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1

Current and future alternative therapies for beta-thalassemia major

de Dreuzy, Edouard, Bhukhai, Kanit, Leboulch, Philippe, Payen, Emmanuel

Journal:

Biomedical Journal

Year:

2016

Language:

english

File:

PDF, 1.05 MB

english, 2016

2

Hemoglobin disorders: lentiviral gene therapy in the starting blocks to enter clinical practice

Sii-Felice, Karine, Giorgi, Marie, Leboulch, Philippe, Payen, Emmanuel

Journal:

Experimental Hematology

Year:

2018

Language:

english

File:

PDF, 1.27 MB

english, 2018

3

A new method (GOREC) for directed mutagenesis and gene repair by homologous recombination

Maurisse, R, Feugeas, J-P, Biet, E, Kuzniak, I, Leboulch, P, Dutreix, M, Sun, J-S

Journal:

Year:

2002

Language:

english

File:

PDF, 144 KB

english, 2002

4

Characterization and receptor specific toxicity of two diphtheria toxin-related interleukin-3 fusion proteins DAB389–mIL-3 and DAB389–(Gly4Ser)2-mIL-3

Dominique Liger, Johanna C vanderSpek, Carole Gaillard, Christophe Cansier, John R Murphy, Philippe Leboulch, Daniel Gillet

Journal:

Year:

1997

Language:

english

File:

PDF, 549 KB

english, 1997

5

Isolation and characterization of the gene encoding the muscle-specific isozyme of human phosphoglycerate mutase

Castella-Escola, Judit, Ojcius, David M., LeBoulch, Philippe, Joulin, Virginie, Blouquit, Yves, Garel, Marie-Claude, Valentin, Colette, Rosa, Raymonde, Climent-Romeo, Fernando, Cohen-Solal, Michel

Journal:

Year:

1990

Language:

english

File:

PDF, 925 KB

english, 1990

6

Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: Analysis of the ability to support expansion of cord blood hematopoietic progenitor cells

Nishioka, Keisuke, Fujimori, Yoshihiro, Hashimoto-Tamaoki, Tomoko, Kai, Shunro, Qiu, Huiying, Kobayashi, Naoya, Tanaka, Noriaki, Westerman, Karen, Leboulch, Philippe, Hara, Hiroshi

Journal:

International Journal of Oncology

Year:

2003

Language:

english

File:

PDF, 2.47 MB

english, 2003

7

TREATMENT OF ACUTE LIVER FAILURE WITH TRANSPLANTATION OF REVERSIBLY IMMORTALIZED HUMAN HEPATOCYTES.

Kobayashi, N., Noguchi, H., Westerman, Karen A., Fujiwara, T., Tanaka, N., Leboulch, Phillipe

Journal:

Transplantation Journal

Year:

2000

File:

PDF, 908 KB

2000

8

Safety Following Autologous Transplantation with Lentiglobin Gene Therapy for Transfusion-Dependent β-Thalassemia (TDT) in the Northstar Hgb-204 Study

Walters, Mark C., Kwiatkowski, Janet L., Rasko, John E.J., Hongeng, Suradej, Schiller, Gary J., Anurathapan, Usanarat, Cavazzana, Marina, Ho, Phoebe Joy, von Kalle, Christof, Kletzel, Morris, Leboulch

Journal:

Biology of Blood and Marrow Transplantation

Year:

2018

Language:

english

File:

PDF, 85 KB

english, 2018

9

2D simulation of hydride blister cracking during a RIA transient with the fuel code ALCYONE

Sercombe, JÃ©rÃ´me, Helfer, Thomas, Federici, Eric, Leboulch, David, Le Jolu, Thomas, Hellouin de MÃ©nibus, Arthur, Bernaudat, Christian

Journal:

EPJ Nuclear Sciences & Technologies

Year:

2016

File:

PDF, 4.72 MB

2016

10

Outcomes of Gene Therapy for Severe Sickle Cell Disease (SCD) via Transplantation of Autologous Hematopoietic Stem Cells Transduced Ex Vivo with a Lentiviral ßAT87Q-Globin Vector

