Volume 104

Bioorganic Chemistry

Volume 104

1

Synthesis, DNA/RNA-interaction and biological activity of benzo[k,l]xanthene lignans

Tumir, Lidija-Marija, ZonjiÄ, Iva, Å½una, Kristina, Brkanac, Sandra RadiÄ, JukiÄ, Marijana, HuÄek, Ana, Durgo, Ksenija, Crnolatac, Ivo, GlavaÅ¡-Obrovac, Ljubica, Cardullo, Nunzio, Pulvirenti, Luan

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.04 MB

2020

2

Novel coumarin-pyridazine hybrids as selective MAO-B inhibitors for the Parkinsonâs disease therapy

RodrÃguez-EnrÃquez, Fernanda, Costas-Lago, MarÃa Carmen, Besada, Pedro, Alonso-Pena, Miguel, Torres-TerÃ¡n, Iria, ViÃ±a, Dolores, Fontenla, JosÃ© Ãngel, Sturlese, Mattia, Moro, Stefano, Quezada, E

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.39 MB

2020

3

Coumarin-chalcone hybrids targeting insulin receptor: Design, synthesis, anti-diabetic activity, and molecular docking

Konidala, Sathish Kumar, Kotra, Vijay, Danduga, Ravi Chandra Sekhara Reddy, Kola, Phani Kumar

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 9.43 MB

2020

4

History of the development of antifungal azoles: A review on structures, SAR, and mechanism of action

Shafiei, Mohammad, Peyton, Lee, Hashemzadeh, Mehrnoosh, Foroumadi, Alireza

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.80 MB

2020

5

Structure based drug discovery and in vitro activity testing for DNA gyrase inhibitors of Salmonella enterica serovar Typhi

Sharma, Priyanka, Kumar, Manoj, Dahiya, Sushila, Sood, Seema, Das, Bimal Kumar, Kaur, Punit, Kapil, Arti

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 7.15 MB

2020

6

Antimicrobial chloro-hydroxylactones derived from the biotransformation of bicyclic halolactones by cultures of Pleurotus ostreatus

Grabarczyk, MaÅgorzata, MÄczka, Wanda, WiÅska, Katarzyna, Å»arowska, Barbara, Maciejewska, Gabriela, GÄbarowska, ElÅ¼bieta, Jerzy Pietr, StanisÅaw

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 522 KB

2020

7

Nonpeptidal compounds from the insect Polyphaga plancyi and their biological evaluation

Zhu, Hong-Jie, Xu, Te, Yan, Yong-Ming, Cheng, Yong-Xian

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.74 MB

2020

8

Design, synthesis, and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors

Wang, Guangcheng, Liu, Wenjing, Tang, Juan, Ma, Xue, Gong, Zipeng, Huang, Yong, Li, Yongjun, Peng, Zhiyun

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 4.76 MB

2020

9

Dimethylated acylphloroglucinol meroterpenoids with anti-oral-bacterial and anti-inflammatory activities from Hypericum elodeoides

Li, Qi-Ji, Tang, Peng-Fei, Zhou, Xin, Lu, Wei-Jia, Xu, Wen-Jun, Luo, Jun, Kong, Ling-Yi

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.76 MB

2020

10

Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis

Abdullah, Maryam Aisyah, Lee, Yu-Ri, Mastuki, Siti Nurulhuda, Leong, Sze Wei, Wan Ibrahim, Wan Norhamidah, Mohammad Latif, Muhammad Alif, Ramli, Aizi Nor Mazila, Mohd Aluwi, Mohd Fadhlizil Fasihi, Moh

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 5.60 MB

2020

11

Design, synthesis, antimicrobial activity and molecular docking studies of some novel di-substituted sulfonylquinoxaline derivatives

Ammar, Yousry A., Farag, Awatef A., Ali, Abeer M., Ragab, Ahmed, Askar, Ahmed A., Elsisi, Doaa M., Belal, Amany

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 4.15 MB

2020

12

Agallolides A-M, including two rearranged ent-atisanes featuring a bicyclo[3.2.1]octane motif, from the Chinese Excoecaria agallocha

Jiang, Zhong-Ping, Yu, Yi, Shen, Li

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 4.13 MB

2020

13

A trifunctional Pt(II) complex alleviates the NHEJ/HR-related DSBs repairs to evade cisplatin-resistance in NSCLC

Wang, Xing, Wang, Yuanjiang, Gou, Shaohua, Chen, Feihong

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 9.12 MB

2020

14

Novel cyclic thiourea derivatives of aminoalcohols at the presence of AlCl3 catalyst as potent Î±-glycosidase and Î±-amylase inhibitors: Synthesis, characterization, bioactivity investigation and molecular docking studies

Sujayev, Afsun, Taslimi, Parham, Garibov, Emin, Karaman, Muhammet, Mahdi Zangeneh, Mohammad

