Volume 21; Issue 3

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Bioorganic & Medicinal Chemistry Letters
Volume 21; Issue 3

Bioorganic & Medicinal Chemistry Letters

Volume 21; Issue 3

1

Kinetic delay of cyclization/elimination-coupled enzyme assays: Analysis and solution

Fengtian Xue, Christopher T. Seto

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 343 KB

english, 2011

2

99mTc- and Re-labeled 6-dialkylamino-2-naphthylethylidene derivatives as imaging probes for β-amyloid plaques

Mengchao Cui, Ruikun Tang, Zijing Li, Huiying Ren, Boli Liu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 574 KB

english, 2011

3

Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors

Wei Shi, Haikun Ma, Yuejiao Duan, Kelly Aubart, Yuhong Fang, Rimma Zonis, Liping Yang, Wenhao Hu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 451 KB

english, 2011

4

Pharmacophore-based design, synthesis, and biological evaluation of novel chloro-pyridazine piperazines as human rhinovirus (HRV-3) inhibitors

Hongliang Wang, Junhai Xiao, Dapeng Gao, Xian Zhang, Hui Yan, Zehui Gong, Tinmin Sun, Song Li

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 512 KB

english, 2011

5

Identification of a novel small molecule targeting UQCRB of mitochondrial complex III and its anti-angiogenic activity

Hye Jin Jung, Ki Hyun Kim, Nam Doo Kim, Gyoonhee Han, Ho Jeong Kwon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 836 KB

english, 2011

6

Synthesis and DNA photocleavage by a pyridine-linked bis-acridine chromophore in the presence of copper(II): Ionic strength effects

Kathryn B. Grant, Carla A. Terry, Lourdes Gude, María-José Fernández, Antonio Lorente

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 616 KB

english, 2011

7

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor

Jason D. Burch, Julie Farand, John Colucci, Claudio Sturino, Yves Ducharme, Richard W. Friesen, Jean-François Lévesque, Sébastien Gagné, Mark Wrona, Alex G. Therien, Marie-Claude Mathieu, Danielle Den

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 755 KB

english, 2011

8

Sodium [2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D2 receptor antagonist

Nicholas Stock, Deborah Volkots, Karin Stebbins, Alex Broadhead, Brian Stearns, Jeffrey Roppe, Timothy Parr, Christopher Baccei, Gretchen Bain, Charles Chapman, Lucia Correa, Janice Darlington, Christ

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 446 KB

english, 2011

9

Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand

Shuo-Bin Chen, Jia-Heng Tan, Tian-Miao Ou, Shi-Liang Huang, Lin-Kun An, Hai-Bin Luo, Ding Li, Lian-Quan Gu, Zhi-Shu Huang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 609 KB

english, 2011

10

Synthesis and preliminary evaluation of curcumin analogues as cytotoxic agents

Qin Zhang, Ying Zhong, Lin-Na Yan, Xun Sun, Tao Gong, Zhi-Rong Zhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 488 KB

english, 2011

11

Synthesis and in vitro cytotoxicity evaluation of some fluorinated hexahydropyrimidine derivatives

Oluropo C. Agbaje, Olugbeminiyi O. Fadeyi, S. Adamson Fadeyi, Lewis. E. Myles, Cosmas O. Okoro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 754 KB

english, 2011

12

Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors

Li Xing, Bruce C. Hamper, Theresa R. Fletcher, Jay M. Wendling, Jeffery Carter, James K. Gierse, Subo Liao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 408 KB

english, 2011

13

Stereoselective first total synthesis, confirmation of the absolute configuration and bioevaluation of botryolide-E

D. Kumar Reddy, V. Shekhar, P. Prabhakar, D. Chanti Babu, D. Ramesh, B. Siddhardha, U.S.N. Murthy, Y. Venkateswarlu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 271 KB

english, 2011

14

Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screening

Anees A. Siddiqui, Ravinesh Mishra, Mohammad Shaharyar, Asif Husain, Mohd. Rashid, Palash Pal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 205 KB

english, 2011

15

Methoxylation of resveratrol: Effects on induction of NAD(P)H Quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties

Wei Zhang, Mei Lin Go

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 280 KB

english, 2011

16

Glucose-lowering activity of novel tetrasaccharide glyceroglycolipids from the fruits of Cucurbita moschata

Zhiguo Jiang, Qizhen Du

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 224 KB

english, 2011

17

Design, synthesis and biological evaluation of new thalidomide analogues as TNF-α and IL-6 production inhibitors

Charlotte Chaulet, Cécile Croix, David Alagille, Sylvain Normand, Adriana Delwail, Laure Favot, Jean-Claude Lecron, Marie-Claude Viaud-Massuard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 620 KB

english, 2011

18

Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities

Jun-Ming Zhao, Ning Li, Hong Zhang, Chun-fu Wu, Hu-Ri Piao, Yu-Qing Zhao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 341 KB

english, 2011

19

Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis

Bhupesh S. Samant, Mugdha G. Sukhthankar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 294 KB

english, 2011

20

1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

Sampath-Kumar Anandan, Heather Kay Webb, Dawn Chen, Yi-Xin (Jim) Wang, Basker R. Aavula, Sylvaine Cases, Ying Cheng, Zung N. Do, Upasana Mehra, Vinh Tran, Jon Vincelette, Joanna Waszczuk, Kathy White,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 339 KB

english, 2011

21

Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor

Sangku Lee, Jae Nyoung Kim, Hyeong Kyu Lee, Kab Seog Yoon, Ki Deok Shin, Byoung-Mog Kwon, Dong Cho Han