Soni, Sandeep, Tisdale, John F., Hsieh, Matthew, Kanter, Julie, Leboulch, Philippe, Cavazzana, Marina

Journal:

Biology of Blood and Marrow Transplantation

Year:

2016

Language:

english

File:

PDF, 49 KB

english, 2016

11

Tolerance by Selective In Vivo Expansion of Foreign Major Histocompatibility Complex-Transduced Autologous Bone Marrow1

Zhang, Jia Lin, Cai, Jin, Walls, Shannon, Jackson, John D., Kuszynski, Charles A., Zhao, Yong, Pawliuk, Robert, Leboulch, Philippe, Fox, Ira J.

Journal:

Transplantation Journal

Year:

2005

Language:

english

File:

PDF, 864 KB

english, 2005

12

Phenotypic and Functional Changes Induced in Hematopoietic Stem/Progenitor Cells After Gamma-Ray Radiation Exposure

Arthur J. Simonnet, Johnny Nehmé, Pierre Vaigot, Vilma Barroca, Philippe Leboulch, Diana Tronik-Le Roux

Journal:

Year:

2009

Language:

english

File:

PDF, 535 KB

english, 2009

13

Study design of the first phase I/II clinical trial of lentivirus-mediated gene therapy of the β-hemoglobinopathies and future strategies for selection of transduced cells

Philippe Leboulch

Journal:

Blood Cells, Molecules, and Diseases

Year:

2007

Language:

english

File:

PDF, 67 KB

english, 2007

14

Gene therapy: Primed for take-off

Leboulch, Philippe

Journal:

Year:

2013

Language:

english

File:

PDF, 448 KB

english, 2013

15

IMPROVEMENT IN DIFFERENTIATED HEPATIC PHENOTYPE OF IMMORTALIZED HEPATOCYTES BY ADENOVIRUS-MEDIATED P21 GENE TRANSFER

Kobayashi, N., Noguchi, H., Totsugawa, T., Watanabe, T., Matsumura, T., Fujiwara, T., Tanaka, N., Westerman, K. A., Leboulch, P.

Journal:

Year:

2001

Language:

english

File:

PDF, 2.18 MB

english, 2001

16

High-Efficiency Transduction of Primary Human Hematopoietic Stem/Progenitor Cells by AAV6 Vectors: Strategies for Overcoming Donor-Variation and Implications in Genome Editing

Ling, Chen, Bhukhai, Kanit, Yin, Zifei, Tan, Mengqun, Yoder, Mervin C., Leboulch, Philippe, Payen, Emmanuel, Srivastava, Arun

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.24 MB

english, 2016

17

In vitroandin vivogene delivery using a lentiviral vector

E Gouze-Decaris, R Pawliuk, C Pilapil, P Leboulch, CH Evans, SC Ghivizzani

Journal:

Arthritis Research & Therapy

Year:

2001

Language:

english

File:

PDF, 217 KB

english, 2001

18

Efficient Cre/loxP Site-Specific Recombination in a HepG2 Human Liver Cell Line

Kobayashi, Naoya, Noguchi, Hirofumi, Westerman, Karen A., Matsumura, Toshihisa, Watanabe, Takamasa, Totsugawa, Toshinori, Fujiwara, Toshiyoshi, Leboulch, Philippe, Tanaka, Noriaki

Journal:

Cell Transplantation

Year:

2000

Language:

english

File:

PDF, 3.10 MB

english, 2000

19

Stem Cell Factor-Displaying Simian Immunodeficiency Viral Vectors Together with a Low Conditioning Regimen Allow for Long-Term Engraftment of Gene-Marked Autologous Hematopoietic Stem Cells in Macaques

Verhoeyen, Els, Relouzat, Francis, Cambot, Marie, Costa, Caroline, Nègre, Didier, Legrand, Faézeh, Joubert, Christophe, Grand, Roger Le, Cosset, François-Loïc, Leboulch, Philippe, Dubart-Kupperschmitt

Journal:

