Volume 6; Issue 7

ACS Medicinal Chemistry Letters

Volume 6; Issue 7

1

Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase

Cox, Bryan D., Prosser, Anthony R., Sun, Yongnian, Li, Zhufang, Lee, Sangil, Huang, Ming B., Bond, Vincent C., Snyder, James P., Krystal, Mark, Wilson, Lawrence J., Liotta, Dennis C.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.90 MB

english, 2015

2

Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors

Wang, Yonghui, Cai, Wei, Cheng, Yaobang, Yang, Ting, Liu, Qian, Zhang, Guifeng, Meng, Qinghua, Han, Fangbin, Huang, Yafei, Zhou, Ling, Xiang, Zhijun, Zhao, Yong-Gang, Xu, Yan, Cheng, Ziqiang, Lu, Siji

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 544 KB

english, 2015

3

Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor

Karpov, Alexei S., Amiri, Payman, Bellamacina, Cornelia, Bellance, Marie-Helene, Breitenstein, Werner, Daniel, Dylan, Denay, Regis, Fabbro, Doriano, Fernandez, Cesar, Galuba, Inga, Guerro-Lagasse, Ste

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.00 MB

english, 2015

4

Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II)

Hoveyda, Hamid R., Fraser, Graeme L., Dutheuil, Guillaume, El Bousmaqui, Mohamed, Korac, Julien, Lenoir, François, Lapin, Alexey, Noël, Sophie

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 720 KB

english, 2015

5

BRD4 Structure–Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536

Chen, Lijia, Yap, Jeremy L., Yoshioka, Makoto, Lanning, Maryanna E., Fountain, Rachel N., Raje, Mithun, Scheenstra, Jacob A., Strovel, Jeffrey W., Fletcher, Steven

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 416 KB

english, 2015

6

Molecular Property Design: Does Everyone Get It?

Leeson, Paul D., Young, Robert J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 617 KB

english, 2015

7

Novel Chalcone–Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus

Sashidhara, Koneni V., Rao, K. Bhaskara, Kushwaha, Pragati, Modukuri, Ram K., Singh, Pratiksha, Soni, Isha, Shukla, P. K., Chopra, Sidharth, Pasupuleti, Mukesh

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 606 KB

english, 2015

8

Rigidified A 3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

Tosh, Dilip K., Crane, Steven, Chen, Zhoumou, Paoletta, Silvia, Gao, Zhan-Guo, Gizewski, Elizabeth, Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.22 MB

english, 2015

9

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

Walsh, Shawn P., Shahripour, Aurash, Tang, Haifeng, Teumelsan, Nardos, Frie, Jessica, Zhu, Yuping, Priest, Birgit T., Swensen, Andrew M., Liu, Jessica, Margulis, Michael, Visconti, Richard, Weinglass,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 676 KB

english, 2015

10

Exploration of Pharmacophore in Chrysosplenol C as Activator in Ventricular Myocyte Contraction

Venkateswararao, Eeda, Son, Min-Jeong, Sharma, Niti, Manickam, Manoj, Boggu, PullaReddy, Kim, Young Ho, Woo, Sun-Hee, Jung, Sang-Hun

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

11

Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics

Hu, Xi-Le, Li, Dan, Shao, Lei, Dong, Xiaojing, He, Xiao-Peng, Chen, Guo-Rong, Chen, Daijie

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.57 MB

english, 2015

12

Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series

Ombouma, Joanna, Vullo, Daniella, Dumy, Pascal, Supuran, Claudiu T., Winum, Jean-Yves

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 323 KB

english, 2015

13

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors

Murray, Christopher W., Berdini, Valerio, Buck, Ildiko M., Carr, Maria E., Cleasby, Anne, Coyle, Joseph E., Curry, Jayne E., Day, James E. H., Day, Phillip J., Hearn, Keisha, Iqbal, Aman, Lee, Lydia Y

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.71 MB

english, 2015

14

Pyrrolopyridine or Pyrazolopyridine Derivatives

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 315 KB

english, 2015

15

Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding

Hameed P, Shahul, Manjrekar, Praveena, Raichurkar, Anandkumar, Shinde, Vikas, Puttur, Jayashree, Shanbhag, Gajanan, Chinnapattu, Murugan, Patil, Vikas, Rudrapatana, Suresh, Sharma, Sreevalli, Kumar, C

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.12 MB

english, 2015

16

Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5- a ]pyridine-3-carboxamides as Novel Antitubercular Agents

Tang, Jian, Wang, Bangxing, Wu, Tian, Wan, Junting, Tu, Zhengchao, Njire, Moses, Wan, Baojie, Franzblauc, Scott G., Zhang, Tianyu, Lu, Xiaoyun, Ding, Ke

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 361 KB

english, 2015

17

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors

He, Rongjun, Yu, Zhi-Hong, Zhang, Ruo-Yu, Wu, Li, Gunawan, Andrea M., Lane, Brandon S., Shim, Joong S., Zeng, Li-Fan, He, Yantao, Chen, Lan, Wells, Clark D., Liu, Jun O., Zhang, Zhong-Yin

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.37 MB

english, 2015

18

Inhibitors of the Epidermal Growth Factor Receptor (EGFR) May Provide Effective Treatment for Lung Adenocarcinoma

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 251 KB

english, 2015

19

Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV

O’Dowd, Hardwin, Shannon, Dean E., Chandupatla, Kishan R., Dixit, Vaishali, Engtrakul, Juntyma J., Ye, Zhengqi, Jones, Steven M., O’Brien, Colleen F., Nicolau, David P., Tessier, Pamela R., Crandon, J

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 562 KB

english, 2015

20

Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer

Zhang, Yong, Seigal, Benjamin A., Terrett, Nicholas K., Talbott, Randy L., Fargnoli, Joseph, Naglich, Joseph G., Chaudhry, Charu, Posy, Shana L., Vuppugalla, Ragini, Cornelius, Georgia, Lei, Ming, Wan

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

21

Potential Treatment for the Respiratory Syncytial Virus Infections (HRSV)

Abdel-Magid, Ahmed F.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 236 KB

english, 2015

22

Novel Pyrazine Amide Compounds

Blass, Benjamin

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 242 KB

english, 2015

23

In This Issue, Volume 6, Issue 7

Kindrachuk, Kristen N.

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.70 MB

english, 2015

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