Volume 16; Issue 1

Organic Process Research & Development

Volume 16; Issue 1

1

Multikilogram-Scale Synthesis of a Chiral Cyclopropanol and an Investigation of the Safe Use of Lithium Acetylide–Ethylene Diamine Complex

Bassan, Ephraim M., Baxter, Carl A., Beutner, Gregory L., Emerson, Khateeta M., Fleitz, Fred J., Johnson, Simon, Keen, Stephen, Kim, Mary M., Kuethe, Jeffrey T., Leonard, William R.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 982 KB

english, 2012

2

Development and a Practical Synthesis of the JAK2 Inhibitor LY2784544

Mitchell, David, Cole, Kevin P., Pollock, Patrick M., Coppert, David M., Burkholder, Timothy P., Clayton, Joshua R.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.43 MB

english, 2012

3

Design and Scale-Up of a Practical Enantioselective Route to 5-Phenylbicyclo[2.2.2]oct-5-en-2-one

Abele, Stefan, Inauen, Roman, Funel, Jacques-Alexis, Weller, Thomas

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 883 KB

english, 2012

4

Process Intensification via Reaction Telescoping and a Preliminary Cost Model to Rapidly Establish Value

Desai, Aman A., Molitor, Erich J., Anderson, John E.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 3.63 MB

english, 2012

5

Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres

Skoda, Erin M., Davis, Gary C., Wipf, Peter

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.92 MB

english, 2012

6

Some Items of Interest to Process R&D Chemists and Engineers

McLaughlin, Mark, Widegren, Magnus, Ramirez, Antonio, Richardson, Paul, Zlota, Andrei, Laird, Trevor

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 497 KB

english, 2012

7

Kinetic Understanding Using NMR Reaction Profiling

Susanne, Flavien, Smith, David S., Codina, Anna

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 786 KB

english, 2012

8

A Review of U.S. Patents in the Field of Organic Process Development Published During August and September 2011

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 760 KB

english, 2012

9

Development and Scale-Up of an Optimized Route to the ALK Inhibitor CEP-28122

Allwein, Shawn P., Roemmele, Renee C., Haley, James J., Mowrey, Dale R., Petrillo, Daniel E., Reif, James J., Gingrich, Diane E., Bakale, Roger P.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 503 KB

english, 2012

10

Large-Scale Synthesis of Singh’s Catalyst in a One-Pot Procedure Starting from Proline

Berkessel, Albrecht, Harnying, Wacharee, Duangdee, Nongnaphat, Neudörfl, Jörg-M., Gröger, Harald

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 299 KB

english, 2012

11

Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B 1

Zhao, Lei, Ma, Xiao-Dong, Chen, Fen-Er

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 733 KB

english, 2012

12

An Efficient, Direct Bis-ortho-chlorination of 4-(Difluoromethoxy)aniline and Its Application to the Synthesis of BMS-665053, a Potent and Selective Pyrazinone-Containing Corticotropin-Releasing Factor-1 Receptor Antagonist

Li, Jianqing, Smith, Daniel, Krishnananthan, Subramaniam, Hartz, Richard A., Dasgupta, Bireshwar, Ahuja, Vijay, Schmitz, William D., Bronson, Joanne J., Mathur, Arvind, Barrish, Joel C., Chen, Bang-Ch

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 303 KB

english, 2012

13

Practical Convergent Laboratory-Scale Synthesis of a CCR5 Receptor Antagonist

Crawford, Jason B., Chen, Gang, Carpenter, Bryon, Wilson, Trevor, Ji, Jenny, Skerlj, Renato T., Bridger, Gary J.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 928 KB

english, 2012

14

Development of Safe One-Pot Synthesis of N -1- and C -2-Substituted Benzimidazole via Reductive Cyclization of o -Nitroarylamine Using Na 2 S 2 O 4

Oda, Shinichi, Shimizu, Hideki, Aoyama, Yasunori, Ueki, Tatsuo, Shimizu, Sumio, Osato, Hiroshi, Takeuchi, Yoshiyuki

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 2.46 MB

english, 2012

15

Green Chemistry is Good Process Chemistry

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 87 KB

english, 2012

16

Efficient Screening and Library Generation in Parallel C–C Coupling Reactions Mediated by Organosilica Silia Cat Palladium Catalysts

Pandarus, Valerica, Gingras, Genevieve, Béland, François, Ciriminna, Rosaria, Pagliaro, Mario

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

17

Catalytic Hydrogenation of Esters. Development of an Efficient Catalyst and Processes for Synthesising ( R )-1,2-Propanediol and 2-( l -Menthoxy)ethanol

Kuriyama, Wataru, Matsumoto, Takaji, Ogata, Osamu, Ino, Yasunori, Aoki, Kunimori, Tanaka, Shigeru, Ishida, Kenya, Kobayashi, Tohru, Sayo, Noboru, Saito, Takao

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 574 KB

english, 2012

18

The Use of in Situ Tools To Monitor the Enantiotropic Transformation of p -Aminobenzoic Acid Polymorphs

Hao, Hongxun, Barrett, Mark, Hu, Yun, Su, Weiyi, Ferguson, Steven, Wood, Barbara, Glennon, Brian

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 3.21 MB

english, 2012

19

Use of in Situ Raman, FBRM, and ATR-FTIR Probes for the Understanding of the Solvent-Mediated Polymorphic Transformation of II–I Etiracetam in Methanol

Herman, Christelle, Haut, Benoît, Douieb, Sélim, Larcy, Aurélie, Vermylen, Valérie, Leyssens, Tom

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 3.58 MB

english, 2012

20

The Use of Glycidyl Ethers Involving Aziridinium Intermediates and Other Methodology for the Preparation of Enantiomerically Pure Drug Candidates

Ayers, Timothy A., Watson, Timothy J. N., Subotkowski, Witold, Daniel, John, Webster, Mark

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 561 KB

english, 2012

21

Invited Academic Review

Senanayake, Chris, Caron, Stéphane

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 103 KB

english, 2012

22

Simultaneous API Particle Size Reduction and Polymorph Transformation Using High Shear

Lo, Ehrlic, Mattas, Elias, Wei, Chenkou, Kacsur, David, Chen, Chien-Kuang

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 2.05 MB

english, 2012

23

Peroxy Radical Activated Addition of tert -Butylcatechol to 2,6-Di- tert -butyl-7-Substituted Quinone Methide Polymerization Retarders

Neilson, Andrew R., Morrison, Christopher F.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 357 KB

english, 2012

24

Overcoming Equilibrium Issues with Carbonyl Reductase Enzymes

Calvin, Susan J., Mangan, David, Miskelly, Iain, Moody, Thomas S., Stevenson, Paul J.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.62 MB

english, 2012

25

Lean Filtration: Approaches for the Estimation of Cake Properties

Murugesan, Saravanababu, Hallow, Daniel M., Vernille, James P., Tom, Jean W., Tabora, Jose E.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.44 MB

english, 2012

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