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1

Aptamer-Derived Peptides as Potent Inhibitors of the Oncogenic RhoGEF Tgat

Nathalie Bouquier, Sylvie Fromont, Jean-Christophe Zeeh, Camille Auziol, Pauline Larrousse, Bruno Robert, Mahel Zeghouf, Jacqueline Cherfils, Anne Debant, Susanne Schmidt

Journal:

Chemistry & Biology

Year:

2009

Language:

english

File:

PDF, 823 KB

english, 2009

2

LG186: An Inhibitor of GBF1 Function that Causes Golgi Disassembly in Human and Canine Cells

Frédéric Boal, Lucie Guetzoyan, Richard B. Sessions, Mahel Zeghouf, Robert A. Spooner, J. Michael Lord, Jacqueline Cherfils, Guy J. Clarkson, Lynne M. Roberts, David J. Stephens

Journal:

Year:

2010

Language:

english

File:

PDF, 1.89 MB

english, 2010

3

Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function

Alan Cochrane, Laura Lea Murley, Mian Gao, Raymond Wong, Kiera Clayton, Nicole Brufatto, Veronica Canadien, Daniel Mamelak, Tricia Chen, Dawn Richards, Mahel Zeghouf, Jack Greenblatt, Christian Burks,

Journal:

Year:

2009

Language:

english

File:

PDF, 877 KB

english, 2009

4

31P Nuclear magnetic resonance study of the flavoprotein component of the Escherichia coli sulfite reductase

Adeline Evrard, Mahel Zeghouf, Marc Fontecave, Claude Roby, Jacques Covès

Journal:

Year:

1999

Language:

english

File:

PDF, 596 KB

english, 1999

5

The Flavoprotein Component of theEscherichia coliSulfite Reductase Can Act as a Cytochrome P450c17 Reductase

Mahel Zeghouf, Geneviève Defaye, Marc Fontecave, Jacques Coves

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 156 KB

english, 1998

6

Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module

Arnaud Gruez, David Pignol, Mahel Zeghouf, Jacques Covès, Marc Fontecave, Jean-Luc Ferrer, Juan Carlos Fontecilla-Camps

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 1.01 MB

english, 2000

7

An Arf1 GTPase mutant with different responses to GEF inhibitors

Sebastian Flisiak, Jean-Christophe Zeeh, Bernard Guibert, Jacqueline Cherfils, Mahel Zeghouf

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 1.45 MB

english, 2008

8

SAXS and X-ray Crystallography Suggest an Unfolding Model for the GDP/GTP Conformational Switch of the Small GTPase Arf6

Valérie Biou, Kaheina Aizel, Pierre Roblin, Aurélien Thureau, Eric Jacquet, Sebastian Hansson, Bernard Guibert, Eric Guittet, Carine van Heijenoort, Mahel Zeghouf, Javier Perez, Jacqueline Cherfils

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.28 MB

english, 2010

9

Regulation of Small GTPases by GEFs, GAPs, and GDIs

Cherfils, J., Zeghouf, M.

Journal:

Physiological Reviews

Year:

2013

Language:

english

File:

PDF, 14.84 MB

english, 2013

10

Chronicles of the GTPase switch

Cherfils, Jacqueline, Zeghouf, Mahel

Journal:

Nature Chemical Biology

Year:

2011

Language:

english

File:

PDF, 536 KB

english, 2011

11

Sequential Peptide Affinity (SPA) System for the Identification of Mammalian and Bacterial Protein Complexes

Zeghouf, Mahel, Li, Joyce, Butland, Gareth, Borkowska, Anna, Canadien, Veronica, Richards, Dawn, Beattie, Bryan, Emili, Andrew, Greenblatt, Jack F.

Journal:

Journal of Proteome Research

Year:

2004

Language:

english

File:

PDF, 202 KB

english, 2004

12

The Flavoprotein Component of the Escherichia coli Sulfite Reductase: Expression, Purification, and Spectral and Catalytic Properties of a Monomeric Form Containing both the Flavin Adenine Dinucleotide and the Flavin Mononucleotide Cofactors

Zeghouf, Mahel, Fontecave, Marc, Macherel, David, Covès, Jacques

Journal:

Year:

1998

Language:

english

File:

PDF, 155 KB

english, 1998

13

EFA6 controls Arf1 and Arf6 activation through a negative feedback loop

Padovani, D., Folly-Klan, M., Labarde, A., Boulakirba, S., Campanacci, V., Franco, M., Zeghouf, M., Cherfils, J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 951 KB

english, 2014

14

Flavin Mononucleotide-Binding Domain of the Flavoprotein Component of the Sulfite Reductase from Escherichia coli

Covès, Jacques, Zeghouf, Mahel, Macherel, David, Guigliarelli, Bruno, Asso, Marcel, Fontecave, Marc

Journal:

Year:

1997

Language:

english

File:

PDF, 153 KB

english, 1997

15

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation

Vives, Virginie, Cres, Gaëlle, Richard, Christian, Busson, Muriel, Ferrandez, Yann, Planson, Anne-Gaelle, Zeghouf, Mahel, Cherfils, Jacqueline, Malaval, Luc, Blangy, Anne

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 1.89 MB

english, 2015

16

High yield production of myristoylated Arf6 small GTPase by recombinant N-myristoyl transferase

Padovani, Dominique, Zeghouf, Mahel, Traverso, José A., Giglione, Carmela, Cherfils, Jacqueline

Journal:

Year:

2013

Language:

english

File:

PDF, 985 KB

english, 2013

17

Fam65b Is a New Transcriptional Target of FOXO1 That Regulates RhoA Signaling for T Lymphocyte Migration

Rougerie, P., Largeteau, Q., Megrelis, L., Carrette, F., Lejeune, T., Toffali, L., Rossi, B., Zeghouf, M., Cherfils, J., Constantin, G., Laudanna, C., Bismuth, G., Mangeney, M., Delon, J.