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 273 KB

english, 2011

22

Synthesis and biological evaluation of indole-chalcone derivatives as β-amyloid imaging probe

Mengchao Cui, Masahiro Ono, Hiroyuki Kimura, Bo Li Liu, Hideo Saji

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 468 KB

english, 2011

23

DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain

Kate M. Clapham, Julia Bardos, M. Raymond V. Finlay, Bernard T. Golding, Edward J. Griffen, Roger J. Griffin, Ian R. Hardcastle, Keith A. Menear, Attilla Ting, Paul Turner, Gail L. Young, Céline Cano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 946 KB

english, 2011

24

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Andrés A. Trabanco, Guillaume Duvey, José María Cid, Gregor J. Macdonald, Philippe Cluzeau, Vanthea Nhem, Rocco Furnari, Nadia Behaj, Géraldine Poulain, Terry Finn, Hilde Lavreysen, Sonia Poli, Alexan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.77 MB

english, 2011

25

Radical-scavenging properties of ferrocenyl chalcones

Gul Nabi, Zai-Qun Liu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 168 KB

english, 2011

26

Synthesis and structure–analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

Song-Wen Lin, Qi Sun, Ze-Mei Ge, Xin Wang, Jia Ye, Run-Tao Li

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 293 KB

english, 2011

27

Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6

Charles Huang, Wilna J. Moree, Said Zamani-Kord, Bin-Feng Li, Fabio C. Tucci, Siobhan Malany, Jianyun Wen, Hua Wang, Samuel R.J. Hoare, Chun Yang, Ajay Madan, Paul D. Crowe, Graham Beaton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 930 KB

english, 2011

28

Compounds from Kadsura angustifolia with anti-HIV activity

Rong Sun, Hong-Chuan Song, Chun-Ren Wang, Kai-Ze Shen, Yao-Bo Xu, Yan-Xiu Gao, Ye-Gao Chen, Jin-Yan Dong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 462 KB

english, 2011

29

Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols

Chung-Kyu Ryu, Yang Hui Kim, Ji-Hee Nho, Jung An Hong, Joo Hee Yoon, Aram Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 352 KB

english, 2011

30

Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents

Yuan Shi, Cheng-He Zhou

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 198 KB

english, 2011

31

Substituted imidazole derivatives as novel cardiovascular agents

Vineet Malhotra, Seema R. Pathak, Rajendra Nath, Devashish Mukherjee, K. Shanker

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 276 KB

english, 2011

32

1H-Imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka

Wullie Arbuckle, Mark Baugh, Simone Belshaw, D. Jonathan Bennett, John Bruin, Jiaqiang Cai, Kenneth S. Cameron, Chris Claxton, Maureen Dempster, Kathryn Everett, Xavier Fradera, William Hamilton, Phil

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 363 KB

english, 2011

33

Synthesis and antitumor activity of novel ribonucleosides with C-5 OH replaced by a diaminopyrimidinyl group

Kerang Wang, Ling Wu, Zhanbin Qin, Xinhao Yan, Xiaoliu Li, Hua Chen, Pingzhu Zhang, Jinchao Zhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 315 KB

english, 2011

34

Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Elise Isabel, Christophe Mellon, Michael J. Boyd, Nathalie Chauret, Denis Deschênes, Sylvie Desmarais, Jean-Pierre Falgueyret, Jacques Yves Gauthier, Karine Khougaz, Cheuk K. Lau, Serge Léger, Dorothy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 888 KB

english, 2011

35

Efficient synthesis of new tetradentate ligands with potential applications for 64Cu PET-imaging

Ewen Bodio, Karine Julienne, Sébastien G. Gouin, Alain Faivre-Chauvet, David Deniaud

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 362 KB

english, 2011

36

Synthesis and in vitro antibacterial activity of 7-(3-alkoxyimino-5-amino/methylaminopiperidin-1-yl)fluoroquinolone derivatives

Yibin Zhang, Guoqing Li, Mingliang Liu, Xuefu You, Lianshun Feng, Kai Lv, Jue Cao, Huiyuan Guo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 438 KB

english, 2011

37

Inhibitory effects of ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit and para-acylated phenols on human cancer cells

Zack E. Bryant, Romy F.J. Janser, Medina Jabarkhail, Melissa S. Candelaria-Lyons, Brittni B. Romero, Severine Van slambrouck, Wim F.A. Steelant, Ingo Janser

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 762 KB

english, 2011

38

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: Improvement of potency in vitro and in vivo

Hiroki Shimizu, Isao Yasumatsu, Tomoaki Hamada, Yoshiyuki Yoneda, Tomonori Yamasaki, Shinji Tanaka, Tadashi Toki, Mika Yokoyama, Kaoru Morishita, Shin Iimura

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 796 KB

english, 2011

39

Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists

Jing Jin, Xiao-Bing Wang, Ling-Yi Kong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 293 KB

english, 2011

40

Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives

Yasuhiro Horita, Takemasa Takii, Ryuji Kuroishi, Taku Chiba, Kenji Ogawa, Laurent Kremer, Yasuo Sato, YooSa Lee, Tomohiro Hasegawa, Kikuo Onozaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 374 KB

english, 2011

41

Structure–activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists

Ronald Palin, Lynn Abernethy, Nasrin Ansari, Kenneth Cameron, Tom Clarkson, Maureen Dempster, David Dunn, Anna-Marie Easson, Darren Edwards, John Maclean, Katy Everett, Helen Feilden, Koc-Kan Ho, Stev

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.89 MB

english, 2011

42

Editorial board

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 30 KB

english, 2011

43

Graphical contents list

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.60 MB

english, 2011

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