Human Gene Therapy

Year:

2012

Language:

english

File:

PDF, 945 KB

english, 2012

20

BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7

Olivier Goupille, Tipparat Penglong, Carine Lefèvre, Marine Granger, Zahra Kadri, Suthat Fucharoen, Leila Maouche-Chrétien, Philippe Leboulch, Stany Chrétien

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 568 KB

english, 2012

21

Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta -globin in engrafted mice

Kalberer, C. P., Pawliuk, R., Imren, S., Bachelot, T., Takekoshi, K. J., Fabry, M., Eaves, C. J., London, I. M., Humphries, R. K., Leboulch, P.

Journal:

Proceedings of the National Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 142 KB

english, 2000

22

Expression of an anti-sickling β-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells

Il-Hoan Oh, Mary E Fabry, R.Keith Humphries, Robert Pawliuk, Philippe Leboulch, Ronald Hoffman, Ronald L Nagel, Connie Eaves

Journal:

Experimental Hematology

Year:

2004

Language:

english

File:

PDF, 423 KB

english, 2004

23

EXPANSION OF PRIMARY HUMAN HEPATOCYTE POPULATIONS BY RETROVIRAL GENE TRANSFER AND ADENOVIRUS-MEDIATED CRELOXP SITE-SPECIFIC RECOMBINATION

Kobayashi, N., Noguchi, H., Fujiwara, T., Tanaka, N., Westerman, K. A., Leboulch, P.

Journal:

Year:

2000

Language:

english

File:

PDF, 1.28 MB

english, 2000

24

TIGHTLY REGULATED HUMAN HEPATOCYTES AS A SOURCE OF A BIOARTIFICIAL LIVER

Kobayashi, N., Noguchi, H., Totsugawa, T., Watanabe, T., Matsumura, T., Fujiwara, T., Tanaka, N., Westerman, K. A., Leboulch, P.

Journal:

Year:

2001

Language:

english

File:

PDF, 2.19 MB

english, 2001

25

Clinical outcomes of lentiviral gene therapy for the beta-hemogolobinpathies

Leboulch, Philippe

Journal:

Experimental Hematology

Year:

2017

Language:

english

File:

PDF, 119 KB

english, 2017

26

Proton irradiation effect on microstructure, strain localization and iodine-induced stress corrosion cracking in Zircaloy-4

L. Fournier, A. Serres, Q. Auzoux, D. Leboulch, G.S. Was

Journal:

Journal of Nuclear Materials

Year:

2009

Language:

english

File:

PDF, 962 KB

english, 2009

27

Repopulation of Athymic Mouse Liver by Cryopreserved Early Human Fetal Hepatoblasts

Mahieu-Caputo, Dominique, Allain, Jean-Etienne, Branger, Julie, Coulomb, Aurore, Delgado, Jean-Paul, Andreoletti, Marion, Mainot, Sylvie, Frydman, René, Leboulch, Philippe, Di Santo, James P., Capron,

Journal:

Human Gene Therapy

Year:

2004

Language:

english

File:

PDF, 356 KB

english, 2004

28

Glycoprotein 170 Induces Platelet-Activating Factor Receptor Membrane Expression and Confers Tumor Cell Hypersensitivity to NK-Dependent Cell Lysis

Geromin, D., Bourge, J.-F., Soulie, A., Pawliuk, R., Fleet, C., Michel, E., Denizot, Y., Berthou, C., Leboulch, P., Sigaux, F., Sasportes, M.

Journal:

The Journal of Immunology

Year:

2004

Language:

english

File:

PDF, 686 KB

english, 2004

29

CONSTRUCTION OF AN IMMORTALIZED LIVER SINUSOIDAL ENDOTHELIAL CELL LINE FOR LIVER-TARGETED TISSUE ENGINEERING

Matsumura, T., Kobayashi, N., Noguchi, H., Totsugawa, T., Watanabe, T., Fujiwara, T., Tanaka, N., Hikida, M., Ohmori, A., Westerman, K. A., Leboulch, P.