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 5.77 MB

2020

15

New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential

Shirinzadeh, Hanif, Neuhaus, Eddy, Ince Erguc, Elif, Tascioglu Aliyev, Alev, Gurer-Orhan, Hande, Suzen, Sibel

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 948 KB

2020

16

Synthesis, biological evaluation and computational studies of acrylohydrazide derivatives as potential Staphylococcus aureus NorA efflux pump inhibitors

Kumar, Gautam, Goutami Godavari, Ambati, Tambat, Rushikesh, Kumar, Siva, Nandanwar, Hemraj, Elizabeth Sobhia, M., Jachak, Sanjay M.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.26 MB

2020

17

Synthesis and biological study of class I selective HDAC inhibitors with NO releasing activity

Ding, Qin'ge, Liu, Chunxi, Zhao, Chunlong, Dong, Hang, Xu, Qifu, James Chou, C., Zhang, Yingjie

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1006 KB

2020

18

Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein

Ono, Yukari, Ninomiya, Masayuki, Kaneko, Daiki, Sonawane, Amol D., Udagawa, Taro, Tanaka, Kaori, Nishina, Atsuyoshi, Koketsu, Mamoru

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 7.72 MB

2020

19

Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers

Abbass, Eslam M., Khalil, Ali Kh., Mohamed, Mohamed M., Eissa, Ibrahim H., El-Naggar, Abeer M.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.40 MB

2020

20

Is oseltamivir suitable for fighting against COVID-19: In silico assessment, in vitro and retrospective study

Tan, Qi, Duan, Limin, Ma, YanLing, Wu, Feng, Huang, Qi, Mao, Kaimin, Xiao, Wenjing, Xia, Hui, Zhang, Shujing, Zhou, E., Ma, Pei, Song, Siwei, Li, YuMei, Zhao, Zilin, Sun, Yice, Li, Zeyu, Geng, Wei, Yi

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.88 MB

2020

21

Targeting EGFR tyrosine kinase: Synthesis, in vitro antitumor evaluation, and molecular modeling studies of benzothiazole-based derivatives

Mokhtar, Amal M., El-Messery, Shahenda M., Ghaly, Mariam A., Hassan, Ghada S.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 7.25 MB

2020

22

Enantiomeric 8-O-4â²-type neolignans from Crataegus pinnatifida exhibit cytotoxic effect via apoptosis and autophagy in Hep3B cells

Shang, Xin-Yue, Guo, Rui, Yu, Xiao-Qi, Lin, Bin, Huang, Xiao-Xiao, Yao, Guo-Dong, Song, Shao-Jiang

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.16 MB

2020

23

Novel enantiopure isoxazolidine and C-alkyl imine oxide derivatives as potential hypoglycemic agents: Design, synthesis, dual inhibitors of Î±-amylase and Î±-glucosidase, ADMET and molecular docking study

Ghannay, Siwar, Snoussi, Mejdi, Messaoudi, Sabri, Kadri, Adel, Aouadi, KaÃ¯ss

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.82 MB

2020

24

Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors

Thacker, Pavitra S., Sridhar Goud, Nerella, Argulwar, Omkar S., Soman, Jyothsna, Angeli, Andrea, Alvala, Mallika, Arifuddin, Mohammed, Supuran, Claudiu T.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 637 KB

2020

25

Synthesis, molecular modeling and antiviral activity of novel 5-fluoro-1H-indole-2,3-dione 3-thiosemicarbazones

SevinÃ§li, Zekiye Åeyma, Duran, Gizem Nur, Ãzbil, Mehmet, KaralÄ±, NilgÃ¼n

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 5.33 MB

2020

26

Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors

Eldin A. Osman, Essam, Hanafy, Noura S., George, Riham F., El-Moghazy, Samir M.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 4.73 MB

2020

27

The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway

Wu, Jing-Shuai, Meng, Qin-Yu, Shi, Xiao-Hui, Liu, Lu-Xin, Zhang, Zhen-Kun, Guan, Hua-Shi, Shao, Chang-Lun, Wang, Chang-Yun

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.72 MB

2020

28

New synthetic analogues of natural 5Z,9Z-dienoic acids: Stereoselective synthesis and study of the anticancer activity

Makarov, Alexey A., Dzhemileva, Lilya U., Salimova, Alfiya R., Makarova, Elina Kh., Ramazanov, Ilfir R., D'yakonov, Vladimir A., Dzhemilev, Usein M.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.07 MB

2020

29

Fluorescently-labelled amyloid paired helical filaments (PHF) in monitoring its fibrillation kinetics

Å midlehner, Tamara, Bonnet, Hugues, Chierici, Sabine, Piantanida, Ivo

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.16 MB

2020

30

Synthesis, in-vitro, in-vivo anti-inflammatory activities and molecular docking studies of acyl and salicylic acid hydrazide derivatives

