Significance of high skin fluxes produced by acyclovir topical formulations for achieving therapeutic levels of drug at the target site in the treatment of cutaneous HSV-1 infections in hairless mice: A closer look at the C* concept: Phenil J. Patel1, Abdel-Halim Ghanem1, William I. Higuchi1, Jer Hsu1, V. Srinivasan2 and Earl R. Kern3. 1Dept. of Pharmaceutics and Pharmaceutical Chemistry, Univ. of Utah, Salt Lake City, UT 84112; 2TheraTech, Inc., 417 Wakara Way, Salt Lake City, UT 84108; 3Dept. of Pediatrics, Univ. of Alabama at Birmingham, AL 35294