Journal:

Year:

2001

Language:

english

File:

PDF, 2.19 MB

english, 2001

30

Cre/loxP-Based Reversible Immortalization of Human Hepatocytes

Kobayashi, Naoya, Noguchi, Hirofumi, Westerman, Karen A., Watanabe, Takamasa, Matsumura, Toshihisa, Totsugawa, Toshinori, Fujiwara, Toshiyoshi, Leboulch, Philippe, Tanaka, Noriaki

Journal:

Cell Transplantation

Year:

2001

File:

PDF, 123 KB

2001

31

Efficient site-directed dna integration into es and hematopoietic cells

S. Faulkes, P. Leboulch, C. Helgason, R.K. Humphries

Journal:

Experimental Hematology

Year:

2000

Language:

english

File:

PDF, 21 KB

english, 2000

32

1085 Bioartificial liver therapy in monkeys using revesibly immortalized human hepatocytes

KOBAYASHI, N, NAKAJI, S, KODAMA, M, LEBOULCH, P, TANAKA, N

Journal:

Year:

2003

Language:

english

File:

PDF, 154 KB

english, 2003

33

Expansion of Human Hepatocyte Populations by a Retroviral Gene Transfer of Simian Virus 40 Large T Antigen

Kobayashi, Naoya, Westerman, Karen A., Taguchi, Takehito, Sakaguchi, Masakiyo, Fujiwara, Toshiyoshi, Urata, Haruo, Kishimoto, Noboru, Hayashi, Nobuyuki, Nakaji, Shuhei, Murakami, Takuro, Leboulch, Phi

Journal:

Year:

2001

Language:

english

File:

PDF, 368 KB

english, 2001

34

Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT

Maruyama, Masanobu, Kobayashi, Naoya, Westerman, Karen A., Sakaguchi, Masakiyo, Allain, Jean E., Totsugawa, Toshinori, Okitsu, Teru, Fukazawa, Takuya, Weber, Anne, Stolz, Donna B., Leboulch, Philippe,

Journal:

Transplantation Journal

Year:

2004

Language:

english

File:

PDF, 925 KB

english, 2004

35

Locus control region activity by 5â²HS3 requires a functional interaction with Î²-globin gene regulatory elements: expression of novel Î²/Î³-globin hybrid transgenes

Rubin, Joel E., Pasceri, Peter, Wu, Xiumei, Leboulch, Philippe, Ellis, James

Journal:

Year:

2000

File:

PDF, 279 KB

2000

36

The effect of iodine content and specimen orientation on stress corrosion crack growth rate in Zircaloy-4

A. Serres, L. Fournier, M. Frégonèse, Q. Auzoux, D. Leboulch

Journal:

Corrosion Science

Year:

2010

Language:

english

File:

PDF, 1.43 MB

english, 2010

37

Placenta Growth Factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers

Anna Eriksson, Renhai Cao, Robert Pawliuk, Sanna-Maria Berg, Monica Tsang, Danielle Zhou, Christina Fleet, Katerina Tritsaris, Steen Dissing, Philippe Leboulch, Yihai Cao

Journal:

Year:

2002

Language:

english

File:

PDF, 665 KB

english, 2002

38

260 Treatment of acute liver failure in the pig with transplantation of reversibly immortalized human hepatocytes

Naoya Kobayashi, Toshinori Totsugawa, Noriaki Tanaka, Philippe Leboulch

Journal:

Year:

2003

Language:

english

File:

PDF, 145 KB

english, 2003

39

Phosphatidylinositol 3-Kinase/Akt Induced by Erythropoietin Renders the Erythroid Differentiation Factor GATA-1 Competent for TIMP-1 Gene Transactivation

Kadri, Z., Maouche-Chretien, L., Rooke, H. M., Orkin, S. H., Romeo, P.-H., Mayeux, P., Leboulch, P., Chretien, S.