Munir, Abida, Khushal, Adil, Saeed, Kiran, Sadiq, Abdul, Ullah, Rahim, Ali, Gowhar, Ashraf, Zaman, Ullah Mughal, Ehsan, Saeed Jan, Muhammad, Rashid, Umer, Hussain, Izhar, Mumtaz, Amara

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.15 MB

2020

31

Reductive domino reaction to access chromeno[2,3-c]isoquinoline-5-amines with antiproliferative activities against human tumor cells

Yue, Xiaoyi, Festa, Alexey A., Storozhenko, Olga A., Varlamov, Alexey V., Subramani, Karthikeyan, Boccarelli, Angelina, Purgatorio, Rosa, Altomare, Cosimo D., Voskressensky, Leonid G.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.78 MB

2020

32

68Ga-Labeled bismacrocyclic methylene phosphonate as potential bone seeking PET radiopharmaceutical

Chauhan, Kanchan, Mann, Garima, Jaswal, Ambika Parmar, Ojha, Himanshu, Mishra, Anil K., Datta, Anupama

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.49 MB

2020

33

Antimycobacterial activity of azepanobetulin and its derivative: In vitro, in vivo, ADMET and docking studies

Kazakova, Oxana, Lopatina, Tatyana, Giniyatullina, Gul'nara, Mioc, Marius, Soica, Codruta

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.07 MB

2020

34

Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents

El-Zahabi, Mohamed Ayman, Sakr, Helmy, El-Adl, Khaled., Zayed, Mohamed, Abdelraheem, Adel S., Eissa, Sally I., Elkady, Hazem, Eissa, Ibrahim H.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.41 MB

2020

35

Synthesis, biological evaluation and molecular docking studies of novel thiopyrimidine analogue as apoptotic agent with potential anticancer activity

Haffez, Hesham, Taha, Heba, Rabie, Maha A., Awad, Samir M., Zohny, Yasser M.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 5.88 MB

2020

36

(+)- and (â)-Corydecumbenines A and B, two pairs of novel quaternary protoberberine alkaloid cycloadduct enantiomers with anti-neuroinflammatory and neuroprotective activities from the rhizomes of Corydalis decumbens

Yin, Xu, Jia, Hongli, Zhang, Qingying, Jiang, Yong, Tu, Pengfei

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.99 MB

2020

37

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Grytsai, Oleksandr, Valiashko, Oksana, Penco-Campillo, Manon, Dufies, Maeva, Hagege, Anais, Demange, Luc, Martial, Sonia, PagÃ¨s, Gilles, Ronco, Cyril, Benhida, Rachid

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 935 KB

2020

38

P2X7 receptor inhibition by 2-amino-3-aryl-1,4-naphthoquinones

de Luna Martins, Daniela, Borges, Adriel Alves, e Silva, Nayane A. do A., Faria, Juliana Vieira, Hoelz, Lucas Villas BÃ´as, de Souza, Hellen ValÃ©rio Chaves Moura, Bello, Murilo Lamim, Boechat, Nubia,

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 4.12 MB

2020

39

Discovery, biological evaluation and docking studies of novel N-acyl-2-aminothiazoles fused (+)-nootkatone from Citrus paradisi Macf. as potential Î±-glucosidase inhibitors

Guo, Yong, Hou, Enhua, Ma, Nannan, Liu, Zhiyan, Fan, Jiangping, Yang, Ruige

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.32 MB

2020

40

Two resveratrol analogs, pinosylvin and 4,4â²-dihydroxystilbene, improve oligoasthenospermia in a mouse model by attenuating oxidative stress via the Nrf2-ARE pathway

Wang, Cheng-niu, Sang, Meng-meng, Gong, Sheng-nan, Yang, Jin-fei, Cheng, C. Yan, Sun, Fei

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 9.16 MB

2020

41

Antidiabetic and cytotoxic polyhydroxylated oleanane and ursane type triterpenoids from Salvia grossheimii

Zare, Somayeh, Mirkhani, Hossein, Firuzi, Omidreza, Moheimanian, Niloofar, Asadollahi, Mojtaba, Pirhadi, Somayeh, Chandran, Jima N., Schneider, Bernd, Jassbi, Amir Reza

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.28 MB

2020

42

Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera

MalanÃk, Milan, Treml, Jakub, LelÃ¡kovÃ¡, Veronika, NykodÃ½movÃ¡, Daniela, Oravec, Michal, Marek, JaromÃr, Å mejkal, Karel

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1000 KB

2020

43

Chlorotrimethylsilane promoted one-flask heterocyclic synthesis of 1,2,4-triazoles from nitrilimines: Modeling studies and bioactivity evaluation of LH-21 and Rimonabant analogues

