Volume 8; Issue 5

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EMBO Molecular Medicine
Volume 8; Issue 5

EMBO Molecular Medicine

Volume 8; Issue 5

1

CRISPR/Cas9‐mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse

Guan, Yuting, Ma, Yanlin, Li, Qi, Sun, Zhenliang, Ma, Lie, Wu, Lijuan, Wang, Liren, Zeng, Li, Shao, Yanjiao, Chen, Yuting, Ma, Ning, Lu, Wenqing, Hu, Kewen, Han, Honghui, Yu, Yanhong, Huang, Yuanhua,

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 1.98 MB

english, 2016

2

Successful correction of hemophilia by CRISPR/Cas9 genome editing in vivo : delivery vector and immune responses are the key to success

Nguyen, Tuan Huy, Anegon, Ignacio

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 148 KB

english, 2016

3

MET inhibition overcomes radiation resistance of glioblastoma stem‐like cells

De Bacco, Francesca, D'Ambrosio, Antonio, Casanova, Elena, Orzan, Francesca, Neggia, Roberta, Albano, Raffaella, Verginelli, Federica, Cominelli, Manuela, Poliani, Pietro L, Luraghi, Paolo, Reato, Gig

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 2.65 MB

english, 2016

4

CSF sTREM2: marking the tipping point between preclinical AD and dementia?

Schindler, Suzanne E, Holtzman, David M

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 236 KB

english, 2016

5

Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients

Gruosso, Tina, Mieulet, Virginie, Cardon, Melissa, Bourachot, Brigitte, Kieffer, Yann, Devun, Flavien, Dubois, Thierry, Dutreix, Marie, Vincent‐Salomon, Anne, Miller, Kyle Malcolm, Mechta‐Grigoriou, F

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 3.36 MB

english, 2016

6

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

Suárez‐Calvet, Marc, Kleinberger, Gernot, Araque Caballero, Miguel Ángel, Brendel, Matthias, Rominger, Axel, Alcolea, Daniel, Fortea, Juan, Lleó, Alberto, Blesa, Rafael, Gispert, Juan Domingo, Sánchez

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 532 KB

english, 2016

7

The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations

Diederichs, Sven, Bartsch, Lorenz, Berkmann, Julia C, Fröse, Karin, Heitmann, Jana, Hoppe, Caroline, Iggena, Deetje, Jazmati, Danny, Karschnia, Philipp, Linsenmeier, Miriam, Maulhardt, Thomas, Möhrman

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 739 KB

english, 2016

8

Pervasive supply of therapeutic lysosomal enzymes in the CNS of normal and Krabbe‐affected non‐human primates by intracerebral lentiviral gene therapy

Meneghini, Vasco, Lattanzi, Annalisa, Tiradani, Luigi, Bravo, Gabriele, Morena, Francesco, Sanvito, Francesca, Calabria, Andrea, Bringas, John, Fisher‐Perkins, Jeanne M, Dufour, Jason P, Baker, Kate C

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 3.87 MB

english, 2016

9

The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ‐dependent inhibition of the AKT pathway

Assad Kahn, Suzana, Costa, Silvia Lima, Gholamin, Sharareh, Nitta, Ryan T, Dubois, Luiz Gustavo, Fève, Marie, Zeniou, Maria, Coelho, Paulo Lucas Cerqueira, El‐Habr, Elias, Cadusseau, Josette, Varlet,

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 1.66 MB

english, 2016

10

The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α

Tosatto, Anna, Sommaggio, Roberta, Kummerow, Carsten, Bentham, Robert B, Blacker, Thomas S, Berecz, Tunde, Duchen, Michael R, Rosato, Antonio, Bogeski, Ivan, Szabadkai, Gyorgy, Rizzuto, Rosario, Mammu

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 2.43 MB

english, 2016

11

Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease

Kretner, Benedikt, Trambauer, Johannes, Fukumori, Akio, Mielke, Janina, Kuhn, Peer‐Hendrik, Kremmer, Elisabeth, Giese, Armin, Lichtenthaler, Stefan F, Haass, Christian, Arzberger, Thomas, Steiner, Har

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 1.27 MB

english, 2016