Journal:

Molecular and Cellular Biology

Year:

2005

Language:

english

File:

PDF, 483 KB

english, 2005

40

Inhibition of the acetyl lysine-binding pocket of bromodomain and extraterminal domain proteins interferes with adipogenesis

Goupille, Olivier, Penglong, Tipparat, Kadri, Zahra, Granger-Locatelli, Marine, Fucharoen, Suthat, Maouche-Chrétien, Leila, Prost, Stéphane, Leboulch, Philippe, Chrétien, Stany

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 2.37 MB

english, 2016

41

Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen

Jin Cai, Masahiro Ito, Karen A Westerman, Naoya Kobayashi, Philippe Leboulch, Ira J Fox

Journal:

Journal of Hepatology

Year:

2000

Language:

english

File:

PDF, 1.11 MB

english, 2000

42

Design of atransprotease lentiviral packaging system that produces high titer virus

Karen A Westerman, Zhujun Ao, Éric A Cohen, Philippe Leboulch

Journal:

Year:

2007

Language:

english

File:

PDF, 918 KB

english, 2007

43

A method to sequence and quantify DNA integration for monitoring outcome in gene therapy

Brady, T., Roth, S. L., Malani, N., Wang, G. P., Berry, C. C., Leboulch, P., Hacein-Bey-Abina, S., Cavazzana-Calvo, M., Papapetrou, E. P., Sadelain, M., Savilahti, H., Bushman, F. D.

Journal:

Nucleic Acids Research

Year:

2011

Language:

english

File:

PDF, 793 KB

english, 2011

44

Skin Ferrochelatase Levels and Photosensitivity

Leboulche, Philippe, Mathews-Roth, Micheline

Journal:

The Journal of Investigative Dermatology

Year:

2005

Language:

english

File:

PDF, 51 KB

english, 2005

45

Transcriptional Behavior of LCR Enhancer Elements Integrated at the Same Chromosomal Locus by Recombinase-Mediated Cassette Exchange

Bouhassira, Eric E., Westerman, Karen, Leboulch, Philippe

Journal:

Year:

1997

File:

PDF, 1.02 MB

1997

46

Activation and inhibition of the erythropoietin receptor by a membrane-anchored erythropoietin

Olivier Negre, Floriane Fusil, Annie Henri, Jean-Marie Villette, Philippe Leboulch, Yves Beuzard, Emmanuel Payen

Journal:

Experimental Hematology

Year:

2008

Language:

english

File:

PDF, 978 KB

english, 2008

47

Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β A(T87Q) - Globin Gene

Negre, Olivier, Eggimann, Anne-Virginie, Beuzard, Yves, Ribeil, Jean-Antoine, Bourget, Philippe, Borwornpinyo, Suparerk, Hongeng, Suradej, Hacein-Bey, Salima, Cavazzana, Marina, Leboulch, Philippe, Pa

Journal:

Human Gene Therapy

Year:

2016

Language:

english

File:

PDF, 630 KB

english, 2016

48

hTERT-TRANSDUCED HUMAN HEPATOCYTES AS A SOURCE OF A BIOARTIFICIAL LIVER

Totsugawa, T., Kobayashi, N., Noguchi, H., Watanabe, T., Matsumura, T., Fujiwara, T., Tanaka, N., Hikida, M., Ohmori, A., Westerman, K. A., Leboulch, P.

Journal:

Year:

2001

Language:

english

File:

PDF, 2.19 MB

english, 2001

49

Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables

Burkhard Hennemann, Eibhlin Conneally, Robert Pawliuk, Philippe Leboulch, Stefan Rose-John, Dianne Reid, Jean Y Chuo, R.Keith Humphries, Connie J Eaves

Journal:

Experimental Hematology

Year:

1999

Language:

english

File:

PDF, 318 KB

english, 1999

50

eGFP reporter genes silence LCR?-globin transgene expression via CpG dinucleotides

DALLE, B, RUBIN, J, ALKAN, O, SUKONNIK, T, PASCERI, P, YAO, S, PAWLIUK, R, LEBOULCH, P, ELLIS, J

Journal:

Molecular Therapy

Year:

2005

Language:

english

File:

PDF, 662 KB

english, 2005

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