Tsai, Shuo-En, Li, Sin-Min, Tseng, Ching-Chun, Chung, Cheng-Yen, Zeng, Yu-Hui, Chieh Lin, Chun, Fuh, Mao-Tsu, Yang, Li-Chan, Yang, Ya-Chen, Wong, Fung-Fuh

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.07 MB

2020

44

TCF3-activated FAM201A enhances cell proliferation and invasion via miR-186-5p/TNKS1BP1 axis in triple-negative breast cancer

Jia, Hongyao, Wu, Di, Zhang, Zhiru, Li, Sijie

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.92 MB

2020

45

Targeting pathogenic fungi, bacteria and fungal-bacterial biofilms by newly synthesized quaternary ammonium derivative of pyridoxine and terbinafine with dual action profile

Garipov, Marsel R., Sabirova, Alina E., Pavelyev, Roman S., Shtyrlin, Nikita V., Lisovskaya, Svetlana A., Bondar, Oksana V., Laikov, Aleksandr V., Romanova, Julia G., Bogachev, Mikhail I., Kayumov, Ai

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.00 MB

2020

46

Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-Î±, IL-6 and histopathological study

Labib, Madlen B., Fayez, Ahmed M., EL-Nahass, EL-Shaymaa, Awadallah, M., Halim, Peter A.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 12.02 MB

2020

47

Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: Synthesis and anticancer activity evaluation

BuÅakowska, Anita, SÅawiÅski, JarosÅaw, Siedlecka-Kroplewska, Kamila, StasiÅojÄ, Grzegorz, Serocki, Marcin, Heldt, Mateusz

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.33 MB

2020

48

Targeted isolation of cytotoxic germacranolide sesquiterpenes from Elephantopus scaber L. using small molecule accurate recognition technology

Bai, Ming, Zhang, Yang-Yang, Dong, Shu-Hui, Ren, Hui, Chen, Jing-Jie, Yao, Guo-Dong, Liu, Qing-Bo, Lin, Bin, Huang, Xiao-Xiao, Song, Shao-Jiang

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 5.47 MB

2020

49

Synthesis and biological evaluation of Î²-ionone oriented proapoptosis agents by enhancing the ROS generation

Yang, Jie, Mu, Wen-Wen, Cao, Yu-Xin, Liu, Guo-Yun

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.80 MB

2020

50

New insight of red seaweed derived Callophycin A as an alternative strategy to treat drug resistance vaginal candidiasis

Ganeshkumar, Arumugam, Suvaithenamudhan, Suvaiyarasan, Elanthamilan, Elaiyappillai, Arun, Ganesan, Bharathi Dileepan, Gowrisivam Anbusivam, Prabhusaran, Nagarajan, Rajaram, Rajendran

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.91 MB

2020

51

A perspective on potential target proteins of COVID-19: Comparison with SARS-CoV for designing new small molecules

Kumar, Devendra, Chauhan, Gaurav, Kalra, Sourav, Kumar, Bhupinder, Gill, Manjinder Singh

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 13.19 MB

2020

52

In vitro study and structure-activity relationship analysis of stilbenoid derivatives as powerful vasorelaxants: Discovery of new lead compound

Chan, Sock Ying, Loh, Yean Chun, Oo, Chuan Wei, Yam, Mun Fei

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.13 MB

2020

53

Drug-like biimidazole derivatives dually target c-MYC/BCL-2 G-quadruplexes and inhibit acute myeloid leukemia

Hu, Ming-Hao, Yu, Bing-Ying, Wang, Xiaodong, Jin, Guangyi

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.23 MB

2020

54

Novel oligomeric neolignans with PTP1B inhibitory activity from the bark of Magnolia officinalis var. biloba

Li, Chuan, Li, Chuang-Jun, Xu, Kai-Ling, Ma, Jie, Huang, Ji-Wu, Ye, Fei, Zang, Ying-Da, Zhang, Dong-Ming

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.65 MB

2020

55

Activity and specificity studies of the new thermostable esterase EstDZ2

Myrtollari, Kamela, Katsoulakis, Nikolaos, Zarafeta, Dimitra, Pavlidis, Ioannis V., Skretas, Georgios, Smonou, Ioulia

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.48 MB

2020

56

Preparation and assessment of a new radiotracer technetium-99m-6-hydrazinonicotinic acid-tyrosine as a targeting agent in tumor detecting through single photon emission tomography

Mogadam, Hemat Yaghoubi, Erfani, Mostafa, Nikpassand, Mohammad, Mokhtary, Masoud

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.77 MB

2020

57

Design, synthesis, and pharmacological evaluation of novel 1,2,4-triazol-3-amine derivatives as potential agonists of GABAA subtype receptors with anticonvulsant and hypnotic effects

Jahani, Reza, Reza Abtahi, Seyed, Nematpour, Manijeh, Fasihi Dastjerdi, Hossein, Chamanara, Mohsen, Hami, Zahra, Paknejad, Babak