Journal:

The Journal of Immunology

Year:

2013

Language:

english

File:

PDF, 1.64 MB

english, 2013

18

RPAP1, a Novel Human RNA Polymerase II-Associated Protein Affinity Purified with Recombinant Wild-Type and Mutated Polymerase Subunits

Jeronimo, C., Langelier, M.-F., Zeghouf, M., Cojocaru, M., Bergeron, D., Baali, D., Forget, D., Mnaimneh, S., Davierwala, A. P., Pootoolal, J., Chandy, M., Canadien, V., Beattie, B. K., Richards, D. P

Journal:

Molecular and Cellular Biology

Year:

2004

Language:

english

File:

PDF, 706 KB

english, 2004

19

A Simplifed Functional Version of the Escherichia coli Sulfite Reductase

Journal:

Journal of Biological Chemistry

Year:

2000

Language:

english

File:

PDF, 603 KB

english, 2000

20

Dual Specificity of the Interfacial Inhibitor Brefeldin A for Arf Proteins and Sec7 Domains

Zeeh, J.-C., Zeghouf, M., Grauffel, C., Guibert, B., Martin, E., Dejaegere, A., Cherfils, J.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 968 KB

english, 2006

21

Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors

Zeghouf, M., Guibert, B., Zeeh, J.-C., Cherfils, J.

Journal:

Biochemical Society Transactions

Year:

2005

Language:

english

File:

PDF, 189 KB

english, 2005

22

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes

Viaud, J., Zeghouf, M., Barelli, H., Zeeh, J.-C., Padilla, A., Guibert, B., Chardin, P., Royer, C. A., Cherfils, J., Chavanieu, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 1.21 MB

english, 2007

23

Protein Profiling with Epstein-Barr Nuclear Antigen-1 Reveals an Interaction with the Herpesvirus-associated Ubiquitin-specific Protease HAUSP/USP7

Holowaty, M. N., Zeghouf, M., Wu, H., Tellam, J., Athanasopoulos, V., Greenblatt, J., Frappier, L.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 797 KB

english, 2003

24

Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2

Aizel, Kaheina, Biou, Valérie, Navaza, Jorge, Duarte, Lionel V., Campanacci, Valérie, Cherfils, Jacqueline, Zeghouf, Mahel, Hughson, Frederick

Journal:

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

25

A Novel Membrane Sensor Controls the Localization and ArfGEF Activity of Bacterial RalF

Folly-Klan, Marcia, Alix, Eric, Stalder, Danièle, Ray, Pampa, Duarte, Lionel V., Delprato, Anna, Zeghouf, Mahel, Antonny, Bruno, Campanacci, Valérie, Roy, Craig R., Cherfils, Jacqueline, Swanson, Mich

Journal:

Year:

2013

Language:

english

File:

PDF, 6.03 MB

english, 2013

26

Allosteric regulation of Arf GTPases and their GEFs at the membrane interface

Nawrotek, Agata, Zeghouf, Mahel, Cherfils, Jacqueline

Journal:

Year:

2016

Language:

english

File:

PDF, 1.20 MB

english, 2016

27

Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors

Zeghouf, M., Guibert, B., Zeeh, J.-C., Cherfils, J.

Journal:

Biochemical Society Transactions

Year:

2005

Language:

english

File:

PDF, 189 KB

english, 2005

28

Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering

Peurois, François, Veyron, Simon, Ferrandez, Yann, Ladid, Ilham, Benabdi, Sarah, Zeghouf, Mahel, Peyroche, Gérald, Cherfils, Jacqueline

Journal:

Biochemical Journal

Year:

2017

Language:

english

File:

PDF, 1.38 MB

english, 2017

29

Family-wide analysis of the inhibition of Arf guanine nucleotide exchange factors with small molecules: evidence for unique inhibitory profiles.

Benabdi, Sarah, Peurois, François, nawrotek, agata, Chikireddy, Jahnavi, Cañeque, Tatiana, Yamori, Takao, Shiina, Isamu, Ohashi, Yoshimi, Dan, Shingo, Rodriguez, Raphaël, Cherfils, Jacqueline, Zeghouf

Journal:

Year:

2017

Language:

english

File:

PDF, 1.29 MB

english, 2017

30

Structure and inhibition of Arf GTPases

Cherfils, J., Zeeh, J.-C., Zeghouf, M., Biou, V., Buosi, V., Thureau, A., van Heijenoort, C., Guittet, E.

Journal:

Acta Crystallographica Section A Foundations of Crystallography

Year:

2008

Language:

english

File:

PDF, 230 KB

english, 2008

31

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

Ferrandez, Yann, Zhang, Wenhua, Peurois, François, Akendengué, Lurlène, Blangy, Anne, Zeghouf, Mahel, Cherfils, Jacqueline

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 6.03 MB

english, 2017

32

Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes

Das, Sanchaita, Malaby, Andrew W., Nawrotek, Agata, Zhang, Wenhua, Zeghouf, Mahel, Maslen, Sarah, Skehel, Mark, Chakravarthy, Srinivas, Irving, Thomas C., Bilsel, Osman, Cherfils, Jacqueline, Lambrigh

Journal:

Year:

2019

Language:

english

File:

PDF, 7.39 MB

english, 2019