Volume 16; Issue 5

Organic Process Research & Development

Volume 16; Issue 5

1

Facile Stoichiometric Reductions in Flow: An Example of Artemisinin

Fan, Xiaolei, Sans, Victor, Yaseneva, Polina, Plaza, Dorota D., Williams, Jonathan, Lapkin, Alexei

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 434 KB

english, 2012

2

Process Development of a Novel Azetidinyl Ketolide Antibiotic

Li, Bryan, Magee, Thomas V., Buzon, Richard A., Widlicka, Daniel W., Bill, Dave R., Brandt, Thomas, Cao, Xiaoping, Coutant, Michael, Dou, Haijian, Granskog, Karl, Flanagan, Mark E., Hayward, Cheryl M.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 2.65 MB

english, 2012

3

Using Continuous Processes to Increase Production

Anderson, Neal G.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 2.57 MB

english, 2012

4

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

Battilocchio, Claudio, Baxendale, Ian R., Biava, Mariangela, Kitching, Matthew O., Ley, Steven V.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 4.12 MB

english, 2012

5

A Review of U.S. Patents in the Field of Organic Process Development Published During December 2011 and January 2012

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 783 KB

english, 2012

6

Atom-Efficient Benzoin Condensation in Liquid–Liquid System Using Quaternary Ammonium Salts: Pseudo-Phase Transfer Catalysis

Yadav, Ganapati D., Kadam, Anup A.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 423 KB

english, 2012

7

Rapid Development and Scale-Up of a 1 H -4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

May, Scott A., Johnson, Martin D., Braden, Timothy M., Calvin, Joel R., Haeberle, Brian D., Jines, Amy R., Miller, Richard D., Plocharczyk, Edward F., Rener, Gregory A., Richey, Rachel N., Schmid, Chr

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 2.72 MB

english, 2012

8

Managing Solids in Microreactors for the Upstream Continuous Processing of Fine Chemicals

Hartman, Ryan L.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 969 KB

english, 2012

9

Convergent, Kilogram Scale Synthesis of an Akt Kinase Inhibitor

Grongsaard, Pintipa, Bulger, Paul G., Wallace, Debra J., Tan, Lushi, Chen, Qinghao, Dolman, Sarah J., Nyrop, Jason, Hoerrner, R. Scott, Weisel, Mark, Arredondo, Juan, Itoh, Takahiro, Xie, Chengfu, Wen

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 3.21 MB

english, 2012

10

Improved Process for Ranolazine: An Antianginal Agent†

Aalla, Sampath, Gilla, Goverdhan, Anumula, Raghupathi Reddy, Kurella, Srinivas, Padi, Pratap Reddy, Vummenthala, Prabhakar Reddy

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 487 KB

english, 2012

11

Process Development of Citalopram/Escitalopram Oxalate: Isolation and Synthesis of Novel Impurities

Pramanik, Chinmoy, Hivarekar, Raghvendra R., Deshmukh, Sanjay S., Tripathy, Narendra K., Kotharkar, Sandeep, Chaudhari, Ashok, Gurjar, Mukund K.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 899 KB

english, 2012

12

Development of an Efficient and Practical Route for the Multikilogram Manufacture of Ethyl 5-Cyano-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate and Ethyl 6-Chloro-5-cyano-2-methylnicotinate, Key Intermediates in the Preparation of P2Y12 Antagonists

Bell, Stephen J., McIntyre, Steve, Garcia, Conchita F., Kitson, Sean L, Therkelsen, Frans, Andersen, Søren M, Zetterberg, Fredrik, Aurell, Carl-Johan, Bollmark, Martin, Ehrl, Robert

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 301 KB

english, 2012

13

Development of an Enantioselective Hydrogenation Based Synthesis of a Glucokinase Activator

Magnus, Nicholas A., Braden, Timothy M., Buser, Jonas Y., DeBaillie, Amy C., Heath, Perry C., Ley, Christopher P., Remacle, Jacob R., Varie, David L., Wilson, Thomas M.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 349 KB

english, 2012

14

Simple Modification To Obtain High Quality Fludarabine

Kshirsagar, Siddheshwar W., Deshpande, Mangesh S., Sonawane, Swapnil P., Maikap, Golak C., Gurjar, Mukund K.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 350 KB

english, 2012

15

Synthesis of Phenylboronic Acids in Continuous Flow by Means of a Multijet Oscillating Disc Reactor System Operating at Cryogenic Temperatures

Sleveland, Dagfinn, Bjørsvik, Hans-René

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 959 KB

english, 2012

16

Isoindolone Formation via Intramolecular Diels–Alder Reaction

Ball, Matthew, Boyd, Alistair, Churchill, Gwydion, Cuthbert, Murray, Drew, Mark, Fielding, Mark, Ford, Gair, Frodsham, Lianne, Golden, Michael, Leslie, Kevin, Lyons, Sarah, McKeever-Abbas, Ben, Stark,