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.90 MB

2020

58

Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes

Su, Hai-Guo, Wang, Qian, Zhou, Lin, Peng, Xing-Rong, Xiong, Wen-Yong, Qiu, Ming-Hua

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 9.26 MB

2020

59

Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors

Saleh, Nashwa M., El-Gaby, Mohamed S.A., ElâAdl, Khaled, Abd El-Sattar, Nour E.A.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 8.09 MB

2020

60

Design, synthesis and structure-activity relationship studies of novel partial FXR agonists for the treatment of fatty liver

Qiu, Qianqian, Wang, Wenling, Zhao, Xiaojuan, Chen, Yanli, Zhao, Shiyuan, Zhu, Jilan, Xu, Xiaojuan, Geng, Rongqing

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.24 MB

2020

61

Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa

Cai, You-Sheng, Cui, Wan-Xiang, Tang, Wei, Guo, Yue-Wei

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 914 KB

2020

62

Combination of DN604 with gemcitabine led to cell apoptosis and cell motility inhibition via p38 MAPK signaling pathway in NSCLC

Wang, Xinyi, Chen, Feihong, Gou, Shaohua

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.24 MB

2020

63

New cembrane-type diterpenoids from the South China Sea soft coral Sinularia crassa and their Î±-glucosidase inhibitory activity

Wu, Meng-Jun, Wang, Hong, Jiang, Cheng-Shi, Guo, Yue-Wei

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 866 KB

2020

64

Metabolites with phytopathogenic fungi inhibitory activities from the mangrove endophytic fungus Botryosphaeria ramose

Hu, Zhibo, Wu, Zhihui, Su, Qinhua, Li, Mingzhe, Wu, Shanshan, Meng, Rongqi, Ding, Weijia, Li, Chunyuan

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 936 KB

2020

65

New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study

Li, Sin-Min, Tsai, Shuo-En, Chiang, Chia-Yin, Chung, Cheng-Yen, Chuang, Tsung-Jui, Tseng, Ching-Chun, Jiang, Wen-Ping, Huang, Guan-Jhong, Lin, Chin-Yu, Yang, Ya-Chen, Fuh, Mao-Tsu, Wong, Fung-Fuh

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 10.94 MB

2020

66

Potent Î±-amylase inhibitors and radical (DPPH and ABTS) scavengers based on benzofuran-2-yl(phenyl)methanone derivatives: Syntheses, in vitro, kinetics, and in silico studies

Ali, Irfan, Rafique, Rafaila, Khan, Khalid Mohammed, Chigurupati, Sridevi, Ji, Xingyue, Wadood, Abdul, Rehman, Ashfaq Ur, Salar, Uzma, Iqbal, Muhammad Shahid, Taha, Muhammad, Perveen, Shahnaz, Ali, Ba

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.61 MB

2020

67

Design and synthesis of novel 4-thiazolidinone derivatives with promising anti-breast cancer activity: Synthesis, characterization, in vitro and in vivo results

Tahmasvand, Raheleh, Bayat, Peyman, Vahdaniparast, Seyyed Mahmood, Dehghani, Soudeh, Kooshafar, Zahra, Khaleghi, Sepideh, Almasirad, Ali, Salimi, Mona

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.57 MB

2020

68

Novel anti-tubercular and antibacterial based benzosuberone-thiazole moieties: Synthesis, molecular docking analysis, DNA gyrase supercoiling and ATPase activity

Omar, Mohamed A., Masaret, Ghada S., Abbas, Eman M.H., Abdel-Aziz, Marwa M., Harras, Marwa F., Farghaly, Thoraya A.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 4.07 MB

2020

69

Discovery of derivatives of 6(7)-amino-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: novel, hypoxia-selective HIF-1Î± inhibitors with strong antiestrogenic potency

Buravchenko, Galina I., Scherbakov, Alexander M., Dezhenkova, Lyubov G., Bykov, Evgeny E., Solovieva, Svetlana E., Korlukov, Alexander A., Sorokin, Danila V., Monzote Fidalgo, Lianet, Shchekotikhin, A

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.87 MB

2020

70

Synthesis of new riboflavin modified ODNs: Effect of riboflavin moiety on the G-quadruplex arrangement and stability

Romanucci, Valeria, Oliva, Rosario, Petraccone, Luigi, Claes, Sandra, Schols, Dominique, Zarrelli, Armando, Di Fabio, Giovanni

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.03 MB

2020

71

Antiproliferative abietane quinone diterpenoids from the roots of Salvia deserta

Zheng, Xiaofeng, Kadir, Abdukriem, Zheng, Guijuan, Jin, Pengfei, Qin, Dongmei, Maiwulanjiang, Maitinuer, Aisa, Haji Akber, Yao, Guangmin

