. K., Sands, A., Zambrowicz, B., Ding, Z.-M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2013

Language:

english

File:

PDF, 546 KB

english, 2013

25

An attractive way of egg white protein by-product use for producing of novel anti-hypertensive peptides

Pokora, M., Zambrowicz, A., Dąbrowska, A., Eckert, E., Setner, B., Szołtysik, M., Szewczuk, Z., Zabłocka, A., Polanowski, A., Trziszka, T., Chrzanowska, J.

Journal:

Year:

2014

Language:

english

File:

PDF, 472 KB

english, 2014

26

Tu1468 Lx1033, a Serotonin Synthesis Inhibitor (SSI), Decreases Levels of Urinary 5-HIAA: Results of a Phase 1 Study

Law, Linda, Ogbaa, Ike, Banks, Phillip, Jackson, Jessica, Frazier, Kenneth, Wilson, Alan G., Zambrowicz, Brian

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 84 KB

english, 2012

27

Tu1334 Fasting Plasma 5-Hydroxyindolacetic Acid (5-HIAA) Correlates With 24-Hour Urinary 5-HIAA; Evaluation of a Simpler Assessment of 5-HIAA

Wilson, Alan G., Ogbaa, Ike, Banks, Phillip, Jackson, Jessica, Frazier, Kenneth, Law, Linda, Zambrowicz, Brian

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 76 KB

english, 2012

28

Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry

Journal:

Current Opinion in Pharmacology

Year:

2003

Language:

english

File:

PDF, 139 KB

english, 2003

29

Mo2021 Lx1606 (Aka LX1032), a Peripheral Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model

Oravecz, Tamas, Jhaver, Kanchan, Yang, Qi M., Wilson, Alan G., Main, Alan J., Zambrowicz, Brian

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 178 KB

english, 2012

30

Tu1333 Lx1033, a Second Generation Locally-Acting Serotonin Synthesis Inhibitor Demonstrates Increased Potency and Favorable Safety Profile in Preclinical Studies

Yang, Qi M., Yu, Wangsheng, Swaffield, Jonathan, Powell, David, Wilson, Alan G., Brommage, Robert, Yalamanchili, Padmaja, Heydorn, William, Main, Alan J., Zambrowicz, Brian

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 76 KB

english, 2012

31

Sa2017 Blocking Peripheral Serotonin Synthesis by Telotristat Etiprate Reduces the Severity of Both Chemical- and Infection-Induced Intestinal Inflammation

Kim, Janice J., Wang, Huaqing, Terc, Joshua D., Sunjic, Ivana, Zambrowicz, Brian, Yang, Qi M., Khan, Waliul I.

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 60 KB

english, 2013

32

Crystallization and preliminary X-ray analysis of Escherichia coli adenylate kinase

Althoff, Steven, Zambrowicz, Brian, Liang, Peng, Glaser, Michael, Phillips, George N.

Journal:

Journal of Molecular Biology

Year:

1988

Language:

english

File:

PDF, 239 KB

english, 1988

33

Disruption of Overlapping Transcripts in the ROSA β geo 26 Gene Trap Strain Leads to Widespread Expression of β -Galactosidase in Mouse Embryos and Hematopoietic Cells

Brian P. Zambrowicz, Akira Imamoto, Steve Fiering, Leonard A. Herzenberg, William G. Kerr and Philippe Soriano

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.81 MB

english, 1997

34

Molecular Embryology: Methods and Protocolsby Paul T. Sharpe; Ivor Mason

Review by: Brian Zambrowicz

Journal:

Quarterly Review of Biology

Year:

2000

Language:

english

File:

PDF, 83 KB

english, 2000

35

The Evaluation of Dipeptidyl Peptidase (DPP)-IV, α-Glucosidase and Angiotensin Converting Enzyme (ACE) Inhibitory Activities of Whey Proteins Hydrolyzed with Serine Protease Isolated from Asian Pumpkin (Cucurbita ficifolia)

Konrad, Babij, Anna, Dąbrowska, Marek, Szołtysik, Marta, Pokora, Aleksandra, Zambrowicz, Józefa, Chrzanowska

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2014

Language:

english

File:

PDF, 653 KB

english, 2014

36

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 44 Volume 44 || Chapter 23 A Path to Innovation: Gene Knockouts Model New Drug Action

Zambrowicz, Brian P.

Year:

2009

Language:

english

File:

PDF, 185 KB

english, 2009

37

Greater Dose-Ranging Effects on A1C Levels Than on Glucosuria With LX4211, a Dual Inhibitor of SGLT1 and SGLT2, in Patients With Type 2 Diabetes on Metformin Monotherapy

Rosenstock, Julio, Cefalu, William T., Lapuerta, Pablo, Zambrowicz, Brian, Ogbaa, Ike, Banks, Phillip, Sands, Arthur

Journal:

Year:

2015

Language:

english

File:

PDF, 1.14 MB

english, 2015

38

Egg-yolk protein by-product as a source of ACE-inhibitory peptides obtained with using unconventional proteinase from Asian pumpkin (Cucurbita ficifolia)

Eckert, Ewelina, Zambrowicz, Aleksandra, Pokora, Marta, Setner, Bartosz, Dąbrowska, Anna, Szołtysik, Marek, Szewczuk, Zbigniew, Polanowski, Antoni, Trziszka, Tadeusz, Chrzanowska, Józefa