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 550 KB

english, 2012

17

A Reactive Distillation Process To Produce 5-Hydroxy-2-methyl-1,3-dioxane from Mixed Glycerol Acetal Isomers

Hong, Xi, McGiveron, Omar, Lira, Carl T., Orjuela, Alvaro, Peereboom, Lars, Miller, Dennis J.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

18

Continuous Dehydration and Hydrogenolysis of Glycerol over Non-Chromium Copper Catalyst: Laboratory-Scale Process Studies

Mane, Rasika B., Rode, Chandrashekhar V.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 2.46 MB

english, 2012

19

Development of a Continuous Schotten–Baumann Route to an Acyl Sulfonamide

White, Timothy D., Berglund, K. Derek, Groh, Jennifer McClary, Johnson, Martin D., Miller, Richard D., Yates, Matthew H.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 758 KB

english, 2012

20

Manufacture of a β-Hydroxyester via a Continuous Reformatsky Process

Loh, Gabriel, Tanigawara, Ryo, Shaik, Salim M., Sa-ei, Kanicha, Wong, Loretta, Sharratt, Paul Nicholas

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 420 KB

english, 2012

21

Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

Brodmann, Tobias, Koos, Peter, Metzger, Albrecht, Knochel, Paul, Ley, Steven V.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.14 MB

english, 2012

22

Intensified Azeotropic Distillation: A Strategy for Optimizing Direct Amidation

Grosjean, Christophe, Parker, Julie, Thirsk, Carl, Wright, Allen R.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.59 MB

english, 2012

23

Rapid Crystallization Process Development Strategy from Lab to Industrial Scale with PAT Tools in Skid Configuration

Kadam, Somnath S., Vissers, Jochem A. W., Forgione, Marco, Geertman, Rob M., Daudey, Peter J., Stankiewicz, Andrzej I., Kramer, Herman J. M.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 3.40 MB

english, 2012

24

Alkylation of Substituted Benzoic Acids in a Continuous Flow Microfluidic Microreactor: Kinetics and Linear Free Energy Relationships

Gholamipour-Shirazi, Azarmidokht, Rolando, Christian

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 384 KB

english, 2012

25

Process Development and Pilot-Plant Synthesis of ( S )- tert -Butyl 1-Oxo-1-(1-(pyridin-2-yl)cyclopropylamino)propan-2-ylcarbamate: Studies on the Scale-Up of Kulinkovich–Szymoniak Cyclopropanation

Li, Wenjie, Gao, Joe J., Lorenz, Jon C., Xu, Jinghua, Johnson, Joe, Ma, Shengli, Lee, Heewon, Grinberg, Nelu, Busacca, Carl A., Lu, Bruce, Senanayake, Chris H.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 231 KB

english, 2012

26

Scalable in Situ Diazomethane Generation in Continuous-Flow Reactors

Rossi, Emiliano, Woehl, Pierre, Maggini, Michele

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.32 MB

english, 2012

27

Process Development of a Potent Glucosylceramide Synthase Inhibitor

Cooper, Christopher G.F., Lee, Edward R., Silva, Richard A., Bourque, André J., Clark, Scott, Katti, Sanjeev, Nivorozhkin, Vitaly

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

28

A Continuous Base-Catalyzed Methylation of Phenols with Dimethyl Carbonate

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 341 KB

english, 2012

29

Scaling Up Biocatalysis Reactions in Flow Reactors

Gasparini, Gilda, Archer, Ian, Jones, Ed, Ashe, Robert

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.74 MB

english, 2012

30

Development and Scale-Up of a Continuous, High-Pressure, Asymmetric Hydrogenation Reaction, Workup, and Isolation

Johnson, Martin D., May, Scott A., Calvin, Joel R., Remacle, Jacob, Stout, James R., Diseroad, William D., Zaborenko, Nikolay, Haeberle, Brian D., Sun, Wei-Ming, Miller, Michael T., Brennan, John

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 875 KB

english, 2012

31

Continuous Flow Oxidation of Alcohols and Aldehydes Utilizing Bleach and Catalytic Tetrabutylammonium Bromide

Leduc, Andrew B., Jamison, Timothy F.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 922 KB

english, 2012

32

Mixing and Dispersion in Small-Scale Flow Systems

Nagy, Kevin D., Shen, Bo, Jamison, Timothy F., Jensen, Klavs F.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