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.20 MB

2020

72

Prenylated xanthones and benzophenones from the fruits of Garcinia bracteata and their potential antiproliferative and anti-inflammatory activities

Xue, Qing, Chen, Yu, Yin, Huijun, Teng, Haida, Qin, Rui, Liu, Hong, Li, Qingqing, Mei, Zhinan, Yang, Guangzhong

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.50 MB

2020

73

Cytochalasins from an endophytic fungus Phoma multirostrata XJ-2-1 with cell cycle arrest and TRAIL-resistance-overcoming activities

Peng, Xiaogang, He, Yangzhou, Gao, Ying, Duan, Fangfang, Chen, Juan, Ruan, Hanli

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.16 MB

2020

74

Inhibition of zika virus infection by fused tricyclic derivatives of 1,2,4,5-tetrahydroimidazo[1,5-a]quinolin-3(3aH)-one

Xu, Bin, Lee, Emily M., Medina, Angelica, Sun, Xia, Wang, Decai, Tang, Hengli, Zhou, Guo-Chun

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.36 MB

2020

75

Discovery of dihydro-Î²-agarofurans from Tripterygium wilfordii with their H2O2-induced SH-SY5Y cell protective effects

Zhou, Le, He, Qing-Jun, Hou, Zi-Lin, Lu, Li-Wei, Wang, Jie, Huang, Xiao-Xiao, Lin, Bin, Song, Shao-Jiang

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.82 MB

2020

76

Synthesis of N-phenylsulfonamide derivatives and investigation of some esterase enzymes inhibiting properties

Akin Kazancioglu, Elif, Senturk, Murat

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 655 KB

2020

77

Structure-activity relationship studies of prostate-specific membrane antigen (PSMA) inhibitors derived from Î±-amino acid with (S)- or (R)-configuration at P1â² region

Kwon, Hongmok, Lim, Hyunwoong, Ha, Hyunsoo, Choi, Doyoung, Son, Sang-Hyun, Nam, Hwanhee, Minn, Il, Byun, Youngjoo

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.93 MB

2020

78

Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates

Skwarecki, Andrzej S., Nowak, MichaÅ G., Milewska, Maria J.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.59 MB

2020

79

Design, synthesis and evaluation of diaryl Î³-dihydropyrone derivatives as cyclocurcumin mimetics and inhibitors of the aggregation of amyloid Î²

Hotsumi, Mayumi, Tajiri, Misato, Makabe, Koki, Konno, Hiroyuki

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.21 MB

2020

80

Enantiomeric chromene derivatives with anticancer effects from Mallotus apelta

Kiem, Phan Van, Nhiem, Nguyen Xuan, Anh, Nguyen Hoang, Yen, Duong Thi Hai, Cuong, Nguyen The, Tai, Bui Huu, Yen, Pham Hai, Nam, Nguyen Hoai, Minh, Chau Van, Chinh, Pham The, Jeon, Yu Hyun, Park, Seon

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.20 MB

2020

81

Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents

Anbar, Hanan S., El-Gamal, Randa, Ullah, Saif, Zaraei, Seyed-Omar, al-Rashida, Mariya, Zaib, Sumera, Pelletier, Julie, SÃ©vigny, Jean, Iqbal, Jamshed, El-Gamal, Mohammed I.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 4.16 MB

2020

82

Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition

Han, Yufei, Tian, Ye, Wang, Ruxin, Fu, Siyu, Jiang, Jia, Dong, Jiawen, Qin, Mingze, Hou, Yunlei, Zhao, Yanfang

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.74 MB

2020

83

Bioassay-guided isolation of cyclooxygenase-2 inhibitory and antioxidant phenylpropanoid derivatives from the roots of Dendropanax dentiger

Yang, Li, Liu, Shengzhang, Liu, Ronghua, He, Junwei

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 529 KB

2020

84

Geissoschizoline, a promising alkaloid for Alzheimerâs disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking

Lima, JosÃ©lia A., R. Costa, Thiago Wilson, da Fonseca, Anna C.C., do Amaral, Rackele F., Nascimento, Maria do Desterro S.B., Santos-Filho, Osvaldo A., de Miranda, Ana LuÃsa P., Ferreira Neto, Denise

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.56 MB

2020

85

Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo[1,5-a]pyrimidine derivatives as potential c-Met inhibitors

Luo, Guolin, Ma, Yanxia, Liang, Xintong, Xie, Guoquan, Luo, Yingqi, Zha, Dailong, Wang, Sheng, Yu, Lihong, Zheng, Xuehua, Wu, Wenhao, Zhang, Chao

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.47 MB

2020

86

Development of activity-based probes for the protein deacylase Sirt1

Goetz, Christopher J., Sprague, Daniel J., Smith, Brian C.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.48 MB