Journal:

Journal of Proteomics

Year:

2014

Language:

english

File:

PDF, 815 KB

english, 2014

39

Effect of LX4211 on Glucose Homeostasis and Body Composition in Preclinical Models

Powell, D. R., DaCosta, C. M., Smith, M., Doree, D., Harris, A., Buhring, L., Heydorn, W., Nouraldeen, A., Xiong, W., Yalamanchili, P., Mseeh, F., Wilson, A., Shadoan, M., Zambrowicz, B., Ding, Z.-M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2014

Language:

english

File:

PDF, 312 KB

english, 2014

40

Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide

Kulke, M. H., O'Dorisio, T., Phan, A., Bergsland, E., Law, L., Banks, P., Freiman, J., Frazier, K., Jackson, J., Yao, J. C., Kvols, L., Lapuerta, P., Zambrowicz, B., Fleming, D., Sands, A.

Journal:

Endocrine Related Cancer

Year:

2014

Language:

english

File:

PDF, 170 KB

english, 2014

41

Biological and functional properties of proteolytic enzyme-modified egg protein by-products

Pokora, Marta, Eckert, Ewelina, Zambrowicz, Aleksandra, Bobak, Łukasz, Szołtysik, Marek, Dąbrowska, Anna, Chrzanowska, Józefa, Polanowski, Antoni, Trziszka, Tadeusz

Journal:

Food Science & Nutrition

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

42

Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)

Lee, E-C., Desai, U., Gololobov, G., Hong, S., Feng, X., Yu, X.-C., Gay, J., Wilganowski, N., Gao, C., Du, L.-L., Chen, J., Hu, Y., Zhao, S., Kirkpatrick, L., Schneider, M., Zambrowicz, B. P., Landes,

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 1016 KB

english, 2009

43

GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4

Sonnenburg, W. K., Yu, D., Lee, E-C., Xiong, W., Gololobov, G., Key, B., Gay, J., Wilganowski, N., Hu, Y., Zhao, S., Schneider, M., Ding, Z.-M., Zambrowicz, B. P., Landes, G., Powell, D. R., Desai, U.

Journal:

The Journal of Lipid Research

Year:

2009

Language:

english

File:

PDF, 640 KB

english, 2009

44

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

Margolis, K. G., Stevanovic, K., Li, Z., Yang, Q. M., Oravecz, T., Zambrowicz, B., Jhaver, K. G., Diacou, A., Gershon, M. D.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.36 MB

english, 2014

45

Study Design and Rationale of a Dose-Ranging Trial of LX4211, a Dual Inhibitor of SGLT1 and SGLT2, in Type 2 Diabetes Inadequately Controlled on Metformin Monotherapy

Lapuerta, Pablo, Rosenstock, Julio, Zambrowicz, Brian, Powell, David R., Ogbaa, Ike, Freiman, Joel, Cefalu, William T., Banks, Phillip, Frazier, Kenny, Kelly, Mike, Sands, Arthur

Journal:

Clinical Cardiology

Year:

2013

Language:

english

File:

PDF, 128 KB

english, 2013

46

LX4211 Therapy Reduces Postprandial Glucose Levels in Patients With Type 2 Diabetes Mellitus and Renal Impairment Despite Low Urinary Glucose Excretion

Zambrowicz, Brian, Lapuerta, Pablo, Strumph, Paul, Banks, Phillip, Wilson, Alan, Ogbaa, Ike, Sands, Arthur, Powell, David

Journal:

Clinical Therapeutics

Year:

2015

Language:

english

File:

PDF, 366 KB

english, 2015

47

Antioxidant and antidiabetic activities of peptides isolated from a hydrolysate of an egg-yolk protein by-product prepared with a proteinase from Asian pumpkin (Cucurbita ficifolia)

Zambrowicz, Aleksandra, Eckert, Ewelina, Pokora, Marta, Bobak, Łukasz, Dąbrowska, Anna, Szołtysik, Marek, Trziszka, Tadeusz, Chrzanowska, Józefa

Journal:

Year:

2015

Language:

english

File:

PDF, 374 KB

english, 2015

48

Disruption of Ini1 Leads to Peri-Implantation Lethality and Tumorigenesis in Mice

Guidi, C. J., Sands, A. T., Zambrowicz, B. P., Turner, T. K., Demers, D. A., Webster, W., Smith, T. W., Imbalzano, A. N., Jones, S. N.

Journal:

Molecular and Cellular Biology

Year:

2001

Language:

english

File:

PDF, 1.05 MB

english, 2001

49

Situs Inversus in Dpcd/Poll-/-, Nme7-/- , and Pkd1l1-/- Mice

Vogel, P., Read, R., Hansen, G. M., Freay, L. C., Zambrowicz, B. P., Sands, A. T.

Journal:

Veterinary Pathology

Year:

2010

Language:

english

File:

PDF, 631 KB

english, 2010

50

Congenital Hydrocephalus in Genetically Engineered Mice

Vogel, P., Read, R. W., Hansen, G. M., Payne, B. J., Small, D., Sands, A. T., Zambrowicz, B. P.

Journal:

Veterinary Pathology

Year:

2012

Language:

english

File:

PDF, 797 KB

english, 2012