33

Streamlined Process for the Conversion of Artemisinin to Artemether

Stringham, Rodger W., Teager, David S.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 254 KB

english, 2012

34

Continuous Flow Production of Thermally Unstable Intermediates in a Microreactor with Inline IR-Analysis: Controlled Vilsmeier–Haack Formylation of Electron-Rich Arenes

van den Broek, Sebastiaan (Bas) A. M. W., Leliveld, Jeroen R., Becker, René, Delville, Mariëlle M. E., Nieuwland, Pieter J., Koch, Kaspar, Rutjes, Floris P. J. T.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.88 MB

english, 2012

35

Development of an Improved Process for Doxercalciferol via a Continuous Photochemical Reaction

Anderson, Bruce G., Bauta, William E., Cantrell, William R.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 2.15 MB

english, 2012

36

Monitoring and Control of a Continuous Grignard Reaction for the Synthesis of an Active Pharmaceutical Ingredient Intermediate Using Inline NIR spectroscopy

Cervera-Padrell, Albert E., Nielsen, Jesper P., Jønch Pedersen, Michael, Müller Christensen, Kim, Mortensen, Asmus R., Skovby, Tommy, Dam-Johansen, Kim, Kiil, Søren, Gernaey, Krist V.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 3.40 MB

english, 2012

37

Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor

Mercadante, Michael A., Kelly, Christopher B., (Xiang) Lee, Christopher, Leadbeater, Nicholas E.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 3.17 MB

english, 2012

38

Pharmaceutical Process Development: Current Chemical and Engineering Challenges Pharmaceutical Process Development: Current Chemical and Engineering Challenges edited by A. JohnBlacker and Michael T.Williams. Royal Sociey of Chemistry : Cambridge, UK . 2011 . 354 pp. Price £121.99. ISBN 978-1-84973-146-1 .

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 109 KB

english, 2012

39

Litigation on the Increase in Pharma?

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 106 KB

english, 2012

40

High Output Continuous Nitration

Gage, James R., Guo, Xiaowen, Tao, Jian, Zheng, Changsheng

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 816 KB

english, 2012

41

Continuous Hydrolysis and Liquid–Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator

Cervera-Padrell, Albert E., Morthensen, Sofie T., Lewandowski, Daniel J., Skovby, Tommy, Kiil, Søren, Gernaey, Krist V.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 2.04 MB

english, 2012

42

Development of a Continuous Flow Scale-Up Approach of Reflux Inhibitor AZD6906

Gustafsson, Tomas, Sörensen, Henrik, Pontén, Fritiof

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 4.74 MB

english, 2012

43

Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications

Öhrngren, Per, Fardost, Ashkan, Russo, Francesco, Schanche, Jon-Sverre, Fagrell, Magnus, Larhed, Mats

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 3.68 MB

english, 2012

44

Selective Continuous Flow Processes Using Fluorine Gas

McPake, Christopher B., Sandford, Graham

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 3.18 MB

english, 2012

45

Multikilogram Synthesis of 4- d -Erythronolactone via Batch and Continuous Processing

Wong, Loretta L., Wong, Run Ling, Loh, Gabriel, Tan, Phyllis E.W., Teoh, Soo Khean, Shaik, Salim M., Sharratt, Paul N., Chew, Wee, Tan, Suat Teng, Wang, David

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 3.24 MB

english, 2012

46

High-Temperature Diels–Alder Reactions: Transfer from Batch to Continuous Mode

Abele, Stefan, Höck, Stefan, Schmidt, Gunther, Funel, Jacques-Alexis, Marti, Roger

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.58 MB

english, 2012

47

Preparative Synthesis via Continuous Flow of 4,4,5,5-Tetramethyl-2-(3-trimethylsilyl-2-propynyl)-1,3,2-dioxaborolane: A General Propargylation Reagent

Fandrick, Daniel R., Roschangar, Frank, Kim, Chunyoung, Hahm, Byoung J., Cha, Myoung H., Kim, Hyoun Y., Yoo, Gyesang, Kim, Taeyun, Reeves, Jonathan T., Song, Jinhua J., Tan, Zhulin, Qu, Bo, Haddad, Ni

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 2.14 MB

english, 2012

48

Lipase-Catalyzed Monostearin Synthesis under Continuous Flow Conditions

Junior, Ivaldo I., Flores, Marcela C., Sutili, Felipe K., Leite, Selma G. F., de M. Miranda, Leandro S., Leal, Ivana C. R., de Souza, Rodrigo O. M. A.

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 1.39 MB

english, 2012

49

Continuous Processes: Go with the Flow!

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 114 KB

english, 2012

50

Development of Continuous Anti-Solvent/Cooling Crystallization Process using Cascaded Mixed Suspension, Mixed Product Removal Crystallizers

Zhang, Haitao, Quon, Justin, Alvarez, Alejandro J., Evans, James, Myerson, Allan S., Trout, Bernhardt

Journal:

Organic Process Research & Development

Year:

2012

Language:

english

File:

PDF, 4.61 MB

english, 2012

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