2020

87

Aminotriazines with indole motif as novel, 5-HT7 receptor ligands with atypical binding mode

KuÅaga, Damian, JaÅkowska, Jolanta, SataÅa, Grzegorz, Latacz, Gniewomir, Åliwa, PaweÅ

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 4.31 MB

2020

88

DNA binding studies of novel diazatruxenones analogs as potential anticancer agents: Synthesis, antitumor investigation, DNA binding, SAR and molecular modeling calculation

El Sayed, Mardia T., Shabaan, Sara N., Sarhan, Alaadin E., El-Messery, Shahenda M., El-Sayed, Selwan M., Hassan, Ghada S.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.86 MB

2020

89

PehuÃ©n (Araucaria araucana) seed residues are a valuable source of natural antioxidants with nutraceutical, chemoprotective and metal corrosion-inhibiting properties

Gallia, MarÃa C., Bachmeier, Evelin, Ferrari, Ana, Queralt, Ignasi, Mazzeo, Marcelo A., Bongiovanni, Guillermina A.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 5.13 MB

2020

90

Design, synthesis and biological evaluation of novel carbohydrate-based sulfonamide derivatives as antitumor agents

Hao, Shuang, Cheng, Xue, Wang, Xin, An, Ran, Xu, Hang, Guo, Mengbi, Li, Chuanchao, Wang, Yitong, Hou, Zhuang, Guo, Chun

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.08 MB

2020

91

Correlation study on methoxylation pattern of flavonoids and their heme-targeted antiplasmodial activity

Ortiz, Sergio, VÃ¡squez-OcmÃn, Pedro G., Cojean, Sandrine, Bouzidi, Chouaha, Michel, Sylvie, FigadÃ¨re, Bruno, Grougnet, RaphaÃ«l, Boutefnouchet, Sabrina, Maciuk, Alexandre

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 857 KB

2020

92

Evaluation and comparison of the commonly used bioassays of human indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO)

Zhang, Shengnan, Guo, Leilei, Yang, Dan, Xing, Zikang, Li, Weirui, Kuang, Chunxiang, Yang, Qing

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.77 MB

2020

93

Discovery and rational design of 2-aminopyrimidine-based derivatives targeting Janus kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3)

Li, Yingxiu, Wang, Peng, Chen, Cong, Ye, Tianyu, Han, Yufei, Hou, Yunlei, Liu, Yajing, Gong, Ping, Qin, Mingze, Zhao, Yanfang

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 6.73 MB

2020

94

Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation

Zhong, LinâFang, Shang, ZhiâChun, Sun, FuâJuan, Zhu, PanâHu, Yin, Yong, Kong, LingâYi, Yang, MingâHua

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 5.13 MB

2020

95

Design, synthesis and the structure-activity relationship of agonists targeting on the ALDH2 catalytic tunnel

Cheng, Ming-Che, Lo, Wei-Chi, Chang, Yu-Wen, Lee, Shoei-Sheng, Chang, Chia-Chuan

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 5.07 MB

2020

96

Core modified 8â17 DNAzymes with 2â²-deoxy-2â²-C-methylpyrimidine nucleosides

Dellafiore, MarÃa, Montserrat, Javier M., Iribarren, Adolfo M.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 707 KB

2020

97

Study on enhanced serum protein protecting and anti-cathepsin activities of various curcumin formulations containing traditional excipients and bio-enhancers

Raghav, Neera, Mor, Nitika

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.97 MB

2020

98

Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors

Abdel-Halim, Mohammad, Tinsley, Heather, Keeton, Adam B., Weam, Mohammed, Atta, Noha H., Hammam, Mennatallah A., Hefnawy, Amr, Hartmann, Rolf W., Engel, Matthias, Piazza, Gary A., Abadi, Ashraf H.

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 921 KB

2020

99

Syntheses and evaluation of daphnetin derivatives as novel G protein-coupled receptor inhibitors and activators

Wang, Yinan, Wang, Jiangming, Fu, Zhe, Sheng, Ruilong, Wu, Wenhui, Fan, Junting, Guo, Ruihua

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 859 KB

2020

100

Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis

El-Azab, Adel S., Abdel-Aziz, Alaa A.-M., AlSaif, Nawaf A., Alkahtani, Hamad M., Alanazi, Mohammed M., Obaidullah, Ahmad J., Eskandrani, Razan O., Alharbi, Amal

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.12 MB

2020

101

Design, synthesis and biological evaluation of novel plumbagin derivatives as potent antitumor agents with STAT3 inhibition

Li, Na, Ou, Jinfeng, Bao, Na, Chen, Cheng, Shi, Zhixian, Chen, Li, Sun, Jianbo

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 5.14 MB

2020

102

Discovery of novel artemisinin-sulfonamide hybrids as potential carbonic anhydrase IX inhibitors with improved antiproliferative activities

An, Ran, Lin, Bin, Zhao, Shuang, Cao, Chun, Wang, Yuanxin, Cheng, Xue, Liu, Yichuang, Guo, Mengbi, Xu, Hang, Wang, Yitong, Hou, Zhuang, Guo, Chun

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.45 MB

2020

103

Editorial Board

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 34 KB

2020

104

Issue TOC

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 4.32 MB

2020

105

Synthesis, physicochemical properties and biological activities of novel alkylphosphocholines with foscarnet moiety

Timko, LukÃ¡Å¡, PisÃ¡rÄik, Martin, Mrva, Martin, GarajovÃ¡, MÃ¡ria, JuhÃ¡sovÃ¡, Anna, MojÅ¾iÅ¡, JÃ¡n, MojÅ¾iÅ¡ovÃ¡, Gabriela, BukovskÃ½, MariÃ¡n, DevÃnsky, Ferdinand, LukÃ¡Ä, MiloÅ¡

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 961 KB

2020

106

Î²,Î³-Diaryl Î±-methylene-Î³-butyrolactones as potent antibacterials against methicillin-resistant Staphylococcus aureus

Hamann, Henry J., Abutaleb, Nader S., Pal, Rusha, Seleem, Mohamed N., Ramachandran, P. Veeraraghavan

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 509 KB

2020

107

Some thiocarbamoyl based novel anticathepsin agents

Kaur, Ravinder, Raghav, Neera

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 104 KB

2020

108

Discovery of a cobalt (III) salen complex that induces apoptosis in Burkitt like lymphoma and leukemia cells, overcoming multidrug resistance in vitro

Hopff, Sina M., Onambele, Liliane A., Brandenburg, Marc, Berkessel, Albrecht, Prokop, Aram

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 39 KB

2020

109

Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity

Cincinelli, Raffaella, Musso, Loana, Guglielmi, Mario B., La Porta, Ilaria, Fucci, Alessandra, Luca D'Andrea, Egildo, Cardile, Francesco, Colelli, Fabiana, Signorino, Giacomo, Darwiche, Nadine, Gervas

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 245 KB

2020

110

Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors

Al-Wahaibi, Lamya H., Gouda, Ahmed M., Abou-Ghadir, Ola F., Salem, Ola I.A., Ali, Asmaa T., Farghaly, Hatem S., Abdelrahman, Mostafa H., Trembleau, Laurent, Abdu-Allah, Hajjaj H.M., Youssif, Bahaa G.M

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 2.67 MB

2020

111

Bioactive sesquiterpene coumarins from the resin of Ferula sinkiangensis targeted on over-activation of microglia

Guo, Tingting, Zhou, Di, Yang, Yanqiu, Zhang, Xueni, Chen, Gang, Lin, Bin, Sun, Yu, Ni, Hui, Liu, Jingyu, Hou, Yue, Li, Ning

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 34 KB

2020

112

Fungal mediated biotransformation of melengestrol acetate, and T-cell proliferation inhibitory activity of biotransformed compounds

Javed, Saira, Atia-tul-Wahab,, Jabeen, Almas, Zhumagaliyeva, Shynar, Abilov, Zharylkasyn A., Atta-ur-Rahman,, Choudhary, M. Iqbal

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.06 MB

2020

113

(2R)- and (2S)- 2-hydroxy- hexanoyl and octanoyl-l-homoserine lactones: New highly potent Quorum Sensing modulators with opposite activities

Zhang, Qiang, Jeanneau, Erwann, Queneau, Yves, SoulÃ¨re, Laurent

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 551 KB

2020

114

Unusual terpenoids from the fruits of Evodia rutaecarpa and their activation on the farnesoid X receptor

Zhang, Ming, He, Xin, Luan, Zhilin, Ning, Jing, Tian, Xiangge, Yu, Zhenlong, Feng, Lei, Li, Dawei, Wang, Chao, Ma, Xiaochi

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 1.04 MB

2020

115

Characterization of a novel thermostable glucose-tolerant GH1 Î²-glucosidase from the hyperthermophile Ignisphaera aggregans and its application in the efficient production of baohuoside I from icariin and total epimedium flavonoids

Xie, Jingcong, Xu, Hao, Jiang, Jianchun, Zhang, Ning, Yang, Jing, Zhao, Jian, Wei, Min

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 4.35 MB

2020

116

Cadinane- and drimane-type sesquiterpenoids produced by Paecilomyces sp. TE-540, an endophyte from Nicotiana tabacum L., are acetylcholinesterase inhibitors

Xu, Kuo, Zhou, Qi, Li, Xiu-Qi, Luo, Tian, Yuan, Xiao-Long, Zhang, Zhong-Feng, Zhang, Peng

Journal:

Bioorganic Chemistry

Year:

2020

File:

PDF, 3.02 MB

2020

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